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SK812017A3 - Spôsob prípravy tapentadolu a jeho medziproduktov - Google Patents

Spôsob prípravy tapentadolu a jeho medziproduktov

Info

Publication number
SK812017A3
SK812017A3 SK81-2017A SK812017A SK812017A3 SK 812017 A3 SK812017 A3 SK 812017A3 SK 812017 A SK812017 A SK 812017A SK 812017 A3 SK812017 A3 SK 812017A3
Authority
SK
Slovakia
Prior art keywords
preparing
tapentadol
diastereomers
formula
intermediates
Prior art date
Application number
SK81-2017A
Other languages
English (en)
Slovak (sk)
Inventor
Duĺ An Berkeĺ
Jozef Markus
Original Assignee
Saneca Pharmaceuticals A. S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Saneca Pharmaceuticals A. S. filed Critical Saneca Pharmaceuticals A. S.
Priority to SK81-2017A priority Critical patent/SK812017A3/sk
Priority to EP18769245.4A priority patent/EP3713911A1/fr
Priority to EA202090197A priority patent/EA202090197A1/ru
Priority to PCT/SK2018/000005 priority patent/WO2019035775A1/fr
Publication of SK812017A3 publication Critical patent/SK812017A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
    • C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C219/28—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SK81-2017A 2017-08-18 2017-08-18 Spôsob prípravy tapentadolu a jeho medziproduktov SK812017A3 (sk)

Priority Applications (4)

Application Number Priority Date Filing Date Title
SK81-2017A SK812017A3 (sk) 2017-08-18 2017-08-18 Spôsob prípravy tapentadolu a jeho medziproduktov
EP18769245.4A EP3713911A1 (fr) 2017-08-18 2018-08-14 Procédé de préparation de tapentadol et de ses intermédiaires
EA202090197A EA202090197A1 (ru) 2017-08-18 2018-08-14 Способ получения тапентадола и его промежуточных соединений
PCT/SK2018/000005 WO2019035775A1 (fr) 2017-08-18 2018-08-14 Procédé de préparation de tapentadol et de ses intermédiaires

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SK81-2017A SK812017A3 (sk) 2017-08-18 2017-08-18 Spôsob prípravy tapentadolu a jeho medziproduktov

Publications (1)

Publication Number Publication Date
SK812017A3 true SK812017A3 (sk) 2019-03-01

Family

ID=65362569

Family Applications (1)

Application Number Title Priority Date Filing Date
SK81-2017A SK812017A3 (sk) 2017-08-18 2017-08-18 Spôsob prípravy tapentadolu a jeho medziproduktov

Country Status (4)

Country Link
EP (1) EP3713911A1 (fr)
EA (1) EA202090197A1 (fr)
SK (1) SK812017A3 (fr)
WO (1) WO2019035775A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119192000B (zh) * 2024-11-26 2025-07-15 苏州盛迪亚生物医药有限公司 连续流反应制备他喷他多或其可药用盐的方法
CN119176758B (zh) * 2024-11-26 2025-05-09 苏州盛迪亚生物医药有限公司 一种固载催化制备他喷他多或其可药用盐的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI401237B (zh) 2006-07-24 2013-07-11 ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備
TWI448447B (zh) 2006-07-24 2014-08-11 Gruenenthal Chemie 製備（１ｒ，２ｒ）-３-（３-二甲胺基-１-乙基-２-甲基-丙基）-酚之方法
CA2656696C (fr) * 2006-07-24 2013-06-11 Janssen Pharmaceutica N.V. Preparation de (2r,3r)-3-(3-methoxyphenyl)-n,n,2-trimethylpentanamine
IT1397189B1 (it) 2009-12-01 2013-01-04 Archimica Srl Nuovo processo per la preparazione di tapentadol e suoi intermedi.
CN102320984B (zh) 2011-07-25 2014-04-02 江苏恩华药业股份有限公司 (r)-3-(3-甲氧基苯基)-n,n,2-三甲基戊-3-烯-1-胺的制备方法
WO2013111161A2 (fr) 2012-01-10 2013-08-01 Msn Laboratories Limited Procédé de préparation de dérivés de 3-aryl-2-méthyl-propanamine et de ses polymorphes
CN103159633B (zh) 2012-07-06 2015-08-12 江苏恩华药业股份有限公司 他喷他多的制备方法及用于制备他喷他多的化合物

Also Published As

Publication number Publication date
EA202090197A1 (ru) 2020-05-27
EP3713911A1 (fr) 2020-09-30
WO2019035775A1 (fr) 2019-02-21

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Legal Events

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