SU604023A1 - Method of simulating myocardial infarction - Google Patents
Method of simulating myocardial infarctionInfo
- Publication number
- SU604023A1 SU604023A1 SU762434817A SU2434817A SU604023A1 SU 604023 A1 SU604023 A1 SU 604023A1 SU 762434817 A SU762434817 A SU 762434817A SU 2434817 A SU2434817 A SU 2434817A SU 604023 A1 SU604023 A1 SU 604023A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- myocardial infarction
- coronary artery
- simulating
- catheters
- simulating myocardial
- Prior art date
Links
- 208000010125 myocardial infarction Diseases 0.000 title claims description 7
- 238000000034 method Methods 0.000 title description 5
- 230000001684 chronic effect Effects 0.000 claims description 2
- 210000004351 coronary vessel Anatomy 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 210000000709 aorta Anatomy 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- 210000003748 coronary sinus Anatomy 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000004165 myocardium Anatomy 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 230000003601 intercostal effect Effects 0.000 description 1
- 229940035363 muscle relaxants Drugs 0.000 description 1
- 239000003158 myorelaxant agent Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 210000005245 right atrium Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Description
1one
Изобрететше относитс к облас1 и медицины , а именно к экспериментальной кардиологаи .The invention relates to the field of medicine and, in particular, to experimental cardiology.
Известен способ моделировани инфаркта миокарда путем наложени лигатуры на коронарную артерию 1 Однако такой способ не позвол ет, провод11ть исследовани динамики обменных процессов в сердечной мышце в различные периоды инфаркта миокарда. The known method of modeling myocardial infarction by imposing a ligature on the coronary artery 1 However, this method does not allow the study of the dynamics of metabolic processes in the heart muscle during different periods of myocardial infarction.
Целью изобретени вл етс обеспече-. ние. исследовани динамики обменных процессов в сердечной мьгшце в различные пе риоды инфаркта миокарда.The aim of the invention is to provide. the studies of the dynamics of metabolic processes in the heart in various periods of myocardial infarction.
Это досшгаетс тем, что производ т вживление катетеров в аорту и коронарный синус, а затем после заживлени операци . онных ран вызывают дозированное сужение коронарной артерии.This is accomplished by inserting catheters into the aorta and the coronary sinus, and then after the healing operation. These wounds cause a dosed narrowing of the coronary artery.
Способ осуществл ют следующим образом .The method is carried out as follows.
Берут опытное животное - собаку весом не менее 15-20 кг. (у крупных животных более рельефно выражены магистральные сосуды). Производ т премедикадию, животное перевод т на исскуственное дыхание с применением малых доз миорелаксантов. Вскрытие грудной клетки производ т справа в 1У-.у межреберь х. Затем под заднюю нисход щую ветвь левой коронарной артерии подвод т петлю из лески, конец которой вывод т над поверхностью кощи. Одновременно во врем операции вс1фывают также правую рем1 ую вену и правую соннуюTake an experienced animal - a dog weighing at least 15-20 kg. (in large animals the main vessels are more pronounced). Premedicadium is produced, the animal is transferred to artificial respiration using small doses of muscle relaxants. The thorax is dissected to the right of the 1I-y intercostal space. Then, under the posterior descending branch of the left coronary artery, a loop is drawn from the fishing line, the end of which is led out above the surface of the box. At the same time, during the operation, the right repair vein and the right carotid bone
артерию, в которую через специальный металличес1Шй зонд ввод т полиэтиленовые катетеры диаметром 1,5-2. мм и длиной 30-50 см.an artery into which polyethylene catheters with a diameter of 1.5-2 are inserted through a special metal probe. mm and a length of 30-50 cm
Один катетер ввод т в коронарный си-A single catheter is inserted into the coronary
нус на глубину 5-6 мм, центральный конец которого фиксируют лигатурами в правое предсердие. Другой катетер подвод т к устью коронарной артерии. После удалени металличесю х зондов периферическиеnous at a depth of 5-6 mm, the central end of which is fixed with ligatures in the right atrium. Another catheter is delivered to the mouth of the coronary artery. After removing the metal probes peripheral
концы катетеров закрепл ют Нй коже шеи. В .конце операции катетеры промывают физиологическим раствором с гепарином-и закрывают полиэтиленовой пробкой; операционные раны закрывают наглухо. ЧерезThe ends of the catheters are attached to the skin of the neck. At the end of the operation, the catheters are washed with saline solution with heparin and closed with a polyethylene stopper; surgical wounds are closed tightly. Through
7-10 дней после заживлени ран производ т дозированное сужение коронарной артерии с помощью устройства, а такнсе с помощью вживленных катетеров производ т исследова ш биохимического состава крови из аорты и коронарного синуса. Эту опе рацию производ т при налажении лигатуры на заднюю нисход щую ветвь левой к6ронарнсй артерии. При налажении лигатуры на переднюю нисход щую ветвь левой коронарной артерии необходимо производить операцию двухмоментно; в начале посде вскрыти грудкой клетки, слева накладывают лигатуру на переднюю нисход щую ветвь коронарной артерии, а затем спуст 7-10 дней после вскрыти грудной клетки справа производ т катетеризащио коронарного синуса и аорты. Через 7-10 дйей после повторной операции животных используют в эксперименте. После пережати коронарной артерии и7-10 days after the healing of wounds, a dosed narrowing of the coronary artery was performed with the help of the device; This operation is performed when a ligature is established on the posterior descending branch of the left artery. When adjusting the ligature to the anterior descending branch of the left coronary artery, it is necessary to perform a two-step operation; open the breast cell at the beginning, the ligature on the anterior descending branch of the coronary artery is placed on the left, and then after 7–10 days after opening the rib cage, a coronary sinus catheterization and aorta are made on the right. After 7-10 days after the second operation, the animals are used in the experiment. After pressing the coronary artery and
воспроизведени инфаркта ктокарда производ т исследование биохимического cocia ва крови в динамике заболевани в течение двух-трех недель. В течении этого периода катетеры функционируют посто нно.reproducing a heart attack infarction a biochemical blood test was performed over a period of two to three weeks. During this period, the catheters function continuously.
Таким образом, в хроническок эксперименте биохимический состав притекающей и оттекающей от миокарда крови изучают: при окклюзии как передней, так и задней нисход щих ветвей левой коронарной артерии .,Thus, in a chronic experiment, the biochemical composition of the blood flowing in and out of the myocardium is studied: in occlusion of both the anterior and posterior descending branches of the left coronary artery.,
Предлагаемый способ позвол ет исследовать биохимический состав крови в дина мике заболевани при инфаркте миокарда.The proposed method allows the study of the biochemical composition of blood in the dynamics of the disease in myocardial infarction.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU762434817A SU604023A1 (en) | 1976-12-29 | 1976-12-29 | Method of simulating myocardial infarction |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU762434817A SU604023A1 (en) | 1976-12-29 | 1976-12-29 | Method of simulating myocardial infarction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU604023A1 true SU604023A1 (en) | 1978-04-25 |
Family
ID=20688499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU762434817A SU604023A1 (en) | 1976-12-29 | 1976-12-29 | Method of simulating myocardial infarction |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU604023A1 (en) |
-
1976
- 1976-12-29 SU SU762434817A patent/SU604023A1/en active
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