SU1583803A1 - Method of determining quinone in iodo-bismuth quinine - Google Patents
Method of determining quinone in iodo-bismuth quinine Download PDFInfo
- Publication number
- SU1583803A1 SU1583803A1 SU884497251A SU4497251A SU1583803A1 SU 1583803 A1 SU1583803 A1 SU 1583803A1 SU 884497251 A SU884497251 A SU 884497251A SU 4497251 A SU4497251 A SU 4497251A SU 1583803 A1 SU1583803 A1 SU 1583803A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- quinine
- iodo
- bismuth
- determining
- sulfuric acid
- Prior art date
Links
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 title claims abstract description 30
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 title claims abstract description 19
- 235000001258 Cinchona calisaya Nutrition 0.000 title claims abstract description 15
- 229960000948 quinine Drugs 0.000 title claims abstract description 15
- 238000000034 method Methods 0.000 title claims abstract description 7
- SAYWRBWZPUHRGX-UHFFFAOYSA-M iodobismuth Chemical compound [Bi]I SAYWRBWZPUHRGX-UHFFFAOYSA-M 0.000 title description 3
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 title 2
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims abstract description 7
- MLIWQXBKMZNZNF-KUHOPJCQSA-N (2e)-2,6-bis[(4-azidophenyl)methylidene]-4-methylcyclohexan-1-one Chemical compound O=C1\C(=C\C=2C=CC(=CC=2)N=[N+]=[N-])CC(C)CC1=CC1=CC=C(N=[N+]=[N-])C=C1 MLIWQXBKMZNZNF-KUHOPJCQSA-N 0.000 claims abstract description 5
- 230000005284 excitation Effects 0.000 claims abstract 2
- LOUPRKONTZGTKE-LHHVKLHASA-N quinidine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-LHHVKLHASA-N 0.000 claims description 8
- 229960001404 quinidine Drugs 0.000 claims description 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 abstract description 2
- CBIXFXPGRXJEAJ-UHFFFAOYSA-N [I].[Bi] Chemical compound [I].[Bi] CBIXFXPGRXJEAJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 5
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- QCDFBFJGMNKBDO-UHFFFAOYSA-N Clioquinol Chemical compound C1=CN=C2C(O)=C(I)C=C(Cl)C2=C1 QCDFBFJGMNKBDO-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
Landscapes
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Изобретение относитс к аналитической химии, а именно к способам определени хинина в хинине йодовисмутате. Цель - повышение селективности и упрощение способа хинин йодовисмута обрабатывают периодатом кали в концентрированной серной кислоте. Интенсивность флуоресценции измер ют при длине волны возбуждени 370 нм и длине волны регистрации излучени 480 нм. 1 табл.This invention relates to analytical chemistry, and specifically to methods for determining quinine in quinine iodo-bismuthate. The goal is to increase the selectivity and simplify the method of quinine iodine bismuth is treated with potassium periodate in concentrated sulfuric acid. The fluorescence intensity is measured at an excitation wavelength of 370 nm and an emission detection wavelength of 480 nm. 1 tab.
Description
Изобретение относитс к аналити- ческой химии, а именно к способам определени хинина, и может быть использовано при анализе препаратов, содержащих хинин йодовисмутат.The invention relates to analytical chemistry, in particular to methods for determining quinine, and can be used in the analysis of preparations containing quinine iodo bismuth.
Целью изобретени вл етс повы- шение селективности в присутствии хинидина| при одновременном упрощении анализа.The aim of the invention is to increase the selectivity in the presence of quinidine | while simplifying analysis.
При изучении оптимальных уело-In the study of optimal
вий протекани флуоресцентной реакции установлено, что интенсивность флуоресценции не измен етс в течение суток.The course of the fluorescent reaction has established that the fluorescence intensity does not change during the day.
Зависимость интенсивности флуоресценции от концентрации перйода- та кали в концентрированной серной кислоте приведена в таблице.The dependence of the fluorescence intensity on the concentration of potassium periodate in concentrated sulfuric acid is given in the table.
Линейна зависимость между концентрацией хинина и интенсивностью флуоресценции наблюдаетс в диапазоне 0,001-8 мкг/мл. Определению не мещает хинидин.A linear relationship between quinine concentration and fluorescence intensity is observed in the range of 0.001-8 µg / ml. The definition does not place quinidine.
Пример. Количественное определение хинина в хинине йодовисму- тате.Example. Quantitative determination of quinine in quinine iodoacid.
0,01 г хинина йодовисмутата (точна навеска) количественно перенос т в мерную колбу на 100 мл, прибавл ют 1,5 мл 1%-ного раствора пер- йодата кали в концентрированной серной кислоте, взбалтывают до полного растворени препарата, после чего довод т объем до метки 1% раствором перйодата кали в концентрированной серной кислоте,0.01 g of quinine iodo-bismuth (quantitatively weighed) is quantitatively transferred into a 100 ml volumetric flask, 1.5 ml of a 1% solution of potassium perodate in concentrated sulfuric acid is added, agitated until complete dissolution of the drug is made. volume up to the mark with a 1% solution of potassium periodate in concentrated sulfuric acid,
К 0,1 мл полученного раствора прибавл ют 9,9 мл 1%-ного раствора перйодата кали и измер ют относительную9.9 ml of a 1% potassium periodate solution was added to 0.1 ml of the resulting solution and the relative
интесивность - флуоресцении. полученного раствора против стандартного раствора хинина. Предел обнаружени равен 0,001 мкг/мл.Intensity - fluorescence. the resulting solution against the standard solution of quinine. The detection limit is 0.001 µg / ml.
Анализу хинина данным способом не мешают хинидин, хингамин. хинозол, энтеросептол, что свидетельствуетQuinidine and hingamin do not interfere with quinine analysis in this way. chinozol, enteroseptol, which indicates
слcl
0000
соwith
0000
соwith
о высокой степени избирательности реакции.about the high degree of selectivity of the reaction.
Таким образом, способ позвол ет как количественно, так и качественно определ ть хинин в присутствии гасителей флуоресценции (йода и висмута ) ихинидина и других соединений, при этом способ осуществл етс одной операцией, что позвол ет упростить анализ.Thus, the method allows quinine to be quantitatively and qualitatively determined in the presence of fluorescence quenchers (iodine and bismuth) of ichinidine and other compounds, and the method is carried out in a single operation, which simplifies the analysis.
Интенсивность флуоресценции,Fluorescence intensity,
28 60 70 50 4028 60 70 50 40
5five
00
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU884497251A SU1583803A1 (en) | 1988-10-24 | 1988-10-24 | Method of determining quinone in iodo-bismuth quinine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU884497251A SU1583803A1 (en) | 1988-10-24 | 1988-10-24 | Method of determining quinone in iodo-bismuth quinine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1583803A1 true SU1583803A1 (en) | 1990-08-07 |
Family
ID=21405516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU884497251A SU1583803A1 (en) | 1988-10-24 | 1988-10-24 | Method of determining quinone in iodo-bismuth quinine |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU1583803A1 (en) |
-
1988
- 1988-10-24 SU SU884497251A patent/SU1583803A1/en active
Non-Patent Citations (1)
| Title |
|---|
| Авторское свидетельство СССР № 1343352, кл. G 01 N 33/48, 1987. Авторское-свидетельство СССР № 1182347, кл. G 01 N 21/64, 1984. * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Baginski et al. | Direct microdetermination of serum calcium | |
| US3973129A (en) | Fluorimetric apparatus and method for analysis of body fluid | |
| Brissette et al. | Determination of the dead time of a stopped-flow fluorometer | |
| JPH0795036B2 (en) | Quantitative measurement of chemical parameters of samples | |
| SU1583803A1 (en) | Method of determining quinone in iodo-bismuth quinine | |
| CN108801993A (en) | A kind of hypochlorous kit of quick high-selectivity analysis | |
| Bailey et al. | Rapid spectrofluorimetric determination of plasma salicylate with edta and terbium | |
| CN108623522A (en) | A kind of hypochlorous method of quick high-selectivity detection | |
| McCleskey | Fluorometric Method for the Determination of Urea in Blood. | |
| SU1182347A1 (en) | Method of determining quinine iodobismuthate | |
| SU1388773A1 (en) | Method of determining carbocromene in preparation of aqueous solution | |
| SU1636741A1 (en) | Method of determination of benzyl alcohol in air | |
| SU1509690A1 (en) | Method of determining salicyclic aldehyde | |
| SU1427253A1 (en) | Method of analyzing samarium in gadolinium oxide | |
| SU1168831A1 (en) | Method of quantitative determining of l.alpha-methyl-beta-(3,4-dioxyphenyl)-ala nine | |
| CN108587606A (en) | A kind of quick high-selectivity analyzes the purposes of hypochlorous fluorescence probe | |
| SU972404A1 (en) | Chloride cotarnine determination method | |
| SU1589157A1 (en) | Method of determining admixture of sulphate quinidine in sulphate quinine | |
| SU958931A1 (en) | Etonium determination method | |
| SU1337739A1 (en) | Method of determining amitryptelene in medicinal compounds | |
| SU1589162A1 (en) | Method of quantitative determination of olein acid in sample of water | |
| SU1644004A1 (en) | Method for quantitative determination of sodium sulfocyl | |
| SU1120240A1 (en) | Method of identifying carbamazepine | |
| SU1286970A1 (en) | Method of determining phenothiazine derivatives | |
| SU826222A1 (en) | Method of quantitative determining of 1,2,3 -benzotrizole |