SU1530630A1 - Method of producing dialdehyde dextrane - Google Patents
Method of producing dialdehyde dextrane Download PDFInfo
- Publication number
- SU1530630A1 SU1530630A1 SU864172211A SU4172211A SU1530630A1 SU 1530630 A1 SU1530630 A1 SU 1530630A1 SU 864172211 A SU864172211 A SU 864172211A SU 4172211 A SU4172211 A SU 4172211A SU 1530630 A1 SU1530630 A1 SU 1530630A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- dextran
- dextrane
- dialdehyde
- hours
- anion exchanger
- Prior art date
Links
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 title claims abstract description 4
- 238000000034 method Methods 0.000 title claims description 3
- 229920002307 Dextran Polymers 0.000 claims abstract description 9
- 150000001450 anions Chemical class 0.000 claims abstract description 4
- 230000003647 oxidation Effects 0.000 claims abstract description 4
- 238000007254 oxidation reaction Methods 0.000 claims abstract description 4
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 claims abstract 4
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000007864 aqueous solution Substances 0.000 claims abstract 2
- 229920001577 copolymer Polymers 0.000 claims abstract 2
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical group OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 claims description 2
- 239000007800 oxidant agent Substances 0.000 claims 2
- 230000001590 oxidative effect Effects 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 229930014626 natural product Natural products 0.000 abstract description 2
- 239000003381 stabilizer Substances 0.000 abstract description 2
- 239000000969 carrier Substances 0.000 abstract 1
- -1 dextran anion Chemical class 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000012153 distilled water Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 150000001299 aldehydes Chemical class 0.000 description 1
- 239000003957 anion exchange resin Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
Landscapes
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Изобретение относитс к химии природных соединений и может быть использовано в биотехнологии и медицине при получении полимерных носителей и стабилизаторов биологически активных соединений. Цель изобретени - регулирование глубины окислени диальдегиддекстрана. Водный раствор декстрана обрабатывают макропористым анионитом в периодатной форме АРА-20т80х на основе сополимера стирола и дивинилбензола при 25 - 50°С в течение 1 - 5 ч при массовом соотношении декстрана и анионита 1:0,2 - 2,0. 2 табл.This invention relates to the chemistry of natural compounds and can be used in biotechnology and medicine in the preparation of polymer carriers and stabilizers of biologically active compounds. The purpose of the invention is to control the depth of oxidation of dialdehyde dextran. The aqueous solution was treated with dextran macroporous anion exchanger in the form of the ARA-periodate 20t80 x based on a copolymer of styrene and divinylbenzene at 25 - 50 ° C for 1 - 5 hours at a weight ratio of dextran anion and 1: 0.2 - 2.0. 2 tab.
Description
Изобретение относитс к химии природных соединений, конкретно к способу получени диальдегиддекстрана (ДАД), который примен етс в биотехнологии и медицине в качестве носител и стабилизатора биологически активных соединений.The invention relates to the chemistry of natural compounds, specifically to a method for producing dialdehyde dextran (DBP), which is used in biotechnology and medicine as a carrier and stabilizer of biologically active compounds.
Целью изобретени вл етс регулирование глубины окислени целевого продукта.The aim of the invention is to control the oxidation depth of the target product.
Пример 1. 10,0 г декстрана (М 65000) раствор ют в 190 мл дистиллированной воды, при этом получают 5%-ный раствор. 10,0 г воздушно- сухого макропористого анионита АРА- 20т80 в периодатной форме заливают дистиллированной водой и выдерживают до полного набухани (2 ч). Влажный анионит отфильтровывает и при перемешивании добавл ют к раствору декстрана . Перемешивают реакционную смесь при 30°С в течение 3 ч. Фильтруют на воронке Бюхнера, анионит на фильтре 2 раза промывают минимальным объемом дистиллированной воды, фильтраты объедин ют о Раствор высушивают при помощи сублимационной сушки. Получают 9,1 г ДАД (содержание альдегидных групп 0,50 ммоль/г, глубина окислени 8,0%),Example 1. 10.0 g of dextran (M 65000) is dissolved in 190 ml of distilled water, thus a 5% solution is obtained. 10.0 g of air-dry macroporous anion exchanger ARA-20t80 in periodate form is poured with distilled water and kept until complete swelling (2 hours). The wet anion exchange resin is filtered off and added with stirring to the dextran solution. The reaction mixture is stirred at 30 ° C for 3 hours. It is filtered on a Buchner funnel, the anion exchanger on the filter is washed 2 times with a minimum volume of distilled water, and the filtrates are combined. The solution is dried using freeze-drying. 9.1 g DBP are obtained (aldehyde content of 0.50 mmol / g, oxidation depth 8.0%),
Примеры 2-5 представлены в табл.1 данные, подтверждающие преимущество предлагаемого способа перед известным - в табл. 2.Examples 2-5 are presented in table.1 data confirming the advantage of the proposed method over the known - in table. 2
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU864172211A SU1530630A1 (en) | 1986-12-30 | 1986-12-30 | Method of producing dialdehyde dextrane |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU864172211A SU1530630A1 (en) | 1986-12-30 | 1986-12-30 | Method of producing dialdehyde dextrane |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1530630A1 true SU1530630A1 (en) | 1989-12-23 |
Family
ID=21276990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU864172211A SU1530630A1 (en) | 1986-12-30 | 1986-12-30 | Method of producing dialdehyde dextrane |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU1530630A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000024784A1 (en) * | 1998-10-26 | 2000-05-04 | Elena Alexandrovna Izaxon | Dextran-containing biologically active substance |
| EA011718B1 (en) * | 2008-03-21 | 2009-04-28 | Государственное Учреждение Научный Центр Клинической и Экспериментальной Медицины Сибирского отделения Российской академии медицинских наук | Method for producing dialdehydedextran |
| RU2542534C1 (en) * | 2013-08-27 | 2015-02-20 | Открытое акционерное общество "Федеральный научно-производственный центр "Алтай" | Method of producing dialdehyde dextran |
-
1986
- 1986-12-30 SU SU864172211A patent/SU1530630A1/en active
Non-Patent Citations (1)
| Title |
|---|
| Вирник А.Д. и др. Декстран и его производные. - Успехи химии. 1975, т. 44, вьт. 7, с. 1280-1307. Патент DD Р 87778, кл. 120.6, опублик. 1972. * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000024784A1 (en) * | 1998-10-26 | 2000-05-04 | Elena Alexandrovna Izaxon | Dextran-containing biologically active substance |
| EA011718B1 (en) * | 2008-03-21 | 2009-04-28 | Государственное Учреждение Научный Центр Клинической и Экспериментальной Медицины Сибирского отделения Российской академии медицинских наук | Method for producing dialdehydedextran |
| RU2542534C1 (en) * | 2013-08-27 | 2015-02-20 | Открытое акционерное общество "Федеральный научно-производственный центр "Алтай" | Method of producing dialdehyde dextran |
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