SU1391653A1 - Agent for prophylaxis and treatment of gastroenteritis of pigs - Google Patents
Agent for prophylaxis and treatment of gastroenteritis of pigs Download PDFInfo
- Publication number
- SU1391653A1 SU1391653A1 SU843826209A SU3826209A SU1391653A1 SU 1391653 A1 SU1391653 A1 SU 1391653A1 SU 843826209 A SU843826209 A SU 843826209A SU 3826209 A SU3826209 A SU 3826209A SU 1391653 A1 SU1391653 A1 SU 1391653A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- acid
- treatment
- drug
- days
- prophylaxis
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title claims abstract description 5
- 208000005577 Gastroenteritis Diseases 0.000 title claims description 3
- 241000282887 Suidae Species 0.000 title claims 3
- 238000011321 prophylaxis Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 claims abstract description 9
- 229940079593 drug Drugs 0.000 claims abstract description 7
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 4
- 230000002265 prevention Effects 0.000 claims description 2
- 230000003449 preventive effect Effects 0.000 claims description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 abstract description 4
- 241001465754 Metazoa Species 0.000 abstract description 4
- 230000000069 prophylactic effect Effects 0.000 abstract description 3
- RXMWXENJQAINCC-DMTCNVIQSA-N 2,5-didehydro-D-gluconic acid Chemical compound OCC(=O)[C@@H](O)[C@H](O)C(=O)C(O)=O RXMWXENJQAINCC-DMTCNVIQSA-N 0.000 abstract description 2
- VBUYCZFBVCCYFD-JJYYJPOSSA-N 2-dehydro-D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)C(O)=O VBUYCZFBVCCYFD-JJYYJPOSSA-N 0.000 abstract description 2
- IZSRJDGCGRAUAR-MROZADKFSA-N 5-dehydro-D-gluconic acid Chemical compound OCC(=O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O IZSRJDGCGRAUAR-MROZADKFSA-N 0.000 abstract description 2
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 abstract description 2
- 239000002253 acid Substances 0.000 abstract description 2
- 239000007864 aqueous solution Substances 0.000 abstract description 2
- 235000012208 gluconic acid Nutrition 0.000 abstract description 2
- 239000000174 gluconic acid Substances 0.000 abstract description 2
- 150000002596 lactones Chemical class 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 abstract description 2
- 230000009965 odorless effect Effects 0.000 abstract description 2
- 235000019614 sour taste Nutrition 0.000 abstract description 2
- 230000037396 body weight Effects 0.000 description 3
- 235000003930 Aegle marmelos Nutrition 0.000 description 1
- 244000058084 Aegle marmelos Species 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 241000589232 Gluconobacter oxydans Species 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Изобретение относитс к ветеринарии . Цель изобретени - повышение профилактической и лечебной эффективности . С профилактической целью животным задают бактериолизин (бализ), представл ющий собой бесцветную или слегка желтоват-ого цвета жидкость без запаха, иногда со слабо специфическим запахом, кислого вкуса, содержащую глюконовую кислоту, 5-кетоглю- коновую кислоту, 2-кетоглюконовую кислоту, 2,5-дикетоглюконовую кислоту , 5-окси-4-пирон-2-карбоновую кислоту и лактоны альдоновых кислот. Препарат вл етс продуцентом штамма Gluconbachter oxydans 1 ЦМПМ В-2380. Препарат в виде водного раствора задают в течение 5 дней один раз внутрь. Дл лечени бализ задают в течение 3 дней в дозе 3,0-4,5 мл/кг массы животного. При профилактике из наблюдавшихс животных в контроле заболело 25%, при применении баллиза 10-15%, а при лечении из 18 заболевших выздоровело 16 против 15 контрол .2 табл. W со со 05 ел соThe invention relates to veterinary medicine. The purpose of the invention is to increase the prophylactic and therapeutic effectiveness. For prophylactic purposes, animals are given bacteriolysin (bales), a colorless or slightly yellowish, odorless liquid, sometimes with a slightly peculiar smell, sour taste, containing gluconic acid, 5-ketogluconic acid, 2-ketogluconic acid, 2 , 5-diketogluconic acid, 5-hydroxy-4-pyrone-2-carboxylic acid and aldonic acid lactones. The drug is a producer of the strain Gluconbachter oxydans 1 CMPM B-2380. The drug in the form of an aqueous solution set within 5 days once inside. For treatment, Balis is administered for 3 days at a dose of 3.0-4.5 ml / kg of animal weight. During the prophylaxis of the observed animals, 25% of the patients in the control got sick, 10-15% when using Ballyz, and 16 of 15 patients recovered from treatment against 15 controls. Table 2. W with co 05 ate with
Description
113113
Изобретение относитс к ветеринарии , а именно к лекарственным средствам , используемым дл профилактики и лечени гастроэнтеритов.This invention relates to veterinary medicine, in particular to drugs used for the prevention and treatment of gastroenteritis.
Целью изобретени вл етс повыше ние профилактической и лечебной эффективности .The aim of the invention is to increase prophylactic and therapeutic efficacy.
Пример I. Профилактическое действие средства. Трем группам подопытных животных задавали препарат бактериолизин (бализ), который представл ет собой бесцветную или слегка желтоватого цвета жидкость без запаха , иногда со слабым специфическим запахом, кислого вкуса и содержит глюконовую кислоту, 5-кетоглюконо- вую кислоту, 2-кетоглюконовую кислоту , 2,5-дикетоглюконовую кислоту, 5-окси- -пирон-2-карбоновую кислоту и лактоны альдоновых кислот. Продуцентом препарата бализ вл етс пггамм Gluconobacter oxydans 1ЦМПМ В-2380. Бализ в виде водного раствора задавали в течение 5 дней один раз в день внутрь и наблюдени проводили в течение 30 дней. Контрольна Example I. The preventive action of the tool. Three groups of experimental animals were given the drug bacteriolysin (bales), which is an odorless, colorless or slightly yellowish liquid, sometimes with a slight specific smell, sour taste and contains gluconic acid, 5-ketogluconic acid, 2-ketogluconic acid, 2 , 5-diketogluconic acid, 5-hydroxy-β-pyrone-2-carboxylic acid and aldonic acid lactones. The drug produced by bales is pggamm Gluconobacter oxydans 1CMPM B-2380. Balis in the form of an aqueous solution was administered orally for 5 days once a day and observations were carried out for 30 days. Control
22
группа получала сухой ацидофилин в дозе 1,5 г/кг массы тела также в течение 5 дней. Данные представлены в табл. 1.the group received dry acidophilus in a dose of 1.5 g / kg body weight also for 5 days. The data presented in Table. one.
Пример 2. Лечебна эффективность . 72 больным энтеритной формой колибактериоза порос там в возрастеExample 2. Therapeutic efficacy. 72 patients with enteritis form of colibacillosis
2-3 дней задавали препарат бализ в дозе 3; 3,5 и 4,5 мл/кг массы тела. Контрольные животные получали антибиотик тетрациклин на физиологическом растворе в дозе 10 тыс. ЕД на кг2-3 days asked the drug Belis at a dose of 3; 3.5 and 4.5 ml / kg body weight. Control animals received the antibiotic tetracycline in a physiological solution at a dose of 10 thousand. Units per kg
массы тела также в течение 3 дней. Данные приведены в табл. 2.body weight also for 3 days. The data are given in table. 2
Средство безвредно дл организма , не обладает кумул тивными свойствами , не вызывает привыкани к немуThe product is harmless to the body, does not possess cumulative properties, does not cause addiction to it.
микроорганизмов, обладает противовоспалительным действием.microorganism, has anti-inflammatory action.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU843826209A SU1391653A1 (en) | 1984-10-11 | 1984-10-11 | Agent for prophylaxis and treatment of gastroenteritis of pigs |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU843826209A SU1391653A1 (en) | 1984-10-11 | 1984-10-11 | Agent for prophylaxis and treatment of gastroenteritis of pigs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1391653A1 true SU1391653A1 (en) | 1988-04-30 |
Family
ID=21151917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU843826209A SU1391653A1 (en) | 1984-10-11 | 1984-10-11 | Agent for prophylaxis and treatment of gastroenteritis of pigs |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU1391653A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1647188A3 (en) * | 1999-01-29 | 2006-08-02 | The Australian National University | A method of controlling fungal pathogens, and agents useful for same |
-
1984
- 1984-10-11 SU SU843826209A patent/SU1391653A1/en active
Non-Patent Citations (1)
| Title |
|---|
| Аликаев В.А. и др. Внутренние незаразные болезни сельскохоз йственных животных. М.: Колос, 1972, с. 454-461. Авторское свидетельство СССР № 1045631, кл. С 12 Р 1/04, 1981. Авторское свидетельство СССР № 363356, кл. С 12 Р 1/06, 1966. * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1647188A3 (en) * | 1999-01-29 | 2006-08-02 | The Australian National University | A method of controlling fungal pathogens, and agents useful for same |
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