SU771152A1 - Lactabacillus plantarum 109 strain as bacteriocin p 109 producent - Google Patents
Lactabacillus plantarum 109 strain as bacteriocin p 109 producent Download PDFInfo
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- SU771152A1 SU771152A1 SU782685277A SU2685277A SU771152A1 SU 771152 A1 SU771152 A1 SU 771152A1 SU 782685277 A SU782685277 A SU 782685277A SU 2685277 A SU2685277 A SU 2685277A SU 771152 A1 SU771152 A1 SU 771152A1
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- 108010062877 Bacteriocins Proteins 0.000 title claims description 9
- 229920001817 Agar Polymers 0.000 claims description 6
- 239000008272 agar Substances 0.000 claims description 6
- 101100346189 Caenorhabditis elegans mpc-1 gene Proteins 0.000 claims description 5
- 101100346198 Caenorhabditis elegans mpc-2 gene Proteins 0.000 claims description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 241000186660 Lactobacillus Species 0.000 claims description 3
- 239000002244 precipitate Substances 0.000 claims description 3
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- 102000016938 Catalase Human genes 0.000 claims description 2
- 108010053835 Catalase Proteins 0.000 claims description 2
- GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 claims description 2
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 2
- NGFMICBWJRZIBI-JZRPKSSGSA-N Salicin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O1)c1c(CO)cccc1 NGFMICBWJRZIBI-JZRPKSSGSA-N 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims description 2
- NGFMICBWJRZIBI-UHFFFAOYSA-N alpha-salicin Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UHFFFAOYSA-N 0.000 claims description 2
- 230000003042 antagnostic effect Effects 0.000 claims description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 229930182830 galactose Natural products 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 229940039696 lactobacillus Drugs 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- 235000013336 milk Nutrition 0.000 claims description 2
- 239000008267 milk Substances 0.000 claims description 2
- 210000004080 milk Anatomy 0.000 claims description 2
- 230000000877 morphologic effect Effects 0.000 claims description 2
- 150000002823 nitrates Chemical class 0.000 claims description 2
- 150000002826 nitrites Chemical class 0.000 claims description 2
- NGFMICBWJRZIBI-UJPOAAIJSA-N salicin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UJPOAAIJSA-N 0.000 claims description 2
- 229940120668 salicin Drugs 0.000 claims description 2
- 235000020183 skimmed milk Nutrition 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 238000004383 yellowing Methods 0.000 claims description 2
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 1
- 240000006024 Lactobacillus plantarum Species 0.000 description 4
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 241000186840 Lactobacillus fermentum Species 0.000 description 2
- 244000057717 Streptococcus lactis Species 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 229920000298 Cellophane Polymers 0.000 description 1
- 108090000317 Chymotrypsin Proteins 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 240000001929 Lactobacillus brevis Species 0.000 description 1
- 241000186673 Lactobacillus delbrueckii Species 0.000 description 1
- 235000013965 Lactobacillus plantarum Nutrition 0.000 description 1
- 241000186869 Lactobacillus salivarius Species 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 229960002376 chymotrypsin Drugs 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229940072205 lactobacillus plantarum Drugs 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229960001322 trypsin Drugs 0.000 description 1
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Description
1one
Изобретение относитс к области микробиологии и касаетс получени нового штампа - продуцента антибиотика бактериоцина, который может быть использован дл бактериоцино- 5 типировани и бактериоциногенотипировани лактобацилл, а также в исследовани х с целью изучени генетических элементов, детерминирующих синтез бактероцина, их функциональных осо- О бенностей, химического состава, механизма действи .The invention relates to the field of microbiology and concerns the production of a new stamp - a bacteriocin antibiotic producer, which can be used for bacteriocinformation and bacteriocinogenotyping of lactobacilli, as well as in studies to study the genetic elements determining bacterocin synthesis, their functional features, chemical composition, mechanism of action.
Известен штамм LactobaciI1 us acidophilus, продуцирующий бактериоцин 1.15A known strain of LactobaciI1 us acidophilus, producing bacteriocin 1.15
Однако спектр действи этих бактерицинов ограничиваетс подавлением роста р да культур L.acidophilus.. L.sa1 ivaгins , L . helveficus, L,fermenti , L.pigurti Hi.buchneri.20However, the spectrum of action of these bactericins is limited by suppressing the growth of a number of L.acidophilus cultures .. L.sa1 ivaagins, L. helveficus, L, fermenti, L.pigurti Hi.buchneri.20
Целью изобретени вл етс получение штамма LactobaclHus plantarum 109, продуцирующего бактериоцин, с более широким спектром действи . J Штс1мм LactobaciHus plantarum 25 109 - продуцент бактериоцина 8109.The aim of the invention is to obtain a bacteriocin-producing strain of LactobaclHus plantarum 109, with a wider spectrum of action. J Pcs1mm LactobaciHus plantarum 25 109 - producing bacteriocin 8109.
Штамм Lactobacillus plantarum 109 .выделен из слюны человека.The strain of Lactobacillus plantarum 109. Isolated from human saliva.
Хранитс в лаборатории культур ВНИИА под номером 1601,30Stored in the laboratory of cultures VNIIA number 1601,30
Культурально-морфологические признаки . На среде МРС-1 (48-часова культура) представл ет собой умеренно полиморфные палочки размером 2-3х хо,5-0,8 мкм, расположенные попарнопоследовательно с закругленными концами . Спор и капсул ire имеет. Волютиновых зерен на образует. Грам-поло жительны. Неподвижны.Cultural and morphological features. On a medium, the MPC-1 (48-hour culture) is a moderately polymorphic bacillus with a size of 2-3 x x0, 5-0.8 µm, located in pairs with rounded ends. Dispute and capsules ire has. Volyutinous grains on forms. Gram-positive. Motionless.
Ацетатный агар. Через 72 часа роста при 37°С в атмосфере СО образует круглые беловато-желтоватого цвета колонии разкюром до 2 мм в диаметре, с выпуклой гладкой, блест щей поверхностью , не прозрачньле, с ровным краем , мелкозернистой структурой, м гкой консистенции.Acetate Agar. After 72 hours of growth at 37 ° C in an atmosphere, CO forms round whitish-yellowish colonies with a height up to 2 mm in diameter, with a convex smooth, shiny surface, not transparent, with a smooth edge, fine-grained structure, soft consistency.
Жидка среда МРС-1. Через 24 часа роста при З7с образует равномерное помутнение и небольшой аморфный осадок .Liquid medium МРС-1. After 24 hours of growth at 37 ° C, it forms a uniform turbidity and a small amorphous precipitate.
1,5%-на агарова среда МРС-1, скошенна через 48 часов роста образует налет беловато-желтоватого цвета с гладкой блест щей поверхностью, непрозрачной , м гкой консистенции,располагающийс на поверхности среды.The 1.5% agar medium MPC-1, sloped after 48 hours of growth, forms a whitish-yellowish bloom with a smooth shiny surface, an opaque, soft consistency, located on the surface of the medium.
Среда МРС-5. Через 24 часа роста равномерное помутнение и небольшой аморфный оссщок.Medium MPC-5. After 24 hours of growth, uniform turbidity and a small amorphous residue.
Фиэиолого-биохимические признаки. акультативный анаэроб. Оптимальный ост при 32-37 С. На среде МРС-2 астет при 15°С,не растет при 50°С, а среде МРС-2 с 0,4 типол растет ерез 24 часа. Обезжиренное молоко 5% дрожжевого автолизата и 1% глюозы створаживает на 2-е сутки.Phyiological and biochemical signs. optional anaerobic. The optimum balance at 32-37 C. On the MPC-2 medium, astatte at 15 ° C does not grow at 50 ° C, and the MPC-2 medium with 0.4 tipol grows after 24 hours. Skimmed milk 5% yeast autolysate and 1% glucose blast on the 2nd day.
На среде Дейвиса створаживание и пожелтение среды на 2-е сутки.Молоко створаживает на 2-е сутки, через 14 суток содержание кислот достигает 0,4.On Davis medium, the blending and yellowing of the medium are on the 2nd day. Milk curd on the 2nd day, after 14 days the acid content reaches 0.4.
Желатину не разжижает. Нитраты в нитриты не восстанавливает.Каталазу не образует.Gelatin does not dilute. Nitrates do not restore nitrites. Catalase does not form.
На среде Гибсона и Абд-Эль-Малека ферментирует глюкозу без образовани газа.On the Gibson and Abd-El-Malek medium, ferment glucose without generating gas.
Ферментирует целлобиозу, сорбит, галактозу, мальтозу, сахарозу, маннозу , маннит, лактозу и салицин с образованием кислоты. Рамнозу и крахмал не расщепл ет.Ferments cellobiose, sorbitol, galactose, maltose, sucrose, mannose, mannitol, lactose and salicin to form acid. Rhamnose and starch does not break down.
Антагонистические свойства. Подавл ет рост tact. sa 1 ivarius , Lact. jugurti, Lact. fermenti, Lact.Iactis, Lact delbrueckti.Antagonistic properties. Suppresses the growth of tact. sa 1 ivarius, Lact. jugurti, Lact. fermenti, Lact.Iactis, Lact delbrueckti.
Получение бактерицина P 109 с помощью предлагаемого штамма.Obtaining bactericin P 109 using the proposed strain.
Суточную культуру L.plantarum 109 засевают уколом на чгиику с 1,5%-ной агаровой средой МРС-1 и выращивают 2 суток, при 37°С в вакуумэксикаторах , в которых воздух заменен углекислым газом. Выращенную макроколонию стерилизуют парами хлороформа , после чего поверхность среды заливают вторым слоем 4 мм О,8%-ной агаровой среды МРС-1, расплавленной и охлажденной до -4бс, смешанной с 0,5 мл 4-часовой индикаторной культуры L. jugurti 329.A daily culture of L.plantarum 109 is inoculated with a chigiku injection with 1.5% agar medium MPC-1 and grown for 2 days at 37 ° C in vacuum extractors, in which the air is replaced by carbon dioxide. The grown macrocolony is sterilized with chloroform vapor, after which the surface of the medium is poured with a second layer of 4 mm O, 8% MPA-1 agar medium, melted and cooled to -4 bs, mixed with 0.5 ml of a 4-hour indicator culture of L. jugurti 329.
После застывани среды посевы выращивают при З7с в течение 2 суток. Вокруг макроколо ин L.plantarum 109 наблюдаетс прозрачна , с нечетким краем, диаметром 30 мм зона подавлени роста индикаторного штамма L.j ugurt i 329 .After solidification of the medium, the crops are grown at 3 ° C for 2 days. Around the macrocolin L.plantarum 109 there is a transparent, with a fuzzy edge, 30 mm in diameter, a zone of growth inhibition of the indicator strain L.j ugurt i 329.
Бактериоцин P 109 не инактивируетс трипсином, химотрипсином, пепсином , папаином, Д К-азой, РНК-азой, лизоцимом. При 100°С не инактивируетс в течение 30 мин. Бактериоцин не реплицируетс при пассажах на индикаторном штамме L.jugurti 329 и хорошо диффундирует в агар. Не диффундирует через целлофан.Bacteriocin P 109 is not inactivated by trypsin, chymotrypsin, pepsin, papain, D K-az, RNA-az, lysozyme. At 100 ° C, not inactivated for 30 minutes. Bacteriocin does not replicate during passages on the L.jugurti 329 indicator strain and diffuses well into the agar. Does not diffuse through cellophane.
При бактериоцинотипировании 585 культур лактобациол разных видов получены следующие данные: из 65 культур L.salivarius культур относились к первому бактериоцинотипу и 56 культур ко второму; из 16 культур L.jugurti 1 штамм относилс к nepsofv бактериоцинотипу и 15 культур ко второму; из 84 культур L.fermenti 1 штамм относилс к первому .иWhen bacteriocotyping 585 cultures of lactobaciols of different species, the following data were obtained: from 65 cultures of L.salivarius cultures belonged to the first bacteriocotype and 56 cultures to the second; from 16 cultures of L. jugurti, 1 strain belonged to nepsofv bacteriocinotype and 15 cultures to the second; from 84 cultures of L.fermenti 1, the strain belonged to the first .and
83 культуры ко второму бактериоцинотипу; из 2 культур L.lactis 1 штамм относилс к первому и 1 ко второму бактериоцинопипу; 1 культура L.delbrueckii относилась к первому бактериоцинотипу .83 cultures for the second bacteriocotype; from 2 cultures of L. lactis 1, the strain belonged to the first and 1 to the second bacteriocinopip; 1 L.delbrueckii culture belonged to the first bacteriocotype.
420 культур L-ас i doph i 1 us , L.hel.r veficus, L.Ieichmahuii, L.easel, L.plantarum, L.brevis, L.buchuerl, L.cellobiosus и L.yiridescens были устойчивьоли к бактериоцину P 109.420 cultures of L-ac i doph i 1 us, L.hel.r veficus, L.Ieichmahuii, L.easel, L.plantarum, L.brevis, L.buchuerl, L.cellobiosus and L.yiridescens were resistant to bacteriocin P 109.
Предлагаемый штамм обладает широким спектром действи на культуры лактобацилл , что позвол ет приводить бактерио.цинотипирование и бактериоцииогенетипирование культур L.jugurti, L.lactis и L.de1Ьгueckгi.The proposed strain has a broad spectrum of action on lactobacillus cultures, which makes it possible to produce bacteriocinotyping and bacteriotionogenesis of cultures of L.jugurti, L.lactis, and L.de1Ьrückгi.
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU782685277A SU771152A1 (en) | 1978-10-03 | 1978-10-03 | Lactabacillus plantarum 109 strain as bacteriocin p 109 producent |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU782685277A SU771152A1 (en) | 1978-10-03 | 1978-10-03 | Lactabacillus plantarum 109 strain as bacteriocin p 109 producent |
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| Publication Number | Publication Date |
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| SU771152A1 true SU771152A1 (en) | 1980-10-15 |
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| SU782685277A SU771152A1 (en) | 1978-10-03 | 1978-10-03 | Lactabacillus plantarum 109 strain as bacteriocin p 109 producent |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4942032A (en) * | 1988-09-23 | 1990-07-17 | Microlife Technics, Inc. | Process for producing a novel antifungal product |
| EP0636318A3 (en) * | 1993-07-26 | 1995-03-22 | Gen Foods Inc | Stabilization of the bactericidal aktivity produced in fermented skim milk. |
-
1978
- 1978-10-03 SU SU782685277A patent/SU771152A1/en active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4942032A (en) * | 1988-09-23 | 1990-07-17 | Microlife Technics, Inc. | Process for producing a novel antifungal product |
| EP0636318A3 (en) * | 1993-07-26 | 1995-03-22 | Gen Foods Inc | Stabilization of the bactericidal aktivity produced in fermented skim milk. |
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