[go: up one dir, main page]

SI3258919T2 - Nazalni praškasti pripravek za zdravljenje hipoglikemije - Google Patents

Nazalni praškasti pripravek za zdravljenje hipoglikemije

Info

Publication number
SI3258919T2
SI3258919T2 SI201630611T SI201630611T SI3258919T2 SI 3258919 T2 SI3258919 T2 SI 3258919T2 SI 201630611 T SI201630611 T SI 201630611T SI 201630611 T SI201630611 T SI 201630611T SI 3258919 T2 SI3258919 T2 SI 3258919T2
Authority
SI
Slovenia
Prior art keywords
hypoglycemia
treatment
powder formulation
nasal powder
nasal
Prior art date
Application number
SI201630611T
Other languages
English (en)
Other versions
SI3258919T1 (sl
Inventor
Sankaram B. Mantripragada
Claude A. Piche
Betsbrugge Jo Jan Filip Van
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55538593&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI3258919(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of SI3258919T1 publication Critical patent/SI3258919T1/sl
Publication of SI3258919T2 publication Critical patent/SI3258919T2/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/724Cyclodextrins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40Cyclodextrins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0043Non-destructive separation of the package, e.g. peeling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/08Inhaling devices inserted into the nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/07General characteristics of the apparatus having air pumping means
    • A61M2205/071General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/073Syringe, piston type

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SI201630611T 2015-02-17 2016-02-16 Nazalni praškasti pripravek za zdravljenje hipoglikemije SI3258919T2 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562117031P 2015-02-17 2015-02-17
PCT/US2016/018003 WO2016133863A1 (en) 2015-02-17 2016-02-16 Nasal powder formulation for treatment of hypoglycemia
EP16710352.2A EP3258919B2 (en) 2015-02-17 2016-02-16 Nasal powder formulation for treatment of hypoglycemia

Publications (2)

Publication Number Publication Date
SI3258919T1 SI3258919T1 (sl) 2020-03-31
SI3258919T2 true SI3258919T2 (sl) 2023-01-31

Family

ID=55538593

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201630611T SI3258919T2 (sl) 2015-02-17 2016-02-16 Nazalni praškasti pripravek za zdravljenje hipoglikemije

Country Status (41)

Country Link
US (3) US10213487B2 (sl)
EP (3) EP3258919B2 (sl)
JP (3) JP6522144B2 (sl)
KR (1) KR102121443B1 (sl)
CN (1) CN107278154B (sl)
AU (2) AU2016220235B2 (sl)
BR (1) BR112017014994B1 (sl)
CA (1) CA2975562C (sl)
CL (1) CL2017002031A1 (sl)
CO (1) CO2017008148A2 (sl)
CR (1) CR20170373A (sl)
CY (1) CY1122716T1 (sl)
DK (1) DK3258919T4 (sl)
DO (1) DOP2017000179A (sl)
EA (1) EA034820B1 (sl)
EC (1) ECSP17053843A (sl)
ES (1) ES2775498T5 (sl)
FI (1) FI3258919T4 (sl)
GT (1) GT201700179A (sl)
HR (1) HRP20200222T4 (sl)
HU (1) HUE049413T2 (sl)
IL (1) IL253273B (sl)
LT (1) LT3258919T (sl)
MA (3) MA41547B1 (sl)
MD (1) MD3258919T3 (sl)
MX (1) MX376200B (sl)
MY (1) MY175669A (sl)
NZ (1) NZ734035A (sl)
PE (1) PE20171334A1 (sl)
PH (1) PH12017501486A1 (sl)
PL (1) PL3258919T5 (sl)
PT (1) PT3258919T (sl)
RS (1) RS59918B2 (sl)
SA (1) SA517382068B1 (sl)
SG (1) SG11201705640PA (sl)
SI (1) SI3258919T2 (sl)
SV (1) SV2017005515A (sl)
TN (1) TN2017000349A1 (sl)
UA (1) UA121874C2 (sl)
WO (1) WO2016133863A1 (sl)
ZA (2) ZA201704944B (sl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3258919T (pt) * 2015-02-17 2020-03-26 Lilly Co Eli Formulação em pó nasal para tratamento da hipoglicemia
US11013873B2 (en) * 2017-01-06 2021-05-25 HealthPartners Institite Methods for treating patients with impaired awareness of hypoglycemia
EP4424362A3 (en) 2017-06-16 2024-11-27 Zealand Pharma A/S Dosage regimes for the administration of glucagon-like-peptide-2 (glp-2) analogues
WO2019038756A1 (en) 2017-08-20 2019-02-28 Solubest Ltd. DRY POWDER COMPOSITIONS FOR INTRANASAL DELIVERY
US11844859B2 (en) 2017-08-20 2023-12-19 Nasus Pharma Ltd. Dry powder compositions for intranasal delivery
MX2020003286A (es) * 2017-09-21 2020-10-01 Scripps Research Inst Nuevas terapias para tratar y prevenir la rinosinusitis crónica.
TWI771669B (zh) 2019-04-26 2022-07-21 美商美國禮來大藥廠 製備穩定胜肽調配物之方法
US10729687B1 (en) 2019-07-09 2020-08-04 Orexo Ab Pharmaceutical composition for nasal delivery
US10653690B1 (en) 2019-07-09 2020-05-19 Orexo Ab Pharmaceutical composition for nasal delivery
US20210283053A1 (en) 2020-03-16 2021-09-16 Zealand Pharma A/S Liquid formulations of glucagon analogues
AU2021276611A1 (en) 2020-05-18 2022-12-15 Orexo Ab New pharmaceutical composition for drug delivery
JP2024541470A (ja) 2021-11-25 2024-11-08 オレクソ・アクチエボラゲット アドレナリンを含む医薬組成物
GB202117016D0 (en) 2021-11-25 2022-01-12 Orexo Ab New pharmaceutical device
CN119454909B (zh) * 2025-01-13 2025-04-08 上海世领制药有限公司 经鼻粘膜给药的胰高血糖素样肽-1受体激动剂的制剂组合物、制备方法、用途及鼻施用器

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58189118A (ja) * 1982-04-30 1983-11-04 Takeda Chem Ind Ltd 経鼻投与製剤
NZ222907A (en) 1986-12-16 1990-08-28 Novo Industri As Preparation for intranasal administration containing a phospholipid absorption enhancing system
US5179079A (en) 1986-12-16 1993-01-12 Novo Nordisk A/S Nasal formulation and intranasal administration therewith
US5059587A (en) 1987-08-03 1991-10-22 Toyo Jozo Company, Ltd. Physiologically active peptide composition for nasal administration
EP0308181A1 (en) * 1987-09-14 1989-03-22 Novo Nordisk A/S Trans-mucosal delivery formulations and a method for preparation thereof
DK49791D0 (da) * 1991-03-20 1991-03-20 Novo Nordisk As Nasalt pulverpraeparat
DE19518810A1 (de) 1995-05-26 1996-11-28 Bayer Ag Nasal-Applikator
JP3098401B2 (ja) * 1995-07-12 2000-10-16 株式会社エルティーティー研究所 経鼻投与用製剤
JPH11292787A (ja) 1995-08-15 1999-10-26 Asahi Chem Ind Co Ltd 生理活性ペプチドを含有する経粘膜投与製剤
US6384016B1 (en) 1998-03-13 2002-05-07 Novo Nordisk A/S Stabilized aqueous peptide solutions
US6398074B1 (en) 1998-03-10 2002-06-04 Valois S.A. Reservoir, reservoir filling method and device for dispensing fluid contained in the reservoir
WO1999047160A1 (en) 1998-03-13 1999-09-23 Novo Nordisk A/S Stabilized aqueous peptide solutions
FR2817847B1 (fr) 2000-12-08 2003-03-28 Tebro Dispositif de distribution de produit fluide ou pulverulent
US6522144B2 (en) 2000-12-22 2003-02-18 Ge Medical Systems Global Technology Company, Llc RF shielding method and apparatus for an open MRI system
WO2003066669A2 (en) 2002-02-04 2003-08-14 Millipore Corporation Process for removing protein aggregates and virus from a protein solution
MXPA06003830A (es) 2003-10-09 2006-07-03 Bioactis Ltd Aparato para abastecer medicina pulverizada para la cavidad nasal.
US20080318837A1 (en) 2003-12-26 2008-12-25 Nastech Pharmaceutical Company Inc. Pharmaceutical Formation For Increased Epithelial Permeability of Glucose-Regulating Peptide
US20060074025A1 (en) * 2003-12-26 2006-04-06 Nastech Pharmaceutical Company Inc. Therapeutic formulations for transmucosal administration that increase glucagon-like peptide-1 bioavailability
US8268791B2 (en) 2004-08-25 2012-09-18 Aegis Therapeutics, Llc. Alkylglycoside compositions for drug administration
JP2009518315A (ja) 2005-12-02 2009-05-07 エムディーアールエヌエー,インコーポレイテッド グルコース調節ペプチドの上皮透過性を増大させるための製剤処方
WO2008152403A1 (en) 2007-06-15 2008-12-18 Zealand Pharma A/S Glucagon analogues
KR20150116912A (ko) 2008-12-15 2015-10-16 질랜드 파마 에이/에스 글루카곤 유사체
JP5635530B2 (ja) 2008-12-15 2014-12-03 ジーランド ファーマ アクティーゼルスカブ グルカゴン類似体
US8680049B2 (en) 2008-12-15 2014-03-25 Zealand Pharma A/S Glucagon analogues
PT2454282E (pt) 2009-07-13 2015-06-23 Zealand Pharma As Análogos de glucagão acilados
GB2472327B (en) 2009-07-31 2013-03-13 Shin Nippon Biomedical Lab Ltd Intranasal granisetron and nasal applicator
US9610329B2 (en) * 2009-10-22 2017-04-04 Albireo Pharma, Inc. Stabilized glucagon solutions
US20130053310A1 (en) * 2010-03-26 2013-02-28 Novo Nordisk A/S Novel glucagon analogues
AR081975A1 (es) 2010-06-23 2012-10-31 Zealand Pharma As Analogos de glucagon
MA34383B1 (fr) 2010-06-24 2013-07-03 Zealand Pharma As Analogues de glucagon
US9216196B2 (en) 2011-05-27 2015-12-22 Jose Schafik Colazo Handal Drink for the rapid replacement of calcium ions in the blood stream
CA2839867A1 (en) 2011-06-22 2012-12-27 Indiana University Research And Technology Corporation Glucagon/glp-1 receptor co-agonists
PE20142113A1 (es) 2011-12-23 2014-12-03 Zealand Pharma As Analogos de glucagon
WO2014004400A2 (en) 2012-06-28 2014-01-03 The Governt. Of The Usa As Represented By The Secretary Of The Department Of Health & Human Services Nasal dry powder delivery system for vaccines and other treatment agents
FI124134B (en) 2012-07-02 2014-03-31 One Way Sport Oy Binding between a ski and a ski boot
TWI608013B (zh) 2012-09-17 2017-12-11 西蘭製藥公司 升糖素類似物
PT3258919T (pt) * 2015-02-17 2020-03-26 Lilly Co Eli Formulação em pó nasal para tratamento da hipoglicemia

Also Published As

Publication number Publication date
EP3258919A1 (en) 2017-12-27
AU2021203035B2 (en) 2023-07-13
EP3258919B1 (en) 2020-01-15
PL3258919T3 (pl) 2020-08-10
JP7362687B2 (ja) 2023-10-17
PE20171334A1 (es) 2017-09-13
ES2775498T5 (es) 2023-01-31
ES2775498T3 (es) 2020-07-27
CN107278154A (zh) 2017-10-20
EP3673900C0 (en) 2025-06-25
US10213487B2 (en) 2019-02-26
PH12017501486A1 (en) 2018-01-15
US12370241B2 (en) 2025-07-29
CN107278154B (zh) 2021-04-09
RS59918B2 (sr) 2023-01-31
MA41547B1 (fr) 2020-04-30
TN2017000349A1 (en) 2019-01-16
US12226456B2 (en) 2025-02-18
JP7094242B2 (ja) 2022-07-01
CO2017008148A2 (es) 2017-11-30
EP3673900B1 (en) 2025-06-25
ECSP17053843A (es) 2017-11-30
EP3673899B1 (en) 2025-06-25
LT3258919T (lt) 2020-02-25
HRP20200222T1 (hr) 2020-05-29
ZA201901241B (en) 2020-10-28
FI3258919T4 (fi) 2023-02-09
SV2017005515A (es) 2018-08-27
CA2975562C (en) 2020-04-28
JP2018507852A (ja) 2018-03-22
EP3258919B2 (en) 2022-11-09
RS59918B1 (sr) 2020-03-31
MD3258919T2 (ro) 2020-07-31
SI3258919T1 (sl) 2020-03-31
WO2016133863A1 (en) 2016-08-25
ZA201704944B (en) 2021-05-26
MY175669A (en) 2020-07-03
US20180000904A1 (en) 2018-01-04
US20230302093A1 (en) 2023-09-28
EP3673899A1 (en) 2020-07-01
MX2017010572A (es) 2017-12-07
BR112017014994A2 (pt) 2018-03-20
CY1122716T1 (el) 2021-03-12
JP2019147817A (ja) 2019-09-05
CA2975562A1 (en) 2016-08-25
EP3673900A1 (en) 2020-07-01
DOP2017000179A (es) 2017-08-31
KR102121443B1 (ko) 2020-06-10
AU2016220235A1 (en) 2017-07-20
CR20170373A (es) 2017-09-18
JP6522144B2 (ja) 2019-05-29
MA52253A (fr) 2021-02-17
HRP20200222T4 (hr) 2022-12-23
JP2021107418A (ja) 2021-07-29
NZ734035A (en) 2019-06-28
AU2021203035A1 (en) 2021-06-10
DK3258919T4 (da) 2022-11-21
HUE049413T2 (hu) 2020-09-28
EA034820B1 (ru) 2020-03-25
GT201700179A (es) 2018-11-23
US20190282666A1 (en) 2019-09-19
MD3258919T3 (ro) 2023-04-30
MA52252A (fr) 2021-02-17
MX376200B (es) 2025-03-07
PT3258919T (pt) 2020-03-26
EP3673899C0 (en) 2025-06-25
DK3258919T3 (da) 2020-03-23
BR112017014994B1 (pt) 2023-12-19
KR20170103934A (ko) 2017-09-13
IL253273A0 (en) 2017-08-31
UA121874C2 (uk) 2020-08-10
PL3258919T5 (pl) 2023-02-27
SG11201705640PA (en) 2017-08-30
EA201791560A1 (ru) 2018-02-28
SA517382068B1 (ar) 2020-10-26
CL2017002031A1 (es) 2018-03-23
AU2016220235B2 (en) 2021-04-29
IL253273B (en) 2019-08-29

Similar Documents

Publication Publication Date Title
ZA201901241B (en) Nasal powder formulation for treatment of hypoglycemia
GB201701039D0 (en) Vertically integrated continuous delivery of an application
EP4591936A3 (en) Treatment of respiratory diseases
SG11201604706TA (en) Stabilized pharmaceutical formulations of insulin aspart
IL253461A0 (en) Hydrogels for the release of therapeutic compounds
IL285882A (en) Medicinal uses for l–4–chlorokynurenine
IL246880A0 (en) Tumor treatment
ZA201705847B (en) Treatment of pain
PL3142641T3 (pl) Preparaty do leczenia nadczynności tarczycy
GB201419540D0 (en) Delivery of drugs
IL258176A (en) Concentrated distribution of an anti-fugatactic factor for cancer treatment
SG11201704169WA (en) Pharmaceutical composition for treatment or palliation of elderly or end-stage cancer patient
IL266243A (en) Use of senicapoc for the treatment of neuropathic pain
ZA201804588B (en) Pharmaceutical formulations for the treatment of diabetes
GB201501800D0 (en) Treatment of medical conditions
IL236381A0 (en) Pharmaceutical preparations for the treatment of cancer
AU2015901032A0 (en) Treatment of respiratory diseases
GB201420778D0 (en) Electronic medical marijuana - canabis drug delivery applicator
AU2015904246A0 (en) Treatment of diabetes
GB201512635D0 (en) Uses of therapeutic compounds