SI3399984T1 - Modulatorji 5'-nukleotidaze, ekto, in njihova uporaba - Google Patents
Modulatorji 5'-nukleotidaze, ekto, in njihova uporabaInfo
- Publication number
- SI3399984T1 SI3399984T1 SI201731439T SI201731439T SI3399984T1 SI 3399984 T1 SI3399984 T1 SI 3399984T1 SI 201731439 T SI201731439 T SI 201731439T SI 201731439 T SI201731439 T SI 201731439T SI 3399984 T1 SI3399984 T1 SI 3399984T1
- Authority
- SI
- Slovenia
- Prior art keywords
- ekto
- nucleotidase
- modulators
- nucleotidase modulators
- Prior art date
Links
- 102000004008 5'-Nucleotidase Human genes 0.000 title 1
- 108010043671 prostatic acid phosphatase Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
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- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
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- C—CHEMISTRY; METALLURGY
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662276564P | 2016-01-08 | 2016-01-08 | |
| US201662324077P | 2016-04-18 | 2016-04-18 | |
| EP17736459.3A EP3399984B1 (en) | 2016-01-08 | 2017-01-06 | Modulators of 5'-nucleotidase, ecto and the use thereof |
| PCT/US2017/012587 WO2017120508A1 (en) | 2016-01-08 | 2017-01-06 | Modulators of 5'-nucleotidase, ecto and the use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3399984T1 true SI3399984T1 (sl) | 2024-01-31 |
Family
ID=59274491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201731439T SI3399984T1 (sl) | 2016-01-08 | 2017-01-06 | Modulatorji 5'-nukleotidaze, ekto, in njihova uporaba |
Country Status (29)
| Country | Link |
|---|---|
| US (5) | US10239912B2 (sl) |
| EP (2) | EP4306525A3 (sl) |
| JP (4) | JP6920344B2 (sl) |
| KR (1) | KR102772803B1 (sl) |
| CN (3) | CN119912510A (sl) |
| AU (2) | AU2017206061B2 (sl) |
| BR (1) | BR112018013827B1 (sl) |
| CA (2) | CA3009196C (sl) |
| CL (1) | CL2018001845A1 (sl) |
| DK (1) | DK3399984T3 (sl) |
| EA (1) | EA038565B1 (sl) |
| ES (1) | ES2963759T3 (sl) |
| FI (1) | FI3399984T3 (sl) |
| HR (1) | HRP20231155T1 (sl) |
| HU (1) | HUE063388T2 (sl) |
| IL (1) | IL260260B2 (sl) |
| LT (1) | LT3399984T (sl) |
| MX (2) | MX2018008350A (sl) |
| MY (1) | MY204877A (sl) |
| PH (1) | PH12018501361A1 (sl) |
| PL (1) | PL3399984T3 (sl) |
| PT (1) | PT3399984T (sl) |
| SA (1) | SA518391985B1 (sl) |
| SG (1) | SG11201805506YA (sl) |
| SI (1) | SI3399984T1 (sl) |
| TW (2) | TW202227095A (sl) |
| UA (1) | UA124529C2 (sl) |
| WO (1) | WO2017120508A1 (sl) |
| ZA (2) | ZA201804350B (sl) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA124529C2 (uk) | 2016-01-08 | 2021-10-05 | Аркус Байосайєнсіз, Інк. | Модулятори екто-5-нуклеотидази та їх застосування |
| US10472364B2 (en) | 2016-09-09 | 2019-11-12 | Calithera Biosciences, Inc. | Ectonucleotidase inhibitors and methods of use thereof |
| CN110022881B (zh) * | 2016-11-18 | 2023-05-02 | 艾库斯生物科学有限公司 | Cd73介导的免疫抑制的抑制剂 |
| MY200641A (en) | 2016-12-08 | 2024-01-08 | Hoffmann La Roche | New isoxazolyl ether derivatives as gaba a alpha5 pam |
| NZ754171A (en) * | 2016-12-22 | 2022-12-23 | Calithera Biosciences Inc | Ectonucleotidase inhibitors and methods of use thereof |
| IL269150B2 (en) | 2017-03-16 | 2025-04-01 | Innate Pharma | Cancer treatment preparations and methods |
| WO2018208980A1 (en) | 2017-05-10 | 2018-11-15 | Oric Pharmaceuticals, Inc. | Cd73 inhibitors |
| JP7274469B2 (ja) | 2017-10-06 | 2023-05-16 | イナート・ファルマ・ソシエテ・アノニム | Cd39/cd73軸によるt細胞活性の回復 |
| US11377469B2 (en) | 2017-11-03 | 2022-07-05 | Oric Pharmaceuticals, Inc. | CD73 inhibitors |
| WO2019129059A1 (zh) * | 2017-12-29 | 2019-07-04 | 上海和誉生物医药科技有限公司 | 一种具有cd73抑制活性的膦酸衍生物、其制备方法和应用 |
| TWI702954B (zh) | 2018-03-01 | 2020-09-01 | 美商美國禮來大藥廠 | Cd73抑制劑 |
| CN112004541A (zh) * | 2018-03-09 | 2020-11-27 | 艾库斯生物科学有限公司 | 肠道外给药的免疫增强药物 |
| KR20210018255A (ko) * | 2018-04-30 | 2021-02-17 | 오릭 파마슈티칼스, 인크. | Cd73 억제제 |
| US12331068B2 (en) | 2018-05-31 | 2025-06-17 | Peloton Therapeutics, Inc. | Compositions and methods for inhibiting CD73 |
| US11377503B2 (en) | 2018-06-18 | 2022-07-05 | Innate Pharma | Antibodies that bind human CD39 and inhibit ATPase activity of a soluble extracellular domain human CD39 polypeptide |
| US20210169911A1 (en) * | 2018-08-17 | 2021-06-10 | The United States Of America,As Represented By The Secretary,Department Of Health And Human Services | Purine and pyrimidine nucleotides as ecto-5'-nucleotidase inhibitors |
| WO2020047082A1 (en) | 2018-08-28 | 2020-03-05 | Eternity Bioscience Inc. | Cd73 inhibitors and therapeutic uses thereof |
| CN110885352B (zh) * | 2018-09-11 | 2023-02-24 | 润佳(苏州)医药科技有限公司 | Cd73抑制剂及其药学应用 |
| US11530234B2 (en) | 2018-09-11 | 2022-12-20 | Risen (Suzhou) Pharma Tech Co., Ltd. | CD73 inhibitors and pharmaceutical uses thereof |
| EP3849992A4 (en) | 2018-09-11 | 2022-06-29 | Risen (Suzhou) Pharma Tech Co., Ltd. | Cd73 inhibitors and pharmaceutical uses thereof |
| EP3893891A4 (en) * | 2018-12-13 | 2022-08-03 | Arcus Biosciences, Inc. | SOLID FORMS OF A CD73 INHIBITOR AND THEIR USE |
| SG11202106963YA (en) | 2019-01-11 | 2021-07-29 | Omeros Corp | Methods and compositions for treating cancer |
| WO2020151707A1 (zh) * | 2019-01-22 | 2020-07-30 | 江苏恒瑞医药股份有限公司 | 一种新型的小分子cd73抑制剂、其制备方法及其在医药上的应用 |
| US12453738B2 (en) | 2019-03-12 | 2025-10-28 | Arcus Biosciences, Inc. | Treatment of oncogene-driven cancers |
| WO2020205538A1 (en) * | 2019-03-29 | 2020-10-08 | Eternity Bioscience Inc. | Cd73 inhibitors and therapeutic uses thereof |
| CA3135487A1 (en) * | 2019-03-29 | 2020-10-08 | Arcus Biosciences, Inc. | Treatment of cancer utilizing an identified adenosine fingerprint |
| JP2022527556A (ja) * | 2019-04-05 | 2022-06-02 | プレリュード・セラピューティクス・インコーポレイテッド | プロテインアルギニンメチルトランスフェラーゼ5の選択的阻害剤 |
| WO2020210938A1 (en) * | 2019-04-15 | 2020-10-22 | Bioardis Llc | Quinazoline derivatives as cd73 inhibitors |
| WO2020210970A1 (en) * | 2019-04-16 | 2020-10-22 | Bioardis Llc | Imidazotriazine derivatives as cd73 inhibitors |
| TWI821559B (zh) * | 2019-04-28 | 2023-11-11 | 大陸商上海和譽生物醫藥科技有限公司 | 一種cd73抑制劑,其製備方法和應用 |
| AU2020293263A1 (en) * | 2019-06-14 | 2022-01-20 | Southern Research Institute | 2,4,7-substituted-7-deaza-2'-deoxy-2'-fluoroarabinosyl nucleoside and nucleotide pro-drugs and uses thereof |
| WO2021040356A1 (en) * | 2019-08-23 | 2021-03-04 | Kainos Medicine, Inc. | C-nucleosides, c-nucleotides and their analogs, equivalents and prodrugs thereof for ectonucleotidase inhibition |
| JP7292501B2 (ja) * | 2019-08-29 | 2023-06-16 | イーライ リリー アンド カンパニー | Cd73阻害剤の結晶形態 |
| WO2021087136A1 (en) | 2019-10-30 | 2021-05-06 | Oric Pharmaceuticals, Inc. | Cd73 inhibitors |
| TW202131932A (zh) * | 2019-11-05 | 2021-09-01 | 美商博奥阿迪斯有限公司 | 作為cd73抑制劑的化合物 |
| US11633416B1 (en) | 2020-03-06 | 2023-04-25 | Arcus Biosciences, Inc. | Oral formulations of CD73 compounds |
| CN119118872A (zh) | 2020-03-19 | 2024-12-13 | 艾库斯生物科学有限公司 | 作为HIF-2α抑制剂的四氢化萘和四氢喹啉化合物 |
| AU2021284273A1 (en) | 2020-06-02 | 2022-12-15 | Arcus Biosciences, Inc. | Antibodies to TIGIT |
| WO2021247188A1 (en) | 2020-06-05 | 2021-12-09 | Bristol-Myers Squibb Company | Cd73 antagonist potency assay and methods of use thereof |
| WO2021257643A1 (en) * | 2020-06-17 | 2021-12-23 | Arcus Biosciences, Inc. | Crystalline forms of a cd73 inhibitor and uses thereof |
| CN115702150A (zh) * | 2020-07-07 | 2023-02-14 | 贝达药业股份有限公司 | Cd73抑制剂及其在医药上的应用 |
| CN116348118A (zh) * | 2020-09-08 | 2023-06-27 | 贝达药业股份有限公司 | Cd73抑制剂及其在医药上的应用 |
| WO2022095975A1 (zh) * | 2020-11-05 | 2022-05-12 | 武汉人福创新药物研发中心有限公司 | Cd73抑制剂及其应用 |
| CN114437038B (zh) * | 2020-11-05 | 2025-07-25 | 武汉人福创新药物研发中心有限公司 | 哒嗪炔烃类化合物及其用途 |
| CN114539340B (zh) * | 2020-11-25 | 2024-06-07 | 润佳(苏州)医药科技有限公司 | Cd73抑制剂及其药学应用 |
| WO2022109741A1 (en) * | 2020-11-25 | 2022-06-02 | Risen (Suzhou) Pharma Tech Co., Ltd. | Cd73 inhibitors and pharmaceutical uses thereof |
| EP4273153A4 (en) * | 2020-12-29 | 2024-05-08 | Zhejiang Vimgreen Pharmaceuticals, Ltd | ADENOSINE A3 RECEPTOR AGONIST, PREPARATION METHOD THEREFOR AND USE THEREOF |
| US20240368204A1 (en) | 2021-05-11 | 2024-11-07 | Xizang Haisco Pharmaceutical Co., Ltd. | Small molecular cd73 antagonist and use thereof |
| JP2024521706A (ja) | 2021-05-21 | 2024-06-04 | アーカス バイオサイエンシーズ,インコーポレーテッド | Axl化合物 |
| TW202313603A (zh) | 2021-05-21 | 2023-04-01 | 美商阿克思生物科學有限公司 | Axl抑制劑化合物 |
| WO2023061319A1 (zh) * | 2021-10-11 | 2023-04-20 | 南京明德新药研发有限公司 | 三并环杂环衍生物 |
| US12103943B2 (en) | 2021-10-26 | 2024-10-01 | Southern Research Institute | Development of novel clofarabine analogs for cancer therapy |
| AU2022376961A1 (en) | 2021-10-29 | 2024-05-16 | Arcus Biosciences, Inc. | Inhibitors of hif-2alpha and methods of use thereof |
| KR20250004779A (ko) | 2022-04-13 | 2025-01-08 | 길리애드 사이언시즈, 인코포레이티드 | Trop-2 발현 암을 치료하기 위한 병용 요법 |
| JP2025516262A (ja) | 2022-05-02 | 2025-05-27 | アーカス バイオサイエンシズ インコーポレイティド | 抗tigit抗体及びその使用 |
| WO2024015251A1 (en) | 2022-07-15 | 2024-01-18 | Arcus Biosciences, Inc. | Inhibitors of hpk1 and methods of use thereof |
| WO2024020034A1 (en) | 2022-07-20 | 2024-01-25 | Arcus Biosciences, Inc. | Cbl-b inhibitors and methods of use thereof |
| CN119768155A (zh) | 2022-09-14 | 2025-04-04 | 艾库斯生物科学有限公司 | 依曲地南的分散体 |
| WO2024076873A1 (en) * | 2022-10-03 | 2024-04-11 | Teon Therapeutics, Inc. | Heterocyclic inhibitors of cd73 for treatment of disease |
| US20240140979A1 (en) * | 2022-10-03 | 2024-05-02 | Teon Therapeutics, Inc. | Heterocyclic inhibitors of cd73 for treatment of disease |
| EP4602041A1 (en) | 2022-10-14 | 2025-08-20 | Arcus Biosciences, Inc. | Hpk1 inhibitors and methods of use thereof |
| AU2023364215A1 (en) | 2022-10-20 | 2025-04-24 | Arcus Biosciences, Inc. | Lyophilized formulations of cd73 compounds |
| US20240425497A1 (en) | 2023-05-05 | 2024-12-26 | Arcus Biosciences, Inc. | Cbl-b Inhibitors and Methods of Use Thereof |
| WO2024243502A1 (en) | 2023-05-25 | 2024-11-28 | Arcus Biosciences, Inc. | Cbl-b inhibitors and methods of use thereof |
| CN117924394A (zh) * | 2023-09-05 | 2024-04-26 | 厦门大学 | 核苷酸类化合物及其制备方法和应用、核素靶向探针及其制备方法和应用、药物组合物 |
| WO2025054339A1 (en) | 2023-09-08 | 2025-03-13 | Arcus Biosciences, Inc. | Triazolopyridine compounds as inhibitors of kit |
| WO2025072330A1 (en) | 2023-09-26 | 2025-04-03 | Arcus Biosciences, Inc. | Kit inhibitor compounds and methods of use thereof |
| TW202517260A (zh) | 2023-10-06 | 2025-05-01 | 美商阿克思生物科學有限公司 | Cbl—b抑制劑及其使用方法 |
| WO2025096979A1 (en) | 2023-11-02 | 2025-05-08 | Arcus Biosciences, Inc. | Thiazole compounds as kit inhibitors and methods of use thereof |
| WO2025113498A1 (zh) * | 2023-12-01 | 2025-06-05 | 无锡和誉生物医药科技有限公司 | 一种cd73抑制剂碱式盐及其制备方法和应用 |
| US20250230168A1 (en) | 2023-12-22 | 2025-07-17 | Gilead Sciences, Inc. | Azaspiro wrn inhibitors |
| WO2025193759A1 (en) | 2024-03-12 | 2025-09-18 | Gilead Sciences, Inc. | Solid forms of an azolopyrimidine compound |
| WO2025233264A1 (en) | 2024-05-07 | 2025-11-13 | Innate Pharma | Use of cd73 blocking agents in combination with anti-cd20 x cd3 t cell engagers |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5569650A (en) * | 1993-06-11 | 1996-10-29 | Sloan-Kettering Institute For Cancer Research | C-nucleoside isosters of analogs thereof and pharmaceutical compositions |
| JP4118958B2 (ja) | 1996-10-09 | 2008-07-16 | ファーマセット,リミティド | テトラホスホネート二環式トリス無水物 |
| US20040266723A1 (en) * | 2000-12-15 | 2004-12-30 | Otto Michael J. | Antiviral agents for treatment of Flaviviridae infections |
| WO2012032513A1 (en) * | 2010-09-07 | 2012-03-15 | Bar-Ilan University | Boranophosphate derivatives for the treatment of osteoarthritis |
| WO2013132489A1 (en) | 2012-03-05 | 2013-09-12 | Bar-Ilan University | Nucleoside 5'-phosphorothioate analogues and uses thereof |
| AU2013257951A1 (en) | 2012-05-11 | 2015-01-22 | Akron Molecules Ag | Use of compounds for the treatment of pain |
| US9090697B2 (en) | 2013-03-15 | 2015-07-28 | Bayer Healthcare Llc | Methods for treating bleeding disorders |
| FR3011240A1 (fr) * | 2013-10-01 | 2015-04-03 | Centre Nat Rech Scient | Inhibiteurs de 5'-nucleotidases et leurs utilisations therapeutiques |
| CN114081946A (zh) * | 2014-03-12 | 2022-02-25 | 耶达研究与开发有限公司 | 降低系统性调节性t细胞水平或活性来治疗cns疾病和损伤 |
| US10654884B2 (en) * | 2014-04-25 | 2020-05-19 | Boehringer Ingelheim International Gmbh | Purine derivatives as CD73 inhibitors for the treatment of cancer |
| AU2016308717A1 (en) | 2015-08-17 | 2018-01-25 | Lupin Limited | Heteroaryl derivatives as PARP inhibitors |
| UY37062A (es) | 2016-01-08 | 2017-08-31 | Syngenta Participations Ag | Derivados de aryl oxadiazol fungicidas |
| AR107321A1 (es) | 2016-01-08 | 2018-04-18 | Celgene Corp | Compuestos antiproliferativos, y sus composiciones farmacéuticas y usos |
| UA124529C2 (uk) | 2016-01-08 | 2021-10-05 | Аркус Байосайєнсіз, Інк. | Модулятори екто-5-нуклеотидази та їх застосування |
| CN112004541A (zh) | 2018-03-09 | 2020-11-27 | 艾库斯生物科学有限公司 | 肠道外给药的免疫增强药物 |
| EP3893891A4 (en) | 2018-12-13 | 2022-08-03 | Arcus Biosciences, Inc. | SOLID FORMS OF A CD73 INHIBITOR AND THEIR USE |
| US11633416B1 (en) | 2020-03-06 | 2023-04-25 | Arcus Biosciences, Inc. | Oral formulations of CD73 compounds |
| WO2021257643A1 (en) | 2020-06-17 | 2021-12-23 | Arcus Biosciences, Inc. | Crystalline forms of a cd73 inhibitor and uses thereof |
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