SU130626A1 - Method of extracting and purifying nystatin - Google Patents
Method of extracting and purifying nystatinInfo
- Publication number
- SU130626A1 SU130626A1 SU639028A SU639028A SU130626A1 SU 130626 A1 SU130626 A1 SU 130626A1 SU 639028 A SU639028 A SU 639028A SU 639028 A SU639028 A SU 639028A SU 130626 A1 SU130626 A1 SU 130626A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- nystatin
- purifying
- extracting
- filter
- dried
- Prior art date
Links
- 238000000034 method Methods 0.000 title description 3
- 229960000988 nystatin Drugs 0.000 title description 3
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 title description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 238000000859 sublimation Methods 0.000 claims description 2
- 230000008022 sublimation Effects 0.000 claims description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 230000003115 biocidal effect Effects 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Peptides Or Proteins (AREA)
Description
Известны способы выделени и очистки нистатина экстракцией метиловым спиртом иа продуцента мицели , высушенного на распылительной сушилке при 130 Однако сушка мицепи при такой темпера туре приводит к значительной инактивации ;антибиотика и к получению материала , требуюиего дальнейшего измельчени до экстракции.Methods are known for the isolation and purification of nystatin by extraction with methyl alcohol of the producer of the mycelium dried on a spray dryer at 130 However, drying the mycelium at this temperature leads to a significant inactivation of the antibiotic and to the preparation of the material requiring further grinding before extraction.
Цепь изобретени повышение выхо- да антибиотика и получени высушенного продукта, не требуюиего дальнейшего измельчени .The circuit of the invention is an increase in the yield of the antibiotic and the production of a dried product that does not require further grinding.
Это достигаетс тем, что мицепийThis is achieved by the fact that
высушивают сублимацией иа замороженного состо ни и производ т экстракцию п{)И помощи др к-фильтра с мешалкой, спужащего одновременно экстрактором и фильтром,dried by sublimation of the frozen state and the extraction of n {) And the help of a different k-filter with a stirrer, which simultaneously coats the extractor and filter, is performed,
Дл oqy даcтвлeни способа продуцент мицели замораживают в вавуум- сушильных шкафах при остаточном дав дении не более мм рт. ст. и поо ледуюиюм удалении льда субпимадиейIn order to produce a method, the mycelium producer is frozen in a vacuum drying oven at a residual pressure of not more than mm Hg. Art. and after ice removal by subpimadia
при температуре i-ennoHOcHTenn не вы ше 9ОС.at i-ennoHOcHTenn temperature not higher than 9 ° C.
Получающийс продукт представл ет собой мелкопористую губчатую массу с содержанием летучих около 5%, причем: разрушение ант;1биоткка в этих услови х очень незначительно.The resulting product is a finely porous spongy mass with a volatile content of about 5%, moreover: the destruction of the ant; 1 biotus under these conditions is very insignificant.
Дальнейшее получение антибиотика из пиофилизированного таким путем мицел осушествл етс экстракцией метиловым спиртом с применением друк-фильтра, снабженного пропеллерной мешалкой и служащего одаювременно экстрактором и фильтромFurther preparation of the antibiotic from the micelles that are pyophilized in this way is carried out by extraction with methyl alcohol using a filter equipped with a propeller stirrer and serving as an extractor and filter.
Метазюльный экстракт нистатина концентрируетс до 1,20 первоначально1-чз объема, выделение же антибиотика происходит при разбавлении конйентрата водой ,The nystatin metazule extract is concentrated to 1.20 initially 1-chz volume, while the release of the antibiotic occurs upon diluting the concentrate with water,
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU639028A SU130626A1 (en) | 1959-09-15 | 1959-09-15 | Method of extracting and purifying nystatin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU639028A SU130626A1 (en) | 1959-09-15 | 1959-09-15 | Method of extracting and purifying nystatin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU130626A1 true SU130626A1 (en) | 1978-09-15 |
Family
ID=48401740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU639028A SU130626A1 (en) | 1959-09-15 | 1959-09-15 | Method of extracting and purifying nystatin |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU130626A1 (en) |
-
1959
- 1959-09-15 SU SU639028A patent/SU130626A1/en active
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