SK9762000A3 - Modified deacetoxycephalosporin c synthase (daocs) and x-ray structure - Google Patents

Modified deacetoxycephalosporin c synthase (daocs) and x-ray structure Download PDF

Info

Publication number: SK9762000A3
Authority: SK; Slovakia
Prior art keywords: atóm; synthase; anisa; deacetoxycephalosporin; enzyme
Prior art date: 1997-12-24

Application number

SK976-2000A

Other languages

English (en)

Slovak (sk)

Inventor

Christopher Joseph Schofield

Jack Edward Baldwin

Peter L Roach

Matthew D Lloyd

Karl Harlos

Inger Andersson

Janos Hajdu

Van Scheltinga Anke Terwisscha

Karin Valegard

S Ramaswamy

Original Assignee

Isis Innovation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-24

Filing date

1998-12-24

Publication date

2001-02-12

1997-12-24 Priority claimed from GBGB9727370.0A external-priority patent/GB9727370D0/en

1998-06-24 Priority claimed from GBGB9813644.3A external-priority patent/GB9813644D0/en

1998-12-24 Application filed by Isis Innovation filed Critical Isis Innovation

2001-02-12 Publication of SK9762000A3 publication Critical patent/SK9762000A3/sk

Links

108030001962 Deacetoxycephalosporin-C synthases Proteins 0.000 title claims abstract description 41
NNQIJOYQWYKBOW-VMAXQDLPSA-N deacetoxycephalosporin-c Chemical class S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@H](N)C(O)=O)[C@H]12 NNQIJOYQWYKBOW-VMAXQDLPSA-N 0.000 title 1
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NNQIJOYQWYKBOW-JWKOBGCHSA-N deacetoxycephalosporin C Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 NNQIJOYQWYKBOW-JWKOBGCHSA-N 0.000 claims abstract description 30
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XWCFYHBHOFBVIV-JWKOBGCHSA-N deacetylcephalosporin C Chemical group S1CC(CO)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@H]21 XWCFYHBHOFBVIV-JWKOBGCHSA-N 0.000 claims description 17
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125000003460 beta-lactamyl group Chemical group 0.000 description 1
210000004899 c-terminal region Anatomy 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Genetics & Genomics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Zoology (AREA)
Chemical Kinetics & Catalysis (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Orthopedic Medicine & Surgery (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Immunology (AREA)
Microbiology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)
Cephalosporin Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

SK976-2000A 1997-12-24 1998-12-24 Modified deacetoxycephalosporin c synthase (daocs) and x-ray structure SK9762000A3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9727370.0A GB9727370D0 (en)	1997-12-24	1997-12-24	Processed based on the structure of deacetoxycephalosporin c synthase
GBGB9813644.3A GB9813644D0 (en)	1998-06-24	1998-06-24	Structure of a cephalosporin synthase
PCT/GB1998/003860 WO1999033994A1 (fr)	1997-12-24	1998-12-24	Desacetoxycephalosporine c synthase (daocs) modifies et structure aux rayons x

Publications (1)

Publication Number	Publication Date
SK9762000A3 true SK9762000A3 (en)	2001-02-12

Family

ID=26312856

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK976-2000A SK9762000A3 (en)	1997-12-24	1998-12-24	Modified deacetoxycephalosporin c synthase (daocs) and x-ray structure

Country Status (8)

Country	Link
EP (1)	EP1047785A1 (fr)
JP (1)	JP2002500015A (fr)
CN (1)	CN1284997A (fr)
AU (1)	AU1772099A (fr)
CA (1)	CA2316401A1 (fr)
PL (1)	PL341396A1 (fr)
SK (1)	SK9762000A3 (fr)
WO (1)	WO1999033994A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0011185D0 (en) *	2000-05-09	2000-06-28	Synpac Pharmaceuticals Limited	Protein
US6699699B2 (en) *	2002-03-26	2004-03-02	Synmax Biochemical Co., Ltd.	Mutated penicillin expandases
US9404139B2 (en) *	2012-01-10	2016-08-02	Orchid Chemicals & Pharmaceuticals Limited	Mutated cephalosporin hydroxylase and its application in deacetylcephalosporanic acid synthesis
CN114958877B (zh) *	2022-06-14	2024-02-20	河南省健康元生物医药研究院有限公司	去乙酰氧基头孢菌素c合成酶突变体及其编码基因与应用
CN119286809B (zh) *	2024-12-10	2025-10-14	河北凯恩利生物技术有限公司	青霉素g扩环酶突变体及多核苷酸、表达载体、用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5082772A (en) *	1988-10-24	1992-01-21	Eli Lilly And Company	Process for preparing deacetylcephalosporin c
US5318896A (en) *	1991-09-11	1994-06-07	Merck & Co., Inc.	Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
WO1997020053A2 (fr) *	1995-11-27	1997-06-05	Gist-Brocades B.V.	Procede ameliore de production de cephalosporines semi-synthetiques par l'activite de l'expandase sur la penicilline g
GB9621486D0 (en) *	1996-10-15	1996-12-04	Isis Innovation	Oxygenase enzymes & method

1998
- 1998-12-24 EP EP98962587A patent/EP1047785A1/fr not_active Withdrawn
- 1998-12-24 CA CA002316401A patent/CA2316401A1/fr not_active Abandoned
- 1998-12-24 AU AU17720/99A patent/AU1772099A/en not_active Abandoned
- 1998-12-24 SK SK976-2000A patent/SK9762000A3/sk unknown
- 1998-12-24 JP JP2000526650A patent/JP2002500015A/ja not_active Withdrawn
- 1998-12-24 CN CN98813793A patent/CN1284997A/zh active Pending
- 1998-12-24 WO PCT/GB1998/003860 patent/WO1999033994A1/fr not_active Ceased
- 1998-12-24 PL PL98341396A patent/PL341396A1/xx unknown

Also Published As

Publication number	Publication date
WO1999033994A1 (fr)	1999-07-08
CA2316401A1 (fr)	1999-07-08
AU1772099A (en)	1999-07-19
JP2002500015A (ja)	2002-01-08
EP1047785A1 (fr)	2000-11-02
PL341396A1 (en)	2001-04-09
CN1284997A (zh)	2001-02-21

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