SK862004A3 - Liquid formulation comprising cetuximab and a fatty acid ester of polyoxyethylene sorbitan - Google Patents

Liquid formulation comprising cetuximab and a fatty acid ester of polyoxyethylene sorbitan Download PDF

Info

Publication number: SK862004A3
Authority: SK; Slovakia
Prior art keywords: cetuximab; solution; liquid pharmaceutical; pharmaceutical composition; polyoxyethylene
Prior art date: 2001-07-13

Application number

SK86-2004A

Other languages

English (en)

Slovak (sk)

Inventor

Hanns-Christian Mahler

Robert Muller

Ulrike Martini-Marr

Udo Haas

Christiane Bachmann

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-13

Filing date

2002-06-18

Publication date

2004-07-07

2002-06-18 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2004-07-07 Publication of SK862004A3 publication Critical patent/SK862004A3/sk

Links

229960005395 cetuximab Drugs 0.000 title claims abstract description 33
-1 fatty acid ester Chemical class 0.000 title claims description 21
235000014113 dietary fatty acids Nutrition 0.000 title claims description 12
239000000194 fatty acid Substances 0.000 title claims description 12
229930195729 fatty acid Natural products 0.000 title claims description 12
229920001214 Polysorbate 60 Polymers 0.000 title claims description 7
239000012669 liquid formulation Substances 0.000 title description 2
239000007788 liquid Substances 0.000 claims abstract description 19
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 15
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 17
239000008363 phosphate buffer Substances 0.000 claims description 12
239000011780 sodium chloride Substances 0.000 claims description 9
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 7
229920000053 polysorbate 80 Polymers 0.000 claims description 7
229920001213 Polysorbate 20 Polymers 0.000 claims description 5
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 5
239000004698 Polyethylene Substances 0.000 claims description 4
239000003795 chemical substances by application Substances 0.000 claims description 4
229920000573 polyethylene Polymers 0.000 claims description 4
229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 3
ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 claims 1
150000002148 esters Chemical class 0.000 claims 1
235000011069 sorbitan monooleate Nutrition 0.000 claims 1
239000001593 sorbitan monooleate Substances 0.000 claims 1
229940035049 sorbitan monooleate Drugs 0.000 claims 1
239000000203 mixture Substances 0.000 abstract description 31
102000001301 EGF receptor Human genes 0.000 abstract description 5
108060006698 EGF receptor Proteins 0.000 abstract description 5
206010028980 Neoplasm Diseases 0.000 abstract description 4
238000009472 formulation Methods 0.000 abstract description 3
102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 abstract 1
108010034265 Vascular Endothelial Growth Factor Receptors Proteins 0.000 abstract 1
239000000243 solution Substances 0.000 description 45
239000007864 aqueous solution Substances 0.000 description 9
239000004615 ingredient Substances 0.000 description 6
238000002360 preparation method Methods 0.000 description 6
239000013543 active substance Substances 0.000 description 5
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 5
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
239000008103 glucose Substances 0.000 description 4
238000000034 method Methods 0.000 description 4
238000000746 purification Methods 0.000 description 4
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
238000002347 injection Methods 0.000 description 3
239000007924 injection Substances 0.000 description 3
238000002156 mixing Methods 0.000 description 3
238000007911 parenteral administration Methods 0.000 description 3
239000002245 particle Substances 0.000 description 3
239000012064 sodium phosphate buffer Substances 0.000 description 3
239000007787 solid Substances 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
238000004587 chromatography analysis Methods 0.000 description 2
230000000052 comparative effect Effects 0.000 description 2
238000011049 filling Methods 0.000 description 2
238000004108 freeze drying Methods 0.000 description 2
238000002523 gelfiltration Methods 0.000 description 2
238000004128 high performance liquid chromatography Methods 0.000 description 2
230000003993 interaction Effects 0.000 description 2
229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
235000019796 monopotassium phosphate Nutrition 0.000 description 2
PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 2
229920005862 polyol Polymers 0.000 description 2
150000003077 polyols Chemical class 0.000 description 2
159000000001 potassium salts Chemical class 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
230000006641 stabilisation Effects 0.000 description 2
238000011105 stabilization Methods 0.000 description 2
239000011550 stock solution Substances 0.000 description 2
238000012360 testing method Methods 0.000 description 2
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
206010067484 Adverse reaction Diseases 0.000 description 1
229920002307 Dextran Polymers 0.000 description 1
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
208000005189 Embolism Diseases 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
108060003951 Immunoglobulin Proteins 0.000 description 1
MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 1
108010058846 Ovalbumin Proteins 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
229920001219 Polysorbate 40 Polymers 0.000 description 1
KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
JAWMENYCRQKKJY-UHFFFAOYSA-N [3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-ylmethyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-8-yl]-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]methanone Chemical compound N1N=NC=2CN(CCC=21)CC1=NOC2(C1)CCN(CC2)C(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F JAWMENYCRQKKJY-UHFFFAOYSA-N 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000008351 acetate buffer Substances 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
230000006838 adverse reaction Effects 0.000 description 1
238000004220 aggregation Methods 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
230000033115 angiogenesis Effects 0.000 description 1
230000006907 apoptotic process Effects 0.000 description 1
239000012752 auxiliary agent Substances 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
239000000872 buffer Substances 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
230000009702 cancer cell proliferation Effects 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
238000011254 conventional chemotherapy Methods 0.000 description 1
238000011188 deamidation reaction Methods 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
239000007857 degradation product Substances 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
238000001514 detection method Methods 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
238000001914 filtration Methods 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
238000005286 illumination Methods 0.000 description 1
102000018358 immunoglobulin Human genes 0.000 description 1
229940027941 immunoglobulin g Drugs 0.000 description 1
238000009169 immunotherapy Methods 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
239000007951 isotonicity adjuster Substances 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
229940092253 ovalbumin Drugs 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
229940068968 polysorbate 80 Drugs 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
230000017854 proteolysis Effects 0.000 description 1
238000001959 radiotherapy Methods 0.000 description 1
239000012088 reference solution Substances 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
BBMHARZCALWXSL-UHFFFAOYSA-M sodium dihydrogenphosphate monohydrate Chemical compound O.[Na+].OP(O)([O-])=O BBMHARZCALWXSL-UHFFFAOYSA-M 0.000 description 1
238000013112 stability test Methods 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
230000002110 toxicologic effect Effects 0.000 description 1
231100000027 toxicology Toxicity 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Mycology (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Preparation (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SK86-2004A 2001-07-13 2002-06-18 Liquid formulation comprising cetuximab and a fatty acid ester of polyoxyethylene sorbitan SK862004A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10133394A DE10133394A1 (de)	2001-07-13	2001-07-13	Flüssige Formulierung enthaltend Cetuximab
PCT/EP2002/006696 WO2003007988A1 (de)	2001-07-13	2002-06-18	Flüssige formulierung enthaltend cetuximab und einen polyoxyethylensorbitanfettsäureester

Publications (1)

Publication Number	Publication Date
SK862004A3 true SK862004A3 (en)	2004-07-07

Family

ID=7691220

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK86-2004A SK862004A3 (en)	2001-07-13	2002-06-18	Liquid formulation comprising cetuximab and a fatty acid ester of polyoxyethylene sorbitan

Country Status (18)

Country	Link
US (1)	US20040170632A1 (de)
EP (1)	EP1406658A1 (de)
JP (1)	JP2004536129A (de)
KR (1)	KR20040018458A (de)
CN (1)	CN1231264C (de)
AR (1)	AR039358A1 (de)
BR (1)	BR0211060A (de)
CA (1)	CA2453342A1 (de)
CZ (1)	CZ2004189A3 (de)
DE (1)	DE10133394A1 (de)
HU (1)	HUP0401046A3 (de)
MX (1)	MXPA04000340A (de)
PE (1)	PE20030433A1 (de)
PL (1)	PL364599A1 (de)
RU (1)	RU2004102395A (de)
SK (1)	SK862004A3 (de)
WO (1)	WO2003007988A1 (de)
ZA (1)	ZA200401161B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2358763C2 (ru) *	2003-02-10	2009-06-20	Элан Фармасьютикалз, Инк.	Композиции иммуноглобулина и способ их получения
DE10355251A1 (de) *	2003-11-26	2005-06-23	Merck Patent Gmbh	Pharmazeutische Zubereitung enthaltend einen Antikörper gegen den EGF-Rezeptor
DE10355904A1 (de) *	2003-11-29	2005-06-30	Merck Patent Gmbh	Feste Formen von anti-EGFR-Antikörpern
RU2390353C2 (ru) *	2004-02-12	2010-05-27	Мерк Патент Гмбх	Высококонцентрированные жидкие композиции анти-egfr антител
CA2562904C (en) *	2004-04-27	2013-07-02	Wellstat Biologics Corporation	Cancer treatment using viruses and camptothecins
JP2008519757A (ja) *	2004-11-12	2008-06-12	メルクパテントゲゼルシャフトミットベシュレンクテルハフトング	抗ｅｇｆｒ抗体の固形物
SI1859793T1 (sl) *	2005-02-28	2011-08-31	Eisai R&D Man Co Ltd	Nova kombinirana uporaba sulfonamidne spojine za zdravljenje raka
RU2419430C2 (ru)	2006-02-09	2011-05-27	Дайити Санкио Компани, Лимитед	Противораковая фармацевтическая композиция
EP2015775B1 (de)	2006-05-03	2011-06-01	Bayer Schering Pharma Aktiengesellschaft	Kombination aus einem anti-edb-fibronektin-domänen-antikörper l19-sip und einem anti-egfr-antikörper
US20080112953A1 (en) *	2006-10-06	2008-05-15	Amgen Inc.	Stable formulations
WO2008051363A2 (en) *	2006-10-20	2008-05-02	Amgen Inc.	Stable polypeptide formulations
CN107773755B (zh) *	2016-08-31	2021-06-22	上海津曼特生物科技有限公司	抗表皮生长因子受体单克隆抗体的注射液制剂
CA3063324A1 (en)	2017-05-16	2018-11-22	Bhami's Research Laboratory, Pvt. Ltd.	High concentration protein formulations with reduced viscosity
KR20210024082A (ko)	2018-06-25	2021-03-04	제이씨알 파마 가부시키가이샤	단백질 함유 수성 액제
EP3843769A4 (de) *	2018-08-31	2022-11-16	Amplyx Pharmaceuticals, Inc.	Verbindungen und verfahren zur behandlung von pilzinfektionen
TW202523354A (zh) *	2023-11-29	2025-06-16	大陸商四川科倫博泰生物醫藥股份有限公司	抗體製劑
WO2025245256A1 (en)	2024-05-22	2025-11-27	Tizona Therapeutics, Inc.	Combination therapy involving anti-hla-g antibodies and anti- egfr antibodies or anti-pd-1 antibodies

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU4128089A (en) *	1988-09-15	1990-03-22	Rorer International (Overseas) Inc.	Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
US5945098A (en) *	1990-02-01	1999-08-31	Baxter International Inc.	Stable intravenously-administrable immune globulin preparation
EP0831880A4 (de) *	1995-06-07	2004-12-01	Imclone Systems Inc	Antikörper und deren fragmente zur hemmung von tumorwachstum
US7060808B1 (en) *	1995-06-07	2006-06-13	Imclone Systems Incorporated	Humanized anti-EGF receptor monoclonal antibody
SI1516628T1 (sl) *	1995-07-27	2013-10-30	Genentech, Inc.	Stabilna izotonična liofilizirana proteinska formulacija

2001
- 2001-07-13 DE DE10133394A patent/DE10133394A1/de not_active Withdrawn
2002
- 2002-06-18 MX MXPA04000340A patent/MXPA04000340A/es unknown
- 2002-06-18 WO PCT/EP2002/006696 patent/WO2003007988A1/de not_active Ceased
- 2002-06-18 CZ CZ2004189A patent/CZ2004189A3/cs unknown
- 2002-06-18 SK SK86-2004A patent/SK862004A3/sk not_active Application Discontinuation
- 2002-06-18 US US10/483,404 patent/US20040170632A1/en not_active Abandoned
- 2002-06-18 KR KR10-2004-7000530A patent/KR20040018458A/ko not_active Withdrawn
- 2002-06-18 CA CA002453342A patent/CA2453342A1/en not_active Abandoned
- 2002-06-18 BR BR0211060-1A patent/BR0211060A/pt not_active IP Right Cessation
- 2002-06-18 RU RU2004102395/15A patent/RU2004102395A/ru not_active Application Discontinuation
- 2002-06-18 EP EP02751038A patent/EP1406658A1/de not_active Withdrawn
- 2002-06-18 CN CNB028141059A patent/CN1231264C/zh not_active Expired - Fee Related
- 2002-06-18 PL PL02364599A patent/PL364599A1/xx unknown
- 2002-06-18 JP JP2003513593A patent/JP2004536129A/ja not_active Withdrawn
- 2002-06-18 HU HU0401046A patent/HUP0401046A3/hu unknown
- 2002-07-11 PE PE2002000618A patent/PE20030433A1/es not_active Application Discontinuation
- 2002-07-12 AR ARP020102605A patent/AR039358A1/es unknown
2004
- 2004-02-12 ZA ZA200401161A patent/ZA200401161B/en unknown

Also Published As

Publication number	Publication date
WO2003007988A1 (de)	2003-01-30
US20040170632A1 (en)	2004-09-02
BR0211060A (pt)	2004-07-20
AR039358A1 (es)	2005-02-16
RU2004102395A (ru)	2005-05-27
CN1231264C (zh)	2005-12-14
PE20030433A1 (es)	2003-05-24
DE10133394A1 (de)	2003-01-30
CZ2004189A3 (cs)	2004-05-12
CN1527724A (zh)	2004-09-08
ZA200401161B (en)	2004-10-22
MXPA04000340A (es)	2004-05-04
HUP0401046A3 (en)	2006-11-28
PL364599A1 (en)	2004-12-13
CA2453342A1 (en)	2003-01-30
HUP0401046A2 (en)	2006-04-28
KR20040018458A (ko)	2004-03-03
EP1406658A1 (de)	2004-04-14
JP2004536129A (ja)	2004-12-02

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HK1065261A (en)	2005-02-18	Liquid formulation comprising cetuximab and a polyoxyethylene sorbitan fatty acid ester
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Legal Events

Date	Code	Title	Description
2013-03-01	FC9A	Refused patent application