SU686734A1 - Remedy for treatment of pneumonia, anemia and dyspepsia - Google Patents

Description

I

This invention relates to medicine and to the treatment of pneumonia.

The use of microbial lipopolysaccharides (prodigiosan) in the treatment of pneumonia is known l.

However, microbial lipopolysaccharides, even in therapeutic doses, exhibit some toxic properties and have a pyrogenic effect.

Polysaccharides A and B, isolated from the gastric mucosa of animals 2j, are used to expand the range of treatments for pneumonia that do not exhibit toxic properties and have no pyrogenic effect.

The preparation is a 2% sterile solution of group-specific polysaccharides A or B, obtained from porcine or loschadny stomachs and subjected to additional purification by dissolving sodium chloride in 0.9% solution followed by precipitation of 6% by volume of ethyl alcohol. Solutions of the drug are apyrogenic and non-toxic.

The Pharmacological Committee of the Ministry of Healthcare and Social Security recommended to allow medical use and industrial production of the drug and gave it the name of Fruglumin.

The drug is administered intramuscularly at intervals of 1-3 days in doses: children up to 1 year old - 1 O mg (O, 5 ml of solution), children more than a year old - 2 O mg (1, O ml of 2% solution). During the course of the liver, 3 to 6 doses of the drug are administered.

Claims (2)

Example 1. Lena Ch. (2 months) was admitted to the clinic in an extremely difficult condition: pronounced effects of exicosis and toxicosis, vomiting, and frequent loose stools up to 2 ° a day. Weight loss ZO, 4%. The occurrence of hypochromic anemia. Comprehensive treatment was combined with four-dose intramuscular administration of fruglumin at a dose of 10 mg. After 3 days, the patient's condition became satisfactory, the stool was normalized, and the appetite was good. Average weekly weight gain for the entire period of treatment is 147 g. In the group of patients up to one year with pneumonia accompanied by anemia, the favorable effect of the use of the drug was expressed in the rapid normalization of red blood indices; an increase in the number of erggs, an increase in their saturation with hemoglobin. After two or three injections of Fruglumin erythrocytes increased by 5OOOOO-15OOOOO 1 mm, the content of hemoglobin in them increased by 2-4 g%. EXAMPLE 2. Igor K. (4.5 months) was admitted to the hospital in a difficult condition: the manifestations of bilateral small-sized patients with HOB pneumonia and hypochromic anemia. Ill For three weeks, he was treated at home. Antibiotics, vitamins, hemotherapy were carried out - the state did not improve. When entering HB 7.3 g%, er. 3550000, a color indicator of 0.63. After the introduction of fruglumin three times, the patient's condition improved significantly, the temperature returned to normal, the appetite improved, and the red blood cells were called normal. Discharged on the 14f-th day in satisfactory condition 4: Hb 10.9 g%, erntrotsvtov 37OOOOO, color noKaaaTifib 0.9. No adverse adverse reactions associated with the administration of fruglumin were observed. The use of fruglumin allows the organism to improve its immunobiological reactivity, stimulate blood formation and has a favorable clinical effect in complex therapy for children with pneumonia combined with dyspepsia, hypotrophy and anemia. Claims The use of polysaccharides A and B, isolated from the mucous membrane of the stomachs of animals, as an agent for the treatment of pneumonia in combination with anemia and dyspepsia. - Sources of information taken into account during the examination 1.Antibiotics. 1972 № 12, p. with. 1109-1125. 2. Health of Belarus, 197O number 6, p. 44-47