SK137697A3 - Dispersible particulate system for desensitizing teeth - Google Patents

Dispersible particulate system for desensitizing teeth Download PDF

Info

Publication number: SK137697A3
Authority: SK; Slovakia
Prior art keywords: composition; clay; laponite; salt; teeth
Prior art date: 1995-04-11

Application number

SK1376-97A

Other languages

English (en)

Slovak (sk)

Inventor

Kenneth Markowitz

Mikhail Y Gelfer

Original Assignee

Block Drug Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-11

Filing date

1996-04-10

Publication date

1998-05-06

1996-04-10 Application filed by Block Drug Co filed Critical Block Drug Co

1998-05-06 Publication of SK137697A3 publication Critical patent/SK137697A3/sk

Links

239000000203 mixture Substances 0.000 claims abstract description 47
239000004927 clay Substances 0.000 claims abstract description 40
XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 claims abstract description 37
229940094522 laponite Drugs 0.000 claims abstract description 36
KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 claims abstract description 17
229910000271 hectorite Inorganic materials 0.000 claims abstract description 17
206010020751 Hypersensitivity Diseases 0.000 claims abstract description 15
238000000034 method Methods 0.000 claims abstract description 12
KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 12
150000003839 salts Chemical group 0.000 claims description 12
229920002678 cellulose Polymers 0.000 claims description 9
239000001913 cellulose Substances 0.000 claims description 9
239000002270 dispersing agent Substances 0.000 claims description 9
239000003975 dentin desensitizing agent Substances 0.000 claims description 7
235000011180 diphosphates Nutrition 0.000 claims description 4
159000000008 strontium salts Chemical class 0.000 claims description 4
150000001875 compounds Chemical class 0.000 claims 3
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 2
150000001447 alkali salts Chemical class 0.000 claims 2
150000004649 carbonic acid derivatives Chemical class 0.000 claims 2
150000001860 citric acid derivatives Chemical class 0.000 claims 2
159000000011 group IA salts Chemical group 0.000 claims 2
150000004820 halides Chemical class 0.000 claims 2
150000002823 nitrates Chemical class 0.000 claims 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 24
PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 24
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
239000004615 ingredient Substances 0.000 description 16
210000005239 tubule Anatomy 0.000 description 15
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 14
210000004268 dentin Anatomy 0.000 description 14
239000012530 fluid Substances 0.000 description 13
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 12
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239000011775 sodium fluoride Substances 0.000 description 12
235000013024 sodium fluoride Nutrition 0.000 description 12
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 11
239000000551 dentifrice Substances 0.000 description 11
239000000377 silicon dioxide Substances 0.000 description 11
239000011734 sodium Substances 0.000 description 11
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210000005036 nerve Anatomy 0.000 description 10
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WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 8
MOYKHGMNXAOIAT-JGWLITMVSA-N isosorbide dinitrate Chemical compound [O-][N+](=O)O[C@H]1CO[C@@H]2[C@H](O[N+](=O)[O-])CO[C@@H]21 MOYKHGMNXAOIAT-JGWLITMVSA-N 0.000 description 8
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208000026935 allergic disease Diseases 0.000 description 5
230000015572 biosynthetic process Effects 0.000 description 5
150000001768 cations Chemical class 0.000 description 5
LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 description 5
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239000000463 material Substances 0.000 description 4
239000001103 potassium chloride Substances 0.000 description 4
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FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 4
238000011160 research Methods 0.000 description 4
229960001866 silicon dioxide Drugs 0.000 description 4
XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 4
238000012360 testing method Methods 0.000 description 4
NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
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229920000663 Hydroxyethyl cellulose Polymers 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
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XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 3
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239000011777 magnesium Substances 0.000 description 3
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239000011736 potassium bicarbonate Substances 0.000 description 3
235000015497 potassium bicarbonate Nutrition 0.000 description 3
229910000028 potassium bicarbonate Inorganic materials 0.000 description 3
TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 3
ZLUJDMIOSISGBX-UHFFFAOYSA-J potassium tetrasodium phosphonato phosphate Chemical compound [O-]P([O-])(=O)OP(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+].[K+] ZLUJDMIOSISGBX-UHFFFAOYSA-J 0.000 description 3
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AZJYLVAUMGUUBL-UHFFFAOYSA-A u1qj22mc8e Chemical compound [F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O=[Si]=O.O=[Si]=O.O=[Si]=O.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 AZJYLVAUMGUUBL-UHFFFAOYSA-A 0.000 description 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
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239000000654 additive Substances 0.000 description 2
125000000129 anionic group Chemical group 0.000 description 2
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238000005520 cutting process Methods 0.000 description 2
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RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 2
239000003792 electrolyte Substances 0.000 description 2
239000003193 general anesthetic agent Substances 0.000 description 2
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229910052500 inorganic mineral Inorganic materials 0.000 description 2
235000010755 mineral Nutrition 0.000 description 2
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230000004048 modification Effects 0.000 description 2
238000012986 modification Methods 0.000 description 2
125000004430 oxygen atom Chemical group O* 0.000 description 2
VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 2
239000010452 phosphate Substances 0.000 description 2
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235000010333 potassium nitrate Nutrition 0.000 description 2
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235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229960003975 potassium Drugs 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
239000001508 potassium citrate Substances 0.000 description 1
229960002635 potassium citrate Drugs 0.000 description 1
QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
235000011082 potassium citrates Nutrition 0.000 description 1
-1 potassium salt Chemical class 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
230000001737 promoting effect Effects 0.000 description 1
229940048084 pyrophosphate Drugs 0.000 description 1
230000004044 response Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
229940085605 saccharin sodium Drugs 0.000 description 1
210000003296 saliva Anatomy 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
229910052710 silicon Inorganic materials 0.000 description 1
239000010703 silicon Substances 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
BFDWBSRJQZPEEB-UHFFFAOYSA-L sodium fluorophosphate Chemical compound [Na+].[Na+].[O-]P([O-])(F)=O BFDWBSRJQZPEEB-UHFFFAOYSA-L 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
229940048086 sodium pyrophosphate Drugs 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
229910052682 stishovite Inorganic materials 0.000 description 1
238000003860 storage Methods 0.000 description 1
229940047908 strontium chloride hexahydrate Drugs 0.000 description 1
AMGRXJSJSONEEG-UHFFFAOYSA-L strontium dichloride hexahydrate Chemical compound O.O.O.O.O.O.Cl[Sr]Cl AMGRXJSJSONEEG-UHFFFAOYSA-L 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
150000005846 sugar alcohols Chemical class 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
238000010998 test method Methods 0.000 description 1
RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
CDVLCTOFEIEUDH-UHFFFAOYSA-K tetrasodium;phosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])([O-])=O CDVLCTOFEIEUDH-UHFFFAOYSA-K 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
230000008719 thickening Effects 0.000 description 1
230000009974 thixotropic effect Effects 0.000 description 1
229910052905 tridymite Inorganic materials 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Birds (AREA)
Inorganic Chemistry (AREA)
Oral & Maxillofacial Surgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Pulmonology (AREA)
Immunology (AREA)
Cosmetics (AREA)
Silicates, Zeolites, And Molecular Sieves (AREA)
Fodder In General (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

SK1376-97A 1995-04-11 1996-04-10 Dispersible particulate system for desensitizing teeth SK137697A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/419,816 US5589159A (en)	1995-04-11	1995-04-11	Dispersible particulate system for desensitizing teeth
PCT/US1996/004852 WO1996032090A1 (fr)	1995-04-11	1996-04-10	Systeme particulaire pouvant etre mis en dispersion pour desensibiliser les dents

Publications (1)

Publication Number	Publication Date
SK137697A3 true SK137697A3 (en)	1998-05-06

Family

ID=23663881

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1376-97A SK137697A3 (en)	1995-04-11	1996-04-10	Dispersible particulate system for desensitizing teeth

Country Status (23)

Country	Link
US (1)	US5589159A (fr)
EP (1)	EP0820270B1 (fr)
JP (1)	JPH11509518A (fr)
KR (1)	KR19980703780A (fr)
CN (1)	CN1102379C (fr)
AR (1)	AR004171A1 (fr)
AT (1)	ATE242624T1 (fr)
AU (1)	AU717149B2 (fr)
BG (1)	BG101949A (fr)
BR (1)	BR9604959A (fr)
CA (1)	CA2217861A1 (fr)
CZ (1)	CZ288829B6 (fr)
DE (1)	DE69628643T2 (fr)
DK (1)	DK0820270T3 (fr)
ES (1)	ES2201180T3 (fr)
HU (1)	HUP9801702A3 (fr)
NZ (1)	NZ305772A (fr)
PL (1)	PL184327B1 (fr)
PT (1)	PT820270E (fr)
RU (1)	RU2163798C2 (fr)
SK (1)	SK137697A3 (fr)
UA (1)	UA48965C2 (fr)
WO (1)	WO1996032090A1 (fr)

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* Cited by examiner, † Cited by third party
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US5885551A (en) *	1997-08-01	1999-03-23	Smetana; Alfred J.	Treatment for dentinal hypersensitivity
US6241972B1 (en) *	1999-02-19	2001-06-05	Block Drug Company, Inc.	Oral care formulation for the treatment of sensitivity teeth
CA2300456C (fr) *	1999-03-12	2004-05-11	Pfizer Products Inc.	Compositions comprenant un sel de potassium comme principe actif, y compris des compositions orales pour reduire la sensibilite des nerfs dentaires et de la dentine comprenant un aromatisant autre que le menthol
US6685920B2 (en) *	1999-11-12	2004-02-03	The Procter & Gamble Company	Method of protecting teeth against erosion
EP1731132B1 (fr)	2000-10-13	2008-12-10	Block Drug Company, Inc.	Compositions dentaires pour dents hypersensibles
US6447756B1 (en) *	2000-11-08	2002-09-10	Colgate Palmolive Company	Desensitizing dual component dentifrice
US6416745B1 (en)	2001-05-03	2002-07-09	Block Drug Company, Inc.	Dental composition for treating hypersensitive teeth
WO2004012693A2 (fr) *	2002-08-05	2004-02-12	Colgate-Palmolive Company	Dentifrice de desensibilisation dentinaire a effets ameliores de protection anticarieuse et de remineralisation
US8652445B2 (en) *	2004-07-02	2014-02-18	Discus Dental, Llc	Dental compositions with sensitivity relief
AU2006226505B2 (en) *	2005-03-21	2012-04-19	Glaxosmithkline Consumer Healthcare (Uk) Ip Limited	Alkyl sulfate free and orthophosphate free dentifrice compostion comprising a fluoride source and a silica dental abrasive
US20070140992A1 (en) *	2005-12-21	2007-06-21	Lynn Schick	Taste masking of essential oils using a hydrocolloid
US20080268001A1 (en) *	2007-04-30	2008-10-30	Lynette Zaidel	Oral care composition to reduce or eliminate dental sensitivity
CN101938977A (zh) *	2008-02-08	2011-01-05	高露洁-棕榄公司	口腔护理产品及其使用和生产方法
US20100047742A1 (en) *	2008-08-25	2010-02-25	Pitcock Jr William Henry	Tubule-blocking silica materials for dentifrices
AR076178A1 (es)	2009-04-01	2011-05-26	Colgate Palmolive Co	Composiciones dentifricas de accion doble para prevenir la hipersensibilidad y promover la remineralizacion
US20110206749A1 (en) *	2010-02-19	2011-08-25	J.M. Huber Corporation	Silica materials for reducing oral malador
US8658139B1 (en)	2010-02-27	2014-02-25	Squigle, Inc.	Prevention and treatment of oral diseases
US20110236444A1 (en) *	2010-03-25	2011-09-29	Darsillo Michael S	Antimicrobial Silica Composites
CN102946841A (zh)	2010-06-23	2013-02-27	高露洁-棕榄公司	治疗用口腔组合物
BR112013011845B8 (pt)	2010-11-12	2019-01-22	Colgate Palmolive Co	enxaguatório bucal compreendendo aminoácido básico e conservante e uso cosmético do enxaguatório bucal
EP2637633B1 (fr)	2010-11-12	2018-07-11	Colgate-Palmolive Company	Produit pour soins buccaux, et ses procédés d'utilisation et de fabrication
US9717929B2 (en) *	2010-12-07	2017-08-01	Colgate-Palmolive Company	Dentifrice compositions containing calcium silicate and a basic amino acid
PH12013501080A1 (en) *	2010-12-07	2019-06-14	Colgate Palmolive Co	Dentifrice compositions containing calcium silicate
JP5720416B2 (ja) *	2011-05-19	2015-05-20	ライオン株式会社	ゲル状口腔用組成物及びその製造方法
MX349989B (es) *	2011-12-21	2017-08-22	Colgate Palmolive Co	Composiciones del cuidado oral.
AU2013408426B2 (en) *	2013-12-16	2017-02-02	Colgate-Palmolive Company	Oral care compositions comprising calcium carbonate and talc
CN105828782B (zh) *	2013-12-16	2019-08-06	高露洁-棕榄公司	包含碳酸钙和粘土的口腔护理组合物
WO2021078685A1 (fr)	2019-10-23	2021-04-29	Unilever Ip Holdings B.V.	Procédé de réduction de l'hypersensibilité dentaire
US11931443B2 (en)	2020-03-27	2024-03-19	Colgate-Palmolive Company	Oral care compositions and methods of use
US20210298996A1 (en)	2020-03-27	2021-09-30	Colgate-Palmolive Company	Oral Care Composition and Methods of Use
AU2022351151B2 (en)	2021-09-23	2025-03-20	Colgate-Palmolive Company	Oral care compositions and methods of use

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JPS5257339A (en) *	1975-11-07	1977-05-11	Kao Corp	Tooth paste composition
US4474750A (en) *	1976-12-27	1984-10-02	Colgate-Palmolive Company	Anticalculus oral composition
US4418053A (en) *	1980-03-17	1983-11-29	Indiana University Foundation	Dental prophylaxis compositions and their use
US4634589A (en) *	1984-05-18	1987-01-06	Wurttembergische Parfumerie-Fabrik Gmbh	Dentifrice for hypersensitive teeth
JPH0742219B2 (ja) *	1984-07-26	1995-05-10	ライオン株式会社	口腔用組成物
US4992258A (en) *	1989-10-23	1991-02-12	Colgate-Palmolive Company	Dentrifice composition
EP0554297B1 (fr) *	1990-10-25	1995-04-12	The Boots Company PLC	Bain de bouche
GB9115154D0 (en) *	1991-07-12	1991-08-28	Patel Bipin C M	Sol-gel composition for producing glassy coatings
GB9115153D0 (en) *	1991-07-12	1991-08-28	Patel Bipin C M	Sol-gel composition for producing glassy coatings
US5250288A (en) *	1991-09-13	1993-10-05	Gillette Canada, Inc.	Method for desensitizing teeth
US5211939A (en) *	1991-09-13	1993-05-18	Gillette Canada	Method for desensitizing teeth
US5240697A (en) *	1991-10-17	1993-08-31	Colgate-Palmolive Company	Desensitizing anti-tartar dentifrice
US5374417A (en) *	1991-10-17	1994-12-20	Colgate Palmolive Company	Desensitizing dentifrice
US5270031A (en) *	1991-12-20	1993-12-14	Block Drug Company Inc.	Dentinal desensitizing compositions

1995
- 1995-04-11 US US08/419,816 patent/US5589159A/en not_active Expired - Lifetime
1996
- 1996-04-10 SK SK1376-97A patent/SK137697A3/sk unknown
- 1996-04-10 CZ CZ19973210A patent/CZ288829B6/cs not_active IP Right Cessation
- 1996-04-10 ES ES96910786T patent/ES2201180T3/es not_active Expired - Lifetime
- 1996-04-10 UA UA97115406A patent/UA48965C2/uk unknown
- 1996-04-10 AT AT96910786T patent/ATE242624T1/de not_active IP Right Cessation
- 1996-04-10 AU AU53885/96A patent/AU717149B2/en not_active Ceased
- 1996-04-10 CA CA002217861A patent/CA2217861A1/fr not_active Abandoned
- 1996-04-10 DK DK96910786T patent/DK0820270T3/da active
- 1996-04-10 PL PL96322719A patent/PL184327B1/pl unknown
- 1996-04-10 RU RU97118435/14A patent/RU2163798C2/ru not_active IP Right Cessation
- 1996-04-10 WO PCT/US1996/004852 patent/WO1996032090A1/fr not_active Ceased
- 1996-04-10 DE DE69628643T patent/DE69628643T2/de not_active Expired - Lifetime
- 1996-04-10 PT PT96910786T patent/PT820270E/pt unknown
- 1996-04-10 HU HU9801702A patent/HUP9801702A3/hu unknown
- 1996-04-10 BR BR9604959A patent/BR9604959A/pt not_active Application Discontinuation
- 1996-04-10 CN CN96194361A patent/CN1102379C/zh not_active Expired - Fee Related
- 1996-04-10 NZ NZ305772A patent/NZ305772A/xx unknown
- 1996-04-10 EP EP96910786A patent/EP0820270B1/fr not_active Expired - Lifetime
- 1996-04-10 KR KR1019970707180A patent/KR19980703780A/ko not_active Abandoned
- 1996-04-10 JP JP8531103A patent/JPH11509518A/ja active Pending
- 1996-04-11 AR ARP960102155A patent/AR004171A1/es unknown
1997
- 1997-10-08 BG BG101949A patent/BG101949A/xx unknown

Also Published As

Publication number	Publication date
HUP9801702A2 (hu)	1998-11-30
EP0820270A1 (fr)	1998-01-28
WO1996032090A1 (fr)	1996-10-17
JPH11509518A (ja)	1999-08-24
CA2217861A1 (fr)	1996-10-17
DK0820270T3 (da)	2003-09-29
NZ305772A (en)	1999-02-25
DE69628643D1 (de)	2003-07-17
AU5388596A (en)	1996-10-30
EP0820270B1 (fr)	2003-06-11
CZ321097A3 (cs)	1998-03-18
HK1004108A1 (en)	1998-11-20
AU717149B2 (en)	2000-03-16
UA48965C2 (uk)	2002-09-16
US5589159A (en)	1996-12-31
ATE242624T1 (de)	2003-06-15
BR9604959A (pt)	1998-07-14
EP0820270A4 (fr)	1999-06-23
CN1102379C (zh)	2003-03-05
KR19980703780A (ko)	1998-12-05
PL184327B1 (pl)	2002-10-31
CN1186426A (zh)	1998-07-01
DE69628643T2 (de)	2004-04-29
RU2163798C2 (ru)	2001-03-10
CZ288829B6 (cs)	2001-09-12
BG101949A (en)	1998-05-29
HUP9801702A3 (en)	1998-12-28
AR004171A1 (es)	1998-11-04
PT820270E (pt)	2003-10-31
PL322719A1 (en)	1998-02-16
ES2201180T3 (es)	2004-03-16

Publication	Publication Date	Title
SK137697A3 (en)	1998-05-06	Dispersible particulate system for desensitizing teeth
US6416745B1 (en)	2002-07-09	Dental composition for treating hypersensitive teeth
RU2552348C2 (ru)	2015-06-10	Композиция для ухода за полостью рта, содержащая аргинин и карбонат кальция
DE69618786T2 (de)	2002-11-07	Wärmeerzeugende zahnpasta
US5182099A (en)	1993-01-26	Preparation for prevention of emission of mercury from amalgam fillings and method
US7182937B2 (en)	2007-02-27	Anhydrous dentrifice formulations for the delivery of incompatible ingredients
CA2420154A1 (fr)	2002-02-28	Composition dentaire pour dents hypersensibles
DE3921133A1 (de)	1990-01-18	Wasserstoffperoxid-freisetzendes stabiles zahnputzmittel
JPS60233008A (ja)	1985-11-19	口腔衛生組成物
JPS59205308A (ja)	1984-11-20	歯および口腔の保護製剤
US5885551A (en)	1999-03-23	Treatment for dentinal hypersensitivity
EP0311260A2 (fr)	1989-04-12	Composition buccales
EP0976386A1 (fr)	2000-02-02	Compositions de polymères désensibilisants
US20020041852A1 (en)	2002-04-11	Dental composition for hypersensitive teeth
US4415550A (en)	1983-11-15	Treatment-and-prophylactic tooth paste possessing anticarious effect
CN104684618A (zh)	2015-06-03	用于治疗牙齿敏感症的方法和组合物
US20070059257A1 (en)	2007-03-15	Dentinal composition for hypersensitive teeth
US20060002865A1 (en)	2006-01-05	Stable baking soda/peroxide with calcium and phosphate whitening product
JPH0635375B2 (ja)	1994-05-11	歯茎洗浄用組成物
PL214004B1 (pl)	2013-06-28	Dwuskladnikowa kompozycja dentystyczna
JP2964182B2 (ja)	1999-10-18	象牙質知覚過敏治療剤
EP0311259A2 (fr)	1989-04-12	Compositions buccales
US8951506B2 (en)	2015-02-10	Formulation and method for treatment of teeth
MXPA97007819A (en)	1998-01-01	System in dispersible particles to insensibilize dien
HK1004108B (en)	2004-04-16	Dispersible particulate system for desensitizing teeth