SK114498A3 - Imidazo triazolo pyrimidinone derivatives, method of preparing them and their use - Google Patents

Imidazo triazolo pyrimidinone derivatives, method of preparing them and their use Download PDF

Info

Publication number: SK114498A3
Authority: SK; Slovakia
Prior art keywords: optionally substituted; alkyl; phenyl; benzyl; substituted
Prior art date: 1996-07-20

Application number

SK1144-98A

Other languages

English (en)

Slovak (sk)

Inventor

Ulrike Kufner-Muhl

Werner Kummer

Gerald Pohl

Wolfram Gaida

Erich Lehr

Joachim Mierau

Thomas Weiser

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-20

Filing date

1997-07-17

Publication date

1999-02-11

1997-07-17 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

1998-06-26 Priority claimed from CA002242097A external-priority patent/CA2242097C/fr

1999-02-11 Publication of SK114498A3 publication Critical patent/SK114498A3/sk

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychology (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SK1144-98A 1996-07-20 1997-07-17 Imidazo triazolo pyrimidinone derivatives, method of preparing them and their use SK114498A3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19629378A DE19629378A1 (de)	1996-07-20	1996-07-20	Neue Triazolopurine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PCT/EP1997/003841 WO1998003511A1 (fr)	1996-07-20	1997-07-17	Nouvelles triazolopurines, procede pour les preparer et leur utilisation comme medicaments
CA002242097A CA2242097C (fr)	1996-07-20	1998-06-26	Imidazotriazolopyrimidines, procedes pour les preparer, et leur utilisation en tant que compositions pharmaceutiques

Publications (1)

Publication Number	Publication Date
SK114498A3 true SK114498A3 (en)	1999-02-11

Family

ID=32963000

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1144-98A SK114498A3 (en)	1996-07-20	1997-07-17	Imidazo triazolo pyrimidinone derivatives, method of preparing them and their use

Country Status (25)

Country	Link
EP (2)	EP0880524B1 (fr)
JP (1)	JP3020281B2 (fr)
CN (1)	CN1219936A (fr)
AT (1)	ATE191913T1 (fr)
AU (1)	AU3695597A (fr)
BG (1)	BG102707A (fr)
BR (1)	BR9710747A (fr)
CA (1)	CA2256736A1 (fr)
CZ (1)	CZ265498A3 (fr)
DE (2)	DE19629378A1 (fr)
DK (1)	DK0880524T3 (fr)
EE (1)	EE9800451A (fr)
ES (1)	ES2147453T3 (fr)
GR (1)	GR3033842T3 (fr)
HR (1)	HRP970395A2 (fr)
HU (1)	HUP9902311A3 (fr)
ID (1)	ID19106A (fr)
IL (1)	IL126453A0 (fr)
NO (1)	NO983860L (fr)
PL (1)	PL328824A1 (fr)
PT (1)	PT880524E (fr)
SK (1)	SK114498A3 (fr)
TR (1)	TR199801659T2 (fr)
WO (1)	WO1998003511A1 (fr)
ZA (1)	ZA976331B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19826843A1 (de) *	1998-06-16	1999-12-23	Boehringer Ingelheim Pharma	Neue Imidazotriazolopyrimidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6492377B1 (en)	1998-06-25	2002-12-10	Boehringer Ingelheim Pharma Kg	Imidazotriazolopyrimidines with adenosine-antagonistic activity
AU9347498A (en) *	1998-08-27	2000-03-21	Boehringer Ingelheim Pharma Kg	Imidazotriazolopyrimidines
US7329668B2 (en)	2003-02-25	2008-02-12	Bristol-Myers Squibb Company	Pyrazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same
US7071333B2 (en)	2003-07-30	2006-07-04	Bristol-Myers Squibb Company	Triazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same
CA2656039A1 (fr)	2006-06-23	2007-12-27	Incyte Corporation	Derives de purinone en tant qu'agonistes du hm74a
JP7474709B2 (ja)	2018-02-27	2024-04-25	インサイト・コーポレイション	Ａ２ａ／ａ２ｂ阻害剤としてのイミダゾピリミジン及びトリアゾロピリミジン
MA52940A (fr)	2018-05-18	2021-04-28	Incyte Corp	Dérivés de pyrimidine fusionnés utilisés en tant qu'inhibiteurs de a2a/a2b
AU2019297361B2 (en)	2018-07-05	2024-06-27	Incyte Corporation	Fused pyrazine derivatives as A2A / A2B inhibitors
US11312719B2 (en)	2018-11-30	2022-04-26	Merck Sharp & Dohme Corp.	9-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use
TWI829857B (zh)	2019-01-29	2024-01-21	美商英塞特公司	作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
CN112778311B (zh) *	2019-11-01	2024-06-04	上海翰森生物医药科技有限公司	含氮并环类衍生物抑制剂、其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA902282B (en) *	1989-03-29	1990-12-28	Merrell Dow Pharma	Selective adenosine receptor compounds
IT1264901B1 (it) *	1993-06-29	1996-10-17	Schering Plough S P A	Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina
JPH083169A (ja) *	1994-06-15	1996-01-09	Yamasa Shoyu Co Ltd	４−メチル−１Ｈ−［１，２，４］トリアゾロ［１，５−ａ］プリン−９（４Ｈ）−オン類

1996
- 1996-07-20 DE DE19629378A patent/DE19629378A1/de not_active Withdrawn
1997
- 1997-07-17 EP EP97933683A patent/EP0880524B1/fr not_active Expired - Lifetime
- 1997-07-17 EP EP99119410A patent/EP0978517A3/fr not_active Withdrawn
- 1997-07-17 PL PL97328824A patent/PL328824A1/xx unknown
- 1997-07-17 EE EE9800451A patent/EE9800451A/xx unknown
- 1997-07-17 HU HU9902311A patent/HUP9902311A3/hu unknown
- 1997-07-17 AU AU36955/97A patent/AU3695597A/en not_active Abandoned
- 1997-07-17 PT PT97933683T patent/PT880524E/pt unknown
- 1997-07-17 AT AT97933683T patent/ATE191913T1/de active
- 1997-07-17 CN CN97194506A patent/CN1219936A/zh active Pending
- 1997-07-17 IL IL12645397A patent/IL126453A0/xx unknown
- 1997-07-17 CZ CZ982654A patent/CZ265498A3/cs unknown
- 1997-07-17 CA CA002256736A patent/CA2256736A1/fr not_active Abandoned
- 1997-07-17 JP JP10505626A patent/JP3020281B2/ja not_active Expired - Fee Related
- 1997-07-17 ES ES97933683T patent/ES2147453T3/es not_active Expired - Lifetime
- 1997-07-17 BR BR9710747A patent/BR9710747A/pt unknown
- 1997-07-17 SK SK1144-98A patent/SK114498A3/sk unknown
- 1997-07-17 WO PCT/EP1997/003841 patent/WO1998003511A1/fr not_active Ceased
- 1997-07-17 ZA ZA976331A patent/ZA976331B/xx unknown
- 1997-07-17 TR TR1998/01659T patent/TR199801659T2/xx unknown
- 1997-07-17 DK DK97933683T patent/DK0880524T3/da active
- 1997-07-17 DE DE59701467T patent/DE59701467D1/de not_active Expired - Lifetime
- 1997-07-18 ID IDP972495A patent/ID19106A/id unknown
- 1997-07-18 HR HR19629378.2A patent/HRP970395A2/hr not_active Application Discontinuation
1998
- 1998-08-20 BG BG102707A patent/BG102707A/xx unknown
- 1998-08-21 NO NO983860A patent/NO983860L/no not_active Application Discontinuation
2000
- 2000-06-30 GR GR20000401543T patent/GR3033842T3/el unknown

Also Published As

Publication number	Publication date
WO1998003511A1 (fr)	1998-01-29
TR199801659T2 (xx)	1998-12-21
EP0880524A1 (fr)	1998-12-02
IL126453A0 (en)	1999-08-17
HRP970395A2 (en)	1998-08-31
PT880524E (pt)	2000-07-31
HUP9902311A3 (en)	2000-06-28
PL328824A1 (en)	1999-02-15
EP0880524B1 (fr)	2000-04-19
DE19629378A1 (de)	1998-01-29
BR9710747A (pt)	1999-08-17
CZ265498A3 (cs)	1998-12-16
GR3033842T3 (en)	2000-10-31
ES2147453T3 (es)	2000-09-01
JP2000501420A (ja)	2000-02-08
BG102707A (bg)	1999-09-30
NO983860L (no)	1998-10-21
ID19106A (id)	1998-06-18
JP3020281B2 (ja)	2000-03-15
EE9800451A (et)	1999-06-15
ZA976331B (en)	1999-01-25
DE59701467D1 (de)	2000-05-25
HUP9902311A2 (hu)	1999-10-28
EP0978517A2 (fr)	2000-02-09
CN1219936A (zh)	1999-06-16
CA2256736A1 (fr)	1998-01-29
DK0880524T3 (da)	2000-07-17
EP0978517A3 (fr)	2003-11-12
NO983860D0 (no)	1998-08-21
AU3695597A (en)	1998-02-10
ATE191913T1 (de)	2000-05-15

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CA2457944C (fr)	2009-09-29	Inhibiteurs polycycliques de la phosphodiesterase v de la guanine
US5736549A (en)	1998-04-07	Hypoxanthine and guanine compounds
EP1116722B1 (fr)	2005-01-12	DERIVES DE [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE
CA2140883A1 (fr)	1994-02-17	Xanthines a substitution asymetrique
CA2112031A1 (fr)	1994-06-25	Derives xanthine
JPS63297381A (ja)	1988-12-05	９−〔２−（ヒドロキシメチル）シクロアルキルメチル〕グアニン類
SK114498A3 (en)	1999-02-11	Imidazo triazolo pyrimidinone derivatives, method of preparing them and their use
EP0156559B1 (fr)	1989-08-02	Dérivés guanine 8-substitués
JP3116230B2 (ja)	2000-12-11	三環式縮合ピリミジン誘導体
CA3158731A1 (fr)	2021-05-27	Composes antagonistes du recepteur de l'adenosine
EP1492793B1 (fr)	2008-01-16	Nouveaux derives de 4-(pyrrolopyrimidin-6-yl)benzenesulphonamide
AU632914B2 (en)	1993-01-14	Selective adenosine receptor agents
DE19816857A1 (de)	1999-10-21	Neue unsymmetrisch substituierte Xanthin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6492377B1 (en)	2002-12-10	Imidazotriazolopyrimidines with adenosine-antagonistic activity
JP4567883B2 (ja)	2010-10-20	新規イミダゾトリアゾロピリミジン、それらの調製方法及び医薬組成物としてのそれらの使用
KR20000064893A (ko)	2000-11-06	트리아졸로퓨린,이의제조방법및이를함유하는약제학적제제
JPS61227584A (ja)	1986-10-09	ポリアザ複素環誘導体
JPWO2003020723A1 (ja)	2004-12-16	［１，２，４］トリアゾロ［１，５−ａ］ピリミジン誘導体
CA2242097C (fr)	2003-05-13	Imidazotriazolopyrimidines, procedes pour les preparer, et leur utilisation en tant que compositions pharmaceutiques
US6949652B2 (en)	2005-09-27	Crystalline forms of 3-isopropyl-6-[4-(2,5-difluoro-phenyl)-oxazol-5-yl]-[1,2,4]triazolo-[4,3-A]pyridine
AU1741899A (en)	1999-06-17	New imidazotriazolopyrimidinones, processes for preparing them and their use as pharmaceutical compositions
JPS60248690A (ja)	1985-12-09	グアニン誘導体
HK1064668B (en)	2008-12-24	Polycyclic guanine phosphodiesterase v inhibitors
HK1038014A (en)	2002-03-01	(1,2,4) TRIAZOLO(1,5-c) PYRIMIDINE DERIVATIVES