[go: up one dir, main page]

SV2008003070A - Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta-hidroxiestero ide deshidrogenasa 1 ref. x-17248 - Google Patents

Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta-hidroxiestero ide deshidrogenasa 1 ref. x-17248

Info

Publication number
SV2008003070A
SV2008003070A SV2008003070A SV2008003070A SV2008003070A SV 2008003070 A SV2008003070 A SV 2008003070A SV 2008003070 A SV2008003070 A SV 2008003070A SV 2008003070 A SV2008003070 A SV 2008003070A SV 2008003070 A SV2008003070 A SV 2008003070A
Authority
SV
El Salvador
Prior art keywords
hydroxiestero
cyclhexilpirazol
lactamas
ide
dehydrogenase
Prior art date
Application number
SV2008003070A
Other languages
English (en)
Inventor
Thomas Daniel Aicher
Alexei Pavlovvych Krasutsky
Thomas Edward Mabry
Ashraf Saeed
Peter Biagio Anzeveno
Renhua Li
Yanping Xu
Nancy June Snyder
Honggi Tian
Owen Brendan Wallace
Gregory Alan Sthephenson
Leonard Larry Winneroski Jr
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SV2008003070A publication Critical patent/SV2008003070A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A NUEVOS COMPUESTOS DE FÓRMULA I: (VER FORMULA); QUE POSEEN ACTIVIDAD ANTAGONISTA DE 11BETA-HSD TIPO 1, ASI COMO TAMBIÉN MÉTODOS PARA PREPARAR TALES COMPUESTOS. EN OTRA MODALIDAD, LA INVENCIÓN DESCRIBE COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN COMPUESTOS DE FÓRMULA I, ASI COMO TAMBIÉN MÉTODOS PARA USAR LOS COMPUESTOS Y COMPOSICIONES PARA TRATAR DIABETES, HIPERGLICEMIA, OBESIDAD, HIPERTENSIÓN, HIPERLIPIDEMIA, SÍNDROME METABÓLICO, Y OTRAS CONDICIONES ASOCIADAS CON LA ACTIVIDAD DE 11BETA-HSD TIPO 1
SV2008003070A 2006-04-21 2008-10-21 Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta-hidroxiestero ide deshidrogenasa 1 ref. x-17248 SV2008003070A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74532006P 2006-04-21 2006-04-21

Publications (1)

Publication Number Publication Date
SV2008003070A true SV2008003070A (es) 2010-01-18

Family

ID=38595048

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2008003070A SV2008003070A (es) 2006-04-21 2008-10-21 Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta-hidroxiestero ide deshidrogenasa 1 ref. x-17248

Country Status (29)

Country Link
US (1) US7981918B2 (es)
EP (1) EP2029579B1 (es)
JP (1) JP5161869B2 (es)
KR (1) KR101055576B1 (es)
CN (1) CN101426783B (es)
AR (1) AR060618A1 (es)
AU (1) AU2007240550B2 (es)
BR (1) BRPI0710229A2 (es)
CA (1) CA2647677C (es)
CO (1) CO6140026A2 (es)
CR (1) CR10400A (es)
DO (1) DOP2007000078A (es)
EA (1) EA015675B1 (es)
EC (1) ECSP088839A (es)
ES (1) ES2533263T3 (es)
IL (1) IL194835A (es)
JO (1) JO3042B1 (es)
MA (1) MA30476B1 (es)
MX (1) MX2008013484A (es)
MY (1) MY148128A (es)
NO (1) NO20084403L (es)
NZ (1) NZ571175A (es)
PE (1) PE20080362A1 (es)
SV (1) SV2008003070A (es)
TN (1) TNSN08405A1 (es)
TW (1) TWI347321B (es)
UA (1) UA95798C2 (es)
WO (1) WO2007124254A2 (es)
ZA (1) ZA200808686B (es)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2435115T3 (es) * 2006-04-21 2013-12-18 Eli Lilly And Company Derivados de bifenilamida-lactama como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1
CN101426780B (zh) 2006-04-21 2013-06-26 伊莱利利公司 作为11-β-羟基甾族化合物脱氢酶1的抑制剂的环己基咪唑内酰胺衍生物
DE602007007614D1 (de) 2006-04-24 2010-08-19 Lilly Co Eli Substituierte pyrrolidinone als hemmer von 11-beta-hydroxysteroiddehydrogenase 1
AU2007244955B2 (en) * 2006-04-24 2011-12-08 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
ATE543798T1 (de) 2006-04-24 2012-02-15 Lilly Co Eli Cyclohexyl-substituierte pyrrolidinone als hemmer von 11-beta-hydroxysteroiddehydrogenase 1
CA2648236C (en) 2006-04-25 2013-05-28 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
MX2008013656A (es) * 2006-04-25 2008-11-10 Lilly Co Eli Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa.
US7968585B2 (en) 2006-04-25 2011-06-28 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
CN101448816B (zh) * 2006-04-28 2013-08-07 伊莱利利公司 作为11-β-羟类固醇脱氢酶1的抑制剂的哌啶基取代的吡咯烷酮类
CA2678577A1 (en) 2007-02-26 2008-09-04 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AR069207A1 (es) 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
WO2009075835A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceutical, Inc CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1
ES2421537T3 (es) 2008-05-01 2013-09-03 Vitae Pharmaceuticals Inc Inhibidores cíclicos de la 11beta-hidroxiesteroide deshidrogenasa 1
CA2729998A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2730499A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2729993A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
WO2010089303A1 (en) 2009-02-04 2010-08-12 Boehringer Ingelheim International Gmbh CYCLIC INHIBITORS OF 11 β-HYDROXYSTEROID DEHYDROGENASE 1
EP2393813B1 (en) * 2009-02-04 2013-07-31 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11 ß-hydroxysteroid dehydrogenase 1 useful for the treatment of diseases related to elevated level of cortisol
US8507493B2 (en) 2009-04-20 2013-08-13 Abbvie Inc. Amide and amidine derivatives and uses thereof
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
EP2440537A1 (en) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
US8883778B2 (en) 2009-07-01 2014-11-11 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
WO2011056737A1 (en) 2009-11-05 2011-05-12 Boehringer Ingelheim International Gmbh Novel chiral phosphorus ligands
US8871208B2 (en) * 2009-12-04 2014-10-28 Abbvie Inc. 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2576570A1 (en) 2010-05-26 2013-04-10 Boehringer Ingelheim International GmbH 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives
WO2011159760A1 (en) 2010-06-16 2011-12-22 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
EP2585444B1 (en) 2010-06-25 2014-10-22 Boehringer Ingelheim International GmbH Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
MX2013004699A (es) 2010-11-02 2013-05-22 Boehringer Ingelheim Int Combinaciones farmaceuticas para el tratamiento de trastornos metabolicos.
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683700B1 (de) 2011-03-08 2015-02-18 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120053A1 (de) 2011-03-08 2012-09-13 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
TWI545113B (zh) * 2011-10-18 2016-08-11 安斯泰來製藥股份有限公司 二環式雜環化合物
AR099936A1 (es) * 2014-04-04 2016-08-31 Sanofi Sa Heterociclos condensados sustituidos como moduladores de gpr119 para el tratamiento de la diabetes, obesidad, dislipidemia y trastornos relacionados
US10858347B2 (en) 2015-12-31 2020-12-08 Karyopharm Therapeutics Inc. Multicyclic compounds and uses thereof
CA3189497A1 (en) 2021-02-25 2022-09-01 Aptabio Therapeutics Inc. 4, 5, 6, 7-tetrahydro-2h-indazol-3-ol derivatives and oxidative stress inhibitory activity thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004056744A1 (en) 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors
EA011021B1 (ru) * 2004-05-07 2008-12-30 Янссен Фармацевтика Н.В. Производные адамантилпирролидин-2-она в качестве ингибиторов 11-бета-гидроксистероид-дегидрогеназы
JP5014983B2 (ja) 2004-05-07 2012-08-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ １１−ベータヒドロキシステロイドデヒドロゲナーゼ阻害剤としてのピロリジン−２−オン及びピペリジン−２−オン誘導体
US8138342B2 (en) 2004-10-12 2012-03-20 High Point Pharmacueticals, LLC 11β-hydroxysteroid dehydrogenase type 1 active spiro compounds
DK1807072T3 (da) 2004-10-29 2009-03-16 Lilly Co Eli Cycloalkyllactamderivater som inhibitorer af 11-beta-hydroxysteroid-dehydrogenase 1
MX2007005527A (es) 2004-11-10 2007-07-09 Incyte Corp Compuestos de lactama y sus usos como farmaceuticos.
EP1830841B1 (en) 2004-12-20 2008-07-02 Eli Lilly And Company Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
WO2006068991A1 (en) 2004-12-21 2006-06-29 Eli Lilly And Company Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
JPWO2006104280A1 (ja) 2005-03-31 2008-09-11 武田薬品工業株式会社 糖尿病の予防・治療剤
ES2322727B1 (es) 2005-07-28 2010-04-22 Universidad Del Pais Vasco Metodo para cuantificar la union receptor acoplado a proteina g (gpcr)-proteina g mediante el empleo de un array de membranas celulares.
US7998959B2 (en) 2006-01-12 2011-08-16 Incyte Corporation Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
CN101426780B (zh) 2006-04-21 2013-06-26 伊莱利利公司 作为11-β-羟基甾族化合物脱氢酶1的抑制剂的环己基咪唑内酰胺衍生物
ES2435115T3 (es) * 2006-04-21 2013-12-18 Eli Lilly And Company Derivados de bifenilamida-lactama como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1
AU2007244955B2 (en) 2006-04-24 2011-12-08 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
ATE543798T1 (de) 2006-04-24 2012-02-15 Lilly Co Eli Cyclohexyl-substituierte pyrrolidinone als hemmer von 11-beta-hydroxysteroiddehydrogenase 1
DE602007007614D1 (de) 2006-04-24 2010-08-19 Lilly Co Eli Substituierte pyrrolidinone als hemmer von 11-beta-hydroxysteroiddehydrogenase 1
MX2008013656A (es) 2006-04-25 2008-11-10 Lilly Co Eli Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa.
US7968585B2 (en) 2006-04-25 2011-06-28 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
CA2648236C (en) 2006-04-25 2013-05-28 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
CN101448816B (zh) 2006-04-28 2013-08-07 伊莱利利公司 作为11-β-羟类固醇脱氢酶1的抑制剂的哌啶基取代的吡咯烷酮类
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.

Also Published As

Publication number Publication date
BRPI0710229A2 (pt) 2011-08-02
WO2007124254A2 (en) 2007-11-01
EP2029579B1 (en) 2014-12-31
IL194835A (en) 2015-04-30
NO20084403L (no) 2008-11-14
CO6140026A2 (es) 2010-03-19
MY148128A (en) 2013-02-28
DOP2007000078A (es) 2007-11-15
ZA200808686B (en) 2009-12-30
EP2029579A2 (en) 2009-03-04
CN101426783A (zh) 2009-05-06
HK1126493A1 (en) 2009-09-04
TNSN08405A1 (en) 2010-04-14
EA015675B1 (ru) 2011-10-31
US7981918B2 (en) 2011-07-19
IL194835A0 (en) 2009-08-03
US20090111800A1 (en) 2009-04-30
CA2647677C (en) 2014-03-18
MA30476B1 (fr) 2009-06-01
CA2647677A1 (en) 2007-11-01
WO2007124254A3 (en) 2007-12-27
EA200870460A1 (ru) 2009-04-28
ES2533263T3 (es) 2015-04-08
JO3042B1 (ar) 2016-09-05
KR101055576B1 (ko) 2011-08-08
ECSP088839A (es) 2008-11-27
MX2008013484A (es) 2008-10-30
TW200811141A (en) 2008-03-01
CR10400A (es) 2009-01-14
JP2009534398A (ja) 2009-09-24
PE20080362A1 (es) 2008-04-25
UA95798C2 (ru) 2011-09-12
AU2007240550B2 (en) 2012-02-23
JP5161869B2 (ja) 2013-03-13
TWI347321B (en) 2011-08-21
AU2007240550A1 (en) 2007-11-01
KR20080109867A (ko) 2008-12-17
AR060618A1 (es) 2008-07-02
CN101426783B (zh) 2013-10-30
NZ571175A (en) 2011-10-28

Similar Documents

Publication Publication Date Title
SV2008003070A (es) Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta-hidroxiestero ide deshidrogenasa 1 ref. x-17248
CR10402A (es) Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1
ECSP088849A (es) Pirrolidinonas sustituidas de pieridinil como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1
CL2012001043A1 (es) Compuestos derivados de hexahidroindenopiridina y/o octahidrobenzoquinolina, inhibidores de 11ß-hidroxiesteroide deshidrogenasa 1 (hsd 1); composiciones farmaceuticas que comprenden a los compuestos; y uso de los compuestos para la preparacion de medicamentos para el tratamiento de trastornos metabolicos.
MX2010005298A (es) Compuestos de carboxamida, sulfonamida y amina para trastornos metabolicos.
IL195030A (en) Dpp iv inhibitor formulations
CL2008000198A1 (es) Compuestos derivados de azacicloalcanos, inhibidores de estearoil-coenzima a delta-9; composicion farmaceutica; y uso para el tratamiento de enfermedades tales como diabetes tipo 2, trastorno de lipidos, obesidad y aterosclerosis.
ATE471311T1 (de) Inhibitoren von11-beta- hydroxysteroiddehydrogenase 1
TNSN08373A1 (en) Azolopyrimidines as inhibitors of cannabinoid 1 activity
EA200801897A1 (ru) Ингибиторы mnk2 на основе 8-гетероарилпурина для лечения метаболических нарушений
SI2021337T1 (sl) Inhibitorji beta hidroksisteroidne dehidrogenaze
ATE482210T1 (de) Oxadiazolderivate als s1p1-rezeptor-agonisten
MX337575B (es) Compuestos de sulfona y métodos para lafabricación y uso de éstos.
CR10479A (es) Modulares bencimidazolicos de vr1
EA200870472A1 (ru) Ингибиторы 11-бета-гидроксистероид-дегидрогеназы типа 1
UA96076C2 (en) Use of trans-clomiphene
MX341849B (es) Nitrilos espirociclicos como inhibidores de proteasa.
BRPI0913291A2 (pt) composto, pró-droga, medicamento, métodos para diminuir a proteína 4 ou tratamento de diabete em um mamífero, e, uso do composto
NI201100117A (es) Antagonistas de 4 -- azetidinil - 1 - heteroaril - ciclohexanol del ccr2.
ECSP13012664A (es) Formas cristalinas de la sal clorhidrato de (4a-r,9a-s)-1-(1h-benzoimidazol-5-carbonil-2,3,4,4a,9,9a-hexahidro-1h-inden[2,1-b]piridin-6-carbonitrilo y su uso como inhibidores de hsd 1
BRPI1007287B8 (pt) composto de carboxamida, composição farmacêutica, e, uso de um composto ou de uma composição farmacêutica
CL2007003841A1 (es) Compuestos derivados de 4(5h-1 lambda-tiazol-2-il)piperidina; composicion farmaceutica que contiene a dichos compuestos; y su uso para tratar diabetes.
CR11665A (es) Farmacoforos duales-antagonistas muscarinicos de pde4
ATE474574T1 (de) Imidazoazephinonverbindungen
CL2007003838A1 (es) Composiciones farmaceuticas que contienen compuestos semisinteticos derivados de los alcaloides de la vinca, utiles para tratar el cancer.