SMT201700387T1 - Terapia di combinazione implicante anticorpi contro claudina 18.2 per il trattamento del cancro - Google Patents

Terapia di combinazione implicante anticorpi contro claudina 18.2 per il trattamento del cancro

Info

Publication number: SMT201700387T1
Authority: SM; San Marino
Prior art keywords: cancer; treatment; combination therapy; antibodies against; therapy involving
Prior art date: 2012-05-23

Application number

SM20170387T

Other languages

English (en)

Inventor

Ugur Sahin

Özlem Türeci

Rita Mitnacht-Kraus

Stefan Denis Jacobs

Magdalena Jadwiga Utsch

Cornelia Adriana Maria Heinz

Christiane Regina Stadler

Original Assignee

Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh

Ganymed Pharmaceuticals Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-05-23

Filing date

2013-05-21

Publication date

2017-09-07

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52544200&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SMT201700387(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2012-05-23 Priority claimed from PCT/EP2012/002210 external-priority patent/WO2013174403A1/en

2013-05-21 Application filed by Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh, Ganymed Pharmaceuticals Gmbh filed Critical Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh

2017-09-07 Publication of SMT201700387T1 publication Critical patent/SMT201700387T1/it

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Cell Biology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Mycology (AREA)
Microbiology (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)

SM20170387T 2012-05-23 2013-05-21 Terapia di combinazione implicante anticorpi contro claudina 18.2 per il trattamento del cancro SMT201700387T1 (it)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
PCT/EP2012/002210 WO2013174403A1 (en)	2012-05-23	2012-05-23	Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
PCT/EP2013/001504 WO2013174510A1 (en)	2012-05-23	2013-05-21	Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
EP13724523.9A EP2852408B1 (en)	2012-05-23	2013-05-21	Combination therapy involving antibodies against claudin 18.2 for treatment of cancer

Publications (1)

Publication Number	Publication Date
SMT201700387T1 true SMT201700387T1 (it)	2017-09-07

Family

ID=52544200

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SM20170387T SMT201700387T1 (it)	2012-05-23	2013-05-21	Terapia di combinazione implicante anticorpi contro claudina 18.2 per il trattamento del cancro

Country Status (9)

Country	Link
EP (6)	EP2852408B1 (it)
CY (2)	CY1119549T1 (it)
DK (1)	DK3254695T3 (it)
HR (1)	HRP20171218T1 (it)
ME (1)	ME02932B (it)
PL (2)	PL2852408T3 (it)
RS (1)	RS56187B1 (it)
SI (1)	SI2852408T1 (it)
SM (1)	SMT201700387T1 (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2852408B1 (en)	2012-05-23	2017-05-17	Ganymed Pharmaceuticals AG	Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
AU2019232762B2 (en) *	2018-03-08	2023-11-16	Phanes Therapeutics, Inc.	Anti-claudin 18.2 antibodies and uses thereof
US20220033491A1 (en)	2018-09-30	2022-02-03	Cafa Therapeutics Limited	Combination therapy of cldn18 antibody and chemotherapy drugs
CN109762067B (zh) *	2019-01-17	2020-02-28	北京天广实生物技术股份有限公司	结合人Claudin 18.2的抗体及其用途
CN111978402B (zh) *	2019-05-24	2022-06-28	三优生物医药(上海)有限公司	新型cldn18.2结合分子
CN111704669B (zh) *	2020-07-13	2022-05-13	北京凯因科技股份有限公司	一种用于治疗晚期胃癌的抗cldn18全人源化抗体
CN112480248B (zh) *	2020-11-24	2023-05-05	三优生物医药(上海)有限公司	与cld18a2特异性结合的分子
CN114685670B (zh) *	2020-12-31	2025-06-27	上海莱馥医疗科技有限公司	Cldn18.2抗体及其应用
CN115073596B (zh) *	2021-03-10	2025-06-27	上海莱馥医疗科技有限公司	一种人源化Claudin18.2抗体及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8601597D0 (en)	1986-01-23	1986-02-26	Wilson R H	Nucleotide sequences
GB8717430D0 (en)	1987-07-23	1987-08-26	Celltech Ltd	Recombinant dna product
GB8809129D0 (en)	1988-04-18	1988-05-18	Celltech Ltd	Recombinant dna methods vectors and host cells
KR100857943B1 (ko)	2000-11-30	2008-09-09	메다렉스, 인코포레이티드	인간 항체의 제조를 위한 형질전환 트랜스염색체 설치류
US20030133939A1 (en)	2001-01-17	2003-07-17	Genecraft, Inc.	Binding domain-immunoglobulin fusion proteins
US7754208B2 (en)	2001-01-17	2010-07-13	Trubion Pharmaceuticals, Inc.	Binding domain-immunoglobulin fusion proteins
PT1558648E (pt)	2002-10-17	2012-04-23	Genmab As	Anticorpos monoclonais humanos contra cd20
EP1790664A1 (en)	2005-11-24	2007-05-30	Ganymed Pharmaceuticals AG	Monoclonal antibodies against claudin-18 for treatment of cancer
EP1997832A1 (en) *	2007-05-29	2008-12-03	Ganymed Pharmaceuticals AG	Monoclonal antibodies against Claudin-18 for treatment of cancer
AU2009273540A1 (en) *	2008-07-25	2010-01-28	Merck Patent Gmbh	Method of determination of receptor binding saturation effected by monoclonal antibodies
WO2011090005A1 (ja) *	2010-01-19	2011-07-28	協和発酵キリン株式会社	大腸癌の治療用医薬および治療方法
EP2852408B1 (en)	2012-05-23	2017-05-17	Ganymed Pharmaceuticals AG	Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
WO2013174403A1 (en)	2012-05-23	2013-11-28	Ganymed Pharmaceuticals Ag	Combination therapy involving antibodies against claudin 18.2 for treatment of cancer

2013
- 2013-05-21 EP EP13724523.9A patent/EP2852408B1/en active Active
- 2013-05-21 DK DK17171169.0T patent/DK3254695T3/da active
- 2013-05-21 PL PL13724523T patent/PL2852408T3/pl unknown
- 2013-05-21 PL PL17171169T patent/PL3254695T3/pl unknown
- 2013-05-21 EP EP17171169.0A patent/EP3254695B1/en not_active Revoked
- 2013-05-21 SM SM20170387T patent/SMT201700387T1/it unknown
- 2013-05-21 EP EP24150410.9A patent/EP4364756A3/en not_active Withdrawn
- 2013-05-21 ME MEP-2017-187A patent/ME02932B/me unknown
- 2013-05-21 SI SI201330741T patent/SI2852408T1/sl unknown
- 2013-05-21 RS RS20170793A patent/RS56187B1/sr unknown
- 2013-05-21 EP EP25163274.1A patent/EP4556070A3/en active Pending
- 2013-05-21 EP EP25164108.0A patent/EP4556071A3/en active Pending
- 2013-05-21 EP EP20194625.8A patent/EP3791896B1/en not_active Revoked
- 2013-05-21 HR HRP20171218TT patent/HRP20171218T1/hr unknown
2017
- 2017-08-17 CY CY20171100876T patent/CY1119549T1/el unknown
2020
- 2020-11-30 CY CY20201101136T patent/CY1123593T1/el unknown

Also Published As

Publication number	Publication date
EP4364756A3 (en)	2024-07-31
CY1123593T1 (el)	2022-03-24
EP2852408B1 (en)	2017-05-17
EP4364756A2 (en)	2024-05-08
EP3254695B1 (en)	2020-09-09
HRP20171218T1 (hr)	2017-10-20
EP3791896B1 (en)	2024-01-10
EP3791896A1 (en)	2021-03-17
EP4556070A2 (en)	2025-05-21
PL3254695T3 (pl)	2021-04-06
CY1119549T1 (el)	2018-03-07
DK3254695T3 (da)	2020-11-30
EP4556070A3 (en)	2025-08-27
EP4556071A2 (en)	2025-05-21
EP3254695A1 (en)	2017-12-13
SI2852408T1 (sl)	2017-10-30
ME02932B (me)	2018-04-20
EP2852408A1 (en)	2015-04-01
PL2852408T3 (pl)	2017-12-29
EP4556071A3 (en)	2025-08-27
RS56187B1 (sr)	2017-11-30

Publication	Publication Date	Title
IL279330A (en)	2021-01-31	Combined treatment including antibodies against Claudin 18.2 for the treatment of cancer
IL276434A (en)	2020-09-30	Combined treatment involving antibodies against claudin 18.2 for the treatment of cancer
IL239981A0 (en)	2015-08-31	Combined therapy involving antibodies against claudin 18.2 for the treatment of cancer
IL240060A0 (en)	2015-09-24	Treatment involving antibodies against claudin 2. 18 for the treatment of cancer
LT2804599T (lt)	2019-04-10	Kombinuota terapija vėžio gydymui
SI2852408T1 (sl)	2017-10-30	Kombinacijska terapija, ki vključuje protitelesa proti claudin 18.2 za zdravljenje raka
IL263781A (en)	2019-01-31	Combined treatment of ovarian cancer
SMT202200458T1 (it)	2023-01-13	Terapia combinata con anticorpi contro la claudina 18.2 per il trattamento del cancro
SI2976360T1 (sl)	2020-04-30	Terapija, ki vključuje protitelesa proti Klavdinu 18.2 za zdravljenje raka
IL233495A0 (en)	2014-08-31	Combination for cancer treatment