SK20182000A3 - Činidlo regulujúce funkciu receptora súvisiaceho s retinoidmi - Google Patents

Činidlo regulujúce funkciu receptora súvisiaceho s retinoidmi Download PDF

Info

Publication number: SK20182000A3
Authority: SK; Slovakia
Prior art keywords: group; hydrocarbon group; optionally substituted; formula; hydrogen atom
Prior art date: 1998-07-01

Application number

SK2018-2000A

Other languages

English (en)

Slovak (sk)

Inventor

Yasuo Sugiyama

Yu Momose

Hiroyuki Kimura

Junichi Sakamoto

Hiroyuki Odaka

Original Assignee

Takeda Chemical Industries, Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-01

Filing date

1999-06-30

Publication date

2001-08-06

1999-06-30 Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.

2001-08-06 Publication of SK20182000A3 publication Critical patent/SK20182000A3/sk

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SBMARNJLGKFMOK-UHFFFAOYSA-N ethyl 3-[4-(2,5-dimethylthiophen-3-yl)-1,3-thiazol-2-yl]benzoate Chemical compound CCOC(=O)C1=CC=CC(C=2SC=C(N=2)C2=C(SC(C)=C2)C)=C1 SBMARNJLGKFMOK-UHFFFAOYSA-N 0.000 description 1
IHVSOHHKYBUBKC-UHFFFAOYSA-N ethyl 3-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]benzoate Chemical compound CCOC(=O)C1=CC=CC(C=2SC=C(N=2)C=2C=CC(Cl)=CC=2)=C1 IHVSOHHKYBUBKC-UHFFFAOYSA-N 0.000 description 1
BYVUWUVJNGMTNO-UHFFFAOYSA-N ethyl 3-[4-(4-ethoxyphenyl)-1,3-thiazol-2-yl]benzoate Chemical compound CCOC(=O)C1=CC=CC(C=2SC=C(N=2)C=2C=CC(OCC)=CC=2)=C1 BYVUWUVJNGMTNO-UHFFFAOYSA-N 0.000 description 1
KJFSDCZVCOSTEN-UHFFFAOYSA-N ethyl 3-[4-(4-propan-2-ylphenyl)-1,3-thiazol-2-yl]benzoate Chemical compound CCOC(=O)C1=CC=CC(C=2SC=C(N=2)C=2C=CC(=CC=2)C(C)C)=C1 KJFSDCZVCOSTEN-UHFFFAOYSA-N 0.000 description 1
LJQXRZQOKPCHKG-UHFFFAOYSA-N ethyl 3-[4-(4-tert-butylphenyl)-1,3-thiazol-2-yl]benzoate Chemical compound CCOC(=O)C1=CC=CC(C=2SC=C(N=2)C=2C=CC(=CC=2)C(C)(C)C)=C1 LJQXRZQOKPCHKG-UHFFFAOYSA-N 0.000 description 1
BGFATQJCXLSSQM-UHFFFAOYSA-N ethyl 4-(2-phenyl-1,3-oxazol-4-yl)benzoate Chemical compound C1=CC(C(=O)OCC)=CC=C1C1=COC(C=2C=CC=CC=2)=N1 BGFATQJCXLSSQM-UHFFFAOYSA-N 0.000 description 1
NNQOQEKTXQXIBG-UHFFFAOYSA-N ethyl 4-(2-pyridin-3-yl-1,3-thiazol-4-yl)benzoate;hydrobromide Chemical compound Br.C1=CC(C(=O)OCC)=CC=C1C1=CSC(C=2C=NC=CC=2)=N1 NNQOQEKTXQXIBG-UHFFFAOYSA-N 0.000 description 1
QXAGGJDSRLQPND-UHFFFAOYSA-N ethyl 4-[2-(4-chlorophenyl)-1,3-oxazol-4-yl]benzoate Chemical compound C1=CC(C(=O)OCC)=CC=C1C1=COC(C=2C=CC(Cl)=CC=2)=N1 QXAGGJDSRLQPND-UHFFFAOYSA-N 0.000 description 1
XAGGXUJJWOXCCM-UHFFFAOYSA-N ethyl 4-[2-[3-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl]benzoate Chemical compound C1=CC(C(=O)OCC)=CC=C1C1=COC(C=2C=C(C=CC=2)C(F)(F)F)=N1 XAGGXUJJWOXCCM-UHFFFAOYSA-N 0.000 description 1
SJZGLLUSXVLDED-UHFFFAOYSA-N ethyl 4-[2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-4-yl]benzoate Chemical compound C1=CC(C(=O)OCC)=CC=C1C1=COC(C=2C=CC(=CC=2)C(F)(F)F)=N1 SJZGLLUSXVLDED-UHFFFAOYSA-N 0.000 description 1
PXVYUFOCYRQHJT-UHFFFAOYSA-N ethyl 4-[2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-5-yl]benzoate Chemical compound C1=CC(C(=O)OCC)=CC=C1C1=CN=C(C=2C=CC(=CC=2)C(F)(F)F)O1 PXVYUFOCYRQHJT-UHFFFAOYSA-N 0.000 description 1
HDHIYCVGRBGMKJ-UHFFFAOYSA-N ethyl 4-[2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl]benzoate Chemical compound C1=CC(C(=O)OCC)=CC=C1C1=CSC(C=2C=CC(=CC=2)C(F)(F)F)=N1 HDHIYCVGRBGMKJ-UHFFFAOYSA-N 0.000 description 1
GJNJYQXGWACZGC-UHFFFAOYSA-N ethyl 4-[5-(4-chlorophenyl)-1,3-oxazol-2-yl]benzoate Chemical compound C1=CC(C(=O)OCC)=CC=C1C1=NC=C(C=2C=CC(Cl)=CC=2)O1 GJNJYQXGWACZGC-UHFFFAOYSA-N 0.000 description 1
QIJAVRQBOSTVSP-UHFFFAOYSA-N ethyl 4-[5-(4-chlorophenyl)-1,3-thiazol-2-yl]benzoate Chemical compound C1=CC(C(=O)OCC)=CC=C1C1=NC=C(C=2C=CC(Cl)=CC=2)S1 QIJAVRQBOSTVSP-UHFFFAOYSA-N 0.000 description 1
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229940079322 interferon Drugs 0.000 description 1
230000003834 intracellular effect Effects 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
239000007928 intraperitoneal injection Substances 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
238000011835 investigation Methods 0.000 description 1
229960002198 irbesartan Drugs 0.000 description 1
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125000001977 isobenzofuranyl group Chemical group C=1(OC=C2C=CC=CC12)* 0.000 description 1
125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 description 1
229960002479 isosorbide Drugs 0.000 description 1
125000001786 isothiazolyl group Chemical group 0.000 description 1
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239000004922 lacquer Substances 0.000 description 1
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239000000787 lecithin Substances 0.000 description 1
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NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 description 1
229940039781 leptin Drugs 0.000 description 1
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229960004773 losartan Drugs 0.000 description 1
KJJZZJSZUJXYEA-UHFFFAOYSA-N losartan Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 description 1
229960004844 lovastatin Drugs 0.000 description 1
PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 description 1
QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 description 1
231100000053 low toxicity Toxicity 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
159000000003 magnesium salts Chemical class 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
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235000011090 malic acid Nutrition 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
229960004678 mefruside Drugs 0.000 description 1
229960004296 megestrol acetate Drugs 0.000 description 1
RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 description 1
239000002207 metabolite Substances 0.000 description 1
229960003105 metformin Drugs 0.000 description 1
XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 1
229940098779 methanesulfonic acid Drugs 0.000 description 1
229960000485 methotrexate Drugs 0.000 description 1
MAPXDKXXJCHPGE-UHFFFAOYSA-N methyl 3-[4-(2,4-difluorophenyl)-1,3-thiazol-2-yl]benzoate Chemical compound COC(=O)C1=CC=CC(C=2SC=C(N=2)C=2C(=CC(F)=CC=2)F)=C1 MAPXDKXXJCHPGE-UHFFFAOYSA-N 0.000 description 1
JTIKVMMDXIKBDX-UHFFFAOYSA-N methyl 3-[4-(3,4-difluorophenyl)-1,3-thiazol-2-yl]benzoate Chemical compound COC(=O)C1=CC=CC(C=2SC=C(N=2)C=2C=C(F)C(F)=CC=2)=C1 JTIKVMMDXIKBDX-UHFFFAOYSA-N 0.000 description 1
KRZIVIQXGQXXGX-UHFFFAOYSA-N methyl 3-[4-(4-ethoxyphenyl)-1,3-thiazol-2-yl]benzoate Chemical compound C1=CC(OCC)=CC=C1C1=CSC(C=2C=C(C=CC=2)C(=O)OC)=N1 KRZIVIQXGQXXGX-UHFFFAOYSA-N 0.000 description 1
SPYJBSBUTWVBQN-UHFFFAOYSA-N methyl 3-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]benzoate Chemical compound COC(=O)C1=CC=CC(C=2SC=C(N=2)C=2C=CC(OC)=CC=2)=C1 SPYJBSBUTWVBQN-UHFFFAOYSA-N 0.000 description 1
OEVTYWOGEORSRE-UHFFFAOYSA-N methyl 3-[4-[3-(trifluoromethoxy)phenyl]-1,3-thiazol-2-yl]benzoate Chemical compound COC(=O)C1=CC=CC(C=2SC=C(N=2)C=2C=C(OC(F)(F)F)C=CC=2)=C1 OEVTYWOGEORSRE-UHFFFAOYSA-N 0.000 description 1
GHAHDSIIDFJEDP-UHFFFAOYSA-N methyl 3-[4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]benzoate Chemical compound COC(=O)C1=CC=CC(C=2SC=C(N=2)C=2C=C(C=CC=2)C(F)(F)F)=C1 GHAHDSIIDFJEDP-UHFFFAOYSA-N 0.000 description 1
UODUSMWTVBWLFV-UHFFFAOYSA-N methyl 3-[4-[4-(trifluoromethyl)phenyl]-1,3-oxazol-2-yl]benzoate Chemical compound COC(=O)C1=CC=CC(C=2OC=C(N=2)C=2C=CC(=CC=2)C(F)(F)F)=C1 UODUSMWTVBWLFV-UHFFFAOYSA-N 0.000 description 1
SKFMZWWGGCJYMA-UHFFFAOYSA-N methyl 3-[4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]benzoate Chemical compound COC(=O)C1=CC=CC(C=2SC=C(N=2)C=2C=CC(=CC=2)C(F)(F)F)=C1 SKFMZWWGGCJYMA-UHFFFAOYSA-N 0.000 description 1
MNDFXDXRMYURMC-UHFFFAOYSA-N methyl 3-carbamoylbenzoate Chemical compound COC(=O)C1=CC=CC(C(N)=O)=C1 MNDFXDXRMYURMC-UHFFFAOYSA-N 0.000 description 1
RHQMXNZXUMLDAV-UHFFFAOYSA-N methyl 4-[4-(2,5-dimethylthiophen-3-yl)-1,3-thiazol-2-yl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1C1=NC(C2=C(SC(C)=C2)C)=CS1 RHQMXNZXUMLDAV-UHFFFAOYSA-N 0.000 description 1
SZBXNVDAXCHNEV-UHFFFAOYSA-N methyl 4-[4-(4-bromophenyl)-1,3-thiazol-2-yl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1C1=NC(C=2C=CC(Br)=CC=2)=CS1 SZBXNVDAXCHNEV-UHFFFAOYSA-N 0.000 description 1
MBOOOHMESVLOQT-UHFFFAOYSA-N methyl 4-[4-(4-methoxyphenyl)-1,3-oxazol-2-yl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1C1=NC(C=2C=CC(OC)=CC=2)=CO1 MBOOOHMESVLOQT-UHFFFAOYSA-N 0.000 description 1
LNVSPOQGHRPJJC-UHFFFAOYSA-N methyl 4-[4-(4-methylphenyl)-1,3-thiazol-2-yl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1C1=NC(C=2C=CC(C)=CC=2)=CS1 LNVSPOQGHRPJJC-UHFFFAOYSA-N 0.000 description 1
RTZIDSXLMIOTOA-UHFFFAOYSA-N methyl 4-[4-(4-propan-2-ylphenyl)-1,3-thiazol-2-yl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1C1=NC(C=2C=CC(=CC=2)C(C)C)=CS1 RTZIDSXLMIOTOA-UHFFFAOYSA-N 0.000 description 1
OPYQXWBBHNEVHG-UHFFFAOYSA-N methyl 4-[4-(4-tert-butylphenyl)-1,3-thiazol-2-yl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1C1=NC(C=2C=CC(=CC=2)C(C)(C)C)=CS1 OPYQXWBBHNEVHG-UHFFFAOYSA-N 0.000 description 1
ZWDBMDZNTYSYCS-UHFFFAOYSA-N methyl 4-[4-(5-chlorothiophen-2-yl)-1,3-oxazol-2-yl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1C1=NC(C=2SC(Cl)=CC=2)=CO1 ZWDBMDZNTYSYCS-UHFFFAOYSA-N 0.000 description 1
FAGRCRBJSNIQFL-UHFFFAOYSA-N methyl 4-[4-(5-chlorothiophen-2-yl)-1,3-thiazol-2-yl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1C1=NC(C=2SC(Cl)=CC=2)=CS1 FAGRCRBJSNIQFL-UHFFFAOYSA-N 0.000 description 1
IJOCFISMLGUJKO-UHFFFAOYSA-N methyl 4-[4-[2-(trifluoromethyl)phenyl]-1,3-oxazol-2-yl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1C1=NC(C=2C(=CC=CC=2)C(F)(F)F)=CO1 IJOCFISMLGUJKO-UHFFFAOYSA-N 0.000 description 1
ZKBWQCVMKDQDEB-UHFFFAOYSA-N methyl 4-[4-[2-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1C1=NC(C=2C(=CC=CC=2)C(F)(F)F)=CS1 ZKBWQCVMKDQDEB-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

SK2018-2000A 1998-07-01 1999-06-30 Činidlo regulujúce funkciu receptora súvisiaceho s retinoidmi SK20182000A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP18669898		1998-07-01
PCT/JP1999/003520 WO2000001679A1 (fr)	1998-07-01	1999-06-30	Regulateurs du recepteur associe aux retinoides

Publications (1)

Publication Number	Publication Date
SK20182000A3 true SK20182000A3 (sk)	2001-08-06

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ID=16193077

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK2018-2000A SK20182000A3 (sk)	1998-07-01	1999-06-30	Činidlo regulujúce funkciu receptora súvisiaceho s retinoidmi

Country Status (16)

Country	Link
US (1)	US6545009B1 (fr)
EP (1)	EP1092711A4 (fr)
KR (1)	KR20010053282A (fr)
CN (1)	CN1314899A (fr)
AU (1)	AU4394799A (fr)
BR (1)	BR9911752A (fr)
CA (1)	CA2332178A1 (fr)
HU (1)	HUP0102470A3 (fr)
ID (1)	ID29247A (fr)
IL (1)	IL140422A0 (fr)
LV (1)	LV12633B (fr)
NO (1)	NO20006667L (fr)
PL (1)	PL345247A1 (fr)
SK (1)	SK20182000A3 (fr)
WO (1)	WO2000001679A1 (fr)
ZA (1)	ZA200007635B (fr)

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1999
- 1999-06-30 BR BR9911752-5A patent/BR9911752A/pt not_active Application Discontinuation
- 1999-06-30 US US09/720,644 patent/US6545009B1/en not_active Expired - Fee Related
- 1999-06-30 PL PL99345247A patent/PL345247A1/xx not_active Application Discontinuation
- 1999-06-30 KR KR1020007014995A patent/KR20010053282A/ko not_active Withdrawn
- 1999-06-30 CA CA002332178A patent/CA2332178A1/fr not_active Abandoned
- 1999-06-30 SK SK2018-2000A patent/SK20182000A3/sk unknown
- 1999-06-30 IL IL14042299A patent/IL140422A0/xx unknown
- 1999-06-30 HU HU0102470A patent/HUP0102470A3/hu unknown
- 1999-06-30 WO PCT/JP1999/003520 patent/WO2000001679A1/fr not_active Ceased
- 1999-06-30 AU AU43947/99A patent/AU4394799A/en not_active Abandoned
- 1999-06-30 CN CN99810103A patent/CN1314899A/zh active Pending
- 1999-06-30 ID IDW20010004D patent/ID29247A/id unknown
- 1999-06-30 EP EP99926853A patent/EP1092711A4/fr not_active Withdrawn
2000
- 2000-12-19 ZA ZA200007635A patent/ZA200007635B/en unknown
- 2000-12-27 NO NO20006667A patent/NO20006667L/no not_active Application Discontinuation
- 2000-12-28 LV LVP-00-177A patent/LV12633B/en unknown

Also Published As

Publication number	Publication date
PL345247A1 (en)	2001-12-03
ZA200007635B (en)	2002-01-02
EP1092711A1 (fr)	2001-04-18
NO20006667L (no)	2001-02-28
AU4394799A (en)	2000-01-24
LV12633B (en)	2001-07-20
WO2000001679A1 (fr)	2000-01-13
NO20006667D0 (no)	2000-12-27
CN1314899A (zh)	2001-09-26
IL140422A0 (en)	2002-02-10
LV12633A (lv)	2001-03-20
BR9911752A (pt)	2001-04-03
KR20010053282A (ko)	2001-06-25
HUP0102470A2 (hu)	2002-04-29
ID29247A (id)	2001-08-16
CA2332178A1 (fr)	2000-01-13
EP1092711A4 (fr)	2002-07-31
US6545009B1 (en)	2003-04-08
HUP0102470A3 (en)	2002-05-28

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SK20182000A3 (sk)	2001-08-06	Činidlo regulujúce funkciu receptora súvisiaceho s retinoidmi
EP1357115B1 (fr)	2009-06-17	Derives d'acide alcanoique, procede de production et utilisation correspondants
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JP6352415B2 (ja)	2018-07-04	新規なヘテロ環化合物
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