[go: up one dir, main page]

SI3596080T1 - Farmakološko aktivni aliciklični-substituirani pirazolo-(1,5-a)pirimidinski derivati - Google Patents

Farmakološko aktivni aliciklični-substituirani pirazolo-(1,5-a)pirimidinski derivati

Info

Publication number
SI3596080T1
SI3596080T1 SI201830495T SI201830495T SI3596080T1 SI 3596080 T1 SI3596080 T1 SI 3596080T1 SI 201830495 T SI201830495 T SI 201830495T SI 201830495 T SI201830495 T SI 201830495T SI 3596080 T1 SI3596080 T1 SI 3596080T1
Authority
SI
Slovenia
Prior art keywords
pharmacologically active
pyrimidine derivatives
substituted pyrazolo
active alicyclic
alicyclic
Prior art date
Application number
SI201830495T
Other languages
English (en)
Inventor
Istvan Borza
Viktor Roman
Janos Eles
Zsuzsa Hadady
Original Assignee
Richter Gedeon Nyrt.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt., filed Critical Richter Gedeon Nyrt.,
Publication of SI3596080T1 publication Critical patent/SI3596080T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI201830495T 2017-03-13 2018-03-12 Farmakološko aktivni aliciklični-substituirani pirazolo-(1,5-a)pirimidinski derivati SI3596080T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU1700108A HU231058B1 (hu) 2017-03-13 2017-03-13 Gyógyászatilag hatékony aliciklusos-szubsztituált pirazolo[1,5-a]pirimidin származékok
PCT/IB2018/051599 WO2018167630A1 (en) 2017-03-13 2018-03-12 PHARMACOLOGICALLY ACTIVE ALICYCLIC-SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES
EP18713016.6A EP3596080B1 (en) 2017-03-13 2018-03-12 Pharmacologically active alicyclic-substituted pyrazolo[1,5-a]pyrimidine derivatives

Publications (1)

Publication Number Publication Date
SI3596080T1 true SI3596080T1 (sl) 2022-01-31

Family

ID=89992389

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201830495T SI3596080T1 (sl) 2017-03-13 2018-03-12 Farmakološko aktivni aliciklični-substituirani pirazolo-(1,5-a)pirimidinski derivati

Country Status (32)

Country Link
US (1) US11026946B2 (sl)
EP (1) EP3596080B1 (sl)
JP (1) JP7153662B2 (sl)
KR (1) KR20190127779A (sl)
CN (1) CN110431142A (sl)
AR (1) AR111176A1 (sl)
AU (1) AU2018235266B2 (sl)
BR (1) BR112019018843A2 (sl)
CA (1) CA3056185A1 (sl)
CL (1) CL2019002601A1 (sl)
CO (1) CO2019010120A2 (sl)
CY (1) CY1124708T1 (sl)
DK (1) DK3596080T3 (sl)
EA (1) EA038756B1 (sl)
EC (1) ECSP19072975A (sl)
ES (1) ES2893824T3 (sl)
GE (1) GEP20217256B (sl)
HR (1) HRP20211850T1 (sl)
HU (2) HU231058B1 (sl)
IL (1) IL268923A (sl)
LT (1) LT3596080T (sl)
MX (1) MX2019011000A (sl)
MY (1) MY195262A (sl)
PE (1) PE20191646A1 (sl)
PH (1) PH12019501968A1 (sl)
PL (1) PL3596080T3 (sl)
PT (1) PT3596080T (sl)
RS (1) RS62533B1 (sl)
SG (1) SG11201907864YA (sl)
SI (1) SI3596080T1 (sl)
UA (1) UA124783C2 (sl)
WO (1) WO2018167630A1 (sl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201991898A1 (ru) 2017-03-13 2020-02-07 Эбайд Терапьютикс, Инк. Двойные ингибиторы magl и faah
HU231057B1 (hu) 2017-03-13 2020-04-28 Richter Gedeon Nyrt Gyógyászatilag hatékony aril-szubsztituált pirazolo[1,5-a]pirimidin származékok
WO2021191838A1 (en) 2020-03-26 2021-09-30 Richter Gedeon Nyrt. NAPHTHYRIDINE AND PYRIDO[3,4-c]PYRIDAZINE DERIVATIVES AS GABAA α5 RECEPTOR MODULATORS
AU2021319420A1 (en) * 2020-08-05 2023-03-16 Richter Gedeon Nyrt. Pharmacologically active heterocyclic-substituted pyrazolo[1,5-a]pyrimidine derivatives
HU231691B1 (hu) 2021-09-29 2025-10-28 Richter Gedeon Nyrt GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok
CN115872095A (zh) * 2022-11-28 2023-03-31 南通三鑫车灯配件有限公司 一种汽车车灯反光罩的生产线流转装置

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2382033C2 (ru) 2004-03-02 2010-02-20 Ф.Хоффманн-Ля Рош Аг Производные 4-(сульфанилпиримидин-4-илметил)морфолина в качестве лигандов gaba-рецептора для лечения тревожности, депрессии и эпилепсии
GB0512844D0 (en) 2005-06-23 2005-08-03 Novartis Ag Organic compounds
KR100753017B1 (ko) 2006-05-25 2007-08-30 한국화학연구원 7-(3,4-디알콕시페닐)-피라졸로[1,5-ａ]피리미딘 화합물을포함하는 관절염, 아토피 피부염, 백혈병을 포함한 암 및알쯔하이머, 우울증 또는 기억력 감소 등의 뇌질환의 치료및 예방을 위한 약제학적 조성물
US8461163B2 (en) * 2008-03-31 2013-06-11 Takeda Pharmaceutical Company Limited Substituted N-(pyrazolo[1,5-a]pyrimidin-5-yl)amides as inhibitors of apoptosis signal-regulating kinase 1
TWI648281B (zh) 2013-10-17 2019-01-21 日商安斯泰來製藥股份有限公司 含硫二環式化合物
US9828381B2 (en) 2015-04-20 2017-11-28 AbbVie Deutschland GmbH & Co. KG Substituted pyrazolopyrimidines and method of use
JP2018199623A (ja) * 2015-10-22 2018-12-20 大正製薬株式会社 含窒素縮合複素環化合物
HU231057B1 (hu) 2017-03-13 2020-04-28 Richter Gedeon Nyrt Gyógyászatilag hatékony aril-szubsztituált pirazolo[1,5-a]pirimidin származékok

Also Published As

Publication number Publication date
AR111176A1 (es) 2019-06-12
EA038756B1 (ru) 2021-10-14
US20200129515A1 (en) 2020-04-30
BR112019018843A2 (pt) 2020-04-14
RS62533B1 (sr) 2021-11-30
PL3596080T3 (pl) 2022-01-31
AU2018235266A1 (en) 2019-10-17
WO2018167630A1 (en) 2018-09-20
EP3596080A1 (en) 2020-01-22
CA3056185A1 (en) 2018-09-20
UA124783C2 (uk) 2021-11-17
CO2019010120A2 (es) 2019-10-09
HU231058B1 (hu) 2020-04-28
MY195262A (en) 2023-01-11
JP7153662B2 (ja) 2022-10-14
IL268923A (en) 2019-10-31
HUP1700108A2 (en) 2018-09-28
PE20191646A1 (es) 2019-11-07
LT3596080T (lt) 2021-11-25
EP3596080B1 (en) 2021-09-01
ES2893824T3 (es) 2022-02-10
PH12019501968A1 (en) 2020-06-29
KR20190127779A (ko) 2019-11-13
JP2020510041A (ja) 2020-04-02
SG11201907864YA (en) 2019-09-27
CY1124708T1 (el) 2022-07-22
AU2018235266B2 (en) 2021-09-30
ECSP19072975A (es) 2019-11-30
EA201992127A1 (ru) 2020-02-06
HRP20211850T1 (hr) 2022-03-04
US11026946B2 (en) 2021-06-08
HUE056562T2 (hu) 2022-02-28
CL2019002601A1 (es) 2020-01-24
CN110431142A (zh) 2019-11-08
MX2019011000A (es) 2019-10-17
PT3596080T (pt) 2021-10-22
DK3596080T3 (da) 2021-11-15
GEP20217256B (en) 2021-05-25

Similar Documents

Publication Publication Date Title
IL260923B (en) History of pyrazolo[5,1-a]pyrazin-4-yl as jak inhibitors
SI3596080T1 (sl) Farmakološko aktivni aliciklični-substituirani pirazolo-(1,5-a)pirimidinski derivati
IL266170A (en) A process for the preparation of pyrazolo[1,5-a]pyrimidines and their salts
IL266305B (en) History of [4,2,1]triazolo[5,1-a]pyrimidine as pde2 inhibitors
EP3268000A4 (en) Pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives as cdk inhibitors
SI3305785T1 (sl) Derivat pirido(3,4-D)pirimidina in njegova farmacevtsko sprejemljiva sol
IL262673A (en) A pyrazolo[5,1-a]pyrimidine compound
IL290419B (en) Imidazo[a-1,5]pyrazine derivatives as inhibitors of pi3k delta
HUE056561T2 (hu) Gyógyászatilag hatékony aril-szubsztituált pirazolo[1,5-a]pirimidin származékok
IL272988A (en) Imidazo-[1,5-A]pyrazine derivatives as PI3K-delta inhibitors
ZA201902893B (en) Pyrido[3, 4-d]pyrimidine derivative and pharmaceutically acceptable salt thereof
EP3196199A4 (en) Substituted n-(pyrrolidine-3-yl)-7h-pyrrolo[2,3-d]pyrimidine-4-amine as janus kinase inhibitor
EP3730492A4 (en) COMPOUND PYRAZOLO [1,5-A] PYRIMIDINE SUBSTITUTE, PHARMACEUTICAL COMPOSITION AND ASSOCIATED USE
EP3618837A4 (en) MULTI-DIRECTIONAL NUCLEOSIDE DERIVATIVES
EP3903788A4 (en) PYRAZOLO[1,5-A] PYRIMIDINE MACROCYCLIC COMPOUND
HUE052997T2 (hu) JAK kináz inhibitor pirazol[1,5-a]pirimidin származékok