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SK4202000A3 - Process of making 3-aryloxy-4-aryl furan-2-ones useful as inhibitors of cox-2 - Google Patents

Process of making 3-aryloxy-4-aryl furan-2-ones useful as inhibitors of cox-2 Download PDF

Info

Publication number
SK4202000A3
SK4202000A3 SK420-2000A SK4202000A SK4202000A3 SK 4202000 A3 SK4202000 A3 SK 4202000A3 SK 4202000 A SK4202000 A SK 4202000A SK 4202000 A3 SK4202000 A3 SK 4202000A3
Authority
SK
Slovakia
Prior art keywords
compound
formula
group
dhqd
reacting
Prior art date
Application number
SK420-2000A
Other languages
English (en)
Slovak (sk)
Inventor
Cheng Y Chen
Robert D Larsen
Lushi Tan
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9815805.8A external-priority patent/GB9815805D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of SK4202000A3 publication Critical patent/SK4202000A3/sk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60Two oxygen atoms, e.g. succinic anhydride

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK420-2000A 1997-09-24 1998-09-21 Process of making 3-aryloxy-4-aryl furan-2-ones useful as inhibitors of cox-2 SK4202000A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6069497P 1997-09-24 1997-09-24
GBGB9815805.8A GB9815805D0 (en) 1998-07-21 1998-07-21 Chemical process
PCT/US1998/019642 WO1999015513A1 (fr) 1997-09-24 1998-09-21 Procede de preparation de 3-aryloxy, 4-aryl furan-2-ones utiles comme inhibiteurs de cox-2

Publications (1)

Publication Number Publication Date
SK4202000A3 true SK4202000A3 (en) 2000-10-09

Family

ID=26314074

Family Applications (1)

Application Number Title Priority Date Filing Date
SK420-2000A SK4202000A3 (en) 1997-09-24 1998-09-21 Process of making 3-aryloxy-4-aryl furan-2-ones useful as inhibitors of cox-2

Country Status (7)

Country Link
EP (1) EP1017687A4 (fr)
JP (1) JP3516658B2 (fr)
CN (1) CN1271352A (fr)
AU (1) AU2247599A (fr)
EA (1) EA002690B1 (fr)
SK (1) SK4202000A3 (fr)
WO (1) WO1999015513A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0108908A (pt) 2000-03-03 2002-12-24 Pfizer Prod Inc Derivados de éteres de pirazol como agentes antiinflamatórios/analgésicos
PT1303265E (pt) 2000-07-20 2007-10-09 Lauras As ''utilização de inibidores da cox-2 como imuno-estimulantes, no tratamento do vih ou da sida''
CN118164933B (zh) * 2024-04-10 2025-04-08 辽宁中医药大学 马齿苋中一种呋喃类新化合物及其提取分离方法与用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352832A (en) * 1992-12-18 1994-10-04 Schering Corporation Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
US5393790A (en) * 1994-02-10 1995-02-28 G.D. Searle & Co. Substituted spiro compounds for the treatment of inflammation
UA57002C2 (uk) * 1995-10-13 2003-06-16 Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі. Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування
US5789413A (en) * 1996-02-01 1998-08-04 Merck Frosst Canada, Inc. Alkylated styrenes as prodrugs to COX-2 inhibitors

Also Published As

Publication number Publication date
EP1017687A1 (fr) 2000-07-12
EP1017687A4 (fr) 2001-10-31
WO1999015513A1 (fr) 1999-04-01
CN1271352A (zh) 2000-10-25
JP3516658B2 (ja) 2004-04-05
JP2001517661A (ja) 2001-10-09
EA002690B1 (ru) 2002-08-29
AU2247599A (en) 1999-04-12
EA200000350A1 (ru) 2000-10-30

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