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SMT201900038T1 - Composti di 6,7-diidropirazolo[1,5-a]pirazin-4(5h)-one e loro utilizzo come modulatori allosterici negativi di recettori mglu2 - Google Patents

Composti di 6,7-diidropirazolo[1,5-a]pirazin-4(5h)-one e loro utilizzo come modulatori allosterici negativi di recettori mglu2

Info

Publication number
SMT201900038T1
SMT201900038T1 SM20190038T SMT201900038T SMT201900038T1 SM T201900038 T1 SMT201900038 T1 SM T201900038T1 SM 20190038 T SM20190038 T SM 20190038T SM T201900038 T SMT201900038 T SM T201900038T SM T201900038 T1 SMT201900038 T1 SM T201900038T1
Authority
SM
San Marino
Prior art keywords
dihydropyrazolo
pyrazin
compounds
allosteric modulators
negative allosteric
Prior art date
Application number
SM20190038T
Other languages
English (en)
Inventor
Gool Michiel Luc Maria Van
Diego Sergio-Alvar Alonso-De
Óscar Delgado-González
Andrés Avelino Trabanco-Suárez
José Ignacio Andrés-Gil
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of SMT201900038T1 publication Critical patent/SMT201900038T1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SM20190038T 2014-08-01 2015-07-30 Composti di 6,7-diidropirazolo[1,5-a]pirazin-4(5h)-one e loro utilizzo come modulatori allosterici negativi di recettori mglu2 SMT201900038T1 (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14179598 2014-08-01
PCT/EP2015/067530 WO2016016380A1 (en) 2014-08-01 2015-07-30 6,7-DIHYDROPYRAZOLO[1,5-α]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
EP15750666.8A EP3177623B1 (en) 2014-08-01 2015-07-30 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglu2 receptors

Publications (1)

Publication Number Publication Date
SMT201900038T1 true SMT201900038T1 (it) 2019-02-28

Family

ID=51257437

Family Applications (1)

Application Number Title Priority Date Filing Date
SM20190038T SMT201900038T1 (it) 2014-08-01 2015-07-30 Composti di 6,7-diidropirazolo[1,5-a]pirazin-4(5h)-one e loro utilizzo come modulatori allosterici negativi di recettori mglu2

Country Status (34)

Country Link
US (3) US10005786B2 (it)
EP (1) EP3177623B1 (it)
JP (1) JP6662846B2 (it)
KR (1) KR102531689B1 (it)
CN (1) CN106573936B (it)
AR (1) AR101392A1 (it)
AU (1) AU2015295298B2 (it)
BR (1) BR112017001726A2 (it)
CA (1) CA2954093C (it)
CL (1) CL2017000192A1 (it)
CY (1) CY1121649T1 (it)
DK (1) DK3177623T3 (it)
EA (1) EA031087B1 (it)
ES (1) ES2708215T3 (it)
HR (1) HRP20181997T1 (it)
HU (1) HUE042871T2 (it)
IL (1) IL250298A0 (it)
JO (1) JOP20150179B1 (it)
LT (1) LT3177623T (it)
MA (1) MA39582B1 (it)
ME (1) ME03320B (it)
MX (1) MX376289B (it)
NZ (1) NZ728122A (it)
PH (1) PH12017500161B1 (it)
PL (1) PL3177623T3 (it)
PT (1) PT3177623T (it)
RS (1) RS58279B1 (it)
SG (1) SG11201700638YA (it)
SI (1) SI3177623T1 (it)
SM (1) SMT201900038T1 (it)
TR (1) TR201901074T4 (it)
TW (1) TWI696624B (it)
WO (1) WO2016016380A1 (it)
ZA (1) ZA201700759B (it)

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Also Published As

Publication number Publication date
HUE042871T2 (hu) 2019-07-29
ES2708215T3 (es) 2019-04-09
MX2017001452A (es) 2017-05-09
PH12017500161A1 (en) 2017-06-28
KR102531689B1 (ko) 2023-05-10
BR112017001726A2 (pt) 2017-11-21
CY1121649T1 (el) 2020-07-31
CA2954093C (en) 2022-11-29
PT3177623T (pt) 2019-02-01
WO2016016380A8 (en) 2017-01-19
MA39582A1 (fr) 2018-06-29
DK3177623T3 (en) 2019-02-25
CL2017000192A1 (es) 2017-07-28
CN106573936A (zh) 2017-04-19
EP3177623A1 (en) 2017-06-14
JP6662846B2 (ja) 2020-03-11
HRP20181997T1 (hr) 2019-01-25
IL250298A0 (en) 2017-03-30
RS58279B1 (sr) 2019-03-29
KR20170031247A (ko) 2017-03-20
US10512646B2 (en) 2019-12-24
TR201901074T4 (tr) 2019-02-21
SG11201700638YA (en) 2017-02-27
US20180256569A1 (en) 2018-09-13
MX376289B (es) 2025-03-07
ME03320B (me) 2019-10-20
US20170217972A1 (en) 2017-08-03
PL3177623T3 (pl) 2019-04-30
JOP20150179B1 (ar) 2021-08-17
US20200121677A1 (en) 2020-04-23
NZ728122A (en) 2022-07-29
EP3177623B1 (en) 2018-11-07
AU2015295298A1 (en) 2017-01-12
AR101392A1 (es) 2016-12-14
US10005786B2 (en) 2018-06-26
CA2954093A1 (en) 2016-02-04
EA031087B1 (ru) 2018-11-30
LT3177623T (lt) 2019-02-11
JP2017522340A (ja) 2017-08-10
AU2015295298B2 (en) 2019-07-11
SI3177623T1 (sl) 2019-01-31
TWI696624B (zh) 2020-06-21
CN106573936B (zh) 2020-01-07
EA201692540A1 (ru) 2017-05-31
WO2016016380A1 (en) 2016-02-04
TW201617346A (zh) 2016-05-16
PH12017500161B1 (en) 2022-05-18
MA39582B1 (fr) 2019-10-31
ZA201700759B (en) 2018-12-19

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