SU565668A1 - Blood purification apparatus - Google Patents

Description

one

The invention is related to the field of medical technology.

A device for blood purification is known comprising a semipermeable membrane, a housing, absorbents, fittings for blood supply and removal, and supporting grids ij.

The chain of the invention is to provide blood purification from toxic substances while reducing the primary volume of filling with donor blood.

To do this, in the proposed device, the housing is divided into a number of chambers, the adsorbent located in each chamber is separated from the outer walls of the support chamber, each chamber is equipped with fittings for supplying and discharging working solutions, and filters are installed between the individual chambers and at the entrance and exit of the housing with adsorbents. The adsorbent of filters is made of carbon fiber material, the filter installed at the inlet contains activated carbon, and the filter installed at the outlet contains letilanovu wool. The activated carbon is made in the form of granules enclosed in capsules of semipermeable material, and the blood flow channel of each chamber has an opening for recirculation of blood.

On the phage. 1 shows a blood purifier, incision; in fig. 2 - device camera.

The housing 1 of the device is divided into chambers 2-6. The adsorbent 7 is located in each chamber and is separated from its outer walls by a support grid 8. Each chamber 2-6 is equipped with fittings 9 for supplying and from, water paciBopoB workers. Filters 10 and 11 are installed between chambers 2, 3 and 3, 4.

Filters 12 and 13 are also installed at the outlet and at the inlet of housing 1, the adsorbent of filters 10 and 11 is made of carbon fiber material, the filter 10 contains activated carbon, and the filter 11 contains letilan wool.

Claims (3)

The activated carbon is in the form of granules enclosed in capsules of semipermeable material 14. The channel 15 of the blood flow of each chamber has a hole a 1 dp of recirculation of blood. The device works as follows. The patient's blood is supplied by a transport pump (not shown) at the inlet 13 through fitting 16. Heparin or necessary medicinal compounds are injected into the blood through fitting 17. If necessary, blood is collected from fitting 17 for analysis. In the same filter, there is a Serbian purification of blood with encapsulated activated carbon from coarse exogenous barbiturate-type dows, halogen-organic compounds, organic toxic compounds, etc. Then the blood flows through channel 15 of the bloodstream to chamber 2. In the chamber cavity, the working solution circulates - glucuronic acid or sulfuric acid from the unit for the transport of working solutions. A positive result also gives a mixture of these acids. The solution washes the layer; the adsorbent and ensures the contact of the blood with the adsorbent through the impermeable Material 14. The presence of two symmetrically located cavities. This makes it possible to vary the chemical effect due to the supply of different types of working solutions. In this cell, chemical exogenous and endogenous binding of poisons, such as cresol, phenol, benzene, toluene, skatole, bilirubin, barburates, with glucoronic and sulfuric acids, occurs, and the reaction is catalyzed by the enzyme aryl sulfatanserase, planted on the rorbent. As a result of a chemical reaction, they form with paired or coplugative compounds such as phenol-cresol-sulfur compounds, phenol-cresol-glucuronium compounds, etc., which either adsorb on the cop-J bent or go into the sphere of circulation of the working equipment. In general, most toxic compounds with carboxyl, hydroxyl, amino, and sulfo groups enter into chemical exposure with glucuronic acid. In the same chamber, a partial diffusion of glucuronic and sulfuric acids into the blood flow channel occurs through the semipermeable material to interact with those toxins that have not been dialyzed through the membrane due to high molecular weight or other (} zhizko-chemical factors. Product interaction The froKsins and acids are enlarged by filters 1 installed in the openings of the septum, and the encapsulation of the fibers provides non-traumatic conditions for the purification of the blood I from the conjugates. Then the blood flows into chamber 3, Amidation reaction. As working solutions, solutions of glutamic or aspartic acid (or a mixture of these acids) are used.Amthiac of blood diffuses through the permeable material 14, enters the chamber 3, the hertz enters the release of aspartate acid with the formation of glutamine and asparagine, respectively. the blood is purified from urea, and the urea is destroyed by the action of urease applied to the adsorbent. The resulting compounds (ammonium carbonate) react with the zirconium compound and are captured by the adsorbent. Partial diffusion of the glutamine occurs in the same chamber, and / or j aspartic acid, into the blood flow channel to interact with the blood ammonia, the interaction products are captured by the enzyme. Depending on the type of disease in K / amer 4, blood is enriched with glucose (then glucose solution is used as a working solution) or blood is dialyzed from excess glucose through a semipermeable membrane (then saline is used as a working solution). After the recovery chamber of the carbon composition, the blood enters the blood flow channel into the chamber 5 of the enzymatic workout, where dialysis of toxins through the semipermeable material is carried out to sections and granules of the liver of an animal (pigs, monkeys, dogs). In case of absence, they are alive; from sections of the liver, the chamber is filled with an adsorbent with grafted / planted enzymatic preparations of the liver. Then the blood through the channel 15 of the blood flow enters the chamber 6 correction of the water and ion composition. Here | dialysis is carried out: through a semipermeable membrane from excessive amounts of water, salts and simultaneous saturation of the blood with ions. The final purification from particles of active substances, coal microparticles and. Biological formations occur in the filter 12 filled with Letilan cotton wool. In the same filter, deheparinization and sampling for analysis take place. The analysis shows whether blood can be returned to the body or should be directed to full or partial recycling, which is partial in individual chambers, carried out through the openings inside the blood flow channel. The device for biochemical normalization of blood has a temperature control system for the working solutions, which provides the temperature of blood at the exit of the device 39 i 0.5 ° C. The invention solves a number of problems related to; imitation of the main specific functions of the liver of a living organism in conditions of severe chemical, traumatic or razopichnogo diseases of the liver. Biochemical device: normalization of the blood takes on the liver and, if necessary, the kidneys (dialysis from urea), which frees the liver from overloads, from the damaging effects of toxins and allows the liver to regenerate the affected cells. DETAILED DESCRIPTION OF THE INVENTION A blood purifier comprising a semipermeable membrane. blood flow channel, support nets, casing, adsorbents, fittings for blood supply and removal, which is characterized by the fact that the casing is divided into a number of to clean the blood from toxic gases while reducing the initial filling volume; chambers, the adsorbent located in each chamber is separated from the outer walls of the chamber by a supporting grid, each chamber is fitted with alloys of popes and working air pockets, and between the individual chambers and at the inlet and outlet of Kopriyc; a filters with adsorbents are installed. 2. A device according to claim 1, characterized in that the adsorbate of the filters is made of carbon fiber material. 3. The device according to claim 1, characterized in that the adsorbent of the filter installed at the inlet contains activated carbon and the adsorbent of the filter; installed at the exit - the Petilano be4. The device according to claim 3, which is activated so that the activated carbon is made in the form of granules enclosed in quits from I semipermeable material. 5. Device pop. This is distinguished by the fact that the blood flow canap each chamber has holes I for recirculation of blood. Sources of information taken into account in the examination: 1. US Patent No. 3742946, cl. 128-124, 1973.