SU890978A3 - Method of preparing c-15003p-0 antibiotic - Google Patents
Method of preparing c-15003p-0 antibiotic Download PDFInfo
- Publication number
- SU890978A3 SU890978A3 SU782627804A SU2627804A SU890978A3 SU 890978 A3 SU890978 A3 SU 890978A3 SU 782627804 A SU782627804 A SU 782627804A SU 2627804 A SU2627804 A SU 2627804A SU 890978 A3 SU890978 A3 SU 890978A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- antibiotic
- preparing
- antibiotic substance
- obtaining
- substances
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title claims abstract 5
- 238000000034 method Methods 0.000 title claims description 7
- 239000012280 lithium aluminium hydride Substances 0.000 claims description 2
- -1 lithium aluminum hydride Chemical compound 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 238000007327 hydrogenolysis reaction Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- QWPXBEHQFHACTK-UHFFFAOYSA-N Maytansinol Natural products CN1C(=O)CC(O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 QWPXBEHQFHACTK-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 229930126263 Maytansine Natural products 0.000 description 1
- 241000549168 Maytenus Species 0.000 description 1
- 241001661641 Verrucosa Species 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- WKPWGQKGSOKKOO-RSFHAFMBSA-N maytansine Chemical compound CO[C@@H]([C@@]1(O)C[C@](OC(=O)N1)([C@H]([C@@H]1O[C@@]1(C)[C@@H](OC(=O)[C@H](C)N(C)C(C)=O)CC(=O)N1C)C)[H])\C=C\C=C(C)\CC2=CC(OC)=C(Cl)C1=C2 WKPWGQKGSOKKOO-RSFHAFMBSA-N 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- SRVJKTDHMYAMHA-WUXMJOGZSA-N thioacetazone Chemical compound CC(=O)NC1=CC=C(\C=N\NC(N)=S)C=C1 SRVJKTDHMYAMHA-WUXMJOGZSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
PURPOSE:Antibiotic substance C-15003 of the formula I [R is -CO-CH(CH -CO-CH(CH2)2, -CO-CH2-CH2-CH3, -CO-CH2-CH(CH3)2]. The substances having R group given above are called as antibiotic substance C-15003p-3, C-15003p-3', and C-15003p-4, respectively.
Description
(5А) СПОСОБ ПОЛУЧЕНИЯ АНТИБ ЮТ1ЖЛ С-15003 Р-0(5A) METHOD FOR OBTAINING ANTIB YUT1ZHL C-15003 R-0
Изобретение относитс к у совершенствованному способу получени антибиотика С-15003 Р-0 (майтанэинола). Известный способ получени майтанэинола заключаетс в том, что его непосредственно экстрагируют из коры растени Putterllckla verrucosa, принадлежащего к зиду Maytenus, или обработкой полученных при этом майтанацина или иайтанбутина литийалюминий гидридом D. Недостатком способа вл етс длительный промежуток времени дл роста растени , содержащего майтанзинол и другие вещества, а также требуетс несколько стадий - рубка, сушка, измельчение , экстракци , введение и очистка, чтобы получить крнечный продукт . Цель изобретени - упрощение процесса получени целевого продукта. Поставленна цель достигаетс тем, что согласно способу получени антибиотика С-15003 Р-0 общей формулыThe invention relates to an improved method for the preparation of the antibiotic C-15003 P-0 (maytaneinol). A known method for producing maytane ethanol is that it is directly extracted from the bark of the plant Putterllckla verrucosa, belonging to the Maytenus zidus, or by processing the resulting maytansin or laitutin lithium aluminum hydride D. substances, as well as several stages — chopping, drying, grinding, extraction, introduction, and purification to obtain the final product. The purpose of the invention is to simplify the process of obtaining the desired product. The goal is achieved by the fact that according to the method of obtaining antibiotic C-15003 P-0 of the general formula
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP52037166A JPS6034556B2 (en) | 1977-03-31 | 1977-03-31 | Antibiotic C-15003 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU890978A3 true SU890978A3 (en) | 1981-12-15 |
Family
ID=12490004
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU772529301A SU741804A3 (en) | 1977-03-31 | 1977-10-07 | Method of preparing antibiotic |
| SU782627804A SU890978A3 (en) | 1977-03-31 | 1978-06-20 | Method of preparing c-15003p-0 antibiotic |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU772529301A SU741804A3 (en) | 1977-03-31 | 1977-10-07 | Method of preparing antibiotic |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS6034556B2 (en) |
| AT (1) | AT364081B (en) |
| BE (2) | BE865589A (en) |
| HU (1) | HU187372B (en) |
| SU (2) | SU741804A3 (en) |
| ZA (2) | ZA781863B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2648992C2 (en) * | 2012-09-26 | 2018-03-29 | Иммуноджен, Инк. | Improved methods of maytansinol acidylation |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7432088B2 (en) * | 2003-05-08 | 2008-10-07 | Immunogen Inc. | Methods for the production of ansamitocins |
| CN116421733B (en) * | 2023-06-08 | 2023-09-12 | 金宇保灵生物药品有限公司 | Vaccine heat-resistant protective agent for live vaccine of swine pasteurellosis |
-
1977
- 1977-03-31 JP JP52037166A patent/JPS6034556B2/en not_active Expired
- 1977-10-07 SU SU772529301A patent/SU741804A3/en active
- 1977-10-13 HU HU802440A patent/HU187372B/en unknown
- 1977-10-14 AT AT0736277A patent/AT364081B/en not_active IP Right Cessation
-
1978
- 1978-03-31 BE BE186486A patent/BE865589A/en not_active IP Right Cessation
- 1978-03-31 ZA ZA00781863A patent/ZA781863B/en unknown
- 1978-03-31 BE BE186487A patent/BE865590A/en not_active IP Right Cessation
- 1978-03-31 ZA ZA00781862A patent/ZA781862B/en unknown
- 1978-06-20 SU SU782627804A patent/SU890978A3/en active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2648992C2 (en) * | 2012-09-26 | 2018-03-29 | Иммуноджен, Инк. | Improved methods of maytansinol acidylation |
| RU2765072C2 (en) * | 2012-09-26 | 2022-01-25 | Иммуноджен, Инк. | Improved maitanzinol acylation methods |
Also Published As
| Publication number | Publication date |
|---|---|
| BE865590A (en) | 1978-10-02 |
| SU741804A3 (en) | 1980-06-15 |
| HU187372B (en) | 1985-12-28 |
| JPS6034556B2 (en) | 1985-08-09 |
| ZA781863B (en) | 1979-03-28 |
| JPS53130693A (en) | 1978-11-14 |
| ZA781862B (en) | 1979-03-28 |
| ATA736277A (en) | 1981-02-15 |
| AT364081B (en) | 1981-09-25 |
| BE865589A (en) | 1978-10-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SU890978A3 (en) | Method of preparing c-15003p-0 antibiotic | |
| KR20020088053A (en) | Method for extracting oleaginous substances from ganoderma lucidum spores | |
| SU1146050A1 (en) | Method of obtaining beta-ecdizon from plant "serratula" | |
| Chester et al. | Three new aliphatic acids from lichens of genus parmelia (subgenus xanthoparmelia) | |
| IE39246B1 (en) | Process for preparing a purified extract of quillata bark | |
| SU685152A3 (en) | Method of synthesis of gamma-butyrolactone | |
| SU1733001A1 (en) | Method for preparation of remedy, showing antiinflammatory and wound-healing action | |
| SU1123701A1 (en) | Method of obtaining saponin from ginseng | |
| SU1117013A1 (en) | Method of obtaining isolated aleuron grains grains of rice | |
| SU1721081A1 (en) | Method of producing absolute tobacco oil | |
| SU396105A1 (en) | METHOD OF MANUFACTURE OF BLACK BAYKH TEA | |
| SU603388A1 (en) | Method of preparing flavonoids exhibiting cholagogic action | |
| SU529171A1 (en) | Method for preparing 1,8-oxazadecalon-4 derivatives | |
| SU596242A1 (en) | Method of preparing magnipherin | |
| SU833253A1 (en) | Method of obtaining polysaccharides possessing emulsifying property | |
| Ishikura et al. | Eriodictyol-7-glucoside and Other Phenolics in the Blue Fruits of Lasiauthus japonica | |
| SU1051087A1 (en) | Process for preparing 2-r-5-(hydroxyhexafluoroisopropyl)furans | |
| SU1005461A1 (en) | Process for producing protein insulators | |
| SU484871A1 (en) | The method of obtaining biologically active polyphenolic compounds from propolis | |
| SU1143423A1 (en) | Method of obtaining flavonoids possessing p-vitamin activity | |
| SU676585A1 (en) | Method of separating alkylcyclohexandioles | |
| SU139402A1 (en) | The method of obtaining strophanthin-K (K-strophanthin-beta) | |
| SU435825A1 (en) | METHOD OF OBTAINING OLEANDRIN | |
| Chi et al. | Coumarins from the Root of Peucedanum insolens Kitagawa | |
| SU592842A1 (en) | Method of producing light brewer's malt |