SU296328A1 - MICROBITSID COMPOSITION - Google Patents

Description

The invention relates to the protection of fabrics, leather, dyes, paper, wood and similar materials and clothes against the effects of fungi and bacteria, in particular to products containing two- or three-chloro-substituted phenoxyether as the active ingredient. A microbicidal composition is proposed, comprising as an active ingredient a two- or trichloro-substituted phenoxy ester of the general formula 0-W- {in which X is hydrogen or chlorine; R is alkyl with one to four carbon atoms; R is alkyl with one carbon unit; or R and R together are a divalent alkylene radical with three to four carbon atoms. The preferred microbicidal composition is a composition containing, as an active ingredient, a compound of the above formula, in which R and R together represent a divalent alkylene radical containing up to four carbon atoms, or when X is chlorine, R is methyl, and R is isobutyl . The compounds according to the invention are prepared by contacting a suitable g, n- or trichlorophenol with a four- or pythycarbon cyclic or aliphatic a-vinyl ether. The coupling reaction to the a-vinyl bond is preferably carried out in the presence of a Lewis type catalyst, for example naphthalenesulfonic acid, in the liquid phase. Normally, the reactions are exothermic, and moderate heating is used to enhance the reaction. Below is a list of compounds that meet the specified formula. 1.2- (2,4-Dichlorophenoxy) -tetrahydropyran 2.2- (2,4,5-Trichlorophenoxy) -tetrahydropyran 3.2- (2,4-Dichlorophenoxy) -tetrahydrofuran 4.2- (2,4,5-Trichlorophenoxy) -tetrahydrofuran 5.1- (2,4-Dichlorophenoxy) -1 - (isobutoxy) ethane 6.1 - (2,4,5 - Trichlorophenoxy) - - (isobutoxy) ethane 7.1- (2,4-Dichlorophenoxy) -1 - (propoxy) ethane

- (2,4-Dichlorophenoxy) -1 - (ethoxy) -ethane

9. 110. one

- (2,4,5-Trichlorophenoxy) - - (ethoxy) ethane I. 1

- (2,4 - Dichlorophenoxy) - - (hexoxy) ethane (2,4,5-Trichlorophenoxy) -1 - (Hexoxy) 12 .1 ethane - (2,4-Dichlorophenoxy) - - (ethoxy) -bu13 .1tan

14.1- (2,4,5 - Trichlorophenoxy) -1 - (ethoxy) butane

- (2,4-Dichlorophenoxy) - 1- (butoxy) -bu15 .1tan (2,4,5-Trichlorophenoxy) - - (butoxy) 16 .1butane

- (2,4-Dichlorophenoxy) - - (Ethoxy) -Pen17 .1Tan - (2,4,5 - Trichlorophenoxy) -1 - (Ethoxy) 18 .1Pentane - (2,4-Dichlorophenoxy) - 1 - (Butoxy) 19 .1 pentane (2,4,5-Trichlorophenoxy) - - (butoxy) 20 .1 pentane

It has been found that the present compounds have bacteriostatic and fungistatic properties.

For maximum effectiveness, the active ingredient is usually mixed with an inert nanofiller. The composition itself can be prepared in both liquid and solid form. The active ingredient without filler may be too strong for them.

The fungistatic and bacteriostatic compositions can be prepared by blending the dissolution of the active ingredient in an organic solvent, followed by dilution with water and adding to another carrier. If necessary, an emulsifier may be used. Clay, talc, pumice, soap, etc. can be used as a solid carrier. The active substance can also be dissolved in liquefied gases, such as fluorochloroethane or methyl chloride, and can be used in the form of aerosols. Glue substances as well as other active substances can be added to the composition.

Since the amount of active ingredient varies depending on the desired microbicidal effect and the nature of the material being processed, it is not possible to give certain limits on its concentration in the microbicidal composition. Determining the optimal concentration for a particular purpose is easy to perform using the usual procedure used by specialists in

this area.

The microbicidal composition according to the invention is most applicable for protecting textile fabrics, for this the active substance is dissolved in acetone and the solution is diluted with water to the desired concentration, then the fabric is washed in this solution and air-dried. In this way, effective amounts of the active substance can be applied to the fabric in a range of from 1 part per million to 5%. The proposed compound, being an effective microbicide in small concentrations, can be used to process white or slightly dyed tissues without deteriorating them.

colors.

Below are examples of the in vitro testing of the proposed microbicidal composition.

Compounds were tested to determine the microbiostatic effect at

contact with growing fungi and bacteria in an artificial environment. For the use of each compound, four vessels with a capacity of 1 ounce (I ounces 31, 103–10 kg) - two malt

broth and two nutritious broth. The test compound at the desired concentration was placed in vessels. The vessels were inoculated with aqueous suspensions of spores of the fungi Aspergillus niger and Penicillium sp. Or the bacteria Escherichia coli and Staphylococcus aureus. The vessels were sealed and kept for one week. The tests were repeated using low concentrations of the active substance to determine the most

low concentrations that can be used to limit the growth of microorganisms. The results are shown in the table.

The lowest effective concentration (hours per million).

 Lowest tested concentration. Nutrient agar as well as in molten Emmons agar in concentrations of 5 and 1 parts per 1 million. Agar was poured into Petri dishes, allowed to harden, and A. niger was seeded on ordinary nutrient agar and 5 Pullularia pullulans - on Emmons agar. The plates were then kept at room temperature for one week and the results were determined. A. niger was partially suppressed at a concentration of active substance of 1 pp to 1 ppm and completely suppressed at a concentration of 5 p. Per 1 ppm. P. pullulans was partially suppressed at a concentration of 5 p. Per 1 ppm. Cotton fabric 2- (2,4-is 5-trichlorophenoxy) -tetrahydropyran was dissolved in acetone so as to obtain a 1% solution of the active substance. From the resulting solution was taken 0.5 liters and transferred into vessels containing 500 ml of tap water 20. In the solutions prepared in this way, the active substance concentration was placed in 10 parts per million solution for 5 minutes, the pieces of the test tissue were placed, and then all the samples were subjected to an air-dry substance to a moist surface. Next, sterile molten and cooled nutrient agar were seeded with A. niger by coating the agar plates with strips of microbial cells. One piece of a wet-dried treated tissue sample was placed on the seeded agar and kept at room temperature for three days. After an incubation period, a zone of 1 mm was formed around the treated sample of tissue, in which there was no spreading fungus. A tissue sample containing an effective amount of a microbiostatic agent showed a stop zone, including the area surrounding the sample where the growth of the fungus was not observed. From the presented experiments, it is clear that the microbicidal composition according to the invention can protect materials from exposure to fungi and bacteria. It goes without saying that various modifications of the invention can be made without changing its essence. The subject matter of the invention is: 1. A microbicidal composition, including an active ingredient based on two or three chlorobenzene phenoxyether, as well as an inert filler, characterized in that, for the purpose of protection, fabrics, leather, paints, soaps, paper, wood and other similar substances, materials from fungi and bacteria, as a two- or three-chloro-substituted phenoxyether, it contains a compound of the general formula u-CH-uR in which X is hydrogen or chlorine; R is alkyl with one to four carbon atoms; R is alkyl with one to six carbon atoms; or R and R together are a divalent alkylene radical with three to four carbon atoms. 2. A composition according to claim 1, characterized in that, as a two- or three-chloro-mixed phenoxyether, it contains a compound of the above formula, in which R and R together represent tetramethylene. 3. A composition according to claim 1, characterized in that as a trichloro-substituted phenoxyether, it contains a compound of the above formula, in which R-methyl and R-isobutyl.