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SI9111110B - Process and device for dosing powders - Google Patents

Process and device for dosing powders Download PDF

Info

Publication number
SI9111110B
SI9111110B SI9111110A SI9111110A SI9111110B SI 9111110 B SI9111110 B SI 9111110B SI 9111110 A SI9111110 A SI 9111110A SI 9111110 A SI9111110 A SI 9111110A SI 9111110 B SI9111110 B SI 9111110B
Authority
SI
Slovenia
Prior art keywords
carrier
powder
coated
fibers
suspension
Prior art date
Application number
SI9111110A
Other languages
Slovenian (sl)
Other versions
SI9111110A (en
Inventor
Arun Rajaram Gupte
Dieter Hochrainer
Gerhard Poss
Juergen Wittekind
Bernd Zierenberg
Adolf Knecht
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4020571A external-priority patent/DE4020571A1/en
Priority claimed from DE19914102793 external-priority patent/DE4102793A1/en
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of SI9111110A publication Critical patent/SI9111110A/en
Publication of SI9111110B publication Critical patent/SI9111110B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/26—Methods or devices for controlling the quantity of the material fed or filled
    • B65B3/34—Methods or devices for controlling the quantity of the material fed or filled by timing of filling operations
    • B65B3/36—Methods or devices for controlling the quantity of the material fed or filled by timing of filling operations and arresting flow by cut-off means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0225—Carbon oxides, e.g. Carbon dioxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/073—Syringe, piston type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/075—Bulb type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8218—Gas operated
    • A61M2205/8225—Gas operated using incorporated gas cartridges for the driving gas

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mechanical Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • External Artificial Organs (AREA)
  • Electrostatic Spraying Apparatus (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Nozzles (AREA)
  • Apparatuses For Bulk Treatment Of Fruits And Vegetables And Apparatuses For Preparing Feeds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Vending Machines For Individual Products (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Basic Packing Technique (AREA)
  • Saccharide Compounds (AREA)
  • Holding Or Fastening Of Disk On Rotational Shaft (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Refuse Collection And Transfer (AREA)
  • Disintegrating Or Milling (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

In order to produce an aerosol, a velvety or velours-like material charged with a powder is brought into an air current.

Claims (12)

1 PATENTNI ZAHTEVKI 1. Nosilec (12), obložen s praškastim pripravkom zdravila, označen s tem, da obstaja iz materiala, ki je v bistvu raven, na katerem so razporejena žametna ali veluma vlakna in je prašek vložen med vlakna.A carrier (12) coated with a powdered preparation of a medicament, characterized in that it consists of a material which is essentially a level at which velvet or velum fibers are arranged and the powder is deposited between the fibers. 2. Nosilec (12) obložen s praškom, po zahtevku 1, označen s tem, da znaša dolžina vlakna 0,1 do 3 mm.Powder-coated carrier (12) according to Claim 1, characterized in that the fiber length is 0.1 to 3 mm. 3. Nosilec (12), obložen s praškom, po zahtevku 1 ali 2, označen s tem, da je sloj, ki nosi vlakna, fleksibilen.Powder-coated carrier (12) according to Claim 1 or 2, characterized in that the fiber-bearing layer is flexible. 4. Nosilec (12), obložen s praškom, po zahtevku 1 ah 2, označen s tem, da je sloj, ki nosi vlakna tog.Powder-coated carrier (12) according to Claim 1 ah 2, characterized in that the layer carrying the fibers is rigid. 5. Nosilec (12), obložen s praškom, po zahtevku 1 do 4, označen s tem, da je celotna ploskev nosilca enakomerno obložena s praškom.Powder-coated carrier (12) according to Claims 1 to 4, characterized in that the entire surface of the carrier is evenly coated with powder. 6. Nosilec (12), obložen s praškom, po zahtevkih 1 do 4, označen s tem, da so samo delne ploskve nosilca obložene s praškom, pri čemer vsebujejo posamezne obložene delne ploskve nosilca vsakokrat posamezno dozo zdravila.Powder-coated carrier (12) according to Claims 1 to 4, characterized in that only the partial surfaces of the carrier are powder-coated, the individual coated partial surfaces of the carrier each containing a single dose of medicament. 7. Nosilec (12), obložen s praškom, po zahtevkih 1 do 6, označen s tem, da je nosilec opremljen na strani, kije obložena s praškom, ali na obeh straneh z zaščitno folijo.Powder-coated carrier (12) according to Claims 1 to 6, characterized in that the carrier is provided on the powder-coated side or on both sides with a protective foil. 8. Postopek za doziranje praškov za inhalacijo, označen s tem, da s plinskim curkom iz nosilca (12) po zahtevkih 1 do 7 izpihamo definirano količino praška in disper-giramo v dihalnem zraku.Method for dosing powders for inhalation, characterized in that a defined amount of powder is blown out of the carrier (12) with a gas jet according to claims 1 to 7 and dispersed in the respiratory air. 9. Postopek po zahtevku 8, označen s tem, da tisto ploskev nosilca (12) iz katere naj izpihamo prašek, omejimo z masko.Method according to Claim 8, characterized in that the surface of the carrier (12) from which the powder is to be blown is bounded by a mask. 10. Postopek za pripravo nosilca (12) po zahtevkih 1 do 7, označen s tem, da prašek enakomerno porazdelimo na nosilcu in z raklom vdelamo v eni ali več stopenj v sloj vlakna.Method for preparing the carrier (12) according to Claims 1 to 7, characterized in that the powder is evenly distributed on the carrier and incorporated into the fiber layer in one or more stages with a squeegee. 11. Postopek za pripravo nosilca (12) po zahtevkih 1 do 7, označen s tem, da prašek 2 nanesemo na žameten ali velumi nosilec v obliki majhne količine suspenzije in suspenzijsko sredstvo uparimo.Process for the preparation of a carrier (12) according to Claims 1 to 7, characterized in that the powder 2 is applied to a velvet or velum carrier in the form of a small amount of suspension and the suspension agent is evaporated. 12. Postopek za doziranje praškov za inhalacijo, označen s tem, da posamezne doze praška nanesemo na nosilec (12) po zahtevkih 1 do 7 v obliki suspenzije, po osušenju aktiviramo, s plinskim curkom pihnemo iz nosilca in dispergiramo v dihalnem zraku. Za BOEHRINGERINGELHEIM KG:Method for dosing powders for inhalation, characterized in that individual doses of powder are applied to the carrier (12) according to claims 1 to 7 in the form of a suspension, activated after drying, blown out of the carrier by a gas jet and dispersed in respiratory air. For BOEHRINGERINGELHEIM KG:
SI9111110A 1990-06-28 1991-06-25 Process and device for dosing powders SI9111110B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4020571A DE4020571A1 (en) 1990-06-28 1990-06-28 METHOD AND DEVICE FOR POWDER DOSING
DE19914102793 DE4102793A1 (en) 1991-01-31 1991-01-31 Medication powder-dosing carrier
YU111091A YU48708B (en) 1990-06-28 1991-06-25 CARRIER COATED WITH POWDER PHARMACEUTICAL PREPARATION, PROCEDURE FOR PREPARING CARRIER AND PROCEDURE FOR DOSAGE OF INHALING POWDERS

Publications (2)

Publication Number Publication Date
SI9111110A SI9111110A (en) 1997-02-28
SI9111110B true SI9111110B (en) 1999-06-30

Family

ID=25894544

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9111110A SI9111110B (en) 1990-06-28 1991-06-25 Process and device for dosing powders

Country Status (24)

Country Link
EP (1) EP0536232B1 (en)
JP (1) JP3307389B2 (en)
KR (1) KR0179375B1 (en)
AT (1) ATE127353T1 (en)
AU (1) AU661274B2 (en)
CA (1) CA2086123C (en)
CZ (1) CZ283510B6 (en)
DE (1) DE59106431D1 (en)
DK (1) DK0536232T3 (en)
ES (1) ES2078530T3 (en)
FI (1) FI104410B (en)
GR (1) GR3017782T3 (en)
HU (1) HU216129B (en)
IE (1) IE69035B1 (en)
IL (1) IL98637A (en)
NO (1) NO304295B1 (en)
NZ (1) NZ238783A (en)
PL (1) PL165973B1 (en)
PT (1) PT98112B (en)
RU (1) RU2068274C1 (en)
SI (1) SI9111110B (en)
UA (1) UA27765C2 (en)
WO (1) WO1992000115A1 (en)
YU (1) YU48708B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048857A (en) * 1989-10-17 2000-04-11 Ellinwood, Jr.; Everett H. Dosing method of administering medicaments via inhalation administration
DE4142238A1 (en) * 1991-12-20 1993-06-24 Boehringer Ingelheim Kg POWDER INHALATOR WITH POWDER SUPPORT FROM REGULAR MICROSTRUCTURES
SE9203570D0 (en) * 1992-11-27 1992-11-27 Astra Ab INHALES FOR MULTIPLE USE
US5388572A (en) * 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5388573A (en) * 1993-12-02 1995-02-14 Tenax Corporation Dry powder inhalator medicament carrier
CZ287811B6 (en) * 1994-10-21 2001-02-14 Glaxo Wellcome Inc Medicament carrier for use in a dry powder inhalator device
US5503869A (en) * 1994-10-21 1996-04-02 Glaxo Wellcome Inc. Process for forming medicament carrier for dry powder inhalator
US5647347A (en) * 1994-10-21 1997-07-15 Glaxo Wellcome Inc. Medicament carrier for dry powder inhalator
GB9610821D0 (en) * 1996-05-23 1996-07-31 Glaxo Wellcome Inc Metering apparatus
US5871010A (en) * 1996-06-10 1999-02-16 Sarnoff Corporation Inhaler apparatus with modified surfaces for enhanced release of dry powders
GB9616047D0 (en) 1996-07-31 1996-09-11 Glaxo Group Ltd Medicament carrier with agglomerated large medicament particles and related method of manufacture thereof
WO2001094027A2 (en) * 2000-06-05 2001-12-13 Nordson Corporation Apparatus and methods for dispensing minute amounts of liquid
JP5020257B2 (en) * 2005-12-22 2012-09-05 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム Inhaler
CN108814979B (en) * 2018-04-17 2020-09-22 吉林省中医药科学院 A solid medicine feed ware for paediatrics
CN113650947B (en) * 2021-08-24 2022-10-18 王霞 Accurate medicine bottle of getting of traditional chinese medicine dripping pill

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2837040C2 (en) * 1978-08-24 1982-10-21 Siemens AG, 1000 Berlin und 8000 München Liquid transport system for an inhalation device
CA2058764A1 (en) * 1989-04-28 1990-10-29 Peter D. Hodson Dry powder inhalation device
GB8909891D0 (en) * 1989-04-28 1989-06-14 Riker Laboratories Inc Device

Also Published As

Publication number Publication date
NO304295B1 (en) 1998-11-30
CA2086123A1 (en) 1991-12-29
KR930701206A (en) 1993-06-11
DE59106431D1 (en) 1995-10-12
IE69035B1 (en) 1996-08-07
PL165973B1 (en) 1995-03-31
AU8063891A (en) 1992-01-23
ATE127353T1 (en) 1995-09-15
KR0179375B1 (en) 1999-04-01
NO925010D0 (en) 1992-12-23
NZ238783A (en) 1994-09-27
IE912245A1 (en) 1992-01-01
WO1992000115A1 (en) 1992-01-09
GR3017782T3 (en) 1996-01-31
YU111091A (en) 1994-11-15
SI9111110A (en) 1997-02-28
PT98112B (en) 1998-12-31
PT98112A (en) 1993-09-30
IL98637A0 (en) 1992-07-15
FI104410B (en) 2000-01-31
ES2078530T3 (en) 1995-12-16
HUT63775A (en) 1993-10-28
AU661274B2 (en) 1995-07-20
YU48708B (en) 1999-07-28
EP0536232A1 (en) 1993-04-14
IL98637A (en) 1998-01-04
UA27765C2 (en) 2000-10-16
JPH05508334A (en) 1993-11-25
CA2086123C (en) 2002-01-01
DK0536232T3 (en) 1996-01-22
JP3307389B2 (en) 2002-07-24
FI925882A0 (en) 1992-12-28
CZ386192A3 (en) 1993-10-13
RU2068274C1 (en) 1996-10-27
FI925882L (en) 1992-12-28
HU9204100D0 (en) 1993-05-28
HU216129B (en) 1999-04-28
CZ283510B6 (en) 1998-04-15
EP0536232B1 (en) 1995-09-06
NO925010L (en) 1993-01-29

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Effective date: 20050406