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SMT202000345T1 - Metodo di trattamento e composizioni comprendenti un doppio inibitore di pi3k delta-gamma chinasi e un corticosteroide - Google Patents

Metodo di trattamento e composizioni comprendenti un doppio inibitore di pi3k delta-gamma chinasi e un corticosteroide

Info

Publication number
SMT202000345T1
SMT202000345T1 SM20200345T SMT202000345T SMT202000345T1 SM T202000345 T1 SMT202000345 T1 SM T202000345T1 SM 20200345 T SM20200345 T SM 20200345T SM T202000345 T SMT202000345 T SM T202000345T SM T202000345 T1 SMT202000345 T1 SM T202000345T1
Authority
SM
San Marino
Prior art keywords
corticosteroid
compositions
treatment
kinase inhibitor
pi3k delta
Prior art date
Application number
SM20200345T
Other languages
English (en)
Inventor
Srikant Viswanadha
Venkata Satya Vakkalanka Swaroop Kumar
Original Assignee
Rhizen Pharmaceuticals S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhizen Pharmaceuticals S A filed Critical Rhizen Pharmaceuticals S A
Publication of SMT202000345T1 publication Critical patent/SMT202000345T1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
SM20200345T 2014-09-03 2015-09-03 Metodo di trattamento e composizioni comprendenti un doppio inibitore di pi3k delta-gamma chinasi e un corticosteroide SMT202000345T1 (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN4287CH2014 2014-09-03
PCT/IB2015/056720 WO2016035032A1 (en) 2014-09-03 2015-09-03 Method of treatment and compositions comprising a dual pi3k delta-gamma kinase inhibitor and a corticosteroid
EP15774713.0A EP3188759B1 (en) 2014-09-03 2015-09-03 Method of treatment and compositions comprising a dual pi3k delta-gamma kinase inhibitor and a corticosteroid

Publications (1)

Publication Number Publication Date
SMT202000345T1 true SMT202000345T1 (it) 2020-07-08

Family

ID=54249540

Family Applications (1)

Application Number Title Priority Date Filing Date
SM20200345T SMT202000345T1 (it) 2014-09-03 2015-09-03 Metodo di trattamento e composizioni comprendenti un doppio inibitore di pi3k delta-gamma chinasi e un corticosteroide

Country Status (26)

Country Link
US (2) US10786504B2 (it)
EP (2) EP3701950A1 (it)
JP (3) JP6559775B2 (it)
KR (1) KR20170044203A (it)
CN (2) CN106714842B (it)
AU (2) AU2015310545B2 (it)
BR (1) BR112017004163A2 (it)
CA (1) CA2958988A1 (it)
CL (1) CL2017000512A1 (it)
CY (1) CY1123075T1 (it)
DK (1) DK3188759T3 (it)
EA (2) EA038527B1 (it)
ES (1) ES2802202T3 (it)
HR (1) HRP20200968T1 (it)
HU (1) HUE049480T2 (it)
IL (2) IL250918B (it)
LT (1) LT3188759T (it)
MX (2) MX376875B (it)
PH (1) PH12017500378A1 (it)
PL (1) PL3188759T3 (it)
PT (1) PT3188759T (it)
RS (1) RS60450B1 (it)
SG (2) SG10202100596SA (it)
SI (1) SI3188759T1 (it)
SM (1) SMT202000345T1 (it)
WO (1) WO2016035032A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022508468A (ja) * 2018-09-14 2022-01-19 ルヒゼン ファーマスティカルズ アクツィエンゲゼルシャフト Ｃｒａｃ阻害剤およびコルチコステロイドを含む組成物ならびにそれらの使用方法
JP7665534B2 (ja) 2019-06-04 2025-04-21 アーカス バイオサイエンシーズ インコーポレイテッド ２，３，５－三置換ピラゾロ［１，５－ａ］ピリミジン化合物
CN116492351B (zh) * 2023-03-13 2024-03-12 香港大学深圳医院 氯替泼诺在制备治疗早发性卵巢功能不全及卵巢响应匮乏药物中的应用

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US4018774A (en) 1976-02-13 1977-04-19 E. R. Squibb & Sons, Inc. Steroidal [16α,17-d]isoxazolidines
SE8106165L (sv) 1981-10-19 1983-04-20 Atlas Copco Ab Forfarande for bergbultning och bergbult
GB0415747D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
DK2240451T3 (da) 2008-01-04 2017-11-20 Intellikine Llc Isoquinolinonderivater substitueret med en purin, der er anvendelig som pi3k-inhibitorer
US11058699B2 (en) 2008-07-01 2021-07-13 Wisconsin Alumni Research Foundation Method and compositions for inhibition of double stranded DNA viruses
EP2411003A4 (en) * 2009-03-24 2012-10-17 Univ Singapore USE OF ARTEMISININE DERIVATIVES IN THE TREATMENT OF ASTHMA AND CHRONIC OBSTRUCTIVE BRONCHO-PNEUMOPATHY (COPD)
EP2475676B1 (en) 2009-09-11 2020-05-27 Chiesi Farmaceutici S.p.A. Pregnane derivatives condensed in the 16,17 position with an N-substituted isoxazolidine ring as anti-inflammatory agents
EP3444242A3 (en) * 2009-11-05 2019-03-20 Rhizen Pharmaceuticals S.A. Novel benzopyran kinase modulators
AU2011210640A1 (en) * 2010-01-28 2012-06-07 The Johns Hopkins University Compositions and methods for reversing corticosteroid resistance or treating respiratory infections
EP3689364A1 (en) * 2010-02-08 2020-08-05 Shenzhen Evergreen Therapeutics Co., Ltd. Methods for the use of progestogen as a glucocorticoid sensitizer
DK2663309T3 (en) 2011-01-10 2017-06-19 Infinity Pharmaceuticals Inc METHODS FOR PRODUCING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES
CA2850081C (en) 2011-03-15 2020-01-07 Chiesi Farmaceutici S.P.A. Isoxazolidine derivatives
PT2705029T (pt) * 2011-05-04 2019-02-01 Rhizen Pharmaceuticals S A Novos compostos como moduladores de proteína quinases
SE540189C2 (en) 2012-05-22 2018-04-24 Epiroc Canada Inc Rock bolt and method of installing the rock bolt and a protecting sleeve for it
US9737521B2 (en) * 2012-11-08 2017-08-22 Rhizen Pharmaceuticals Sa Pharmaceutical compositions containing a PDE4 inhibitor and a PI3 delta or dual PI3 delta-gamma kinase inhibitor
CN204282361U (zh) 2014-12-11 2015-04-22 湖南科技大学 一种带钢丝网的软土地基充气锚杆

Also Published As

Publication number Publication date
JP2017525739A (ja) 2017-09-07
EA201790379A1 (ru) 2017-06-30
SG10202100596SA (en) 2021-02-25
PL3188759T3 (pl) 2020-11-02
CN106714842A (zh) 2017-05-24
NZ729419A (en) 2021-08-27
DK3188759T3 (da) 2020-06-29
EA202092492A1 (ru) 2021-07-30
CA2958988A1 (en) 2016-03-10
CN113332439A (zh) 2021-09-03
AU2021200051A1 (en) 2021-02-18
HRP20200968T1 (hr) 2020-10-16
EP3188759A1 (en) 2017-07-12
PH12017500378A1 (en) 2017-07-17
WO2016035032A1 (en) 2016-03-10
AU2015310545A1 (en) 2017-03-16
IL280686A (en) 2021-03-25
RS60450B1 (sr) 2020-07-31
ES2802202T3 (es) 2021-01-15
HUE049480T2 (hu) 2020-09-28
KR20170044203A (ko) 2017-04-24
IL250918A0 (en) 2017-04-30
JP2021191804A (ja) 2021-12-16
US20170281630A1 (en) 2017-10-05
BR112017004163A2 (pt) 2017-12-05
AU2015310545B2 (en) 2020-10-22
EP3701950A1 (en) 2020-09-02
CN106714842B (zh) 2021-07-02
LT3188759T (lt) 2020-07-10
US20210030757A1 (en) 2021-02-04
MX2020011472A (es) 2020-12-07
EP3188759B1 (en) 2020-04-01
JP2019172708A (ja) 2019-10-10
PT3188759T (pt) 2020-07-02
IL250918B (en) 2021-02-28
US10786504B2 (en) 2020-09-29
SG11201701499YA (en) 2017-03-30
EA038527B1 (ru) 2021-09-10
CY1123075T1 (el) 2021-10-29
CL2017000512A1 (es) 2017-11-03
SI3188759T1 (sl) 2020-08-31
MX2017002878A (es) 2017-05-30
MX376875B (es) 2025-03-07
JP6559775B2 (ja) 2019-08-14

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