SU1726371A1 - Cobalt (ii) hydroselenite (2-water) - Google Patents
Cobalt (ii) hydroselenite (2-water) Download PDFInfo
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- SU1726371A1 SU1726371A1 SU904805083A SU4805083A SU1726371A1 SU 1726371 A1 SU1726371 A1 SU 1726371A1 SU 904805083 A SU904805083 A SU 904805083A SU 4805083 A SU4805083 A SU 4805083A SU 1726371 A1 SU1726371 A1 SU 1726371A1
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- USSR - Soviet Union
- Prior art keywords
- selenium
- cobalt
- biomass
- hydroselenite
- spirulina
- Prior art date
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- XLJKHNWPARRRJB-UHFFFAOYSA-N cobalt(2+) Chemical compound [Co+2] XLJKHNWPARRRJB-UHFFFAOYSA-N 0.000 title claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title description 8
- 239000011669 selenium Substances 0.000 claims abstract description 20
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229910052711 selenium Inorganic materials 0.000 claims abstract description 18
- 239000002028 Biomass Substances 0.000 claims abstract description 14
- 150000001875 compounds Chemical class 0.000 claims abstract description 7
- 240000002900 Arthrospira platensis Species 0.000 claims description 10
- 235000016425 Arthrospira platensis Nutrition 0.000 claims description 9
- 229940082787 spirulina Drugs 0.000 claims description 9
- 150000004683 dihydrates Chemical class 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 4
- 238000009825 accumulation Methods 0.000 claims description 2
- 239000011781 sodium selenite Substances 0.000 claims description 2
- 235000015921 sodium selenite Nutrition 0.000 claims description 2
- 101100164114 Caenorhabditis elegans asb-1 gene Proteins 0.000 claims 1
- 229910003424 Na2SeO3 Inorganic materials 0.000 claims 1
- 239000002994 raw material Substances 0.000 abstract description 2
- 241000192700 Cyanobacteria Species 0.000 abstract 1
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940091258 selenium supplement Drugs 0.000 description 12
- 239000000243 solution Substances 0.000 description 5
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- ASKVAEGIVYSGNY-UHFFFAOYSA-N cobalt(2+);dihydrate Chemical compound O.O.[Co+2] ASKVAEGIVYSGNY-UHFFFAOYSA-N 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- JYEZJKNOMNWVLJ-UHFFFAOYSA-N cobalt tetrahydrate Chemical compound O.O.O.O.[Co] JYEZJKNOMNWVLJ-UHFFFAOYSA-N 0.000 description 1
- ZOTKGJBKKKVBJZ-UHFFFAOYSA-L cobalt(2+);carbonate Chemical compound [Co+2].[O-]C([O-])=O ZOTKGJBKKKVBJZ-UHFFFAOYSA-L 0.000 description 1
- HIYNGBUQYVBFLA-UHFFFAOYSA-D cobalt(2+);dicarbonate;hexahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Co+2].[Co+2].[Co+2].[Co+2].[Co+2].[O-]C([O-])=O.[O-]C([O-])=O HIYNGBUQYVBFLA-UHFFFAOYSA-D 0.000 description 1
- 229910000001 cobalt(II) carbonate Inorganic materials 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
- 235000019797 dipotassium phosphate Nutrition 0.000 description 1
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- RUTXIHLAWFEWGM-UHFFFAOYSA-H iron(3+) sulfate Chemical compound [Fe+3].[Fe+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O RUTXIHLAWFEWGM-UHFFFAOYSA-H 0.000 description 1
- 229910000360 iron(III) sulfate Inorganic materials 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
- 229910052939 potassium sulfate Inorganic materials 0.000 description 1
- 235000011151 potassium sulphates Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- QYHFIVBSNOWOCQ-UHFFFAOYSA-N selenic acid Chemical compound O[Se](O)(=O)=O QYHFIVBSNOWOCQ-UHFFFAOYSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229960001471 sodium selenite Drugs 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
Landscapes
- Fertilizers (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
слcl
сwith
Изобретение относитс к новому биологически активному химическому соединению - гидроселениту кобальта (II) дигидрату формулы CofHSeOate H O, используемого в альгобиотехнологии дл получени биомассы сине-зеленой микроводоросли спирулины с повышенным содержанием органически св занного селена, котора может служить в качестве биологического сырь дл получени селенсодержащих лекарственных препаратов.The invention relates to a new biologically active chemical compound, cobalt (II) hydroselenite, a dihydrate of the formula CofHSeOate HO, used in algobiotechnology for obtaining biomass of blue-green microalga spirulina with an increased content of organically bound selenium, which can serve as a biological raw material for obtaining selenium-containing drugs .
Наиболее близким соединением по строению к предлагаемому вл етс 1Ма25еОз, который примен етс дл получени селен со держа щей биомассы.The closest compound in structure to the present invention is 1Ma25EO3, which is used to produce selenium with biomass.
Однако содержание селена в биомассе спирулины при использовании селенита натри недостаточно высоко и варьирует в пределах 16,2-18,5 мг /100 г АСБ.However, the content of selenium in the biomass of spirulina using sodium selenite is not high enough and varies in the range of 16.2-18.5 mg / 100 g of ABS.
Целью изобретени вл етс увеличение содержани количества органически св занного селена в биомассе сине-зеленой микроводоросли спирулины.The aim of the invention is to increase the amount of organically bound selenium in the biomass of the blue-green microalgae spirulina.
Поставленна цель достигаетс тем, что в качестве вещества, обеспечивающего повышение содержани селена в биомассе, используют новое химическое соединение - гидроселенит кобальта (II) дигидрат.This goal is achieved by using a new chemical compound, cobalt (II) hydrocelenite dihydrate, as a substance providing an increase in the selenium content in biomass.
Пример. Синтез гидроселенита кобальта (II) дигидрата.Example. Synthesis of cobalt (II) dihydrate hydroselenite.
Дл получени гидроселенита кобальта (II) дигидрата использовали селенистую кислоту (Н25еОз) и основной карбонат кобальта (llHCoOHJjCOs Основной карбонат кобальта (II) получали при смешивании водных растворов , содержащих рассчитанные количества CoCI и Na 2 СОз соответственно. Осадок промывали на фильтре водой до полОSelenic acid (H25eOz) and cobalt basic carbonate (llHCoOHJjCOs Basic cobalt (II) carbonate was obtained by mixing aqueous solutions containing the calculated amounts of CoCl and Na 2 CO 2, respectively, to obtain hydroselenite cobalt dihydrate dihydrate).
со VIco VI
ного удалени посторонних ионов. Синтез Со(НЗеОз)2-2Н20 проводили по следующей методике.removal of foreign ions. Synthesis of Co (NZeOz) 2-2H20 was performed according to the following procedure.
К теплому раствору, полученному при растворении 2 г (0,016 моль) Н2$еОз в 10 мл воды, прибавл ли при посто нном перемешивании 1,22 г (0,008 моль) свежеприготовленного (. Полученный раствор отфильтровывали и оставл ли при комнатной температуре дл кристаллизации. Че- рез два дн из раствора выпадали призматические кристаллы красного цвета. Кристаллы отфильтровывали, промывали водой и сушили на воздухе. Выход продукта составил 2,28 г (84%).To the warm solution obtained by dissolving 2 g (0.016 mol) of H2 $ eOz in 10 ml of water, 1.22 g (0.008 mol) of freshly prepared (. The resulting solution was filtered and left at room temperature for crystallization was added with constant stirring. After two days, prismatic red crystals fell out of solution, the crystals were filtered off, washed with water and dried in air. The yield of the product was 2.28 g (84%).
Найдено, %: Со 16,34; Se 44,02 Со(НЗеОз)2-2Н20Found,%: Co 16.34; Se 44.02 Co (NZeOz) 2-2H20
Вычислено, %: Со 16,80; Se 45,00 Физические свойства Со(НЗеОз) М 350,892 г/моль.Calculated,%: With 16.80; Se 45.00 Physical properties of Co (NSeOz) M 350.892 g / mol.
Гидроселенит кобальта (II) дигидрат представл ет собой призматические кристаллы красного цвета. Вещество устойчиво на воздухе. Хорошо растворимо в воде, спирте, частично в ацетонитриле,//эфф 5,12 М.Б. характерно дл октаэдрического окружени кобальта (II). Наличие двух координированных молекул воды доказано на основании спектров ЯМР Н (jSHaO 120 М.Д. относительно свободной воды) и термогравиметрических исследований. Температура удалени двух молекул воды составл ет Л-100-110°С. Дальнейшее разложение комплекса наблюдаетс при| 400°С и сопровождаетс ступенчатым выделением Н20 и 2Se02. Обща убыль, массы составл ет 75%, что хорошо согласуетс со схемойCobalt (II) hydrocelenite dihydrate is a red prismatic crystal. The substance is stable in air. It is well soluble in water, alcohol, partially in acetonitrile, // eff 5.12 M.B. typical of the octahedral environment of cobalt (II). The presence of two coordinated water molecules was proved on the basis of NMR H spectra (jSHaO 120 MD relative to free water) and thermogravimetric studies. The temperature for removal of two water molecules is L-100-110 ° C. Further decomposition of the complex is observed at | 400 ° C and is accompanied by step release of H20 and 2Se02. The total loss, mass is 75%, which is in good agreement with the scheme
Со(НЗеОз)2-2Н20 Со(НЗеОз)2 + 2Н20 Со(НЗеОз)2 + СогОз + 2Se02 +Н20Co (NZeOz) 2-2H20 Co (NZeOz) 2 + 2H20 Co (NZeOz) 2 + CoGOz + 2Se02 + H20
Таким образом, вышеприведенные данные подтверждают образование гидроселе- нита кобальта (II) и наличие двух кристаллизационных молекул воды.Thus, the above data confirm the formation of cobalt (II) hydroselenite and the presence of two crystallization water molecules.
П р и м е р. В колбы объемом 0,25 л с известной питательной средой № 16 Громова следующего состава, г/л; бикарбонат натри 16,8; гидрофосфат кали 0,5; нитратPRI me R. In a flask with a volume of 0.25 l with a known nutrient medium No. 16 of Gromov of the following composition, g / l; sodium bicarbonate 16.8; potassium hydrogen phosphate 0.5; nitrate
натри 2,5; сульфат кали 1,0; хлорид натри 1,0; сульфат магни 0,2; хлорид кальци 0,04; сульфат железа 0,01; ЕДТА 0,08; раствор микроэлементов 1,0мл/л, вносили различные концентрации гидроселенитаsodium 2.5; potassium sulfate 1.0; sodium chloride 1.0; magnesium sulfate 0.2; calcium chloride 0.04; ferric sulfate 0.01; EDTA 0.08; trace element solution 1.0 ml / l, various concentrations of hydroselenite were added
кобальта (II) дигидрата и инокулум спирули- ны S. platensis (Nordst.) Geitl из расчета 0,3- 0,4 г/л сухого вещества.cobalt (II) dihydrate and spirulina inoculum S. platensis (Nordst.) Geitl at the rate of 0.3-0.4 g / l of dry matter.
Культивирование осуществл ли в нако- пительном режиме при периодическом перемешивании , посто нном освещении 12-15 тыс. эрг см2-с)в первые сутки и 18-21 тыс. эрг/(см -д|в последующие дни, при температуре 35 ± 2°С. После п ти суток культи- вировани водорослевую биомассуCultivation was carried out in the accumulative mode with periodic stirring, constant illumination of 12–15 thousand erg cm2 – s) on the first day and 18–21 thousand erg / (cm – d | on the following days, at a temperature of 35 ± 2 ° C. After five days of cultivation the algal biomass
отдел ли фильтрованием, промывали 1,5%- ным раствором уксуснокислого аммони и высушивали. Селен в биомассе определ ли методом А.Г. Матросова.separated by filtration, washed with a 1.5% ammonium acetate solution and dried. Selenium in biomass was determined by the method of A.G. Matrosov.
Результаты проведенных исследованийThe results of the research
представлены в таблице.presented in the table.
Использование гидроселенита кобальта (II) дигидрата в концентрации 10-20 мг/л обеспечивает увеличение на 87,46-147,35%The use of cobalt (II) dihydrate hydroselenite at a concentration of 10-20 mg / l provides an increase of 87.46-147.35%
содержани селена в биомассе спирулины по сравнению с при одновременно высокой продуктивности спирулины - 1,82- 1,85 г/л АСБ.the content of selenium in the biomass of spirulina compared with while simultaneously high productivity of spirulina - 1.82-1.85 g / l of ASB.
Изучение состо ни селена в биомассе,Study of the state of selenium in biomass,
полученной предлагаемым способом, показало , что 52,2-54/6% селена включены в белковую фракцию, а 47,8-45,4% содержатс в составе фракции низкомолекул рныхobtained by the proposed method showed that 52.2-54 / 6% selenium is included in the protein fraction, and 47.8-45.4% is contained in the composition of the low molecular weight fraction
соединений - олигопептидов, аминокислот.compounds - oligopeptides, amino acids.
Формул.а изобретени Formula of invention
Гидроселенит кобальта (II) дигидрат формулы Со(НЗеОз)2 2Н20 в качестве вещества , используемого дл получени биомассы спирулины с повышенным содержанием органически св занного селена.Hydroselenite cobalt (II) is a dihydrate of the formula Co (N3deO3) 2 2H20 as a substance used to obtain the biomass of spirulina with a high content of organically bound selenium.
N Э25еОз использовалс в концентрации , обеспечивающей максимальное накоплениеN E25eOz was used at a concentration that ensures maximum accumulation
селена -50, 0 мг/л.selenium -50, 0 mg / l.
Claims (1)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU904805083A SU1726371A1 (en) | 1990-03-21 | 1990-03-21 | Cobalt (ii) hydroselenite (2-water) |
| MD94-0254A MD174C2 (en) | 1990-03-21 | 1994-07-20 | Hydroselenium of cobalt (II) dehydrated |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU904805083A SU1726371A1 (en) | 1990-03-21 | 1990-03-21 | Cobalt (ii) hydroselenite (2-water) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1726371A1 true SU1726371A1 (en) | 1992-04-15 |
Family
ID=21503349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU904805083A SU1726371A1 (en) | 1990-03-21 | 1990-03-21 | Cobalt (ii) hydroselenite (2-water) |
Country Status (2)
| Country | Link |
|---|---|
| MD (1) | MD174C2 (en) |
| SU (1) | SU1726371A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994013782A1 (en) * | 1992-12-16 | 1994-06-23 | Biotechna Limited | Ionic binding of microbial biomass |
| RU2333762C2 (en) * | 2006-08-17 | 2008-09-20 | ГОУ ВПО Пятигорская ГФА Росздрава | Method for obtaining zinc selenite compound as medication with neuroprotective effect |
| WO2015150857A1 (en) * | 2014-04-01 | 2015-10-08 | Khowdairy Manal Mohamed | Method of making metal based cationic surfactant nano particles and their use |
| CN104787732B (en) * | 2015-03-13 | 2016-09-14 | 哈尔滨工程大学 | Solid phase preparation method of cobalt 0.85 selenium compound |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD4167C1 (en) * | 2010-12-23 | 2012-12-31 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Device and method for excision of quadrangular cartilage of the nasal septum |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4530846A (en) * | 1983-02-15 | 1985-07-23 | Universal Foods Corporation | Method for the production of selenium yeast |
-
1990
- 1990-03-21 SU SU904805083A patent/SU1726371A1/en active
-
1994
- 1994-07-20 MD MD94-0254A patent/MD174C2/en not_active IP Right Cessation
Non-Patent Citations (1)
| Title |
|---|
| Патент US № 4530846, кл. 426-62, 1985. * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994013782A1 (en) * | 1992-12-16 | 1994-06-23 | Biotechna Limited | Ionic binding of microbial biomass |
| RU2333762C2 (en) * | 2006-08-17 | 2008-09-20 | ГОУ ВПО Пятигорская ГФА Росздрава | Method for obtaining zinc selenite compound as medication with neuroprotective effect |
| WO2015150857A1 (en) * | 2014-04-01 | 2015-10-08 | Khowdairy Manal Mohamed | Method of making metal based cationic surfactant nano particles and their use |
| CN104787732B (en) * | 2015-03-13 | 2016-09-14 | 哈尔滨工程大学 | Solid phase preparation method of cobalt 0.85 selenium compound |
Also Published As
| Publication number | Publication date |
|---|---|
| MD174C2 (en) | 1995-07-31 |
| MD174B1 (en) | 1995-03-31 |
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