SU1108729A1 - Methyl ester of n-[4-(3,3-dimethyltriazeno)-phenylsulfonyl]-carbamic acid displaying diuretic activity - Google Patents
Methyl ester of n-[4-(3,3-dimethyltriazeno)-phenylsulfonyl]-carbamic acid displaying diuretic activity Download PDFInfo
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- SU1108729A1 SU1108729A1 SU823491597A SU3491597A SU1108729A1 SU 1108729 A1 SU1108729 A1 SU 1108729A1 SU 823491597 A SU823491597 A SU 823491597A SU 3491597 A SU3491597 A SU 3491597A SU 1108729 A1 SU1108729 A1 SU 1108729A1
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- SU
- USSR - Soviet Union
- Prior art keywords
- dimethyltriazeno
- phenylsulfonyl
- methyl ester
- carbamic acid
- diuretic activity
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Метиловый эфир .Methyl ether.
Description
Изобретение относитс к области органической химии, к синтезу нового биологически активного соединени - метилового эфира (3,3диметилтриаз ено)фенилсульфонилТ карбаминовой кислоты, про вл ющего диуретическое действие, которое может найти применение В медицине.The invention relates to the field of organic chemistry, to the synthesis of a new biologically active compound - methyl ester of (3,3-dimethyltriazeno)phenylsulfonyl-T carbamic acid, exhibiting a diuretic effect, which can find application in medicine.
Целью изобретени вл етс расширение арсенала веществ воздействи на живой организм, обладающих диуретическим действием, высокой стабильностью .The aim of the invention is to expand the arsenal of substances that have an effect on a living organism, possessing a diuretic effect and high stability.
Полезные свойства определ ютс химической структурой метилового эфира (3,3-диметилтриазено) -фенилсульфонил карбаминовой кислоты,котора выражаетс следующей структурной формулой /The beneficial properties are determined by the chemical structure of the methyl ester of (3,3-dimethyltriazeno)-phenylsulfonyl carbamic acid, which is expressed by the following structural formula /
(CH3)(O)-S02NHCOOCH3j(CH3)(O)-S02NHCOOCH3j
чh
Новое соедийение получают ацили .рованием 4-(3,3-диметилтриазено)бензолс ульфамида метиловым эфиром хлоругольной кислоты.The new compound is obtained by acylation of 4-(3,3-dimethyltriazeno)benzenesulfamide with methyl chlorocarbonate.
Пример. 9,12 г (0,04 моль) 4-(3,3-диметилтриазено)бензолсульфаExample: 9.12 g (0.04 mol) 4-(3,3-dimethyltriazeno)benzenesulfonate
МИДа раствор ют в 250 мл ацетона, MID is dissolved in 250 ml of acetone,
i прибавл ют 27,6 г (0,2 моль) безводного поташа. В полученную суспензию i add 27.6 g (0.2 mol) of anhydrous potash. To the resulting suspension
(Л при перемешивании и комнатной температуре , по капл м, прибавл ют 7,6 мл (0,1 моль) метилового эфира хлоругольной кислоты.(With stirring and at room temperature, 7.6 ml (0.1 mol) of methyl chlorocarbonate are added dropwise.
Реакционную смесь при перемешивании кип т т 6 ч. Метиловый эфир N|j4- (3,3-диметилтриаз ено) фенилсульфонил карбоновой кислоты и избыток по00 таша фильтруют, раствор ют в 100 мл The reaction mixture was boiled for 6 hours with stirring. Methyl ester of N|j4-(3,3-dimethyltriaz eno)phenylsulfonyl carboxylic acid and excess of 00% were filtered and dissolved in 100 ml
ю воды и раствор нейтрализуют конц. НС1 до рН 7 при температуре 2-5 С. Выпавший продукт фильтруют, промывасо ют водой и сушат на воздухе.Кристаллизуют , из этанола. Получают 8 г (69,8%) продукта с температурой плавлени 158-159С; молекул рный вес 286,312. -Найдено ,%: С 41,97; Н 4,92; N 19,40; S 10,8.water and the solution is neutralized with conc. HCl to pH 7 at a temperature of 2-5 C. The precipitated product is filtered, washed with water and dried in air. Crystallized from ethanol. Obtained 8 g (69.8%) of product with a melting point of 158-159 C; molecular weight 286.312. -Found, %: C 41.97; H 4.92; N 19.40; S 10.8.
vv
Вычислено,%: С 41,95; Н 4,93; Ы 19,57; S 11,2.Calculated,%: C 41.95; H 4.93; S 19.57; S 11.2.
Исследовани провод т в хронических опытах на крысах, у которых ежесуточно определ ют диурез, потреблеThe studies are conducted in chronic experiments on rats, in which diuresis, consumption and energy are determined daily.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU823491597A SU1108729A1 (en) | 1982-09-10 | 1982-09-10 | Methyl ester of n-[4-(3,3-dimethyltriazeno)-phenylsulfonyl]-carbamic acid displaying diuretic activity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU823491597A SU1108729A1 (en) | 1982-09-10 | 1982-09-10 | Methyl ester of n-[4-(3,3-dimethyltriazeno)-phenylsulfonyl]-carbamic acid displaying diuretic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1108729A1 true SU1108729A1 (en) | 1990-10-30 |
Family
ID=21029191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU823491597A SU1108729A1 (en) | 1982-09-10 | 1982-09-10 | Methyl ester of n-[4-(3,3-dimethyltriazeno)-phenylsulfonyl]-carbamic acid displaying diuretic activity |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU1108729A1 (en) |
-
1982
- 1982-09-10 SU SU823491597A patent/SU1108729A1/en active
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