SK8282000A3 - Conjugates useful in the treatment of prostate cancer, pharmaceutical composition containing the same and use thereof - Google Patents

Conjugates useful in the treatment of prostate cancer, pharmaceutical composition containing the same and use thereof Download PDF

Info

Publication number: SK8282000A3
Authority: SK; Slovakia
Prior art keywords: seq; ser; trans; hyp; chg
Prior art date: 1997-12-02

Application number

SK828-2000A

Other languages

English (en)

Slovak (sk)

Inventor

Stephen F Brady

Dong-Mei Feng

Victor M Garsky

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-02

Filing date

1998-11-25

Publication date

2000-11-07

1998-03-02 Priority claimed from GBGB9804399.5A external-priority patent/GB9804399D0/en

1998-11-25 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2000-11-07 Publication of SK8282000A3 publication Critical patent/SK8282000A3/sk

Links

206010060862 Prostate cancer Diseases 0.000 title claims abstract description 18
208000000236 Prostatic Neoplasms Diseases 0.000 title claims abstract description 18
239000008194 pharmaceutical composition Substances 0.000 title claims description 11
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239000002254 cytotoxic agent Substances 0.000 claims abstract description 34
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239000003814 drug Substances 0.000 claims abstract description 30
231100000599 cytotoxic agent Toxicity 0.000 claims abstract description 29
206010004446 Benign prostatic hyperplasia Diseases 0.000 claims abstract description 9
208000004403 Prostatic Hyperplasia Diseases 0.000 claims abstract description 9
239000000126 substance Substances 0.000 claims abstract description 8
102000007066 Prostate-Specific Antigen Human genes 0.000 claims abstract 6
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-1 bicyclo [2.2.2] octanyl Chemical group 0.000 claims description 37
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UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
210000002381 plasma Anatomy 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
230000000750 progressive effect Effects 0.000 description 1
150000003147 proline derivatives Chemical class 0.000 description 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
201000005825 prostate adenocarcinoma Diseases 0.000 description 1
210000005267 prostate cell Anatomy 0.000 description 1
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235000019833 protease Nutrition 0.000 description 1
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125000003226 pyrazolyl group Chemical group 0.000 description 1
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125000000714 pyrimidinyl group Chemical group 0.000 description 1
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125000000168 pyrrolyl group Chemical group 0.000 description 1
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230000004083 survival effect Effects 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
GFYHSKONPJXCDE-UHFFFAOYSA-N sym-collidine Natural products CC1=CN=C(C)C(C)=C1 GFYHSKONPJXCDE-UHFFFAOYSA-N 0.000 description 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
125000006089 thiamorpholinyl sulfoxide group Chemical group 0.000 description 1
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125000000335 thiazolyl group Chemical group 0.000 description 1
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125000001544 thienyl group Chemical group 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
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230000001988 toxicity Effects 0.000 description 1
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VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
230000008733 trauma Effects 0.000 description 1
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
108010077037 tyrosyl-tyrosyl-phenylalanine Proteins 0.000 description 1
239000004474 valine Substances 0.000 description 1
KDQAABAKXDWYSZ-PNYVAJAMSA-N vinblastine sulfate Chemical compound OS(O)(=O)=O.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 KDQAABAKXDWYSZ-PNYVAJAMSA-N 0.000 description 1
229960004982 vinblastine sulfate Drugs 0.000 description 1
GBABOYUKABKIAF-IELIFDKJSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-IELIFDKJSA-N 0.000 description 1
229960002066 vinorelbine Drugs 0.000 description 1
CILBMBUYJCWATM-PYGJLNRPSA-N vinorelbine ditartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC CILBMBUYJCWATM-PYGJLNRPSA-N 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Toxicology (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Urology & Nephrology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SK828-2000A 1997-12-02 1998-11-25 Conjugates useful in the treatment of prostate cancer, pharmaceutical composition containing the same and use thereof SK8282000A3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US6711097P	1997-12-02	1997-12-02
GBGB9804399.5A GB9804399D0 (en)	1998-03-02	1998-03-02	Conjugates useful in the treatment of prostate cancer
PCT/US1998/025358 WO1999028345A1 (fr)	1997-12-02	1998-11-25	Conjugues utiles dans le traitement du cancer de la prostate

Publications (1)

Publication Number	Publication Date
SK8282000A3 true SK8282000A3 (en)	2000-11-07

Family

ID=26313204

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK828-2000A SK8282000A3 (en)	1997-12-02	1998-11-25	Conjugates useful in the treatment of prostate cancer, pharmaceutical composition containing the same and use thereof

Country Status (26)

Country	Link
US (2)	US20060148718A1 (fr)
EP (1)	EP1036093A1 (fr)
JP (1)	JP2001525337A (fr)
KR (1)	KR100580137B1 (fr)
CN (1)	CN1181092C (fr)
AR (1)	AR016427A1 (fr)
AU (1)	AU744652B2 (fr)
BG (1)	BG65486B1 (fr)
BR (1)	BR9815116A (fr)
CA (1)	CA2311615A1 (fr)
DZ (1)	DZ2665A1 (fr)
EA (1)	EA002745B1 (fr)
EE (1)	EE200000333A (fr)
HR (1)	HRP20000367A2 (fr)
HU (1)	HUP0100350A3 (fr)
ID (1)	ID24735A (fr)
IL (1)	IL136167A0 (fr)
IS (1)	IS5502A (fr)
NO (1)	NO20002804L (fr)
NZ (1)	NZ504615A (fr)
PE (1)	PE20000009A1 (fr)
PL (1)	PL197006B1 (fr)
SK (1)	SK8282000A3 (fr)
TR (1)	TR200002260T2 (fr)
TW (1)	TW577897B (fr)
WO (1)	WO1999028345A1 (fr)

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NZ512171A (en) *	1998-12-11	2004-07-30	Medarex Inc	Prodrug compound comprising a therapeutic agent, an oligopeptide with a non-genetically encoded amino acid, a stabilizing group and optionally a linker group
GB9924759D0 (en) *	1999-10-19	1999-12-22	Merck Sharp & Dohme	Process for preparing peptide intermediates
US7842581B2 (en)	2003-03-27	2010-11-30	Samsung Electronics Co., Ltd.	Methods of forming metal layers using oxygen gas as a reaction source and methods of fabricating capacitors using such metal layers
SI2187965T1 (sl)	2007-08-17	2020-03-31	Purdue Research Foundation Office Of Technology Commercialization	Konjugati vezalca ligand-veznika PSMA in metode za uporabo
US9951324B2 (en)	2010-02-25	2018-04-24	Purdue Research Foundation	PSMA binding ligand-linker conjugates and methods for using
CN104955484B (zh) *	2012-08-15	2019-01-15	文森医学公司	用于前列腺癌成像的前列腺特异性抗原药剂及其使用方法
WO2014074218A1 (fr) *	2012-11-12	2014-05-15	Redwood Bioscience, Inc.	Composés et procédés pour produire un conjugué
KR102318999B1 (ko)	2012-11-15	2021-10-29	엔도사이트, 인코포레이티드	Psma 발현 세포에 의해 야기되는 질병을 치료하기 위한 컨쥬게이트
EP2992531B1 (fr)	2013-04-30	2019-06-19	Hewlett-Packard Enterprise Development LP	Vitesse d'accès à une mémoire
WO2015055318A1 (fr)	2013-10-18	2015-04-23	Deutsches Krebsforschungszentrum	Inhibiteurs marqués de l'antigène membranaire spécifique de la prostate (psma), leur utilisation comme agents d'imagerie et agents pharmaceutiques pour le traitement du cancer de la prostate
EP3777898B1 (fr)	2013-11-14	2025-01-01	Endocyte, Inc.	Composés pour la tomographie par émission de positrons
US10188759B2 (en)	2015-01-07	2019-01-29	Endocyte, Inc.	Conjugates for imaging
SG11202010217YA (en)	2018-04-17	2020-11-27	Endocyte Inc	Methods of treating cancer
CN120097930A (zh)	2019-05-20	2025-06-06	因多塞特股份有限公司	制备psma缀合物的方法
WO2022136586A1 (fr)	2020-12-22	2022-06-30	Cobiores Nv	Composés comprenant une fraction tétrapeptidique
WO2022167664A1 (fr)	2021-02-07	2022-08-11	Cobiores Nv	Composés comprenant une fraction tétrapeptidique

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US4296105A (en) *	1978-08-03	1981-10-20	Institut International De Pathologie Cellulaire Et Moleculaire	Derivatives of doxorubicine, their preparation and use
US4719312A (en) *	1978-10-02	1988-01-12	Merck & Co., Inc.	Lysosometropic detergent therapeutic agents
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DE3484691D1 (de) *	1983-04-29	1991-07-18	Omnichem Sa	Konjugierte vinblastin-verbindungen und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
FR2546163B1 (fr) *	1983-05-16	1987-10-09	Centre Nat Rech Scient	Nouveaux derives acyles hydrosolubles de peptides ou d'amino-acides, leur preparation et leur application
FR2626882B1 (fr) *	1988-02-08	1991-11-08	Ire Celltarg Sa	Conjugues de derives de vinca comportant une chaine detergente en position c-3
US5391723A (en) *	1989-05-31	1995-02-21	Neorx Corporation	Oligonucleotide conjugates
EP0647450A1 (fr) *	1993-09-09	1995-04-12	BEHRINGWERKE Aktiengesellschaft	Prodrogues améliorées pour activation médiée par enzyme
US6143864A (en) *	1994-06-28	2000-11-07	Merck & Co., Inc.	Peptides
US5599686A (en) *	1994-06-28	1997-02-04	Merck & Co., Inc.	Peptides
US5866679A (en) *	1994-06-28	1999-02-02	Merck & Co., Inc.	Peptides
EP0855910A4 (fr) *	1995-10-18	2000-07-05	Merck & Co Inc	Conjugues utiles pour traiter l'adenome prostatique benin
JP2001501601A (ja) *	1996-09-12	2001-02-06	メルクエンドカンパニーインコーポレーテッド	前立腺ガンの治療において有用な共役体
US5998362A (en) *	1996-09-12	1999-12-07	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
HRP970566A2 (en) *	1996-10-30	1998-08-31	Jones Deborah Defeo	Conjugates useful in the treatment of prostate canser

1998
- 1998-11-25 JP JP2000523236A patent/JP2001525337A/ja active Pending
- 1998-11-25 TR TR2000/02260T patent/TR200002260T2/xx unknown
- 1998-11-25 AU AU16123/99A patent/AU744652B2/en not_active Ceased
- 1998-11-25 HR HR20000367A patent/HRP20000367A2/hr not_active Application Discontinuation
- 1998-11-25 ID IDW20001039A patent/ID24735A/id unknown
- 1998-11-25 EP EP98960550A patent/EP1036093A1/fr not_active Withdrawn
- 1998-11-25 HU HU0100350A patent/HUP0100350A3/hu unknown
- 1998-11-25 BR BR9815116-9A patent/BR9815116A/pt not_active Application Discontinuation
- 1998-11-25 SK SK828-2000A patent/SK8282000A3/sk unknown
- 1998-11-25 EE EEP200000333A patent/EE200000333A/xx unknown
- 1998-11-25 IL IL13616798A patent/IL136167A0/xx not_active IP Right Cessation
- 1998-11-25 WO PCT/US1998/025358 patent/WO1999028345A1/fr not_active Ceased
- 1998-11-25 NZ NZ504615A patent/NZ504615A/en unknown
- 1998-11-25 EA EA200000603A patent/EA002745B1/ru not_active IP Right Cessation
- 1998-11-25 CN CNB988132826A patent/CN1181092C/zh not_active Expired - Fee Related
- 1998-11-25 KR KR1020007005969A patent/KR100580137B1/ko not_active Expired - Fee Related
- 1998-11-25 PL PL340768A patent/PL197006B1/pl not_active IP Right Cessation
- 1998-11-25 CA CA002311615A patent/CA2311615A1/fr not_active Abandoned
- 1998-11-30 DZ DZ980275A patent/DZ2665A1/fr active
- 1998-12-01 AR ARP980106090A patent/AR016427A1/es active IP Right Grant
- 1998-12-01 PE PE1998001170A patent/PE20000009A1/es not_active Application Discontinuation
- 1998-12-02 TW TW087119985A patent/TW577897B/zh not_active IP Right Cessation
2000
- 2000-05-19 IS IS5502A patent/IS5502A/is unknown
- 2000-05-31 NO NO20002804A patent/NO20002804L/no not_active Application Discontinuation
- 2000-06-27 BG BG104563A patent/BG65486B1/bg unknown
2006
- 2006-02-24 US US11/362,251 patent/US20060148718A1/en not_active Abandoned
- 2006-09-26 US US11/481,999 patent/US20070021350A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EA002745B1 (ru)	2002-08-29
PL197006B1 (pl)	2008-02-29
KR20010032687A (ko)	2001-04-25
HUP0100350A2 (hu)	2001-08-28
IL136167A0 (en)	2001-05-20
US20070021350A1 (en)	2007-01-25
TR200002260T2 (tr)	2000-12-21
PE20000009A1 (es)	2000-01-27
NO20002804L (no)	2000-07-21
AU744652B2 (en)	2002-02-28
HUP0100350A3 (en)	2001-09-28
NZ504615A (en)	2003-05-30
AR016427A1 (es)	2001-07-04
CA2311615A1 (fr)	1999-06-10
HRP20000367A2 (en)	2000-12-31
AU1612399A (en)	1999-06-16
NO20002804D0 (no)	2000-05-31
TW577897B (en)	2004-03-01
EP1036093A1 (fr)	2000-09-20
BG104563A (en)	2001-04-30
KR100580137B1 (ko)	2006-05-16
US20060148718A1 (en)	2006-07-06
ID24735A (id)	2000-08-03
PL340768A1 (en)	2001-02-26
EA200000603A1 (ru)	2000-12-25
BG65486B1 (bg)	2008-09-30
DZ2665A1 (fr)	2003-03-22
WO1999028345A1 (fr)	1999-06-10
IS5502A (is)	2000-05-19
BR9815116A (pt)	2000-10-10
JP2001525337A (ja)	2001-12-11
CN1181092C (zh)	2004-12-22
EE200000333A (et)	2001-08-15
CN1284086A (zh)	2001-02-14

Publication	Publication Date	Title
AU715632B2 (en)	2000-02-03	Conjugates useful in the treatment of prostate cancer
US20020103136A1 (en)	2002-08-01	Conjugates useful in the treatment of prostate cancer
AU726434B2 (en)	2000-11-09	Conjugates useful in the treatment of prostate cancer
US5998362A (en)	1999-12-07	Conjugates useful in the treatment of prostate cancer
AU740597B2 (en)	2001-11-08	Conjugates useful in the treatment of prostate cancer
US6174858B1 (en)	2001-01-16	Conjugates useful in the treatment of prostate cancer
SK8282000A3 (en)	2000-11-07	Conjugates useful in the treatment of prostate cancer, pharmaceutical composition containing the same and use thereof
US20070244055A1 (en)	2007-10-18	Conjugates useful in the treatment of prostate cancer
US6127333A (en)	2000-10-03	Conjugates useful in the treatment of prostate cancer
US20020115596A1 (en)	2002-08-22	Conjugates useful in the treatment of prostate cancer
JP2000506494A (ja)	2000-05-30	良性前立腺過形成の治療に有用な複合体
US20040081659A1 (en)	2004-04-29	Conjugates useful in the treatment of prostate cancer
AU749063B2 (en)	2002-06-20	Conjugates useful in the treatment of prostrate cancer
MXPA00005434A (en)	2002-02-26	Conjugates useful in the treatment of prostate cancer
CZ20002056A3 (cs)	2000-11-15	Konjugáty použitelné v léčbě karcinomu prostaty