TH8968A - Peptides with renin-inhibiting agility Preparation and benefits of these substances - Google Patents
Peptides with renin-inhibiting agility Preparation and benefits of these substancesInfo
- Publication number
- TH8968A TH8968A TH9001000211A TH9001000211A TH8968A TH 8968 A TH8968 A TH 8968A TH 9001000211 A TH9001000211 A TH 9001000211A TH 9001000211 A TH9001000211 A TH 9001000211A TH 8968 A TH8968 A TH 8968A
- Authority
- TH
- Thailand
- Prior art keywords
- substances
- alkyl
- renin
- group
- agility
- Prior art date
Links
- 239000000126 substance Substances 0.000 title claims abstract 6
- 102100028255 Renin Human genes 0.000 title 1
- 108090000783 Renin Proteins 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 3
- 239000003814 drug Substances 0.000 claims abstract 2
- 229940079593 drug Drugs 0.000 claims abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 208000012866 low blood pressure Diseases 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- HTYIXCKSEQQCJO-UHFFFAOYSA-N phenaglycodol Chemical compound CC(C)(O)C(C)(O)C1=CC=C(Cl)C=C1 HTYIXCKSEQQCJO-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 230000036454 renin-angiotensin system Effects 0.000 abstract 1
- 230000000452 restraining effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Abstract
สารประกอบต่างๆของสูตร (I) (สูตรเคมี) ซึ่ง R1 คือหมู่เฮเทโรไซคลิคที่มี 5 หรือ 6 อะตอม หรือ -NR7 R8 ซึ่ง R7 คือ แอลดีล และ R8 คือออพซันนัลลี สับสทิทิวเทคเฟนิล, ออพซันนัลลี สับสทิทิวเทคเฟนิล แอลคิลหรือไซโคลแอลคิล; R2 คือออพซันนัลลี สับสทิทิวเทคเฟนิลหรือแนฟธิล; R3 คือไธเอโซ ลิล; R4 คือไซโคลเฮกซิล หรือ ไอโซโพรพิล; R5 คือแอลคิล; และ R6 คือแอลคิล] และเกลือต่างๆของสารเหล่านี้ มีความยับ ยั้งเรมินและดังนั้นจึงมีความว่องไวในการทำให้ความดันโลหิต ต่ำ และมีค่าในการตรวจวินิจฉัยและรักษาความดันโลหิตสูงที่ เกิดจากความล้มเหลวในระบบเรนิน-แองจิโอเทนซิน สารประกอบ เหล่านี้อาจจะเตรียมขึ้นได้ โดยการทำปฏิกิริยากันของกรดอะมิโนต่างๆหรืออนุพันธ์ต่างๆ ของสารเหล่านี้ที่เหมาะสม : สิทธิบัตรยา Compounds of formula (I) (chemical formula) where R1 is a heterocyclic group with 5 or 6 atoms, or -NR7 R8, where R7 is an aldel and R8 is an opsunally. Substitutex Phenyl Alkyl or cycloalkyl; R2 is the opsnally. Substitute styutect, phenyl or naphthyl; R3 is thiazolin; R4 is cyclohexyl or isopropyl; R5 is alkyl; And R6 is alkyl] and the salts of these substances are restraining remin and therefore are very agile in low blood pressure and valuable in the diagnosis and treatment of hypertension at Caused by a failure in the renin-angiotensin system, these compounds may be prepared. By the interaction of various amino acids or their derivatives. Of these substances suitable: drug patents.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH8968A true TH8968A (en) | 1991-06-03 |
Family
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