SU1822149A1 - 4-oxo-1,4-dihydropyrimidine hydrochlorides having hypotensive, immunostimulating and antiallergic activities - Google Patents
4-oxo-1,4-dihydropyrimidine hydrochlorides having hypotensive, immunostimulating and antiallergic activitiesInfo
- Publication number
- SU1822149A1 SU1822149A1 SU4893391/04A SU4893391A SU1822149A1 SU 1822149 A1 SU1822149 A1 SU 1822149A1 SU 4893391/04 A SU4893391/04 A SU 4893391/04A SU 4893391 A SU4893391 A SU 4893391A SU 1822149 A1 SU1822149 A1 SU 1822149A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- compound
- dihydropyrimidine
- immunostimulating
- hypotensive
- hydrochlorides
- Prior art date
Links
- YAYOVHRLVOHYMW-UHFFFAOYSA-N 1h-pyrimidin-6-one;hydrochloride Chemical class Cl.O=C1C=CN=CN1 YAYOVHRLVOHYMW-UHFFFAOYSA-N 0.000 title abstract 2
- 208000001953 Hypotension Diseases 0.000 title abstract 2
- 230000003266 anti-allergic effect Effects 0.000 title abstract 2
- 208000021822 hypotensive Diseases 0.000 title abstract 2
- 230000001077 hypotensive effect Effects 0.000 title abstract 2
- 230000003308 immunostimulating effect Effects 0.000 title abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 229940125904 compound 1 Drugs 0.000 abstract 3
- RLFWWDJHLFCNIJ-UHFFFAOYSA-N 4-aminoantipyrine Chemical compound CN1C(C)=C(N)C(=O)N1C1=CC=CC=C1 RLFWWDJHLFCNIJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- JVNXBQANPCDBGN-UHFFFAOYSA-N n-acetyl-3-oxo-2-phenylbutanamide Chemical compound CC(=O)NC(=O)C(C(C)=O)C1=CC=CC=C1 JVNXBQANPCDBGN-UHFFFAOYSA-N 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
FIELD: chemical-pharmaceutical industry; used as compounds having hypotensive, immunostimulating and antiallergic activities. SUBSTANCE: 4-oxo-1.4-dihydropyrimidine hydrochlorides of the general formula:or. Compound 1: mol. weight 422.5, mp 335-377 C (from acetonitrill), LD= 2670 mg/kg. Compound II: mol. weight 320.5, mp 268-270 C, LD= 1420 mg/kg. Reagent 1: N-acetyl-2-phenylacetoacetamide. Reagent 2: 4-aminoantipyrine (for compound 1) or 2-aminotysol (for compound II). The process is carried out in icy acetic acid at the boiling point and the resultant product is converted into hydrochloride. The yield of compound 1 61% and the yield of compound II 53%. EFFECT: improved properties of the title product. 5 tbl
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU4893391/04A SU1822149A1 (en) | 1991-12-25 | 1991-12-25 | 4-oxo-1,4-dihydropyrimidine hydrochlorides having hypotensive, immunostimulating and antiallergic activities |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU4893391/04A SU1822149A1 (en) | 1991-12-25 | 1991-12-25 | 4-oxo-1,4-dihydropyrimidine hydrochlorides having hypotensive, immunostimulating and antiallergic activities |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1822149A1 true SU1822149A1 (en) | 1994-09-30 |
Family
ID=60537227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU4893391/04A SU1822149A1 (en) | 1991-12-25 | 1991-12-25 | 4-oxo-1,4-dihydropyrimidine hydrochlorides having hypotensive, immunostimulating and antiallergic activities |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU1822149A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2652993C1 (en) * | 2017-06-07 | 2018-05-04 | федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации | New 2-styryl-derivative of 4-(2,6-dimethyl-4-oxo-5-phenyl-4h-pyrimidine-1-yl)-benzsulfamide having endothelioprotective activity |
-
1991
- 1991-12-25 SU SU4893391/04A patent/SU1822149A1/en active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2652993C1 (en) * | 2017-06-07 | 2018-05-04 | федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации | New 2-styryl-derivative of 4-(2,6-dimethyl-4-oxo-5-phenyl-4h-pyrimidine-1-yl)-benzsulfamide having endothelioprotective activity |
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