SK9492003A3 - Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions - Google Patents

Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions Download PDF

Info

Publication number: SK9492003A3
Authority: SK; Slovakia
Prior art keywords: alkyl; group; aryl; hydrochloride; substituted
Prior art date: 2001-01-26

Application number

SK949-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Teddy Kosoglou

Rudyard Joseph Ress

John Strony

Enrico P Veltri

William Hauer

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-26

Filing date

2002-01-25

Publication date

2003-12-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27500817&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK9492003(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-01-25 Application filed by Schering Corp filed Critical Schering Corp

2003-12-02 Publication of SK9492003A3 publication Critical patent/SK9492003A3/sk

Links

150000003432 sterols Chemical class 0.000 title claims abstract description 134
239000003112 inhibitor Substances 0.000 title claims abstract description 113
229930182558 Sterol Natural products 0.000 title claims abstract description 101
235000003702 sterols Nutrition 0.000 title claims abstract description 101
238000010521 absorption reaction Methods 0.000 title claims abstract description 80
239000002327 cardiovascular agent Substances 0.000 title claims abstract description 50
229940125692 cardiovascular agent Drugs 0.000 title claims abstract description 50
230000002792 vascular Effects 0.000 title claims abstract description 29
238000011282 treatment Methods 0.000 title claims description 42
239000000203 mixture Substances 0.000 claims abstract description 117
230000001225 therapeutic effect Effects 0.000 claims abstract description 46
238000000034 method Methods 0.000 claims abstract description 42
208000008589 Obesity Diseases 0.000 claims abstract description 19
235000020824 obesity Nutrition 0.000 claims abstract description 19
206010012601 diabetes mellitus Diseases 0.000 claims abstract description 13
230000036470 plasma concentration Effects 0.000 claims abstract description 5
150000001875 compounds Chemical class 0.000 claims description 206
125000000217 alkyl group Chemical group 0.000 claims description 159
-1 R-substituted benzyloxy Chemical group 0.000 claims description 157
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 126
229910052739 hydrogen Inorganic materials 0.000 claims description 106
125000003118 aryl group Chemical group 0.000 claims description 88
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 88
150000003839 salts Chemical class 0.000 claims description 77
125000001424 substituent group Chemical group 0.000 claims description 71
239000001257 hydrogen Substances 0.000 claims description 69
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 61
229910052736 halogen Inorganic materials 0.000 claims description 61
239000012453 solvate Substances 0.000 claims description 57
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 52
150000002367 halogens Chemical class 0.000 claims description 52
125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 46
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 35
125000003545 alkoxy group Chemical group 0.000 claims description 35
229940002612 prodrug Drugs 0.000 claims description 35
239000000651 prodrug Substances 0.000 claims description 35
235000012000 cholesterol Nutrition 0.000 claims description 31
125000002947 alkylene group Chemical group 0.000 claims description 30
125000001072 heteroaryl group Chemical class 0.000 claims description 26
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 25
230000015572 biosynthetic process Effects 0.000 claims description 24
239000012190 activator Substances 0.000 claims description 22
241000124008 Mammalia Species 0.000 claims description 20
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 19
MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical compound O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 claims description 16
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 15
125000004432 carbon atom Chemical group C* 0.000 claims description 15
125000005843 halogen group Chemical group 0.000 claims description 15
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 13
125000001544 thienyl group Chemical group 0.000 claims description 13
229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims description 12
229910052799 carbon Inorganic materials 0.000 claims description 12
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 12
239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims description 12
125000004076 pyridyl group Chemical group 0.000 claims description 12
125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 11
239000008194 pharmaceutical composition Substances 0.000 claims description 11
125000003003 spiro group Chemical group 0.000 claims description 11
UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 claims description 10
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 claims description 10
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 claims description 10
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims description 10
239000000460 chlorine Substances 0.000 claims description 10
125000002883 imidazolyl group Chemical group 0.000 claims description 10
125000003226 pyrazolyl group Chemical group 0.000 claims description 10
125000000168 pyrrolyl group Chemical group 0.000 claims description 10
IBBLRJGOOANPTQ-JKVLGAQCSA-N quinapril hydrochloride Chemical compound Cl.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 IBBLRJGOOANPTQ-JKVLGAQCSA-N 0.000 claims description 10
229960003042 quinapril hydrochloride Drugs 0.000 claims description 10
125000000335 thiazolyl group Chemical group 0.000 claims description 10
GHOSNRCGJFBJIB-UHFFFAOYSA-N Candesartan cilexetil Chemical compound C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C3=NNN=N3)C(OCC)=NC2=CC=CC=1C(=O)OC(C)OC(=O)OC1CCCCC1 GHOSNRCGJFBJIB-UHFFFAOYSA-N 0.000 claims description 9
239000002333 angiotensin II receptor antagonist Substances 0.000 claims description 9
125000002541 furyl group Chemical group 0.000 claims description 9
125000002757 morpholinyl group Chemical group 0.000 claims description 9
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 9
125000003386 piperidinyl group Chemical group 0.000 claims description 9
239000011734 sodium Substances 0.000 claims description 9
229910052708 sodium Inorganic materials 0.000 claims description 9
RMMXLENWKUUMAY-UHFFFAOYSA-N telmisartan Chemical compound CCCC1=NC2=C(C)C=C(C=3N(C4=CC=CC=C4N=3)C)C=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C(O)=O RMMXLENWKUUMAY-UHFFFAOYSA-N 0.000 claims description 9
GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 claims description 8
ZNIFSRGNXRYGHF-UHFFFAOYSA-N Clonidine hydrochloride Chemical compound Cl.ClC1=CC=CC(Cl)=C1NC1=NCCN1 ZNIFSRGNXRYGHF-UHFFFAOYSA-N 0.000 claims description 8
239000000674 adrenergic antagonist Substances 0.000 claims description 8
125000003282 alkyl amino group Chemical group 0.000 claims description 8
229940030600 antihypertensive agent Drugs 0.000 claims description 8
239000002220 antihypertensive agent Substances 0.000 claims description 8
125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims description 8
125000000842 isoxazolyl group Chemical group 0.000 claims description 8
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 8
229910052757 nitrogen Inorganic materials 0.000 claims description 8
125000004433 nitrogen atom Chemical group N* 0.000 claims description 8
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims description 8
125000000714 pyrimidinyl group Chemical group 0.000 claims description 8
125000000719 pyrrolidinyl group Chemical group 0.000 claims description 8
125000003161 (C1-C6) alkylene group Chemical group 0.000 claims description 7
229940127291 Calcium channel antagonist Drugs 0.000 claims description 7
JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical group C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 claims description 7
FDJCVHVKXFIEPJ-JCNFZFLDSA-N Delapril hydrochloride Chemical compound Cl.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N(CC(O)=O)C1CC2=CC=CC=C2C1)CC1=CC=CC=C1 FDJCVHVKXFIEPJ-JCNFZFLDSA-N 0.000 claims description 7
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 7
239000000480 calcium channel blocker Substances 0.000 claims description 7
150000001721 carbon Chemical group 0.000 claims description 7
239000011737 fluorine Substances 0.000 claims description 7
229910052731 fluorine Inorganic materials 0.000 claims description 7
125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims description 7
XLFWDASMENKTKL-UHFFFAOYSA-N molsidomine Chemical compound O1C(N=C([O-])OCC)=C[N+](N2CCOCC2)=N1 XLFWDASMENKTKL-UHFFFAOYSA-N 0.000 claims description 7
125000001624 naphthyl group Chemical group 0.000 claims description 7
HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims description 7
125000003373 pyrazinyl group Chemical group 0.000 claims description 7
RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims description 7
125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims description 7
SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims description 6
239000002053 C09CA06 - Candesartan Substances 0.000 claims description 6
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
102000000853 LDL receptors Human genes 0.000 claims description 6
108010001831 LDL receptors Proteins 0.000 claims description 6
RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims description 6
DOQPXTMNIUCOSY-UHFFFAOYSA-N [4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]-[2-(3,4-dimethoxyphenyl)ethyl]-methylazanium;chloride Chemical compound [H+].[Cl-].C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 DOQPXTMNIUCOSY-UHFFFAOYSA-N 0.000 claims description 6
229920000080 bile acid sequestrant Polymers 0.000 claims description 6
229960000932 candesartan Drugs 0.000 claims description 6
FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 claims description 6
229960002925 clonidine hydrochloride Drugs 0.000 claims description 6
239000003218 coronary vasodilator agent Substances 0.000 claims description 6
239000002934 diuretic Substances 0.000 claims description 6
125000000592 heterocycloalkyl group Chemical class 0.000 claims description 6
YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical compound [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 claims description 6
RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 claims description 6
125000002971 oxazolyl group Chemical group 0.000 claims description 6
FLSLEGPOVLMJMN-YSSFQJQWSA-N quinaprilat Chemical compound C([C@H](N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)C(O)=O)CC1=CC=CC=C1 FLSLEGPOVLMJMN-YSSFQJQWSA-N 0.000 claims description 6
229920006395 saturated elastomer Polymers 0.000 claims description 6
229960002855 simvastatin Drugs 0.000 claims description 6
YKFCISHFRZHKHY-NGQGLHOPSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;trihydrate Chemical compound O.O.O.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1.OC(=O)[C@](N)(C)CC1=CC=C(O)C(O)=C1 YKFCISHFRZHKHY-NGQGLHOPSA-N 0.000 claims description 5
YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims description 5
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 5
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 5
DGFYECXYGUIODH-UHFFFAOYSA-N Guanfacine hydrochloride Chemical compound Cl.NC(N)=NC(=O)CC1=C(Cl)C=CC=C1Cl DGFYECXYGUIODH-UHFFFAOYSA-N 0.000 claims description 5
WQVZLXWQESQGIF-UHFFFAOYSA-N Labetalol hydrochloride Chemical compound Cl.C=1C=C(O)C(C(N)=O)=CC=1C(O)CNC(C)CCC1=CC=CC=C1 WQVZLXWQESQGIF-UHFFFAOYSA-N 0.000 claims description 5
JXRAXHBVZQZSIC-JKVLGAQCSA-N Moexipril hydrochloride Chemical compound Cl.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC(OC)=C(OC)C=C2C1)C(O)=O)CC1=CC=CC=C1 JXRAXHBVZQZSIC-JKVLGAQCSA-N 0.000 claims description 5
PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 claims description 5
230000001800 adrenalinergic effect Effects 0.000 claims description 5
125000000304 alkynyl group Chemical group 0.000 claims description 5
ZPBWCRDSRKPIDG-UHFFFAOYSA-N amlodipine benzenesulfonate Chemical compound OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl ZPBWCRDSRKPIDG-UHFFFAOYSA-N 0.000 claims description 5
102000012740 beta Adrenergic Receptors Human genes 0.000 claims description 5
108010079452 beta Adrenergic Receptors Proteins 0.000 claims description 5
KVWNWTZZBKCOPM-UHFFFAOYSA-M bretylium tosylate Chemical group CC1=CC=C(S([O-])(=O)=O)C=C1.CC[N+](C)(C)CC1=CC=CC=C1Br KVWNWTZZBKCOPM-UHFFFAOYSA-M 0.000 claims description 5
229960004195 carvedilol Drugs 0.000 claims description 5
229940083181 centrally acting adntiadrenergic agent methyldopa Drugs 0.000 claims description 5
229910052801 chlorine Inorganic materials 0.000 claims description 5
125000000753 cycloalkyl group Chemical group 0.000 claims description 5
WQVZLXWQESQGIF-WJKBNZMCSA-N dilevalol hydrochloride Chemical compound Cl.C([C@@H](C)NC[C@H](O)C=1C=C(C(O)=CC=1)C(N)=O)CC1=CC=CC=C1 WQVZLXWQESQGIF-WJKBNZMCSA-N 0.000 claims description 5
125000001475 halogen functional group Chemical group 0.000 claims description 5
125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims description 5
229960003091 labetalol hydrochloride Drugs 0.000 claims description 5
PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims description 5
IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 claims description 5
IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 claims description 5
FYPMFJGVHOHGLL-UHFFFAOYSA-N probucol Chemical compound C=1C(C(C)(C)C)=C(O)C(C(C)(C)C)=CC=1SC(C)(C)SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 FYPMFJGVHOHGLL-UHFFFAOYSA-N 0.000 claims description 5
229960003912 probucol Drugs 0.000 claims description 5
HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 claims description 5
125000004768 (C1-C4) alkylsulfinyl group Chemical group 0.000 claims description 4
RZPZLFIUFMNCLY-WLHGVMLRSA-N (e)-but-2-enedioic acid;1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol Chemical compound OC(=O)\C=C\C(O)=O.CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1 RZPZLFIUFMNCLY-WLHGVMLRSA-N 0.000 claims description 4
JDZOTSLZMQDFLG-BTJKTKAUSA-N (z)-but-2-enedioic acid;2-(2,2-dicyclohexylethyl)piperidine Chemical compound OC(=O)\C=C/C(O)=O.C1CCCNC1CC(C1CCCCC1)C1CCCCC1 JDZOTSLZMQDFLG-BTJKTKAUSA-N 0.000 claims description 4
SKQDKFOTIPJUSV-UHFFFAOYSA-N 4-[2-[[2-hydroxy-3-(2-methylphenoxy)propyl]amino]ethoxy]benzamide Chemical compound CC1=CC=CC=C1OCC(O)CNCCOC1=CC=C(C(N)=O)C=C1 SKQDKFOTIPJUSV-UHFFFAOYSA-N 0.000 claims description 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
208000031226 Hyperlipidaemia Diseases 0.000 claims description 4
RGHAZVBIOOEVQX-UHFFFAOYSA-N Metoprolol succinate Chemical compound OC(=O)CCC(O)=O.COCCC1=CC=C(OCC(O)CNC(C)C)C=C1.COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 RGHAZVBIOOEVQX-UHFFFAOYSA-N 0.000 claims description 4
DXHWOBBGGCYHNV-UHFFFAOYSA-N [4-[3-(dibutylamino)propoxy]phenyl]-(2-ethylindolizin-3-yl)methanone;hydron;chloride Chemical compound Cl.C1=CC(OCCCN(CCCC)CCCC)=CC=C1C(=O)C1=C(CC)C=C2N1C=CC=C2 DXHWOBBGGCYHNV-UHFFFAOYSA-N 0.000 claims description 4
GOEMGAFJFRBGGG-UHFFFAOYSA-N acebutolol Chemical compound CCCC(=O)NC1=CC=C(OCC(O)CNC(C)C)C(C(C)=O)=C1 GOEMGAFJFRBGGG-UHFFFAOYSA-N 0.000 claims description 4
125000004414 alkyl thio group Chemical group 0.000 claims description 4
125000005529 alkyleneoxy group Chemical group 0.000 claims description 4
229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims description 4
239000004004 anti-anginal agent Substances 0.000 claims description 4
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125000004104 aryloxy group Chemical class 0.000 claims description 4
125000002047 benzodioxolyl group Chemical class O1OC(C2=C1C=CC=C2)* 0.000 claims description 4
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NDTSRXAMMQDVSW-UHFFFAOYSA-N benzthiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(S(N2)(=O)=O)=C1N=C2CSCC1=CC=CC=C1 NDTSRXAMMQDVSW-UHFFFAOYSA-N 0.000 claims description 4
VHYCDWMUTMEGQY-UHFFFAOYSA-N bisoprolol Chemical compound CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1 VHYCDWMUTMEGQY-UHFFFAOYSA-N 0.000 claims description 4
229960000830 captopril Drugs 0.000 claims description 4
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SUAJWTBTMNHVBZ-UHFFFAOYSA-N clonitrate Chemical compound [O-][N+](=O)OCC(CCl)O[N+]([O-])=O SUAJWTBTMNHVBZ-UHFFFAOYSA-N 0.000 claims description 4
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Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SK949-2003A 2001-01-26 2002-01-25 Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions SK9492003A3 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US26460001P	2001-01-26	2001-01-26
US26427501P	2001-01-26	2001-01-26
US26439601P	2001-01-26	2001-01-26
US32384201P	2001-09-21	2001-09-21
PCT/US2002/001196 WO2002058731A2 (fr)	2001-01-26	2002-01-25	Combinaisons d'inhibiteur(s) de l'absorption de sterols et d'agents cardio-vasculaires pour le traitement d'affections vasculaires

Publications (1)

Publication Number	Publication Date
SK9492003A3 true SK9492003A3 (en)	2003-12-02

Family

ID=27500817

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK949-2003A SK9492003A3 (en)	2001-01-26	2002-01-25	Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions

Country Status (27)

Country	Link
US (1)	US20030069221A1 (fr)
EP (3)	EP1385548B1 (fr)
JP (1)	JP2004517919A (fr)
KR (2)	KR20080077033A (fr)
CN (1)	CN1582168A (fr)
AR (2)	AR032643A1 (fr)
AT (1)	ATE362757T1 (fr)
AU (1)	AU2002241903B2 (fr)
BR (1)	BR0206644A (fr)
CA (1)	CA2434436A1 (fr)
CY (1)	CY1106791T1 (fr)
CZ (1)	CZ20032031A3 (fr)
DE (1)	DE60220269T2 (fr)
DK (1)	DK1385548T3 (fr)
EC (1)	ECSP074704A (fr)
ES (1)	ES2286233T3 (fr)
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2002
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- 2002-01-25 EP EP02707500A patent/EP1385548B1/fr not_active Revoked
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- 2002-01-25 CA CA002434436A patent/CA2434436A1/fr not_active Abandoned
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- 2002-01-25 US US10/057,339 patent/US20030069221A1/en not_active Abandoned
- 2002-01-25 ES ES02707500T patent/ES2286233T3/es not_active Expired - Lifetime
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- 2002-01-25 EP EP08013763A patent/EP2039357A2/fr not_active Withdrawn
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- 2002-01-25 WO PCT/US2002/001196 patent/WO2002058731A2/fr not_active Ceased
- 2002-01-25 DE DE60220269T patent/DE60220269T2/de not_active Revoked
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Also Published As

Publication number	Publication date
NO20033358L (no)	2003-09-12
CZ20032031A3 (cs)	2003-12-17
WO2002058731A2 (fr)	2002-08-01
BR0206644A (pt)	2004-02-25
IL156585A0 (en)	2004-01-04
ES2286233T3 (es)	2007-12-01
NZ545332A (en)	2007-09-28
KR20080077033A (ko)	2008-08-20
IL190173A0 (en)	2008-08-07
HUP0303923A2 (hu)	2004-03-01
CA2434436A1 (fr)	2002-08-01
EP1541175A2 (fr)	2005-06-15
AR066143A2 (es)	2009-07-29
US20030069221A1 (en)	2003-04-10
RU2003126186A (ru)	2005-03-10
CY1106791T1 (el)	2012-05-23
AU2002241903B2 (en)	2005-11-24
JP2004517919A (ja)	2004-06-17
DE60220269T2 (de)	2008-01-17
EP2039357A2 (fr)	2009-03-25
AR032643A1 (es)	2003-11-19
WO2002058731A3 (fr)	2003-11-20
PL369033A1 (en)	2005-04-18
CN1582168A (zh)	2005-02-16
KR20040025889A (ko)	2004-03-26
HK1060854A1 (en)	2004-08-27
MXPA03006724A (es)	2003-10-24
ATE362757T1 (de)	2007-06-15
DK1385548T3 (da)	2007-09-10
EP1385548B1 (fr)	2007-05-23
PT1385548E (pt)	2007-08-24
EP1385548A2 (fr)	2004-02-04
DE60220269D1 (de)	2007-07-05
SI1385548T1 (sl)	2007-10-31
NO20033358D0 (no)	2003-07-25
EP1541175A3 (fr)	2006-04-12
ECSP074704A (es)	2008-01-23

Publication	Publication Date	Title
AU2002241903B2 (en)	2005-11-24	Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions
AU2002241903A1 (en)	2003-02-06	Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions
AU2002247019B9 (en)	2007-03-08	Combinations of peroxisome proliferator-activated receptor (PPAR) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
AU2002336609B2 (en)	2006-08-24	Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
SK287746B6 (sk)	2011-08-04	Použitie substituovaných azetidinónových zlúčenín na liečenie sitosterolémie
AU2002243557A1 (en)	2003-02-06	The use of substituted azetidinone compounds for the treatment of sitosterolemia
CZ20032039A3 (cs)	2004-01-14	Farmaceutický prostředek
AU2002247019A1 (en)	2003-02-06	Combinations of peroxisome proliferator-activated receptor (PPAR) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
EP1353696A2 (fr)	2003-10-22	Combinaisons d'activateur(s) du recepteur active par le proliferateur de peroxysome et d'inhibiteur(s) d'absorption des sterols, et traitements pour troubles vasculaires
AU2002237927A1 (en)	2003-02-06	Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions
AU2002336609A1 (en)	2003-06-26	Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
ZA200305692B (en)	2004-10-25	Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions.
HK1077499A (en)	2006-02-17	Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions
WO2007136696A2 (fr)	2007-11-29	Utilisation d'azétidinones substituées pour le traitement de la sitostérolémie
HK1060854B (en)	2007-09-07	Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions

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