SU577036A1 - Method of pre-operational treatment of cervical carcinoma - Google Patents
Method of pre-operational treatment of cervical carcinomaInfo
- Publication number
- SU577036A1 SU577036A1 SU7402061284A SU2061284A SU577036A1 SU 577036 A1 SU577036 A1 SU 577036A1 SU 7402061284 A SU7402061284 A SU 7402061284A SU 2061284 A SU2061284 A SU 2061284A SU 577036 A1 SU577036 A1 SU 577036A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- treatment
- cervical carcinoma
- operational treatment
- tumor
- operational
- Prior art date
Links
- 238000000034 method Methods 0.000 title description 5
- 208000019065 cervical carcinoma Diseases 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 description 6
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 3
- 229960000485 methotrexate Drugs 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 208000002495 Uterine Neoplasms Diseases 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 229940044683 chemotherapy drug Drugs 0.000 description 1
- 229960004397 cyclophosphamide Drugs 0.000 description 1
- 230000002380 cytological effect Effects 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- BRZOTEHEMOQUOY-UHFFFAOYSA-N n-[bis(aziridin-1-yl)phosphoryl]benzamide Chemical compound C=1C=CC=CC=1C(=O)NP(=O)(N1CC1)N1CC1 BRZOTEHEMOQUOY-UHFFFAOYSA-N 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
II
Изобретение относитс к области медицины , а именно гинекологии.This invention relates to the field of medicine, namely gynecology.
Известен способ предоперационного лечени рака шейки матки путем введени химиотерапевтических препаратов, например тистэф , бензотеф, циклофосфан и др. 11 .There is a known method of preoperative treatment of cervical cancer by administering chemotherapeutic drugs, such as tistef, benzotef, cyclophosphamide, etc. 11.
Целью изобретени вл етс повьпление лечебного эффекта путем воздействи на. вес пролиферативный пул плоскоклеточной опухолевой ткани.The aim of the invention is to reverse the therapeutic effect by acting. the weight of the proliferative pool of squamous tumor tissue.
Это постигаетс тем, что ввод т энао . лимфатически смесь метотрексата и тиотэфа с одновременным местным воздействием опивомициновой мазью.This is comprehended by the introduction of enao. lymphatic mixture of methotrexate and thioteph with simultaneous local exposure to opivomycin ointment.
Способ осуществл ют следующим обра-зом .The method is carried out as follows.
Ежедневно больной ввод т во влагалище тампон С О, оливомииииовой мазью так, чтобы он тесно прилегал к раковой поверхности на шейке матки. Тампон оставл ют на 6-8 час. Введение тампона провод т в зависимости от состо ни местного процесса до 20 дней.Every day, the patient is inserted into the vagina with a tampon C O, with olivomiiovoy ointment so that it is closely adjacent to the cancer surface on the cervix. The swab is left for 6-8 hours. Depending on the state of the local process, the insertion of a tampon is carried out for up to 20 days.
В первые дни лечени ввод т также полихимиопрепараты . Одновременно в оОе ноги In the first days of treatment, polychemical preparations are also administered. At the same time in oOe legs
эндолимфатически при помощи аппарата дл лимфоинфузии ввод т коктейшг, включающие 10О мг тиотэфа и 10О-20О мг метотрексата .endolymphatically, using a lymphoinfusion apparatus, cocktails are included, including 10 O mg thioteph and 10 O-20 O mg methotrexate.
В процессе лечени опухоль уменьшаетс в размерах, уменьшаетс кровоточивость, с поверхности опухоли отторгаютс некротические массы. К концу лечени оп)холь рассасиваетс , на месте опухоли остаютс учасТ1СИ эпителии та в вЙце пленок желтоватого цвета.In the course of treatment, the tumor is reduced in size, the bleeding decreases, and necrotic masses are rejected from the surface of the tumor. By the end of the treatment, the chol resolves, and the site of the epithelium remains in the place of the tumor in a yellowish-colored film.
При цитологическом исслрцовании хгазков с noBepxHociH опухоли выражены /luгенеративные изменени в оп ХОле М:Г. клетклх вплоть цо лизиса псслецних.In cytological examination of noctures with noBepxHociH, tumors show pronounced / lugenative changes in the op XLE of M: H. cells up to the cis lysis of patients.
Положительный зпключаеугс в повышении эффекгивносги предоперационного лечени , исключаюшего лучевую а ераиию.A positive response in enhancing the effectiveness of preoperative treatment, excluding radiotherapy.
Ф о р М у л а и 3 о б р е т е и и F o r M o l a and 3 o b e t e i u
Способ предоперационного лечени рака мюйки матки, включаю1гшй общее химиоторапевтическое и местное воздействиь;A method for the preoperative treatment of uterine uterine cancer, including general chemotherapy and local effects;
57703(; ,.57703 (;,.
33
л и ч а ю ш и и с тем, что. с цельюогиювременным местным возцействием олиповьпчени лечебного э4х)екта путем воздей-вомициновой мазью.l and h and w and so that. for the purpose of the temporary local impact of medical treatment of e4x) ect by means of vomitsinovoy ointment.
стви на весь пролиферативный пул шюско-Источшти информации, прин тые во вникле««нойоп тсолевой ткани, ввод т энцолим-маше при экспертизе. , . . оFor the entire proliferative pool of Shusko-Istochshti information, taken in the case of “noyoprotein tissue”, they are introduced into the enzolim-mache during the examination. , . about
аатин-ски смесь метотрексата и тиотэфа с5 1.рнкопоги ,Киев, 1971, вып. 2, с. 135-137aatin-ski mixture of methotrexate and thioteph c5 2, s. 135-137
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU7402061284A SU577036A1 (en) | 1974-09-16 | 1974-09-16 | Method of pre-operational treatment of cervical carcinoma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU7402061284A SU577036A1 (en) | 1974-09-16 | 1974-09-16 | Method of pre-operational treatment of cervical carcinoma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU577036A1 true SU577036A1 (en) | 1977-10-25 |
Family
ID=20596440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU7402061284A SU577036A1 (en) | 1974-09-16 | 1974-09-16 | Method of pre-operational treatment of cervical carcinoma |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU577036A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130101616A1 (en) * | 2003-09-08 | 2013-04-25 | James Dao | Compositions of botanical extracts for cancer therapy |
-
1974
- 1974-09-16 SU SU7402061284A patent/SU577036A1/en active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130101616A1 (en) * | 2003-09-08 | 2013-04-25 | James Dao | Compositions of botanical extracts for cancer therapy |
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