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SV2009002861A - AMIDA PYRIMIDINE COMPOUNDS AS PGDS INHIBITORS - Google Patents

AMIDA PYRIMIDINE COMPOUNDS AS PGDS INHIBITORS

Info

Publication number
SV2009002861A
SV2009002861A SV2008002861A SV2008002861A SV2009002861A SV 2009002861 A SV2009002861 A SV 2009002861A SV 2008002861 A SV2008002861 A SV 2008002861A SV 2008002861 A SV2008002861 A SV 2008002861A SV 2009002861 A SV2009002861 A SV 2009002861A
Authority
SV
El Salvador
Prior art keywords
amida
pyrimidine compounds
compound
pgds inhibitors
pgds
Prior art date
Application number
SV2008002861A
Other languages
Spanish (es)
Inventor
Suzanne C Aldous
John Ziqi Jiang
Jinqi Lu
Liang Ma
Lan Mu
Harry Randall Munson
Jeffrey Stephen Sabol
Sukanthini Thurairatnam
Christopher Loren Vandeusen
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38007055&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SV2009002861(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of SV2009002861A publication Critical patent/SV2009002861A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

ESTA INVENCIÓN SE REFIERE A UN COMPUESTO DE FÓRMULA (I): (VER FORMULA); EN LA QUE R1, R2, R3 Y L1 SON COMO SE HAN DEFINIDO ANTERIORMENTE, UNA COMPOSICIÓN FARMACÉUTICA QUE COMPRENDE EL COMPUESTO, Y EL USO DEL COMPUESTO PARA TRATAR TRASTORNOS ALÉRGICOS Y/O INFLAMATORIOS, PARTICULARMENTE TRASTORNOS TALES COMO RINITIS ALÉRGICA, ASMA Y/O ENFERMEDAD PULMONAR OBSTRUCTIVA CRÓNICA (COPD)THIS INVENTION REFERS TO A FORMULA COMPOUND (I): (SEE FORMULA); IN WHICH R1, R2, R3 AND L1 ARE AS DEFINED PREVIOUSLY, A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THE COMPOUND, AND THE USE OF THE COMPOUND TO TREAT ALLERGIC AND / OR INFLAMMATORY DISORDERS, PARTICULARLY SUCH AS / OR RICHTISTICAL DISORDERS, CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

SV2008002861A 2005-12-19 2008-04-04 AMIDA PYRIMIDINE COMPOUNDS AS PGDS INHIBITORS SV2009002861A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75173005P 2005-12-19 2005-12-19
US11/612,249 US20070155827A1 (en) 2005-12-19 2006-12-18 Use of benzo-fused heterocycle sulfamide derivatives for the treatment of depression

Publications (1)

Publication Number Publication Date
SV2009002861A true SV2009002861A (en) 2009-02-23

Family

ID=38007055

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2008002861A SV2009002861A (en) 2005-12-19 2008-04-04 AMIDA PYRIMIDINE COMPOUNDS AS PGDS INHIBITORS

Country Status (25)

Country Link
US (1) US20070155827A1 (en)
EP (1) EP1973539B1 (en)
JP (1) JP5190376B2 (en)
KR (1) KR101415532B1 (en)
CN (1) CN101336106B (en)
AT (1) ATE464895T1 (en)
AU (1) AU2006331733B2 (en)
BR (1) BRPI0620014A2 (en)
CA (1) CA2634112C (en)
CR (1) CR10165A (en)
CY (1) CY1110669T1 (en)
DE (1) DE602006013883D1 (en)
DK (1) DK1973539T3 (en)
EA (1) EA015392B1 (en)
ES (1) ES2342846T3 (en)
IL (1) IL192103A (en)
MY (1) MY148459A (en)
NI (1) NI200800176A (en)
NO (1) NO20083036L (en)
NZ (1) NZ569045A (en)
PL (1) PL1973539T3 (en)
PT (1) PT1973539E (en)
SI (1) SI1973539T1 (en)
SV (1) SV2009002861A (en)
WO (1) WO2007075751A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY147767A (en) 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
MX2007014613A (en) * 2005-05-20 2008-04-02 Johnson & Johnson Process for preparation of sulfamide derivatives.
US8497298B2 (en) 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US8691867B2 (en) 2005-12-19 2014-04-08 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
US8937096B2 (en) 2005-12-19 2015-01-20 Janssen Pharmaceutica Nv Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
EP2026790A2 (en) 2006-05-19 2009-02-25 Janssen Pharmaceutica, N.V. Co-therapy for the treatment of epilepsy and related disorders
KR101511574B1 (en) 2008-03-26 2015-04-15 얀센 파마슈티카 엔.브이. Use of benzo-fused heterocycle sulfamide derivatives for the treatment of anxiety
US20090247617A1 (en) * 2008-03-26 2009-10-01 Abdel-Magid Ahmed F Process for the preparation of benzo-fused heteroaryl sulfamates
US20090247616A1 (en) * 2008-03-26 2009-10-01 Smith-Swintosky Virginia L Use of benzo-fused heterocyle sulfamide derivatives for the treatment of anxiety
MX2010011498A (en) * 2008-04-29 2010-11-12 Nsab Af Neurosearch Sweden Ab Modulators of dopamine neurotransmission.
DK2271634T3 (en) * 2008-04-29 2014-05-05 Integrative Res Lab Sweden Ab Modulators of dopamine neurotransmission
EP2271635A1 (en) * 2008-04-29 2011-01-12 NSAB, Filial af NeuroSearch Sweden AB, Sverige Modulators of dopamine neurotransmission
WO2010008776A2 (en) 2008-06-23 2010-01-21 Janssen Pharmaceutica Nv Disposable patch and reusable sensor assembly for use in medical device localization and mapping systems
US8815939B2 (en) * 2008-07-22 2014-08-26 Janssen Pharmaceutica Nv Substituted sulfamide derivatives
EP2760851A1 (en) 2011-09-29 2014-08-06 Janssen Pharmaceutica, N.V. Process for the preparation of sulfamide derivatives
KR20140082762A (en) 2011-09-29 2014-07-02 얀센 파마슈티카 엔.브이. Improved process for the preparation of sulfamide derivatives
KR20250077661A (en) 2023-11-23 2025-06-02 재단법인 환동해산업연구원 Extract from seaweed with anti-depressant and anti-obesity effects and its manufacturing method

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2527861A (en) * 1948-05-07 1950-10-31 Monsanto Chemicals Mono alkyl sulfamides
BE636655A (en) * 1962-09-14
US3318952A (en) * 1964-01-22 1967-05-09 Sandoz Ag Dibenzylsulfamides
US3383414A (en) * 1964-08-26 1968-05-14 Sandoz Ag Benzocycloalkyl sulfamides
US3539573A (en) * 1967-03-22 1970-11-10 Jean Schmutz 11-basic substituted dibenzodiazepines and dibenzothiazepines
US3621096A (en) * 1969-04-03 1971-11-16 Univ North Carolina Antidepressant method and composition for same comprising a tricyclic antidepressant and a thyroid hormone
US3689669A (en) * 1970-10-09 1972-09-05 Univ Of North Carolina The Antidepressant method and composition
US5212326A (en) * 1979-08-20 1993-05-18 Abbott Laboratories Sodium hydrogen divalproate oligomer
FR2479825A1 (en) * 1980-04-04 1981-10-09 Fabre Sa Pierre BENZODIOXAN 1,4 METHOXY-2 PROPANOLAMINES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
US4513006A (en) * 1983-09-26 1985-04-23 Mcneil Lab., Inc. Anticonvulsant sulfamate derivatives
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
GB8607684D0 (en) * 1986-03-27 1986-04-30 Ici America Inc Thiazepine compounds
US4831031A (en) * 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
US5158952A (en) * 1988-11-07 1992-10-27 Janssen Pharmaceutica N.V. 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
US5238945A (en) * 1989-04-11 1993-08-24 H. Lundbeck A/S Method of treating psychoses
GB8908085D0 (en) * 1989-04-11 1989-05-24 Lundbeck & Co As H New therapeutic use
US5273993A (en) * 1989-06-12 1993-12-28 A. H. Robins Company, Incorporated Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals
US5194446A (en) * 1989-06-12 1993-03-16 A. H. Robins Company, Incorporated Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals
US5192785A (en) * 1989-09-03 1993-03-09 A. H. Robins Company, Incorporated Sulfamates as antiglaucoma agents
US5229382A (en) * 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
AU651244B2 (en) * 1991-09-19 1994-07-14 Mcneilab, Inc. Process for the preparation of chlorosulfate and sulfamate derivatives of 2,3:4,5-bis-0-(1-methylethylidene)-beta-D- fructopyranose and (1-methylcyclohexyl)methanol
US5242942A (en) * 1992-04-28 1993-09-07 Mcneilab, Inc. Anticonvulsant fructopyranose cyclic sulfites and sulfates
US5258402A (en) * 1992-06-11 1993-11-02 Mcneil-Ppc, Inc. Imidate derivatives of pharmaceutically useful anticonvulsant sulfamates
US5312925A (en) * 1992-09-01 1994-05-17 Pfizer Inc. Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride
US5384327A (en) * 1992-12-22 1995-01-24 Mcneilab, Inc. Anticonvulsant sorbopyranose sulfamates
CA2216648A1 (en) * 1995-02-15 1996-08-22 Bearsden Bio, Inc. Alkylcarboxy amino acids-modulators of the kainate receptor
JP3235448B2 (en) * 1995-03-24 2001-12-04 ダイソー株式会社 Method for producing 1,4-benzodioxane derivative
US5998380A (en) * 1995-10-13 1999-12-07 New England Medical Center Hospitals, Inc. Treatment of migraine
WO1997019682A1 (en) * 1995-12-01 1997-06-05 Synaptic Pharmaceutical Corporation Aryl sulfonamide and sulfamide derivatives and uses thereof
US5753693A (en) * 1996-06-28 1998-05-19 Ortho Pharmaceutical Corporation Anticonvulsant derivatives useful in treating manic-depressive bipolar disorder
US5753694A (en) * 1996-06-28 1998-05-19 Ortho Pharmaceutical Corporation Anticonvulsant derivatives useful in treating amyotrophic lateral sclerosis (ALS)
SK284305B6 (en) * 1996-06-28 2005-01-03 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant sulfamate derivatives useful in treating obesity
ATE293458T1 (en) * 1996-08-23 2005-05-15 Algos Pharm Corp PREPARATION CONTAINING ANTICONVULSIVE AGENTS FOR THE TREATMENT OF NEUROPATHIC PAIN
US20020015713A1 (en) * 1996-10-24 2002-02-07 Murdock Robert W. Methods and transdermal compositions for pain relief
US5760007A (en) * 1997-07-16 1998-06-02 Ortho Pharmaceutical Corporation Anticonvulsant derivatives useful in treating neuropathic pain
US5935933A (en) * 1997-07-16 1999-08-10 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivatives useful in treating neuropathic pain
AU9021298A (en) * 1997-08-15 1999-03-08 Carolyn Ann Fairbanks Agmatine as a treatment for neuropathic pain
MXPA01007350A (en) * 1999-01-19 2003-06-06 Johnson & Johnson Anticonvulsant derivatives useful in treating cluster headaches.
EP1158973B1 (en) * 1999-02-24 2005-05-04 University Of Cincinnati Use of sulfamate derivatives for treating impulse control disorders
MXPA01010218A (en) * 1999-04-08 2002-03-27 Johnson & Johnson Anticonvulsant derivatives useful in lowering lipids.
JP2003521471A (en) * 1999-04-08 2003-07-15 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド Anticonvulsant drug derivatives useful for treating chronic neurodegenerative diseases
KR100758609B1 (en) * 1999-08-20 2007-09-13 오르토-맥네일 파마슈티칼, 인코퍼레이티드 Compositions Containing Tramadol Compounds And Anticonvulsant Drugs
US6322503B1 (en) * 2000-02-17 2001-11-27 G. Roger Sparhawk, Jr. Method of diagnosing, tracking, and treating depression
PL365680A1 (en) * 2000-07-07 2005-01-10 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivatives useful for preventing the development of type ii diabetes mellitus and syndrome x
US6627653B2 (en) * 2000-08-02 2003-09-30 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivatives useful for the treatment of depression
US7256184B2 (en) * 2000-10-16 2007-08-14 Rodriguez Victorio C Treatment of aging disorders in humans
AU2002240235B2 (en) * 2001-01-30 2006-07-06 Merck & Co., Inc. Acyl sulfamides for treatment of obesity, diabetes and lipid disorders
US6559293B1 (en) * 2002-02-15 2003-05-06 Transform Pharmaceuticals, Inc. Topiramate sodium trihydrate
US8637512B2 (en) * 2002-07-29 2014-01-28 Glaxo Group Limited Formulations and method of treatment
US6949518B1 (en) * 2003-06-25 2005-09-27 Pao-Hsien Chu Methods for treating macular degeneration with topiramate
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
TW200612905A (en) * 2004-06-16 2006-05-01 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
US20060276528A1 (en) * 2004-08-24 2006-12-07 Abdel-Magid Ahmed F Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents
CA2578407A1 (en) * 2004-08-24 2006-03-02 Janssen Pharmaceutica N.V. Novel benzo-fused heteroaryl sulfamide derivatives useful as anticonvulsant agents
BRPI0610046A2 (en) * 2005-04-22 2010-05-25 Wyeth Corp benzodioxane and benzodioxolane derivatives and uses of these
MX2007014613A (en) * 2005-05-20 2008-04-02 Johnson & Johnson Process for preparation of sulfamide derivatives.
US20070155824A1 (en) * 2005-12-19 2007-07-05 Smith-Swintosky Virginia L Use of benzo-fused heterocycle sulfamide derivatives for disease modification / epileptogenesis
US8937096B2 (en) * 2005-12-19 2015-01-20 Janssen Pharmaceutica Nv Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
US8497298B2 (en) * 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US8716231B2 (en) * 2005-12-19 2014-05-06 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain
AR058389A1 (en) * 2005-12-19 2008-01-30 Janssen Pharmaceutica Nv USE OF SULFAMIDE BENZO-FUSED HETEROCICLIC DERIVATIVES FOR THE TREATMENT OF OBESITY
KR101174777B1 (en) * 2005-12-27 2012-08-20 엘지디스플레이 주식회사 Patterning Method and Method of manufacturing Liquid Crystal Display Device using the same
WO2007137164A2 (en) * 2006-05-19 2007-11-29 Janssen Pharmaceutica N.V. Co-therapy for the treatment of epilepsy and related disorders
EP2026790A2 (en) * 2006-05-19 2009-02-25 Janssen Pharmaceutica, N.V. Co-therapy for the treatment of epilepsy and related disorders
WO2009089210A1 (en) * 2008-01-07 2009-07-16 Janssen Pharmaceutica N. V. Preparation of sulfamide derivatives
US20090247618A1 (en) * 2008-03-26 2009-10-01 Ballentine Scott A Process for preparation of benzo-fused heteroaryl derivatives
US20090247617A1 (en) * 2008-03-26 2009-10-01 Abdel-Magid Ahmed F Process for the preparation of benzo-fused heteroaryl sulfamates
WO2010008776A2 (en) * 2008-06-23 2010-01-21 Janssen Pharmaceutica Nv Disposable patch and reusable sensor assembly for use in medical device localization and mapping systems
US8815939B2 (en) * 2008-07-22 2014-08-26 Janssen Pharmaceutica Nv Substituted sulfamide derivatives
EP2760851A1 (en) * 2011-09-29 2014-08-06 Janssen Pharmaceutica, N.V. Process for the preparation of sulfamide derivatives
KR20140082762A (en) * 2011-09-29 2014-07-02 얀센 파마슈티카 엔.브이. Improved process for the preparation of sulfamide derivatives

Also Published As

Publication number Publication date
HK1125040A1 (en) 2009-07-31
IL192103A0 (en) 2009-08-03
MY148459A (en) 2013-04-30
KR20080089414A (en) 2008-10-06
CA2634112C (en) 2014-08-05
US20070155827A1 (en) 2007-07-05
PL1973539T3 (en) 2010-09-30
EA200870090A1 (en) 2008-12-30
CY1110669T1 (en) 2015-06-10
IL192103A (en) 2012-10-31
CR10165A (en) 2009-01-14
BRPI0620014A2 (en) 2011-10-25
CN101336106A (en) 2008-12-31
SI1973539T1 (en) 2010-08-31
DE602006013883D1 (en) 2010-06-02
AU2006331733A1 (en) 2007-07-05
AU2006331733B2 (en) 2013-01-10
ATE464895T1 (en) 2010-05-15
JP5190376B2 (en) 2013-04-24
WO2007075751A1 (en) 2007-07-05
CN101336106B (en) 2012-09-05
PT1973539E (en) 2010-05-25
NI200800176A (en) 2012-05-28
EP1973539B1 (en) 2010-04-21
KR101415532B1 (en) 2014-07-04
NO20083036L (en) 2008-09-05
ES2342846T3 (en) 2010-07-15
CA2634112A1 (en) 2007-07-05
DK1973539T3 (en) 2010-08-02
JP2009520034A (en) 2009-05-21
EA015392B1 (en) 2011-08-30
EP1973539A1 (en) 2008-10-01
NZ569045A (en) 2011-05-27

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