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SI3254675T1 - Peroralni farmacevtski sestavki, ki vsebujejo amorfni CDDO-Me, z zapoznelim sproščanjem - Google Patents

Peroralni farmacevtski sestavki, ki vsebujejo amorfni CDDO-Me, z zapoznelim sproščanjem

Info

Publication number
SI3254675T1
SI3254675T1 SI201031906T SI201031906T SI3254675T1 SI 3254675 T1 SI3254675 T1 SI 3254675T1 SI 201031906 T SI201031906 T SI 201031906T SI 201031906 T SI201031906 T SI 201031906T SI 3254675 T1 SI3254675 T1 SI 3254675T1
Authority
SI
Slovenia
Prior art keywords
oral dosage
delayed release
dosage compositions
contain amorphous
cddo
Prior art date
Application number
SI201031906T
Other languages
English (en)
Inventor
Jiang Zhang
Colin J. Meyer
Original Assignee
Reata Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42335073&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI3254675(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Reata Pharmaceuticals, Inc. filed Critical Reata Pharmaceuticals, Inc.
Publication of SI3254675T1 publication Critical patent/SI3254675T1/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/275Nitriles; Isonitriles
    • A61K31/277Nitriles; Isonitriles having a ring, e.g. verapamil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1635Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J63/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI201031906T 2009-02-13 2010-02-12 Peroralni farmacevtski sestavki, ki vsebujejo amorfni CDDO-Me, z zapoznelim sproščanjem SI3254675T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15260809P 2009-02-13 2009-02-13
EP17181174.8A EP3254675B1 (en) 2009-02-13 2010-02-12 Delayed release, oral dosage compositions that contain amorphous cddo-me

Publications (1)

Publication Number Publication Date
SI3254675T1 true SI3254675T1 (sl) 2019-08-30

Family

ID=42335073

Family Applications (2)

Application Number Title Priority Date Filing Date
SI201031570T SI2395979T1 (sl) 2009-02-13 2010-02-12 Peroralni farmacevtski sestavki, ki vsebujejo amorfni CDDO-Me, z zapoznelim sproščanjem
SI201031906T SI3254675T1 (sl) 2009-02-13 2010-02-12 Peroralni farmacevtski sestavki, ki vsebujejo amorfni CDDO-Me, z zapoznelim sproščanjem

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI201031570T SI2395979T1 (sl) 2009-02-13 2010-02-12 Peroralni farmacevtski sestavki, ki vsebujejo amorfni CDDO-Me, z zapoznelim sproščanjem

Country Status (30)

Country Link
US (2) US8747901B2 (sl)
EP (2) EP2395979B1 (sl)
JP (1) JP5775464B2 (sl)
KR (2) KR101483203B1 (sl)
CN (2) CN105232471A (sl)
AU (1) AU2010213594B2 (sl)
BR (1) BRPI1008023B8 (sl)
CA (1) CA2752048C (sl)
CO (1) CO6361904A2 (sl)
CY (2) CY1119595T1 (sl)
DK (2) DK2395979T3 (sl)
EA (1) EA023652B1 (sl)
ES (2) ES2646816T3 (sl)
HK (1) HK1220130A1 (sl)
HR (2) HRP20171639T1 (sl)
HU (2) HUE035013T2 (sl)
IL (1) IL214258A (sl)
LT (2) LT2395979T (sl)
MX (1) MX2011008344A (sl)
MY (1) MY173715A (sl)
NO (1) NO2395979T3 (sl)
NZ (1) NZ594488A (sl)
PL (2) PL3254675T3 (sl)
PT (2) PT2395979T (sl)
SG (1) SG173601A1 (sl)
SI (2) SI2395979T1 (sl)
SM (2) SMT201900432T1 (sl)
TR (1) TR201909743T4 (sl)
WO (1) WO2010093944A2 (sl)
ZA (1) ZA201105630B (sl)

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US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
CN104739841B (zh) 2008-01-11 2018-06-01 里亚塔医药公司 合成三萜类化合物及用以治病之方法
BRPI0911422B8 (pt) 2008-04-18 2021-05-25 Reata Pharmaceuticals Inc compostos moduladores inflamatórios antioxidantes, composição farmacêutica e usos dos mesmos
KR101665042B1 (ko) 2008-04-18 2016-10-11 리타 파마슈티컬스 잉크. 소염성 골격군을 포함하는 화합물 및 사용 방법
US8124799B2 (en) 2008-04-18 2012-02-28 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
EP2279197B1 (en) 2008-04-18 2014-11-05 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring
WO2010011782A1 (en) 2008-07-22 2010-01-28 Trustees Of Dartmouth College Monocyclic cyanoenones and methods of use thereof
KR101483203B1 (ko) 2009-02-13 2015-01-15 리아타 파마슈티컬즈, 아이엔씨. 무정형 cddo-me를 포함하는, 지연 방출형 경구 투여 조성물
AU2011240690C1 (en) 2010-04-12 2014-11-06 Reata Pharmaceuticals Holdings, LLC Method of treating obesity using antioxidant inflammation modulators
JP5857068B2 (ja) 2010-12-17 2016-02-10 リアタ ファーマシューティカルズ インコーポレイテッド 抗酸化炎症モジュレーターとしてのピラゾリルおよびピリミジニル三環式エノン
TR201909788T4 (tr) 2011-03-11 2019-07-22 Reata Pharmaceuticals Inc C4-monometil triterpenoid türevleri ve bunların kullanım yöntemleri.
CN103156861B (zh) * 2011-12-08 2015-11-25 陈丽梅 齐敦果酸衍生物及其可药用盐在治疗糖尿病眼病中的应用
US9504679B2 (en) 2011-12-19 2016-11-29 Bjoern Colin Kahrs Pharmaceutical compositions comprising glitazones and Nrf2 activators
US20130158077A1 (en) 2011-12-19 2013-06-20 Ares Trading S.A. Pharmaceutical compositions
DK2841445T3 (en) 2012-04-27 2017-09-11 Reata Pharmaceuticals Inc 2,2-DIFLUOROPROPIONAMIDE DERIVATIVES OF BARDOXOLONMETHYL, POLYMORPHE FORMS THEREOF AND PROCEDURES FOR USING IT
US8981144B2 (en) 2012-05-08 2015-03-17 Trustees Of Dartmouth College Method for synthesizing 2-cyano-3,12-dioxoolean-1, 9(11)-dien-28-oic acid methyl ester and derivatives thereof
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
US9556222B2 (en) 2012-06-15 2017-01-31 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
US9512094B2 (en) 2012-09-10 2016-12-06 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
BR112015005168A2 (pt) 2012-09-10 2017-08-15 Reata Pharmaceuticals Inc Derivados de c17-alcanodiila e alquenodiila de ácido oleanólico e métodos de uso dos mesmos
WO2014040073A1 (en) 2012-09-10 2014-03-13 Reata Pharmaceuticals, Inc. C13-hydroxy derivatives of oleanolic acid and methods of use thereof
AR096046A1 (es) 2013-04-24 2015-12-02 Abbvie Inc Derivados de 2,2-difluoropropanamida de metil bardoxolona, formas polimórficas y métodos de uso
TWI716341B (zh) 2013-08-23 2021-01-21 美商瑞塔醫藥有限責任公司 使用齊墩果酸(bardoxolone methyl)或其類似物治療和預防內皮功能障礙之方法
EP3212195A4 (en) 2014-10-31 2018-06-06 The Regents of The University of California Compositions and methods for treating hiv-associated cognitive dysfunction
NZ734292A (en) 2015-02-12 2022-09-30 Reata Pharmaceuticals Inc Imidazolyl tricyclic enones as antioxidant inflammation modulators
ES2865163T3 (es) 2015-09-23 2021-10-15 Reata Pharmaceuticals Inc Derivados de ácido oleanólico modificado en C4 para la inhibición de il-17 y otros usos
MA46749A (fr) 2016-11-08 2019-09-18 Reata Pharmaceuticals Inc Méthodes de traitement du syndrome d'alport à l'aide d'un méthyle de bardoxolone ou d'analogues de ce dernier
TWI831738B (zh) 2016-12-16 2024-02-11 美商瑞塔醫藥有限責任公司 用於抑制RORγ及其他用途的嘧啶三環烯酮衍生物
WO2019014412A1 (en) 2017-07-13 2019-01-17 Pliva Hrvatska D.O.O. NOVEL CRYSTALLINE POLYMORPHIC FORMS OF METHYL BARDOXOLONE
CN112004529B (zh) 2018-04-06 2023-08-08 比利时胶囊公司 包含聚[(甲基丙烯酸甲酯)-共-(甲基丙烯酸)]的低纵横比颗粒的喷雾干燥方法
JP7498122B2 (ja) 2018-06-15 2024-06-11 リアタ ファーマシューティカルズ インコーポレイテッド IL-17およびRORγの阻害用のピラゾール化合物およびイミダゾール化合物
EP3810141A1 (en) 2018-06-20 2021-04-28 Reata Pharmaceuticals, Inc. Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith
KR20210096162A (ko) 2018-11-27 2021-08-04 쿄와 기린 가부시키가이샤 의약 조성물
US12344631B2 (en) 2019-07-19 2025-07-01 Reata Pharmaceuticals, Inc. C17 polar-substituted heteroaromatic synthetic triterpenoids and methods of use thereof
IL298008A (en) 2020-05-09 2023-01-01 Reata Pharmaceuticals Holdings Llc Methods for treating covid-19 with the help of bardoxolone methyl or its analogs
AU2021397631A1 (en) 2020-12-11 2023-07-20 Reata Pharmaceuticals Holdings, LLC Synthetic triterpenoids for use in therapy
CN114558019A (zh) * 2022-03-26 2022-05-31 中国科学院昆明动物研究所 一种Rab13基因抑制剂及应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US7435755B2 (en) * 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
JP2008110962A (ja) * 2006-08-02 2008-05-15 Santen Pharmaceut Co Ltd Nrf2活性化物質を有効成分として含む角結膜障害の予防または治療剤
JP4315182B2 (ja) * 2006-10-30 2009-08-19 ミツミ電機株式会社 カメラモジュール
JP2008247898A (ja) * 2007-03-08 2008-10-16 Santen Pharmaceut Co Ltd トリテルペノイドを有効成分として含有する酸化ストレスが関連する眼疾患の予防又は治療剤
US8088824B2 (en) 2007-08-15 2012-01-03 Reata Pharmaceuticals Inc. Forms of CDDO methyl ester
CN104739841B (zh) * 2008-01-11 2018-06-01 里亚塔医药公司 合成三萜类化合物及用以治病之方法
KR101483203B1 (ko) 2009-02-13 2015-01-15 리아타 파마슈티컬즈, 아이엔씨. 무정형 cddo-me를 포함하는, 지연 방출형 경구 투여 조성물

Also Published As

Publication number Publication date
HRP20171639T1 (hr) 2017-12-15
US20120022156A1 (en) 2012-01-26
KR101483203B1 (ko) 2015-01-15
SMT201700527T1 (it) 2018-01-11
SI2395979T1 (sl) 2017-12-29
ES2731601T3 (es) 2019-11-18
CY1119595T1 (el) 2018-03-07
EP3254675A1 (en) 2017-12-13
ZA201105630B (en) 2012-04-25
US20140235711A1 (en) 2014-08-21
EA023652B1 (ru) 2016-06-30
AU2010213594A1 (en) 2011-08-18
ES2646816T3 (es) 2017-12-18
MY173715A (en) 2020-02-18
KR20140016441A (ko) 2014-02-07
NZ594488A (en) 2013-10-25
LT2395979T (lt) 2017-12-11
IL214258A (en) 2017-06-29
EA201190092A1 (ru) 2012-02-28
JP2012518008A (ja) 2012-08-09
CO6361904A2 (es) 2012-01-20
LT3254675T (lt) 2019-06-25
JP5775464B2 (ja) 2015-09-09
BRPI1008023B1 (pt) 2019-12-31
PT3254675T (pt) 2019-06-14
EP2395979A2 (en) 2011-12-21
NO2395979T3 (sl) 2018-01-20
CA2752048A1 (en) 2010-08-19
HK1220130A1 (zh) 2017-04-28
SG173601A1 (en) 2011-09-29
WO2010093944A2 (en) 2010-08-19
BRPI1008023B8 (pt) 2023-04-11
CA2752048C (en) 2014-11-25
KR20110118721A (ko) 2011-10-31
HUE035013T2 (en) 2018-05-02
CY1122066T1 (el) 2020-11-25
PT2395979T (pt) 2017-11-16
SMT201900432T1 (it) 2019-09-09
CN105232471A (zh) 2016-01-13
MX2011008344A (es) 2011-09-29
US8747901B2 (en) 2014-06-10
CN102387789A (zh) 2012-03-21
PL2395979T3 (pl) 2018-02-28
PL3254675T3 (pl) 2019-09-30
EP2395979B1 (en) 2017-08-23
WO2010093944A3 (en) 2011-08-11
AU2010213594B2 (en) 2013-11-14
US9155721B2 (en) 2015-10-13
DK3254675T3 (da) 2019-06-24
IL214258A0 (en) 2011-09-27
DK2395979T3 (da) 2017-11-27
TR201909743T4 (tr) 2019-07-22
BRPI1008023A2 (pt) 2016-03-15
HRP20191092T1 (hr) 2019-11-29
EP3254675B1 (en) 2019-05-15
HUE044005T2 (hu) 2019-09-30

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