SI9300330A - Peroralna formulacija za zelodcno protibakterijsko terapijo, postopek izdelave in uporaba - Google Patents

Peroralna formulacija za zelodcno protibakterijsko terapijo, postopek izdelave in uporaba Download PDF

Info

Publication number: SI9300330A
Authority: SI; Slovenia
Prior art keywords: formulation; active; infections; gastrointestinal tract; stomach
Prior art date: 1992-06-24

Application number

SI9300330A

Other languages

English (en)

Slovenian (sl)

Inventor

Karl-Erik Lennart Falk

John Albert Sjoegren

Original Assignee

Astra Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-24

Filing date

1993-06-23

Publication date

1993-12-31

1993-06-23 Application filed by Astra Ab filed Critical Astra Ab

1993-12-31 Publication of SI9300330A publication Critical patent/SI9300330A/sl

Links

238000002360 preparation method Methods 0.000 title claims abstract description 10
238000000034 method Methods 0.000 title claims abstract description 4
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230000000844 anti-bacterial effect Effects 0.000 title description 2
239000000203 mixture Substances 0.000 claims abstract description 37
238000009472 formulation Methods 0.000 claims abstract description 29
208000015181 infectious disease Diseases 0.000 claims abstract description 11
210000002438 upper gastrointestinal tract Anatomy 0.000 claims abstract description 9
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210000002784 stomach Anatomy 0.000 claims description 15
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239000013543 active substance Substances 0.000 claims description 9
SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims description 6
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YFAGHNZHGGCZAX-JKIFEVAISA-N dicloxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=C(Cl)C=CC=C1Cl YFAGHNZHGGCZAX-JKIFEVAISA-N 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
NOCJXYPHIIZEHN-UHFFFAOYSA-N difloxacin Chemical compound C1CN(C)CCN1C(C(=C1)F)=CC2=C1C(=O)C(C(O)=O)=CN2C1=CC=C(F)C=C1 NOCJXYPHIIZEHN-UHFFFAOYSA-N 0.000 description 1
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230000001079 digestive effect Effects 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000035475 disorder Diseases 0.000 description 1
229960003722 doxycycline Drugs 0.000 description 1
229940079593 drug Drugs 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
IDYZIJYBMGIQMJ-UHFFFAOYSA-N enoxacin Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNCC1 IDYZIJYBMGIQMJ-UHFFFAOYSA-N 0.000 description 1
229960002549 enoxacin Drugs 0.000 description 1
210000000981 epithelium Anatomy 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
210000003608 fece Anatomy 0.000 description 1
XBJBPGROQZJDOJ-UHFFFAOYSA-N fleroxacin Chemical compound C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN(CCF)C2=C1F XBJBPGROQZJDOJ-UHFFFAOYSA-N 0.000 description 1
229960003306 fleroxacin Drugs 0.000 description 1
201000006585 gastric adenocarcinoma Diseases 0.000 description 1
229960002442 glucosamine Drugs 0.000 description 1
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ZWCXYZRRTRDGQE-SORVKSEFSA-N gramicidina Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC=O)C(C)C)CC(C)C)C(=O)NCCO)=CNC2=C1 ZWCXYZRRTRDGQE-SORVKSEFSA-N 0.000 description 1
238000005469 granulation Methods 0.000 description 1
230000003179 granulation Effects 0.000 description 1
150000004677 hydrates Chemical class 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
229940079905 intestinal adsorbents bismuth preparations Drugs 0.000 description 1
239000008101 lactose Substances 0.000 description 1
229960000433 latamoxef Drugs 0.000 description 1
230000036210 malignancy Effects 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
239000013563 matrix tablet Substances 0.000 description 1
229960003085 meticillin Drugs 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
229960004023 minocycline Drugs 0.000 description 1
239000007912 modified release tablet Substances 0.000 description 1
230000003232 mucoadhesive effect Effects 0.000 description 1
210000004877 mucosa Anatomy 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
210000003097 mucus Anatomy 0.000 description 1
YCWSUKQGVSGXJO-NTUHNPAUSA-N nifuroxazide Chemical compound C1=CC(O)=CC=C1C(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 YCWSUKQGVSGXJO-NTUHNPAUSA-N 0.000 description 1
229960003888 nifuroxazide Drugs 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
229960001699 ofloxacin Drugs 0.000 description 1
229960002313 ornidazole Drugs 0.000 description 1
229960001019 oxacillin Drugs 0.000 description 1
UWYHMGVUTGAWSP-JKIFEVAISA-N oxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=CC=CC=C1 UWYHMGVUTGAWSP-JKIFEVAISA-N 0.000 description 1
239000002245 particle Substances 0.000 description 1
230000008506 pathogenesis Effects 0.000 description 1
230000008756 pathogenetic mechanism Effects 0.000 description 1
235000019371 penicillin G benzathine Nutrition 0.000 description 1
229940056360 penicillin g Drugs 0.000 description 1
229940056367 penicillin v Drugs 0.000 description 1
208000011906 peptic ulcer disease Diseases 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 description 1
229960002292 piperacillin Drugs 0.000 description 1
WCMIIGXFCMNQDS-IDYPWDAWSA-M piperacillin sodium Chemical compound [Na+].O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C([O-])=O)C(C)(C)S[C@@H]21 WCMIIGXFCMNQDS-IDYPWDAWSA-M 0.000 description 1
229960003342 pivampicillin Drugs 0.000 description 1
ZEMIJUDPLILVNQ-ZXFNITATSA-N pivampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)[C@H](C(S3)(C)C)C(=O)OCOC(=O)C(C)(C)C)=CC=CC=C1 ZEMIJUDPLILVNQ-ZXFNITATSA-N 0.000 description 1
229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
239000004584 polyacrylic acid Substances 0.000 description 1
229950005134 polycarbophil Drugs 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
239000004926 polymethyl methacrylate Substances 0.000 description 1
229920002689 polyvinyl acetate Polymers 0.000 description 1
239000011118 polyvinyl acetate Substances 0.000 description 1
229910000160 potassium phosphate Inorganic materials 0.000 description 1
235000011009 potassium phosphates Nutrition 0.000 description 1
239000008213 purified water Substances 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
230000028327 secretion Effects 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
238000009331 sowing Methods 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
229960004306 sulfadiazine Drugs 0.000 description 1
SEEPANYCNGTZFQ-UHFFFAOYSA-N sulfadiazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC=N1 SEEPANYCNGTZFQ-UHFFFAOYSA-N 0.000 description 1
229960005404 sulfamethoxazole Drugs 0.000 description 1
JLKIGFTWXXRPMT-UHFFFAOYSA-N sulphamethoxazole Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 JLKIGFTWXXRPMT-UHFFFAOYSA-N 0.000 description 1
239000013589 supplement Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
229960004576 temafloxacin Drugs 0.000 description 1
229960004659 ticarcillin Drugs 0.000 description 1
OHKOGUYZJXTSFX-KZFFXBSXSA-N ticarcillin Chemical compound C=1([C@@H](C(O)=O)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)C=CSC=1 OHKOGUYZJXTSFX-KZFFXBSXSA-N 0.000 description 1
229960005053 tinidazole Drugs 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
150000004684 trihydrates Chemical class 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
229910000406 trisodium phosphate Inorganic materials 0.000 description 1
235000019801 trisodium phosphate Nutrition 0.000 description 1
229920003176 water-insoluble polymer Polymers 0.000 description 1
239000001993 wax Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

SI9300330A 1992-06-24 1993-06-23 Peroralna formulacija za zelodcno protibakterijsko terapijo, postopek izdelave in uporaba SI9300330A (sl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE9201930A SE9201930D0 (sv)	1992-06-24	1992-06-24	Gastric antibacterial treatment

Publications (1)

Publication Number	Publication Date
SI9300330A true SI9300330A (sl)	1993-12-31

Family

ID=20386583

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9300330A SI9300330A (sl)	1992-06-24	1993-06-23	Peroralna formulacija za zelodcno protibakterijsko terapijo, postopek izdelave in uporaba

Country Status (5)

Country	Link
AU (1)	AU4517893A (fr)
IS (1)	IS4030A (fr)
SE (1)	SE9201930D0 (fr)
SI (1)	SI9300330A (fr)
WO (1)	WO1994000112A1 (fr)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0995447A1 (fr) *	1993-09-09	2000-04-26	Takeda Chemical Industries, Ltd.	Formulation comprenant un agent antibactérien et un agent antiulcère
WO1995026753A1 (fr) *	1994-04-01	1995-10-12	Tsumura & Co.	Procede de production de comprimes a liberation prolongee et de comprimes enteriques
PT758244E (pt)	1994-05-06	2002-04-29	Pfizer	Formas de dosagem libertacao controlada de azitromicina
US5840737A (en)	1996-01-04	1998-11-24	The Curators Of The University Of Missouri	Omeprazole solution and method for using same
IL119627A (en) *	1996-11-17	2002-03-10	Yissum Res Dev Co	PHARMACEUTICAL PREPARATIONS FOR THE CONTROLLED-RELEASE OF AN ACTIVE AGENT COMPRISING AT LEAST ONE β-LACTAM ANTIBIOTIC AGENT
SE9700885D0 (sv) *	1997-03-12	1997-03-12	Astra Ab	New pharmaceutical formulation
US6428813B1 (en)	1997-03-25	2002-08-06	Takeda Chemical Industries, Ltd.	Gastrointestinal mucosa-adherent pharmaceutical composition
GB9710699D0 (en) *	1997-05-24	1997-07-16	Danbiosyst Uk	Gastro-retentive controlled release system
US6694692B2 (en)	1998-10-16	2004-02-24	Francesco Piccone	Modular formwork elements and assembly
JP2006522099A (ja) *	2003-04-04	2006-09-28	ファルマシアコーポレーション	複合粒状体からなる経口徐放性圧縮錠
US8993599B2 (en)	2003-07-18	2015-03-31	Santarus, Inc.	Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
EP1689368B1 (fr)	2003-12-04	2016-09-28	Bend Research, Inc	Procédé d'atomisation/congélation faisant appel à une extrudeuse pour la préparation de compositions médicamenteuses cristallines multiparticulaires
US6984403B2 (en)	2003-12-04	2006-01-10	Pfizer Inc.	Azithromycin dosage forms with reduced side effects
NZ548844A (en) *	2004-01-06	2011-03-31	Panacea Biotec Ltd	Controlled release pharmaceutical composition comprising an acid-insoluble polymer and bioadhesive polymer
US8906940B2 (en)	2004-05-25	2014-12-09	Santarus, Inc.	Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
EP1784167A2 (fr) *	2004-08-27	2007-05-16	Spherics, Inc.	Comprimes multicouche et formes posologiques bioadhesives
CN101410109A (zh) *	2006-03-24	2009-04-15	万能药生物有限公司	抗生素的调节释放组合物及其制备方法
RU2006132127A (ru) *	2006-09-06	2008-03-20	Государственное Учреждение Научный Центр Здоровьядетей Российской Академии Медицинских Наук (Гу Нцзд Рамн) (Ru)	Применение нифуроксазида в качестве компонента комбинированной лекарственной терапии заболеваний, ассоциированных с helicobacter pylori, и способ лечения, направленный на эрадикацию возбудителя

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9010039D0 (en) *	1990-05-03	1990-06-27	Reckitt & Colmann Prod Ltd	Medicament preparation
AU8219191A (en) *	1990-06-14	1992-01-07	Kalmo Enterprises, Inc.	Stable aqueous drug suspensions
ZA919764B (en) *	1990-12-11	1992-09-30	Brocades Pharma Bv	Heterocyclic carboxylic esters,methods for their preparation and their use for the preparation of gastro-intestinal medicines

1992
- 1992-06-24 SE SE9201930A patent/SE9201930D0/xx unknown
1993
- 1993-06-09 IS IS4030A patent/IS4030A/is unknown
- 1993-06-11 AU AU45178/93A patent/AU4517893A/en not_active Abandoned
- 1993-06-11 WO PCT/SE1993/000521 patent/WO1994000112A1/fr not_active Ceased
- 1993-06-23 SI SI9300330A patent/SI9300330A/sl unknown

Also Published As

Publication number	Publication date
SE9201930D0 (sv)	1992-06-24
IS4030A (is)	1993-12-25
WO1994000112A1 (fr)	1994-01-06
AU4517893A (en)	1994-01-24

Publication	Publication Date	Title
SI9300330A (sl)	1993-12-31	Peroralna formulacija za zelodcno protibakterijsko terapijo, postopek izdelave in uporaba
JP3725542B2 (ja)	2005-12-14	ピコサルフェート剤形
US5559096A (en)	1996-09-24	Pharmaceutical compositions against gastric disorders
EP1025841B1 (fr)	2002-06-05	Tablettes d'amoxycilline bicouches
CN1041798C (zh)	1999-01-27	具有抑制胃酸分泌作用的物质与可被酸降解的抗生素的协同组合物
RU2590979C2 (ru)	2016-07-10	Составы l-ментола, состоящие из множества частиц, и связанные с ними способы
JP3633936B2 (ja)	2005-03-30	センナ剤形
NZ220096A (en)	1990-04-26	Omeprazole compositions
EP1341524B1 (fr)	2011-10-19	Preparation pharmaceutique en pate comprenant un ingredient actif labile en milieu acide
IL136827A (en)	2007-05-15	Pharmaceutical dosage form for oral administration with prolonged release
JP2000514051A (ja)	2000-10-24	ベンズイミダゾール誘導体を活性成分とする経口投与用の安定な薬剤形およびその製造方法
CA2628907A1 (fr)	2007-06-07	Forme de dosage pharmaceutique pour la voie orale comprenant comme ingredients actifs un inhibiteur de la pompe a protons ainsi que de l'acide acetylsalicylique
EP2601938A1 (fr)	2013-06-12	Compositions pharmqaceutiques pour le traitement de maladies associées à Hélicobacter pylori
EP1341523B1 (fr)	2013-01-23	Preparation pharmaceutique sous forme de suspension contenant un ingredient actif labile en milieu acide
UA120249C2 (uk)	2019-11-11	Фармацевтичні композиції для лікування від helicobacter pylori
WO2005027876A1 (fr)	2005-03-31	Compositions pharmaceutiques de benzimidazole et leurs procedes de preparation
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