SU1674850A1 - Method for treatment of calves and piglets with gastroenteric diseases - Google Patents

Abstract

This invention relates to the field of veterinary medicine. The purpose of the invention is to increase the efficiency of the method in the treatment of gastrointestinal diseases complicated by pathogenic microflora from the group of prote and enterococci. A method for treating bacterial gastrointestinal diseases of tel and piglets includes oral administration of an antimicrobial agent and 0.05-0.1% chlorhexidine water, and the administration is carried out 2-3 times a day at a daily dose of 10 -30 mg / kg body weight for calves and 0.2–10 mg / kg body weight for pigs. Neovietin is used as an antimicrobial agent for calves at a dose of 10–12 mg / kg body weight. Levomix prices are used as an antimicrobial agent for the pigs, and administration is carried out 2-3 times a day at a daily dose of 20-35 mg / kg body weight. 1 hp f-ly. J

Description

The invention relates to veterinary medicine.

The purpose of the invention is to increase the efficiency of the method in the treatment of gastrointestinal diseases complicated by pathogenic microflora from the group of prote and enterococci.

Example 1. An aqueous solution of a neovietin antibiotic is prepared as follows: neovetin sulfate is dissolved in a physiological solution of sodium chloride at the rate of 20-24 mg in 1 ml of liquid and set at 0.5 ml per 1 kg of animal weight.

An aqueous solution of chlorhexidine is prepared in distilled water at a 0.1% concentration by dissolving 1000 mg of the basic substance (5 ml of a 20% solution of

commercial drug) in 1000 ml of water. Set 10 ml per 1 kg of animal mass (single dose).

It is possible to simultaneously and jointly use the antibiotic and chlorhexidine in the same solution, in this case the single dose of the antibiotic is dissolved in a 0.1% chlorhexidine solution also in the volume of a single dose.

Example 2. All bodies of the control and experimental groups receive neovetin by mouth 2 times in a therapeutic dose using a syringe with a rubber hose 1 hour before taking milk or colostrum.

Chlorhexidine is assigned to the first group of the body t (15) through the rubber hose 1 time per day.

ABOUT

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2 hours before drinking colostrum or milk at a dose of 10 mg / kg and a concentration of 0.1%. The duration of treatment on average in the group was 3.1 days. There was no death case.

Group II of tel (15) chlorhexidine is given 2 times a day at a dose of 10 mg / kg (daily dose of 20 mg / kg) and a concentration of 0.1%. The duration of treatment in the average group was 1.7 days. There was no death case.

Group III t t chlorhexidine set 3 times a day in the same dose and concentration (daily dose of 30 mg / kg). The average duration of treatment for the group was 1.5 days. There was no death case.

Group IV of the body (15) chlorhexidine is administered orally at a dose of 5 mg / kg once at a concentration of 0.05% once a day. The duration of treatment was 3.9 days. There was no death case.

In the control group V of the body (20), only an aqueous solution of the neovietin antibiotic is obtained 2 times a day. The duration of treatment was 3.1 days. There was no death case.

The treatment of the pigs was carried out as follows.

Example 3. An aqueous suspension of levomycetin is prepared by mixing a portion of levomycetin with water based on the content of the preparation in 2 ml of 10-17.5 mg. They assign a pig there through a syringe with a rubber hose over

1 ml per 0.5 kg of animal weight. If the piglet weighs 1 kg, it is given 2 ml of suspension, with a weight of 1.5 kg - 3 ml, etc. An aqueous solution of chlorhexidine is prepared in distilled water at a concentration of 0.1 or 0.05, depending on the dose and frequency of the drug.

The solution is also set via a syringe with a hose in a volume constituting a single dose. All of the control and experimental groups of chloramphenicol are injected there inside

2 times a day in a therapeutic dose.

The group of piglets (100) chlorhexidine is given once in 0.1 mg per kg of animal weight in a 0.1% concentration. 88 recovered and 12 pigs fell. Treatment efficacy was 88%.

Group II of pigs (100) chlorhexidine was administered orally at a concentration of 0.05% at 0.1 mg per 1 kg of animal weight twice (daily dose was 0.2 mg / kg). After treatment, 91 patients recovered and 9 pigs fell. The effectiveness of treatment was 91%.

In group III, pigs (100) chlorhexidine is administered in a 0.05% concentration 2 times a day, 1 ml (0.5 mg) per kg of animal weight. 97 recovered, 3 pigs fell. The efficacy of treatment was 97%.

Group IV of the (100) chlorhexidine is given in a concentration of 0.1% at 5 mg / kg of animal weight 2 times a day (daily dose was 10 mg / kg). 94 recovered, 6 pigs fell. Treatment efficacy 94%.

Chlorhexidine of the V group is given in a concentration of 0.1% 2 times a day at 7.5 mg / kg

mass of the animal. After giving chlorhexidine, after about 1 hour, the animals experience a stressful state that manifests itself in the form of convulsions, and in some animals a coma is noted.

The sixth group of pigs (100) is a control; it receives only inside chloramphenicol 2 times a day in a therapeutic dose. 88 recovered, fell 12. The effectiveness of treatment was

For calves, it is advisable to apply chlorhexidine twice with the best therapeutic efficacy at a concentration of 0.1% at a daily dose of 10-30 mg / kg, and for piglets at a daily dose of 0.2-10 mg / kg of animal weight at a concentration of 0, 1-0.05% when used twice.

Chlorhexidine needs to be dissolved only in distilled or desalted water, since the presence of salts or other

impurities in water entails the formation of insoluble precipitates of unexplored composition and mechanism of action.

To improve the taste of chlorhexidine solution, it is advisable to add glucose to it at the rate of 100 g per 1 liter of the finished solution.

Claims (2)

1. A method of treating bacterial gastrointestinal diseases of calves and pigs, including the administration of an antimicrobial agent and a surfactant, characterized in that, in order to increase the effectiveness of the method in treating gastrointestinal diseases complicated by pathogenic microflora from the protein group and enterococci, chlorhexidine is used as a surfactant in the form of 0.05-0.1% an aqueous solution, the administration of which is carried out 2-3 times a day at a daily dose of 10-30 mg / kg body weight for calves and 0.2-10 mg / kg body weight for pigs. 2. The method according to claim 1, characterized in that chloramphenicol is used as an antimicrobial agent for piglets, and its administration is carried out 2-3 times a day at a daily dose of 20-35 mg / kg body weight.