SK9442001A3 - Imidazo[4,5-c]-pyridine-4-on-derivatives, process for the preparation thereof, use thereof and pharmaceutical composition comprising same - Google Patents

Imidazo[4,5-c]-pyridine-4-on-derivatives, process for the preparation thereof, use thereof and pharmaceutical composition comprising same Download PDF

Info

Publication number: SK9442001A3
Authority: SK; Slovakia
Prior art keywords: group; formula; compounds; salts; physiologically acceptable
Prior art date: 1999-01-08

Application number

SK944-2001A

Other languages

English (en)

Slovak (sk)

Inventor

Werner Mederski

Horst Juraszyk

Hanns Wurziger

Christos Tsaklakidis

Dieter Dorsch

Sabine Bernotat-Danielowski

Guido Melzer

Soheila Anzali

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-08

Filing date

1999-12-21

Publication date

2002-05-09

1999-12-21 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2002-05-09 Publication of SK9442001A3 publication Critical patent/SK9442001A3/sk

Links

238000000034 method Methods 0.000 title claims description 13
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238000012545 processing Methods 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
229940039716 prothrombin Drugs 0.000 description 1
238000000746 purification Methods 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
238000010992 reflux Methods 0.000 description 1
238000011160 research Methods 0.000 description 1
125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
150000003354 serine derivatives Chemical class 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229940074545 sodium dihydrogen phosphate dihydrate Drugs 0.000 description 1
239000011877 solvent mixture Substances 0.000 description 1
239000008347 soybean phospholipid Substances 0.000 description 1
239000007921 spray Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
125000000547 substituted alkyl group Chemical group 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
125000000542 sulfonic acid group Chemical group 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
150000003462 sulfoxides Chemical class 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000003826 tablet Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
125000005425 toluyl group Chemical group 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
238000010626 work up procedure Methods 0.000 description 1
239000008096 xylene Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SK944-2001A 1999-01-08 1999-12-21 Imidazo[4,5-c]-pyridine-4-on-derivatives, process for the preparation thereof, use thereof and pharmaceutical composition comprising same SK9442001A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19900471A DE19900471A1 (de)	1999-01-08	1999-01-08	Imidazo[4,5c]-pyridin-4-on-derivate
PCT/EP1999/010236 WO2000040583A2 (fr)	1999-01-08	1999-12-21	Derives d'imidazo[4,5-c]pyridine-4-one

Publications (1)

Publication Number	Publication Date
SK9442001A3 true SK9442001A3 (en)	2002-05-09

Family

ID=7893790

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK944-2001A SK9442001A3 (en)	1999-01-08	1999-12-21	Imidazo[4,5-c]-pyridine-4-on-derivatives, process for the preparation thereof, use thereof and pharmaceutical composition comprising same

Country Status (16)

Country	Link
EP (1)	EP1149099A2 (fr)
JP (1)	JP2002534429A (fr)
KR (1)	KR20010086085A (fr)
CN (1)	CN1333772A (fr)
AR (1)	AR022220A1 (fr)
AU (1)	AU3041700A (fr)
BR (1)	BR9916774A (fr)
CA (1)	CA2357771A1 (fr)
CZ (1)	CZ20012407A3 (fr)
DE (1)	DE19900471A1 (fr)
HU (1)	HUP0105054A3 (fr)
NO (1)	NO20013384L (fr)
PL (1)	PL349341A1 (fr)
SK (1)	SK9442001A3 (fr)
WO (1)	WO2000040583A2 (fr)
ZA (1)	ZA200106454B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2232202T3 (es)	1998-12-23	2005-05-16	Bristol-Myers Squibb Pharma Company	Heterobiciclos que contienen nitrogeno como inhibidores del factor xa.
AU2001268712A1 (en)	2000-06-23	2002-01-08	Bristol-Myers Squibb Company	1 - (heteroaryl-phenyl) - condensed pyrazol derivatives as factor Xa inhibitors
US6878710B2 (en)	2001-05-22	2005-04-12	Bristol-Myers Squibb Pharma Company	Bicyclic inhibitors of factor Xa
GB0215293D0 (en)	2002-07-03	2002-08-14	Rega Foundation	Viral inhibitors
GB0225399D0 (en) *	2002-10-31	2002-12-11	Merck Sharp & Dohme	Therapeutic agents
WO2004050637A2 (fr)	2002-12-03	2004-06-17	Axys Pharmaceuticals, Inc.	Derives de 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine utilises en tant qu'inhibiteurs du facteur viia
KR20050122220A (ko)	2003-03-25	2005-12-28	다케다 샌디에고, 인코포레이티드	디펩티딜 펩티다제 억제제
EP1625122A1 (fr)	2003-05-14	2006-02-15	Takeda San Diego, Inc.	Inhibiteurs de dipeptidyl peptidase
US7579357B2 (en)	2003-08-13	2009-08-25	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
PT1706403E (pt)	2003-12-22	2012-04-23	Gilead Sciences Inc	Compostos de imidazo[4,5-c]piridina e métodos de tratamento antiviral
DK1841765T5 (da)	2004-12-21	2009-12-21	Gilead Sciences Inc	Imidazo[4,5-C]pyridinforbindelse og fremgangsmåde til antiviral behandling
WO2007009883A1 (fr)	2005-07-15	2007-01-25	F. Hoffmann-La Roche Ag	Nouvelles amines cycliques fusionnés avec hétéroaryle
PL1942898T5 (pl)	2005-09-14	2014-10-31	Takeda Pharmaceuticals Co	Inhibitory peptydazy dipeptydylowej do leczenia cukrzycy
WO2007035629A2 (fr)	2005-09-16	2007-03-29	Takeda Pharmaceutical Company Limited	Inhibiteurs de dipeptidylpeptidase
WO2007112347A1 (fr)	2006-03-28	2007-10-04	Takeda Pharmaceutical Company Limited	Inhibiteurs de la dipeptidyl peptidase
HRP20090078A2 (en)	2006-07-07	2009-06-30	Gilead Sciences	Novel pyridazine compound and use thereof
TW200838536A (en)	2006-11-29	2008-10-01	Takeda Pharmaceutical	Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
UA99466C2 (en)	2007-07-06	2012-08-27	Гилиад Сайенсиз, Инк.	Crystalline pyridazine compound
JP6689821B2 (ja) *	2014-08-12	2020-04-28	シンジェンタパーティシペーションズアーゲー	硫黄含有置換基を有する殺有害生物的に活性な複素環式誘導体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW219935B (fr) *	1991-12-25	1994-02-01	Mitsubishi Chemicals Co Ltd
EP1039907A4 (fr) *	1997-12-01	2001-09-19	Merck & Co Inc	Inhibiteurs de thrombine

1999
- 1999-01-08 DE DE19900471A patent/DE19900471A1/de not_active Withdrawn
- 1999-12-21 KR KR1020017007074A patent/KR20010086085A/ko not_active Withdrawn
- 1999-12-21 EP EP99964639A patent/EP1149099A2/fr not_active Withdrawn
- 1999-12-21 CN CN99815465A patent/CN1333772A/zh active Pending
- 1999-12-21 JP JP2000592291A patent/JP2002534429A/ja active Pending
- 1999-12-21 HU HU0105054A patent/HUP0105054A3/hu unknown
- 1999-12-21 BR BR9916774-3A patent/BR9916774A/pt not_active Application Discontinuation
- 1999-12-21 PL PL99349341A patent/PL349341A1/xx unknown
- 1999-12-21 AU AU30417/00A patent/AU3041700A/en not_active Abandoned
- 1999-12-21 SK SK944-2001A patent/SK9442001A3/sk unknown
- 1999-12-21 CZ CZ20012407A patent/CZ20012407A3/cs unknown
- 1999-12-21 WO PCT/EP1999/010236 patent/WO2000040583A2/fr not_active Ceased
- 1999-12-21 CA CA002357771A patent/CA2357771A1/fr not_active Abandoned
2000
- 2000-01-07 AR ARP000100062A patent/AR022220A1/es unknown
2001
- 2001-07-06 NO NO20013384A patent/NO20013384L/no not_active Application Discontinuation
- 2001-08-06 ZA ZA200106454A patent/ZA200106454B/en unknown

Also Published As

Publication number	Publication date
CZ20012407A3 (cs)	2001-12-12
PL349341A1 (en)	2002-07-15
AU3041700A (en)	2000-07-24
NO20013384D0 (no)	2001-07-06
WO2000040583A2 (fr)	2000-07-13
KR20010086085A (ko)	2001-09-07
ZA200106454B (en)	2002-11-06
BR9916774A (pt)	2001-10-30
EP1149099A2 (fr)	2001-10-31
CA2357771A1 (fr)	2000-07-13
CN1333772A (zh)	2002-01-30
DE19900471A1 (de)	2000-07-13
NO20013384L (no)	2001-07-06
HUP0105054A3 (en)	2002-12-28
AR022220A1 (es)	2002-09-04
WO2000040583A3 (fr)	2000-09-21
HUP0105054A2 (hu)	2002-05-29
JP2002534429A (ja)	2002-10-15

Publication	Publication Date	Title
SK9442001A3 (en)	2002-05-09	Imidazo[4,5-c]-pyridine-4-on-derivatives, process for the preparation thereof, use thereof and pharmaceutical composition comprising same
AU752574B2 (en)	2002-09-26	Imidazo(4,5-C-)-pyridine-4-one derivatives with factor XA inhibiting effect
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KR20060023154A (ko)	2006-03-13	혈전증 치료용 응고 인자 ｘａ 및 ｖｉｉａ의 저해제로서의피롤리딘-１,２-디카르복실산-１-[(４-에티닐-페닐)-아미드]-２-[(페닐)-아미드] 유도체
SK12152001A3 (sk)	2002-03-05	Derivát pyrazol-3-ónu ako faktor Xa inhibítorov, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje
AU2002363366B2 (en)	2007-11-22	Derivatives of phenoxy-N- 4-(isothiazolidin-1,1-dioxid-2YL)pheny!-valerian- acid amide and other compounds as inhibitors of the coagulation factor XA in the treatment of thromboembolic diseases and tumors
JP4409941B2 (ja)	2010-02-03	第Ｘａ因子阻害剤としてのフェニル誘導体
JP4699985B2 (ja)	2011-06-15	カルボキサミド誘導体及びその第Ｘａ因子の阻害剤としての使用
JP4567439B2 (ja)	2010-10-20	カルボン酸アミド
JP2005530754A (ja)	2005-10-13	血栓塞栓症に有効なセミカルバジド誘導体
SK2652001A3 (en)	2001-09-11	2-oxo-i(2h)-quinoline derivatives
JP2004525119A (ja)	2004-08-19	フェニル誘導体および血栓塞栓性疾患または腫瘍の処置におけるこれらの使用
MXPA01006942A (en)	2002-05-09	Imidazo[4,5-c]-pyridine-4-on-derivatives
HUP0301957A2 (hu)	2003-11-28	Karbaminsav-észterek mint Xa-faktor inhibitorok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
KR20040095256A (ko)	2004-11-12	세미카르바자이드 유도체 및 항혈전제로서의 이의 용도
CZ2001680A3 (cs)	2001-05-16	Derivát 2-oxo-2H-chinoIinu, způsob jeho přípravy, jeho použití a farmaceutický prostředek, který ho obsahuje
JP2004505106A (ja)	2004-02-19	アセトアミド誘導体並びに凝固第Ｘａおよび第ＶＩＩａ因子の阻害剤としてのその使用
SK492004A3 (en)	2004-05-04	Carbohydrate derivatives