SU612636A3 - Способ получени -гомостероидов - Google Patents

Способ получени -гомостероидов

Info

Publication number: SU612636A3
Authority: SU; USSR - Soviet Union
Prior art keywords: homosteroids; obtaining; literature; complex metal; group
Prior art date: 1972-03-29

Application number

SU742008892A

Other languages

English (en)

Inventor

Фюрст Андор

Алиг Лео

Мюллер Марсель

Original Assignee

Ф.Гоффманн Ля Рош И Ко (Фирма)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1972-03-29

Filing date

1974-03-27

Publication date

1978-06-25

1974-03-27 Application filed by Ф.Гоффманн Ля Рош И Ко (Фирма) filed Critical Ф.Гоффманн Ля Рош И Ко (Фирма)

1978-06-25 Application granted granted Critical

1978-06-25 Publication of SU612636A3 publication Critical patent/SU612636A3/ru

Classifications

- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B19/00—Oxazine dyes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Rheumatology (AREA)
Pharmacology & Pharmacy (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Steroid Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

Изобретение относитс к способу получени новых, не описанных в литературе D -гомостероидов, которые обладают биологической активностью и могут найти применение в медицине. В литературе описано восстановление кетогрупп стероидов до оксигрупп ; помседью комплексных гидридов метал лов l . Использование известной реакции в данном случае приводит к получению новых, не описанных в литературе 1)-гсййостер/ идов общей Формулы СНгК .( . где водород, или метил. - независимо друг от друга окси- или ацетоксигруппа. Целью изобретени вл етс синте новых биологически активных соединений . Это достигаетс предлагаемьм спо собом получени соединений вышеуказа ной формулы 1, заключающимс в том, что В-гомостероид общей формулы гдейб, имеют вышеуказан .....мV т v о о irT-u п U а СГ ТТПв ные значени , X и X - защитна з.л кетогруппы семикарбазидна или X вмес те сТ1 и - защитна дл кетогруппы бисметилендиоксигруппа, подвергают восстановлению комплексна гидридом металла с последующим сн тием защитной группы и вьиелением целевого продукта..,. В случае, если и 1 одновременно представл ют собой оксигруппы, то 0-кетогруппа может быть защищена образованием 17, 20, 21 - бисметилендиоксипроизводного . в качестве комплексного гидрида металла предпочтительно используют алюмогидрид лити или боргидрид натри .

SU742008892A 1972-03-29 1974-03-27 Способ получени -гомостероидов SU612636A3 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH466672A CH571018A5 (ru)	1972-03-29	1972-03-29

Publications (1)

Publication Number	Publication Date
SU612636A3 true SU612636A3 (ru)	1978-06-25

Family

ID=4280344

Family Applications (7)

Application Number	Title	Priority Date	Filing Date
SU731901008A SU697054A3 (ru)	1972-03-29	1973-03-27	Способ получени -гомостероидов или их 1,2-дегидропроизводных
SU2008893A SU492080A3 (ru)	1972-03-29	1973-03-27	Способ получени -гомостероидов
SU2008890A SU517263A3 (ru)	1972-03-29	1974-03-27	Способ получени д-гомостероидов
SU2008473A SU538665A3 (ru)	1972-03-29	1974-03-27	Способ получени д-гомостероидов
SU2008896A SU506288A3 (ru)	1972-03-29	1974-03-27	Способ получени -гомостероидов
SU2008891A SU509211A3 (ru)	1972-03-29	1974-03-27	Способ получени д-гомостероидов
SU742008892A SU612636A3 (ru)	1972-03-29	1974-03-27	Способ получени -гомостероидов

Family Applications Before (6)

Application Number	Title	Priority Date	Filing Date
SU731901008A SU697054A3 (ru)	1972-03-29	1973-03-27	Способ получени -гомостероидов или их 1,2-дегидропроизводных
SU2008893A SU492080A3 (ru)	1972-03-29	1973-03-27	Способ получени -гомостероидов
SU2008890A SU517263A3 (ru)	1972-03-29	1974-03-27	Способ получени д-гомостероидов
SU2008473A SU538665A3 (ru)	1972-03-29	1974-03-27	Способ получени д-гомостероидов
SU2008896A SU506288A3 (ru)	1972-03-29	1974-03-27	Способ получени -гомостероидов
SU2008891A SU509211A3 (ru)	1972-03-29	1974-03-27	Способ получени д-гомостероидов

Country Status (27)

Country	Link
JP (2)	JPS5844360B2 (ru)
KR (3)	KR780000672B1 (ru)
AR (1)	AR208389A1 (ru)
AT (1)	AT326282B (ru)
AU (1)	AU468918B2 (ru)
BE (1)	BE797412A (ru)
CA (1)	CA1006156A (ru)
CH (1)	CH571018A5 (ru)
DD (1)	DD105216A5 (ru)
DE (1)	DE2314592C2 (ru)
DK (1)	DK135722B (ru)
ES (13)	ES413083A1 (ru)
FI (1)	FI52099C (ru)
FR (1)	FR2182911B1 (ru)
GB (1)	GB1365469A (ru)
HU (2)	HU170428B (ru)
IE (1)	IE37444B1 (ru)
IL (1)	IL41752A (ru)
LU (1)	LU67304A1 (ru)
NL (1)	NL176945C (ru)
NO (1)	NO139524C (ru)
PH (1)	PH9660A (ru)
PL (7)	PL92130B1 (ru)
SE (2)	SE404530B (ru)
SU (7)	SU697054A3 (ru)
YU (4)	YU81573A (ru)
ZA (1)	ZA731563B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NO140672C (no) *	1973-03-28	1979-10-17	Hoffmann La Roche	Analogifremgangsmaate ved fremstilling av nye anti-inflammatorisk virksomme steroider
DE2442615A1 (de) *	1974-09-04	1976-03-18	Schering Ag	Neue d-homo-steroide
SE411351B (sv) *	1974-10-07	1979-12-17	Hoffmann La Roche	Forfarande for framstellning av d-homosteroider tillhorande pregnanserien
SE427276B (sv) *	1975-04-03	1983-03-21	Hoffmann La Roche	Forfarande for framstellning av d-homosteroider
AT356301B (de) *	1976-09-03	1980-04-25	Hoffmann La Roche	Verfahren zur herstellung von neuen d-homo- steroiden
US4202841A (en) *	1977-08-25	1980-05-13	Hoffmann-La Roche Inc.	D-Homopregnanes
DE3038855A1 (de) *	1980-10-10	1982-05-27	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Neue d-homo-kortikoide, ihre herstellung und verwendung
DE3409554A1 (de) *	1984-03-13	1985-09-19	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue 6(alpha)-methyl-d-homo-kortikoide
JP5987451B2 (ja)	2012-04-25	2016-09-07	富士ゼロックス株式会社	後処理装置及び画像形成装置

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2860158A (en) *	1954-10-18	1958-11-11	Sterling Drug Inc	Compounds of the perhydrochrysene series and preparation thereof

1972
- 1972-03-29 CH CH466672A patent/CH571018A5/xx not_active IP Right Cessation
1973
- 1973-01-01 AR AR247212A patent/AR208389A1/es active
- 1973-03-06 ZA ZA731563A patent/ZA731563B/xx unknown
- 1973-03-12 AU AU53207/73A patent/AU468918B2/en not_active Expired
- 1973-03-12 IL IL41752A patent/IL41752A/en unknown
- 1973-03-19 FI FI730839A patent/FI52099C/fi active
- 1973-03-23 IE IE470/73A patent/IE37444B1/xx unknown
- 1973-03-23 DE DE2314592A patent/DE2314592C2/de not_active Expired
- 1973-03-26 NL NLAANVRAGE7304193,A patent/NL176945C/xx not_active IP Right Cessation
- 1973-03-26 PH PH14464*UA patent/PH9660A/en unknown
- 1973-03-27 SU SU731901008A patent/SU697054A3/ru active
- 1973-03-27 DD DD169749A patent/DD105216A5/xx unknown
- 1973-03-27 LU LU67304A patent/LU67304A1/xx unknown
- 1973-03-27 YU YU00815/73A patent/YU81573A/xx unknown
- 1973-03-27 SU SU2008893A patent/SU492080A3/ru active
- 1973-03-27 YU YU315/73A patent/YU35775B/xx unknown
- 1973-03-28 HU HUHO1719A patent/HU170428B/hu unknown
- 1973-03-28 CA CA167,420A patent/CA1006156A/en not_active Expired
- 1973-03-28 KR KR7300503A patent/KR780000672B1/ko not_active Expired
- 1973-03-28 DK DK170673AA patent/DK135722B/da not_active IP Right Cessation
- 1973-03-28 JP JP48034733A patent/JPS5844360B2/ja not_active Expired
- 1973-03-28 AT AT270973A patent/AT326282B/de not_active IP Right Cessation
- 1973-03-28 BE BE129332A patent/BE797412A/xx not_active IP Right Cessation
- 1973-03-28 SE SE7304403A patent/SE404530B/xx unknown
- 1973-03-28 ES ES413083A patent/ES413083A1/es not_active Expired
- 1973-03-28 HU HUHO1558A patent/HU166580B/hu unknown
- 1973-03-28 NO NO1286/73A patent/NO139524C/no unknown
- 1973-03-29 PL PL1973181066A patent/PL92130B1/pl unknown
- 1973-03-29 GB GB1511273A patent/GB1365469A/en not_active Expired
- 1973-03-29 PL PL1973181064A patent/PL98712B1/pl unknown
- 1973-03-29 PL PL1973181062A patent/PL92077B1/pl unknown
- 1973-03-29 PL PL1973181065A patent/PL92076B1/pl unknown
- 1973-03-29 FR FR7311339A patent/FR2182911B1/fr not_active Expired
- 1973-03-29 PL PL1973181063A patent/PL98710B1/pl unknown
- 1973-03-29 PL PL1973161579A patent/PL86797B1/pl unknown
- 1973-03-29 PL PL1973181067A patent/PL98714B1/pl unknown
1974
- 1974-03-27 SU SU2008890A patent/SU517263A3/ru active
- 1974-03-27 SU SU2008473A patent/SU538665A3/ru active
- 1974-03-27 SU SU2008896A patent/SU506288A3/ru active
- 1974-03-27 SU SU2008891A patent/SU509211A3/ru active
- 1974-03-27 SU SU742008892A patent/SU612636A3/ru active
1975
- 1975-08-01 ES ES439956A patent/ES439956A1/es not_active Expired
- 1975-08-01 ES ES439951A patent/ES439951A1/es not_active Expired
- 1975-08-01 ES ES439957A patent/ES439957A1/es not_active Expired
- 1975-08-01 ES ES439950A patent/ES439950A1/es not_active Expired
- 1975-08-01 ES ES439954A patent/ES439954A1/es not_active Expired
- 1975-08-01 ES ES439948A patent/ES439948A1/es not_active Expired
- 1975-08-01 ES ES439953A patent/ES439953A1/es not_active Expired
- 1975-08-01 ES ES439958A patent/ES439958A1/es not_active Expired
- 1975-08-01 ES ES439949A patent/ES439949A1/es not_active Expired
- 1975-08-01 ES ES439955A patent/ES439955A1/es not_active Expired
- 1975-08-01 ES ES439952A patent/ES439952A1/es not_active Expired
- 1975-08-01 ES ES439959A patent/ES439959A1/es not_active Expired
1976
- 1976-02-27 SE SE7602850A patent/SE7602850L/xx unknown
1978
- 1978-04-29 KR KR7801294A patent/KR780000673B1/ko not_active Expired
- 1978-04-29 KR KR7801305A patent/KR780000675B1/ko not_active Expired
1979
- 1979-03-08 YU YU568/79A patent/YU35452B/xx unknown
- 1979-03-08 YU YU569/79A patent/YU35453B/xx unknown
1982
- 1982-10-01 JP JP57171109A patent/JPS6052160B2/ja not_active Expired

Also Published As

Publication number	Publication date
LU67304A1 (ru)	1974-10-09
DK135722C (ru)	1977-11-14
SE404530B (sv)	1978-10-09
FI52099C (fi)	1977-06-10
ES439955A1 (es)	1977-06-01
DE2314592C2 (de)	1983-04-14
JPS495960A (ru)	1974-01-19
PH9660A (en)	1976-01-27
SU509211A3 (ru)	1976-03-30
ES439952A1 (es)	1977-07-01
YU56979A (en)	1980-09-25
ES439957A1 (es)	1977-06-01
SU538665A3 (ru)	1976-12-05
CH571018A5 (ru)	1975-12-31
HU170428B (ru)	1977-06-28
NL176945B (nl)	1985-02-01
DE2314592A1 (de)	1973-10-11
FR2182911B1 (ru)	1976-10-22
IE37444L (en)	1973-09-29
SU492080A3 (ru)	1975-11-15
PL98714B1 (pl)	1978-05-31
ES413083A1 (es)	1976-06-01
ES439956A1 (es)	1977-06-01
YU35452B (en)	1981-02-28
ES439951A1 (es)	1977-07-01
ES439958A1 (es)	1977-06-01
KR780000675B1 (en)	1978-12-26
CA1006156A (en)	1977-03-01
DK135722B (da)	1977-06-13
PL86797B1 (ru)	1976-06-30
SU697054A3 (ru)	1979-11-05
ZA731563B (en)	1973-11-28
SU517263A3 (ru)	1976-06-05
JPS5877899A (ja)	1983-05-11
ATA270973A (de)	1975-02-15
AR208389A1 (es)	1976-12-27
JPS6052160B2 (ja)	1985-11-18
IE37444B1 (en)	1977-07-20
GB1365469A (en)	1974-09-04
YU56879A (en)	1980-09-25
IL41752A (en)	1977-11-30
KR780000672B1 (en)	1978-12-26
IL41752A0 (en)	1973-05-31
PL92076B1 (ru)	1977-03-31
NL7304193A (ru)	1973-10-02
ES439959A1 (es)	1977-06-01
FR2182911A1 (ru)	1973-12-14
NL176945C (nl)	1985-07-01
YU35775B (en)	1981-06-30
BE797412A (fr)	1973-09-28
ES439953A1 (es)	1977-06-16
PL98710B1 (pl)	1978-05-31
FI52099B (ru)	1977-02-28
ES439950A1 (es)	1977-07-01
SU506288A3 (ru)	1976-03-05
PL98712B1 (pl)	1978-05-31
SE7602850L (sv)	1976-02-27
YU35453B (en)	1981-02-28
AT326282B (de)	1975-12-10
AU5320773A (en)	1974-09-12
HU166580B (ru)	1975-04-28
AU468918B2 (en)	1976-01-29
NO139524B (no)	1978-12-18
PL92130B1 (ru)	1977-03-31
PL92077B1 (ru)	1977-03-31
NO139524C (no)	1979-03-28
ES439948A1 (es)	1977-07-01
KR780000673B1 (en)	1978-12-26
ES439954A1 (es)	1977-06-01
DD105216A5 (ru)	1974-04-12
ES439949A1 (es)	1977-07-01
JPS5844360B2 (ja)	1983-10-03
YU81573A (en)	1980-12-31

Publication	Publication Date	Title
NL180098C (nl)	1987-01-02	Werkwijze ter bereiding van zeer zuiver tereftaalzuur door oxydatie van p-tolualdehyde.
SU612636A3 (ru)	1978-06-25	Способ получени -гомостероидов
GB1254983A (en)	1971-11-24	Process for the isolation of s-adenosyl-1-methionine and of s-adenosyl-1-ethionine
BE844858A (fr)	1977-02-04	Procede perfectionne pour la preparation d'alcools de guerbet en utilisant des catalyseurs de plomb insolubles
GB1167993A (en)	1969-10-22	Novel Chemical Compounds, Process for Making Same and Method of Treatment
GB1160539A (en)	1969-08-06	Process for Producing Iodine Pentafluoride
JPS51141793A (en)	1976-12-06	Method of forming calcium sulfate whisker
JPS5227720A (en)	1977-03-02	Process for preparation of leucylagumatine compounds
GB1036815A (en)	1966-07-20	Method of producing n-methyleneglycinonitrile
JPS5254087A (en)	1977-05-02	Production prostaglandins
JPS55151556A (en)	1980-11-26	Production of 4-(3-isopropylamino-2-hydroxy-propoxy)indole
JPS539715A (en)	1978-01-28	Crystallization of dl-acetylmethionine
GB1088395A (en)	1967-10-25	Improvements in or relating to sulphonyl urea derivatives
JPS5236654A (en)	1977-03-22	Process for preparation of steroid derivatives
JPS51141895A (en)	1976-12-07	Process for preparing 1,4-diaza-bicyclo(2,2,2)octane
JPS5236596A (en)	1977-03-19	Method for production of high purity cryolite
JPS52232A (en)	1977-01-05	Process for purification of hydroquinone
JPS5212987A (en)	1977-01-31	Manufacture of na glutamate
JPS53112859A (en)	1978-10-02	Production of 1-methyladamantane
JPS523061A (en)	1977-01-11	Process for preparing 4-cyanoimidazole-5-carbamic acid esters
JPS52108922A (en)	1977-09-12	Process for separating tartaric acid from solution containg the same
JPS5227755A (en)	1977-03-02	Preparation of benzophenone derivatives
YU35105B (en)	1980-09-25	Process for preparing acetylamine derivatives of 2,4,6-triiodo-benzoic acid
JPS5262291A (en)	1977-05-23	Preparation of 7-aamino-deacetoxycephalosporanic acid derivatives
JPS5236976A (en)	1977-03-22	Process for production of semiconductor elements