SU551871A1 - 2-arylpiperazino-2-phenylindanones possessing psychotropic properties - Google Patents
2-arylpiperazino-2-phenylindanones possessing psychotropic properties Download PDFInfo
- Publication number
- SU551871A1 SU551871A1 SU742009483A SU2009483A SU551871A1 SU 551871 A1 SU551871 A1 SU 551871A1 SU 742009483 A SU742009483 A SU 742009483A SU 2009483 A SU2009483 A SU 2009483A SU 551871 A1 SU551871 A1 SU 551871A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- phenylindanones
- arylpiperazino
- psychotropic properties
- possessing
- possessing psychotropic
- Prior art date
Links
- 230000000506 psychotropic effect Effects 0.000 title claims description 3
- 239000000460 chlorine Substances 0.000 claims description 2
- 229910052801 chlorine Inorganic materials 0.000 claims description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical compound C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
(54) 2-АРИЛИИПЕРАЗИНО-2- ФЕНИЛИИДАНОНЫ, . ОБЛАДАЮЩИЕ ПСИХОТРОПНЬМИ СВОЙСТВАМИ системе бемзол-петролейный эфир (3jV и кристаллизацией из петролейного эфира. Выход 2-хлор 2-фенилин анона2 ,4 г 50% , бесцветные кристаллы с т.пл.. Пример 2. Получение 2- N-фенилпиперазино -2-фенилиндано а-1. 2,4 г 0,01 моль 2-хлор-2-фени-линданона-i раствор ют в 30 мл иоксана ,прибавл ют 3,2 г 0,02 моль Ы-фенилпиперазина в 30 мл диоксана. и оставл ют на ночь. Отдел ют гндррбрсзмид пиперазина, фильтрат выливакэт в воду. Выпавшее масл нистое вещество хроматографируют на колонке с окисью алюмини в системе растворите лей хлороформ - бензол 4г1 и крнс таллизируют из спирта. Получают 1,9 г (52% желтоватых кристаллов 2-fК-фенилпиперазино -2-фенилинданона-1 с т. пл. Д25-12б с. Таким же образом получают и другие 2-N-apилпипepaзинo-2-фeнилиндaнoны-l общей формулы экспериментальные данные о которых даны в табл.2. Т а б л-и ц а 1(54) 2-aryliuminerasin-2-phenyldianones,. OWNERS OF PSYCHOTROPIC PROPERTIES of the system benzol-petroleum ether (3jV and crystallization from petroleum ether. Yield 2-chlorine 2-phenyline anona2, 4 g 50%, colorless crystals with m.p. Example 2. Preparation of 2- N-phenylpiperazino -2- phenylindano a-1. 2.4 g of 0.01 mol of 2-chloro-2-phenyl-lindanone-i is dissolved in 30 ml of ioxane, 3.2 g of 0.02 mol of N-phenylpiperazine in 30 ml of dioxane and left overnight. Separate piperazine gdrrbrszmid, the filtrate is poured into water. The oily precipitated substance is chromatographed on a column of alumina in a solvent system design - benzene 4g1 and crns are gallified from alcohol. 1.9 g are obtained (52% yellowish crystals of 2-fK-phenylpiperazino -2-phenylindanone-1 with a melting point of D25-12b p. Other 2-N are obtained in the same way -apilpipazino-2-phenylindanones-l of the general formula, the experimental data are given in Table 2. Table 1
а-фвн -З-ССо-метохонфвнихй- 9400a-fvn-3-SSO-metohonfvnyh- 9400
Таблица 2table 2
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU742009483A SU551871A1 (en) | 1974-03-26 | 1974-03-26 | 2-arylpiperazino-2-phenylindanones possessing psychotropic properties |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU742009483A SU551871A1 (en) | 1974-03-26 | 1974-03-26 | 2-arylpiperazino-2-phenylindanones possessing psychotropic properties |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU551871A1 true SU551871A1 (en) | 1981-09-07 |
Family
ID=20579922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU742009483A SU551871A1 (en) | 1974-03-26 | 1974-03-26 | 2-arylpiperazino-2-phenylindanones possessing psychotropic properties |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU551871A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2268884C2 (en) * | 2001-08-10 | 2006-01-27 | Ф.Хоффманн-Ля Рош Аг | Arylsulfonyl derivatives possessing affinity to 5-ht6 receptor and method for their preparing |
-
1974
- 1974-03-26 SU SU742009483A patent/SU551871A1/en active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2268884C2 (en) * | 2001-08-10 | 2006-01-27 | Ф.Хоффманн-Ля Рош Аг | Arylsulfonyl derivatives possessing affinity to 5-ht6 receptor and method for their preparing |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IT1002937B (en) | PURIFICATION OF HYDROXYACETIC ACID | |
| PT64673A (en) | PROCESS FOR THE PREPARATION OF NEW SUBSTITUTED PERHALOALCOYLAMIDINES AS CARDIAC STIMULANTS | |
| ES396212A1 (en) | N-(1-bicyclic aryl-propyl-2)-n'-bicyclic aryl-piperazines | |
| SU551871A1 (en) | 2-arylpiperazino-2-phenylindanones possessing psychotropic properties | |
| SU567404A3 (en) | Method of preparation of 2-nitro imidazole derivatives | |
| SU517587A1 (en) | Method for preparing 2-oxphenylurea derivatives | |
| BE829999A (en) | PROCESS FOR SYNTHESIS OF BIS (2-N, N-DIMETHYLAM INO) ETHYL ETHER-OXIDE | |
| BE803213A (en) | NEW AZOMETHINS OF 4-AMINO-5-H-1,2,4-TRIAZINE-5-ONES, THEIR PREPARATION PROCESS AS HERBICIDES | |
| SU584771A3 (en) | Method of preparing substituted quinoxalinediones or salts thereof | |
| SU539527A3 (en) | The method of obtaining 1-4-methyl-3- (2-quinoxalinylmethylene) carbazate | |
| BE817890A (en) | PROCESS FOR THE PREPARATION OF AROMATIC ALDEHYDES | |
| US5608058A (en) | Processing for purifying crown compounds | |
| KR930012741A (en) | Method for preparing 4-hydroxymethyltetrahydropyran | |
| SE8001009L (en) | PROCEDURE FOR PREPARING 7-ACYLINDOLIN-2-ONER | |
| SU335946A1 (en) | The method of obtaining 5- (-alkylamino-acylamino) -benzodioxanes-1,4 | |
| ATE50253T1 (en) | THIDIAZOL DERIVATIVES ACTIVE ON THE CENTRAL NERVOUS SYSTEM, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICALS CONTAINING THEM. | |
| Moore et al. | Heterocyclic Studies. XXII. The Rearrangement of 2, 3-Dihydro-1, 2-diazepin-4-ols to Furfurylhydrazine1 | |
| BE834142A (en) | PURIFICATION OF CRUDE CYANURIC ACID | |
| NO136982C (en) | PROCEDURES FOR PURIFICATION OF PARTICULAR COPPER SULFID | |
| FR2435474A1 (en) | NEW COMPOUNDS USEFUL IN THE SYNTHESIS OF THROMBOXANE B2 | |
| SU493464A1 (en) | The method of obtaining complexes of iodine or bromine-trinitromethane | |
| ES407866A1 (en) | Preparation of n -diethylaminoethyl - 2 - methoxy- 5 - methyl sulphonylbenzamide | |
| SU362819A1 (en) | USSR Academy of Sciences | |
| SU434085A1 (en) | ||
| SU544654A1 (en) | Method for producing dianyl glutaconaldehyde hydrochloride |