TH124140A - 5- anilino imidazopyridine And how to use it - Google Patents
5- anilino imidazopyridine And how to use itInfo
- Publication number
- TH124140A TH124140A TH801006499A TH0801006499A TH124140A TH 124140 A TH124140 A TH 124140A TH 801006499 A TH801006499 A TH 801006499A TH 0801006499 A TH0801006499 A TH 0801006499A TH 124140 A TH124140 A TH 124140A
- Authority
- TH
- Thailand
- Prior art keywords
- therapy
- immidazopyridine
- methods
- imidazopyridine
- anilino
- Prior art date
Links
- WPNUHKLNPWQADQ-UHFFFAOYSA-N n-phenyl-1h-imidazo[4,5-b]pyridin-5-amine Chemical compound C=1C=C2NC=NC2=NC=1NC1=CC=CC=C1 WPNUHKLNPWQADQ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 3
- JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 claims 2
- 108010081348 HRT1 protein Hairy Proteins 0.000 claims 2
- 102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 102000001291 MAP Kinase Kinase Kinase Human genes 0.000 abstract 1
- 108060006687 MAP kinase kinase kinase Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
Abstract
DC60 (09/06/52) การประดิษฐ์เกี่ยวข้องกับการอิมมิดาโซไพริดีนตามสูตร I ที่มีฤทธิ์ต้านมะเร็งและ/ หรือต้านการอักเสบ และอย่างจำเพาะเจาะจงมากกว่า จะเกี่ยวข้องกับอิมมิดาโซไพริดีนซึ่งยับยั้งฤทธิ์ MEK ไคเนส การประดิษฐ์จะจัดหาองค์ประกอบและวิธีการซึ่งมีประโยชน์สำหรับการยับยั้ง การเจริญเติบโตของเซลล์ที่ผิดปกติ หรือการบำบัดความผิดปกติเกี่ยวกับการเพิ่มจำนวนมากเกิน, หรือ การบำบัดโรคเกี่ยวกับการอักเสบในสัตว์เลี้ยงลูกด้วยนม อีกทั้งการประดิษฐ์จะเกี่ยวข้องกับวิธีการ ในการใช้สารประกอบสำหรับการวินิจฉัยหรือการบำบัดแบบในหลอดทดลอง, ในแหล่ง, และในกาย ของเซลล์สัตว์เลี้ยงลูกด้วยนม, หรือสภาวะทางพยาธิวิทยาที่เกี่ยวข้อง สิทธิบัตรยา DC60 (09/06/52) Invention involved immidazopyridine based on formula I with anticancer and / or anti-inflammatory effects. And more specifically It involves immidazopyridine, which inhibits the activity of MEK kinase. The fabrication provides elements and methods that are useful for inhibition. Abnormal cell growth Or therapy of hypercholesterolemia, or therapy of inflammatory disease in mammals Moreover, the invention relates to methods. In the use of compounds for diagnostic or in vitro therapy, in situ, and in vivo of mammalian cells, or associated pathological conditions.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TH124140A true TH124140A (en) | 2013-05-31 |
Family
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