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SV2002000246A - Inhibidores no peptidilo del alv-4 dependiente de la union de celulas utiles en el tratamiento de enfermedades inflamatorias autoinmune y respiratorias ref. pc10801/20119/bb - Google Patents

Inhibidores no peptidilo del alv-4 dependiente de la union de celulas utiles en el tratamiento de enfermedades inflamatorias autoinmune y respiratorias ref. pc10801/20119/bb

Info

Publication number
SV2002000246A
SV2002000246A SV2000000246A SV2000000246A SV2002000246A SV 2002000246 A SV2002000246 A SV 2002000246A SV 2000000246 A SV2000000246 A SV 2000000246A SV 2000000246 A SV2000000246 A SV 2000000246A SV 2002000246 A SV2002000246 A SV 2002000246A
Authority
SV
El Salvador
Prior art keywords
replaced
rent
group constituted
autoimmune
cyclalkyl
Prior art date
Application number
SV2000000246A
Other languages
English (en)
Inventor
Louis Stanley Chupak
Allen Jacob Duplantier
Lau Wan Fang
Anthony John Milici
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of SV2002000246A publication Critical patent/SV2002000246A/es

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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE DESCRIBE UN GENERO DE COMPUESTOS NO PEPTIDICOS, SIENDO LOS CITADOS COMPUESTOS INHIBIDORES DE VLA-4 UTILES EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS AUTOINMUNES Y RESPIRATORIAS Y COMPRENDIENDO LOS CITADOS COMPUESTOS DE FORMULA (1.0.0) VER FORMUALS Y SALES Y OTROS DERIVADOS PROFARMACOS DE ESTE FARMACEUTICAMENTE AEPTABLES , EN EL QUE:A ES ALQUILO (C1-C6), CICLOALQUILO, ARILO, HETEROARILO O HETROCICLILO OPCIONALMENTE SUSTITUIDOS CON 0 A 3 R9 O ES UN MIEBRO SELECCIONADO DEL GRUPO CONSTITUIDO POR LOS SIGUIENTES RADICALES: A1-NHC(=O)NH-A2-, A1-NHC(=O)O-A2-, A1- OC(=O)NH-2-A2-, A1-SO2NH-A2-, A1-(CH2)R-O-A2-, A1-O-(CH2)R-A2-, A1-(CH2)R-A2-, ESTANDO A1 Y AA2 CADA UNO SELECCIONADO INDEPENDIENTEMENTE DEL GRUPO CONSTITUIDO POR HIDROGENO, ARILO, ALQUILO (c1-C6), ALQUENILO (C2-C6), ALQUINILO(C2-C6), CICLOALQUILO, HETEROARILO Y HETEROCICLILO SUSTITUIDO CON 0 A 3 R9;B ES UN MIEMBRO SELECCIONADO INDEPENDIENTEMENTE DEL GRUPO CONSTITUIDO POR LOS SIGUIENTES,E ES UN ENLACE SENCILLO, -O-, -NR10-, -CH=CH-, -C=C-, -S(=O)Q, -CR11R12NR10-, O -CR11R12-;X ES -O-, -C(=O)-, -S(=O)Q- O -NR10-; X1, X2 Y X3 SE SELECCIONAN CADA UNO INDEPENDIENTEMENTE DEL GRUPO CONSTITUIDO POR CH, CR9 O N; Y ES UN ENLACE SENCILLO, -C(=O)-, -C(=S)- O -S(=O)2-; -R7 ES ALQUILO (C1-C6), (CH2)KOR5, (CH2)KNR5C(=O)R5, (CH2)KNR6C(=O)OR5, (CH2)KNR6SO2R5, (CH2)KNR6R5, F, CF3, OCF3, ARILO SUSTITUIDO CON 0 A 3 R9, HETROCICLILO SUSTITUIDO CON 0 A 3 R9, HETEROARILO, SUSTITUIDO CON 0 A 3 R9, CICLOALQUILO SUSTITUIDO CON A 3 R9, HETEROARILO SUSTITUIDO CON 0 A 3 R9, CICLOALQUILO SUSTITUIDO CON 0 A 3 R9, O R7 PUEDE TOMARSE CONJUNTAMENTE CON R8 PARA FORMAR UN ANILLO CICLOALQUILO O HETEROCICLILO, O R7 PUEDE TOMARSE CONJUNTAMENTE CON R11 PARA FORMAR UN ANILLO CICLOALQUILO O HETERCICLILO; Y R8 ES HIDROGENO, F, ALQUILO (C1-C6) O ALCOXI (C1-C6).
SV2000000246A 1999-12-28 2000-12-22 Inhibidores no peptidilo del alv-4 dependiente de la union de celulas utiles en el tratamiento de enfermedades inflamatorias autoinmune y respiratorias ref. pc10801/20119/bb SV2002000246A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17326099P 1999-12-28 1999-12-28

Publications (1)

Publication Number Publication Date
SV2002000246A true SV2002000246A (es) 2002-07-16

Family

ID=22631221

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2000000246A SV2002000246A (es) 1999-12-28 2000-12-22 Inhibidores no peptidilo del alv-4 dependiente de la union de celulas utiles en el tratamiento de enfermedades inflamatorias autoinmune y respiratorias ref. pc10801/20119/bb

Country Status (35)

Country Link
US (4) US20020049236A1 (es)
EP (1) EP1244656A1 (es)
JP (1) JP2003519697A (es)
KR (1) KR20020067050A (es)
CN (1) CN1413210A (es)
AP (1) AP2002002565A0 (es)
AR (1) AR029216A1 (es)
AU (1) AU2018301A (es)
BG (1) BG106867A (es)
BR (1) BR0016818A (es)
CA (1) CA2396087A1 (es)
CO (1) CO5261616A1 (es)
CR (1) CR6682A (es)
CZ (1) CZ20022072A3 (es)
EA (1) EA004673B1 (es)
EE (1) EE200200372A (es)
GT (1) GT200000226A (es)
HU (1) HUP0203897A3 (es)
IL (1) IL149758A0 (es)
IS (1) IS6382A (es)
MA (1) MA26861A1 (es)
NO (1) NO20023085L (es)
NZ (1) NZ518886A (es)
OA (1) OA12126A (es)
PA (1) PA8509301A1 (es)
PE (1) PE20010987A1 (es)
PL (1) PL357109A1 (es)
SK (1) SK8692002A3 (es)
SV (1) SV2002000246A (es)
TN (1) TNSN00256A1 (es)
TR (1) TR200201668T2 (es)
UY (1) UY26512A1 (es)
WO (1) WO2001051487A1 (es)
YU (1) YU41202A (es)
ZA (1) ZA200205142B (es)

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