SU1743330A3 - Cockroach control method - Google Patents

Abstract

Cockroach populations are controlled using the (S)-(+) enantiomer of hydroprene (Ethyl (2E, 4E)-3,7,11-trimethyl-2,4-dodecadienoate), which has superior juvenile hormone activity to the (R)-(-) enantiomer. Compositions for this purpose comprise (a) (S)-(+) hydroprene; (b) a diluent; and (c), where the diluent is a solvent, a propellant, a surfactant or a thickener.

Description

This invention relates to chemical means of controlling domestic insects.

The purpose of the invention is to increase the effectiveness of the fight against cockroaches.

This goal is achieved by using for treatment of infected foci (5) - (+) - ethyl ester of 3,7,11-trimethyldo-decadien-2,4-oic acid (5) - (+) - hydropren).

(GH + Nidroprene, which is used in this method, is hydroprene containing more than 50 wt.% Of (5) - (+) - enantiomer. It is preferable to use hydroprene, consisting mainly of (5) - (+) hydROprine, t. E. containing more than 75 wt.% of it. Preferably, if used hydroprene contains less than 10 wt.%, preferably less than 5 wt.%, (P) -enantiomer, Most preferably, if it contains almost no (P) -enantiomer, t i.e. contains less than 2 wt.%.

The agent can be used in the form of a composition containing: (5H +) HYD-roprene, a diluent and (if a solvent is used as a diluent) at least one auxiliary additive selected from the group consisting of a propellant, a surfactant active substance and thickener.

The diluent is a liquid or solid acceptable for agricultural use material that can be added to the active ingredient to produce a form that is easy to use. Carriers and solvents can be used as diluents, for example calcium carbonate, talc, kaolin, clay, diatomaceous earth, resins, and such as polyvinyl chloride, urea polyesters, ethylene vinyl acetate, polypropylene, polyethylene, xylene, petroleum products (for example, naphtha, gasoline, naphtha, hydrocarbons, such as pentane, hexane, octane), alcohols,

4 CO CO SO O

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for example, isopropanol, chlorinated hydrocarbons (for example, CbteCla. CC1CCH3), glycol monoalkyl ethers, water, etc.

Propellant is an acceptable gas for use in agriculture, pressurized in a liquefied state in a container with a valve that, when opened, sprays the contents of the container.

The surfactant used in the proposed method is an emulsifiable material that is acceptable for use in agriculture, sprayed ™, wettability, dispersible ™ of compositions.

A thickener is a material that increases the viscosity of a fluid.

(5) - (+) - hydroprene can be obtained in a known manner, by separating hydroprene into (S) - and (H) -enantiomers or by synthesizing it from the corresponding starting isomer,

(5) - (+) - hydroprene has a unique combination of properties compared with other juvenoids, which allows it to be used as a means to combat the means to combat cockroach populations,

Thus, it is stable in the habitat of cockroaches, it has sufficient volatility to transfer from one surface to another, due to which it penetrates into the refuges of cockroaches and spreads there, remaining accessible to the cockroaches in them. In addition, (5) - (+) - hydroprene causes sterility of cockroaches and has other types of juvenile activity. These properties of its very essential for effective control of cockroaches. (S) - (+) - hydroprene has a high activity, which, compared with hydroprene-racemate, reduces its consumption and reduces the contamination of food and human dwellings.

In determining the activity of (5) - (+) - hydroprene, it was established that an almost pure (W) enantiomer inhibits Prussian reproduction at a rate of several tenth micrograms per m. To combat other types of cockroaches, such as Periplaneta americana and Blatta orientalis, higher consumption is required.

To use (5) - (+) - hydroprene in an aerosol form, it is advisable to prepare the composition of the active component using a harmless volatile solvent and propellant.

Examples of a volatile solvent are chlorinated alkanes, such as methylene chloride or 1,1,1-trichloroethane.

Examples of suitable propellant are low-boiling alkanes, such as propane or butane, or fluorinated hydrocarbons.

To use (3) - (+) - hydroprene in

the form of a preparation for spraying, for example an emulsion concentrate or a preparation ready for use, an appropriate composition based on the active ingredient may be prepared using an emulsifier and a solvent.

Examples of a suitable emulsifier are sorbitol, fatty acid esters, polyethoxylated fatty esters

5 acids of alcohols or phenols, sodium dodecylbenzoate, etc.

Examples of a suitable solvent are aromatic hydrocarbons, such as xylene.

0 Solid compositions, such as dusts or powders, contain (3) - (+) - hydroprene and a solid carrier.

Calcium carbonate, diatomic earth, clay, etc. are suggested as solid carriers.

(SH + Nidroprene can also be used in solid compositions in which it evaporates from a solid carrier. Such compositions are, for example, aromatized discs and stripes, the latter being preferred.

Solid compositions, such as flavored discs and strips, include (5) - (+) - hydroprene, a polymer, and preferably a plasticizer.

Polymers (resins) use polyvinyl chloride, polyethylene, polyurethane, polypropylene, acrylic resins or nylon (preferably used in

Quality of polymer polyvinyl chloride).

When using (5) - (+) - hydroprene in the form of bait, it is advisable to mix the active ingredient with food products. For example, suitable for

5 uses in food bait are corn meal, corn syrup, dog food, and the like.

(3) - (+) hydroprene can also be used in the form of microcapsules, preferably made of gelatin or nylon. Such compositions contain a thickener, such as xanthan gum.

Compositions based on (3) - (+) - hydraulic fluid may contain, in addition, conventional

5 additives, such as UV stabilizers, heat stabilizers, antioxidants, etc. They may also contain known insecticides, such as organophosphates and pyrethroids, which can destroy a part of the population of cockroaches or other insects.

in the initial period after the composition has been processed by their location. The compositions are prepared by known methods. The content of (5) - (+) - hydroprene in such compositions is 0.01-80 wt.%.

The proposed tool in the form of aerosols contains 0.01-10 wt.% Concentrates

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emulsions and compositions for spraying an ultra-small volume of 0.3-80 wt.%, ready for use of the composition for spraying 0.5 to 10 wt.% and bait or strips of 1-15 wt.% (GH +) - hydroprene.

PRI me R 1. Aerosol.

Prepare three mixtures of the composition, wt.%:

PRI mme R 2. The emulsion concentrate. Prepare a mixture of composition, wt.%: (3) - (+) - hydroprene (100%) 10

Antioxidant (bottled oxytoluene) 0.2

Emulsifier (sorbitol polyoxy-ester ether) 30.8

Solvent (aliphatic hydrocarbon) 59.0

PRI me R 3. Ready to use preparation for spraying. Prepare a mixture of composition, wt.%: (3) - (+) - hydroprene (100%) 0.4

Water91,86

Antioxidant (bottled oxytoluene) 0.44

Emulsifier (polyoxyethylenesorbitol ether) 2.0

Chelating agent (sodium salt EDTA) 5.0

Buffering agent (citric acid) 0.3 PRI me R 4. Bait. Prepare a mixture of composition, wt.%: (3) - (+) - hydroprene (100%) 1.0 CH2Cl2 5.0 Cornmeal 94.0 PRI me R 5. Dust. Preparing a mixture of the composition, wt.%: (5H +) - hydroprene (100%) 10.0 Ethylene glycol 4.5 Antioxidant (bottled oxytoluene) vO, 5 Silica 85 PRI me R 6, Preparations for spraying containing 15 and 45 mg (3) - (+) - hydraulically in the form of a composition as shown in example 1 (A and B) are sprayed in an 85 m spray chamber with three other test materials in it I

five

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five

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five

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(treated vinyl tile, glass plate and unpainted plywood), which are placed at a distance of 1.8; 2-7 and 3.7 m from the preparation. The mixture was allowed to settle for 20 minutes, after which the paper and the test materials were removed from the chamber. Cigarette paper is subjected to extraction and the extracts are analyzed for the content of (5H +) - hydroprene (in micrograms per 1 cm of the substrate). These amounts are in the range of 0.005-0.053 µg / cm2.

After removal from the chamber, the treated test materials are placed in the laboratory at normal temperature and pressure. Within 1 hour after removal, 10-12 Prussians are placed on each of the processed materials at the fifth to sixth stages of development. Cockroaches are given food, water and create shelter.

Containers are monitored daily for the first ten days. During this time, food and water are added as needed. All cockroaches that, during the first ten days of testing, turned into adult individuals, are removed and destroyed (cockroaches in the last ten days of the last stage of development are insensitive to juveniles before molting).

After ten days, the containers are monitored daily (starting from the seventh to the fourteenth day), registering the following indicators: the total number of surviving cockroaches; stage of development of each cockroach (adult or nymph); gender of all adult cockroaches, IH effect on adult cockroaches, if any; carrying ostek; vitality osteki; FI - offspring; Last control carried out on the twelfth week after ten

days from the date of processing.

Based on the data obtained, the effect of juvenile hormone (IH) treatment is evaluated.

The overall effect of (H) -hydroprene on IH is significantly higher than the effect of the racemic mixture used as ethanol. If we compare such indicators as the total number of fi-nymphs and the number of fi-nymphs of females capable of mating and bearing offspring, it turns out that by their activity with respect to the control of reproduction (5) - (+) - hydroprene in 7 times the racemic mixture (Table 1).

Example. Using a syringe, apply a drop of solution (5) - (+) - hydroprene or a racemic mixture in acetone of different concentrations on glass and plywood plates. The plates treated in this way are used as bottom for cages. Water, food and 50 Prussians in the fourth stage of development are placed in each of the cages. Cages are incubated for 2 months at 27 ° C, 50% relative humidity and illumination for 16 hours a day. The efficacy of the drugs is evaluated on the basis of data on the morphological effects and 100% inhibition of reproduction. According to these experiments (SH +), hydroprene provides 100% inhibition of reproduction at a concentration of 0.1 µg / cm, while the minimum concentration of the racemic mixture of hydroprene, at which a 100% control is achieved, is 10 µg / cm2 and 1 µg / cm2 for plywood (Table 2).

(5) - (+) - forms of hydroprene are suitable for juvenile hormones for a variety of insects:

Yellow fever mosquito Aedis aegypti

Yellow flour worm Tenebrio moilitor

Big wax mole Gaileria Mellonella

Housefly Mussa domestica

Scoop Hellothis virescens

The effectiveness of drugs

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However, (5) - (+} - the form does not have a significantly superior effect in relation to the racemic form (Table 3).

The only insect that is much more susceptible to the (5) - (+) - form than to the racemic form is the domestic fly. The housefly is a species of the Muscidae family of the order Diptera.

The yellow fever mosquito belongs to the same unit Diptera, but to another family (Culicudae). The differences in activity observed for typical species belonging to one species (Diptera) show that the order of activity (8) - (+} FORM1) cannot be predicted for insects of one order.

The relative activity of (5) - (+) - forms against the large wax moth (Galberidae family) and scoops (Noctuidae family), each of which is a member of the order Lepidoptera (subdivided into 50 families), is unsatisfactory: the test results in respect large wax moths are given in Table. 3 show that go (5) - (+) - form and racemate have equal activity. The relative activity of the (5) - (+) - forms against the yellow mealworm (Tenebrionidae family) - 30 members of Coleoptera (divided into 46 families) is also low.

Cockroaches are members of the Blattidae family belonging to the Orthoptera unit. (5) - (+) - hydroprene is effective against members of one of these families.

Claims (1)

Invention Formula five 0 five 35 A method for controlling cockroaches, including the use of juvenile hormones, characterized in that (3) - (+) - ethyl ester 3,7,11-trimethyldodecadien-2.4 is used as a juvenile hormone -aic acid in a dose of 0.38-0.53 mg / m. Table 1  The result is probably erroneous - a labeling error. table 2 Table 3