SU530684A1 - Medication for the treatment of chronic nicotinism - Google Patents

Description

The invention relates to the field of methicine and can be used in chronic nicotineism cp.

Anabasin is known to be used as an insecticide for cp of agricultural crops. L.

The purpose of the invention is the use of anabasine hyarochloric as a stimulant of respiratory depression of chronic liver: nicotinism.

Anabazin hy- drochloria is a compound c6-piperidine - B - lidirine hydrochloride with structural form

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Anabazine hydrochloride is prepared as follows: 1 O g of freshly distilled anabazine is dissolved in 5 O ml of acetone. After adding 3 x 32 g of ammonium chloride, the solution is heated in a water bath at the boiling point of the solvent to stop the release of ammonia. Ammonia absorb 1 n. sulfuric acid. On the special day, the hydrochloride is sucked off and washed with dry acetone. Output 11.9 (97.5%), by the amount of ammonia exhaled -

yield 92%. After recrystallization from a mixture of acetone with alcohol, Hporgizrag anabazina has t. Jin. 194-195 S.

1OO g of anabasine base is dissolved in 2OO ml. absolute isopropyl alcohol and with constant stirring and cooling with ice, nip 86 g of a 30% solution of hydrogen chloride in absintuous isopropyl alcohol of pH 5.56 (while the temperature of the reaction mixture does not exceed 2 O – 25 C). The precipitated anabasine hydrochloride precipitate is sucked off, washed twice with a calculation of 15 O ml with acetone and the technical product obtained in this way is recrystallized from 4-X volumes of absolute isopropyl alcohol.

Claims (1)

The precipitated crystals of anabasine hydrochloride are sucked off, washed with a display of 3 volumes of acetone and squeezed well. The resulting pharmacopoeial anabasine hydrochloride is air dried; and then for 2–3 h at 4 ° –5 ° C under a reduced pressure of 0, 5 – O, 6 atm. Pharmacopoeial Anabasine hydrochloride has so-called. 216-22 ° C. Anabazine hydrohporitsa presents one white gabbette with a green burg and small inclusions of the same color, oval, flat or flat with a bevel. The taste of tablets is bitter-sweet. In consigning one envelope includes weight. h: Anabazine hydrochloride O, OOZ Sugar powder: O, 1 Starch0 0158 Calcium stearate O, OO12 Anabazine hydrochloride weakens the effects of nicotine and reduces the visitor's health. Smoking cessation occurs in most cases already in the first days. Anabazine hydrochloride tablets are mapogoksichny. It is taken internally at the tongue at the beginning with one tablet every 2 hours. A total of 8 tablets per day for 5 grams with a corresponding decrease in the number of cigarettes smoked. When oggsugvii signs of a decrease in the desire to smoke, the bake is stopped and a new attempt is made in 2-3 months. With the beneficial effect of treatment about dopajup by speedukdey “bcheme. On the other hand, the 12 price is 1 tablet 2.5 hours, a total of 6 tablets per day. From the 13th to the 16th day - 1 tablet every 3 hours, a total of 5 tablets per day. From 17 to 2O, the price is 1 gabg of each 5 hours, only 3 tablets per price. From 2 to 25 price - 1-2 tablets per price. Complete cessation of smoking should be no later than 8-1Occ from the beginning of the liver. After the cessation of treatment, it is not necessary to smoke a single cigarette. Anabazin Gitsrokhlorid contraindicated in patients with severe hypertension, atherosperpo®® “Rovotherapy. headaches, nausea, a slight increase in arterial blood pressure during the first hours of prescription of the drug. These phenomena disappear quickly when the drug is withdrawn. Tablets.anabazina gitsrokhloritsa produced in a container of orange glass. Claims of the invention The use of anabasine hydrochloric acid as a complication of chronic liver nicotineism. Sources of information taken into account during the examination: 1. Hammerman A. F. The course of pharmacology, I960, p. 384.