SI4028017T1 - 1,4-dihidrobenzo(d)pirazolo(3,4-f)(1,3)diazepin derivati in sorodne spojine kot modulatorji lrrk2, nuak1 in/ali tyk2 kinaze za zdravljenje npr. avtoimunske bolezni - Google Patents
1,4-dihidrobenzo(d)pirazolo(3,4-f)(1,3)diazepin derivati in sorodne spojine kot modulatorji lrrk2, nuak1 in/ali tyk2 kinaze za zdravljenje npr. avtoimunske bolezniInfo
- Publication number
- SI4028017T1 SI4028017T1 SI202030353T SI202030353T SI4028017T1 SI 4028017 T1 SI4028017 T1 SI 4028017T1 SI 202030353 T SI202030353 T SI 202030353T SI 202030353 T SI202030353 T SI 202030353T SI 4028017 T1 SI4028017 T1 SI 4028017T1
- Authority
- SI
- Slovenia
- Prior art keywords
- nuak1
- lrrk2
- npr
- dihydrobenzo
- pyrazolo
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 title 1
- 101000970023 Homo sapiens NUAK family SNF1-like kinase 1 Proteins 0.000 title 1
- 101000844245 Homo sapiens Non-receptor tyrosine-protein kinase TYK2 Proteins 0.000 title 1
- 108010020246 Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Proteins 0.000 title 1
- 102100032693 Leucine-rich repeat serine/threonine-protein kinase 2 Human genes 0.000 title 1
- ORQJPWRNWPJVTJ-UHFFFAOYSA-N N1N=CC2=C1C1=C(N=CN2)C=CC=C1 Chemical class N1N=CC2=C1C1=C(N=CN2)C=CC=C1 ORQJPWRNWPJVTJ-UHFFFAOYSA-N 0.000 title 1
- 102100021732 NUAK family SNF1-like kinase 1 Human genes 0.000 title 1
- 102100032028 Non-receptor tyrosine-protein kinase TYK2 Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 238000011282 treatment Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P27/00—Drugs for disorders of the senses
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- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Toxicology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962899908P | 2019-09-13 | 2019-09-13 | |
| PCT/IB2020/000730 WO2021048620A1 (en) | 2019-09-13 | 2020-09-11 | 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as lrrk2, nuak1 and/or tyk2 kinase modulators for the treatment of e.g. autoimmune disease |
| EP20788868.6A EP4028017B1 (en) | 2019-09-13 | 2020-09-11 | 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as lrrk2, nuak1 and/or tyk2 kinase modulators for the treatment of e.g. autoimmune diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI4028017T1 true SI4028017T1 (sl) | 2024-04-30 |
Family
ID=72801756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI202030353T SI4028017T1 (sl) | 2019-09-13 | 2020-09-11 | 1,4-dihidrobenzo(d)pirazolo(3,4-f)(1,3)diazepin derivati in sorodne spojine kot modulatorji lrrk2, nuak1 in/ali tyk2 kinaze za zdravljenje npr. avtoimunske bolezni |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20220380374A1 (sl) |
| EP (2) | EP4028017B1 (sl) |
| JP (2) | JP2022548246A (sl) |
| KR (1) | KR20220062038A (sl) |
| CN (2) | CN114793435B (sl) |
| AU (1) | AU2020344216A1 (sl) |
| CA (1) | CA3154123A1 (sl) |
| DK (1) | DK4028017T3 (sl) |
| ES (1) | ES2969088T3 (sl) |
| FI (1) | FI4028017T3 (sl) |
| HU (1) | HUE065093T2 (sl) |
| IL (1) | IL291335A (sl) |
| PL (1) | PL4028017T3 (sl) |
| PT (1) | PT4028017T (sl) |
| RS (1) | RS65045B1 (sl) |
| SI (1) | SI4028017T1 (sl) |
| WO (1) | WO2021048620A1 (sl) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115103844A (zh) * | 2019-09-13 | 2022-09-23 | 原真股份有限公司 | 用于治疗例如自身免疫性疾病的作为lrrk2、nuak1和/或tyk2激酶调节剂的1,4-二氢苯并[d]吡唑并[3,4-f][1,3]二氮杂卓衍生物和相关化合物 |
| RS65045B1 (sr) * | 2019-09-13 | 2024-02-29 | Origenis Gmbh | Derivati 1,4-dihidrobenzo[d]pirazolo[3,4-f][1,3]diazepina i srodna jedinjenja kao modulatori kinaze lrrk2, nuak1 i/ili tyk2 za lečenje npr. autoimunih bolesti |
| IL312330A (en) | 2021-10-25 | 2024-06-01 | Kymera Therapeutics Inc | Tyk2 degraders and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009300357B2 (en) * | 2008-09-23 | 2014-07-03 | The Johns Hopkins University | Fused diimidazodiazepine compounds and methods of use and manufacture thereof |
| SG194216A1 (en) * | 2011-04-21 | 2013-11-29 | Origenis Gmbh | Heterocyclic compounds as kinase inhibitors |
| EP3350178B1 (en) * | 2015-09-14 | 2021-10-20 | Pfizer Inc. | Novel imidazo [4,5-c]quinoline and imidazo [4,5-c][1,5]naphthyridine derivatives as lrrk2 inhibitors |
| CN115103844A (zh) * | 2019-09-13 | 2022-09-23 | 原真股份有限公司 | 用于治疗例如自身免疫性疾病的作为lrrk2、nuak1和/或tyk2激酶调节剂的1,4-二氢苯并[d]吡唑并[3,4-f][1,3]二氮杂卓衍生物和相关化合物 |
| RS65045B1 (sr) * | 2019-09-13 | 2024-02-29 | Origenis Gmbh | Derivati 1,4-dihidrobenzo[d]pirazolo[3,4-f][1,3]diazepina i srodna jedinjenja kao modulatori kinaze lrrk2, nuak1 i/ili tyk2 za lečenje npr. autoimunih bolesti |
-
2020
- 2020-09-11 RS RS20240045A patent/RS65045B1/sr unknown
- 2020-09-11 WO PCT/IB2020/000730 patent/WO2021048620A1/en not_active Ceased
- 2020-09-11 KR KR1020227011532A patent/KR20220062038A/ko active Pending
- 2020-09-11 JP JP2022516097A patent/JP2022548246A/ja active Pending
- 2020-09-11 CA CA3154123A patent/CA3154123A1/en active Pending
- 2020-09-11 AU AU2020344216A patent/AU2020344216A1/en active Pending
- 2020-09-11 CN CN202080078998.0A patent/CN114793435B/zh active Active
- 2020-09-11 HU HUE20788868A patent/HUE065093T2/hu unknown
- 2020-09-11 US US17/642,142 patent/US20220380374A1/en not_active Abandoned
- 2020-09-11 SI SI202030353T patent/SI4028017T1/sl unknown
- 2020-09-11 DK DK20788868.6T patent/DK4028017T3/da active
- 2020-09-11 ES ES20788868T patent/ES2969088T3/es active Active
- 2020-09-11 EP EP20788868.6A patent/EP4028017B1/en active Active
- 2020-09-11 CN CN202411291626.2A patent/CN119775277A/zh active Pending
- 2020-09-11 PL PL20788868.6T patent/PL4028017T3/pl unknown
- 2020-09-11 EP EP23205855.2A patent/EP4327884A3/en active Pending
- 2020-09-11 PT PT207888686T patent/PT4028017T/pt unknown
- 2020-09-11 FI FIEP20788868.6T patent/FI4028017T3/fi active
-
2022
- 2022-03-13 IL IL291335A patent/IL291335A/en unknown
-
2025
- 2025-02-26 JP JP2025028912A patent/JP2025081660A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4327884A3 (en) | 2024-05-01 |
| HUE065093T2 (hu) | 2024-05-28 |
| KR20220062038A (ko) | 2022-05-13 |
| AU2020344216A1 (en) | 2022-03-31 |
| ES2969088T3 (es) | 2024-05-16 |
| FI4028017T3 (fi) | 2024-01-11 |
| CN119775277A (zh) | 2025-04-08 |
| WO2021048620A1 (en) | 2021-03-18 |
| DK4028017T3 (da) | 2024-01-15 |
| CN114793435B (zh) | 2024-10-01 |
| EP4028017A1 (en) | 2022-07-20 |
| CA3154123A1 (en) | 2021-03-18 |
| RS65045B1 (sr) | 2024-02-29 |
| JP2022548246A (ja) | 2022-11-17 |
| CN114793435A (zh) | 2022-07-26 |
| EP4327884A2 (en) | 2024-02-28 |
| EP4028017B1 (en) | 2023-12-06 |
| US20220380374A1 (en) | 2022-12-01 |
| PL4028017T3 (pl) | 2024-03-18 |
| IL291335A (en) | 2022-05-01 |
| PT4028017T (pt) | 2024-01-16 |
| JP2025081660A (ja) | 2025-05-27 |
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