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SI3197277T1 - Sonde za slikanje proteina huntingtina - Google Patents

Sonde za slikanje proteina huntingtina

Info

Publication number
SI3197277T1
SI3197277T1 SI201531778T SI201531778T SI3197277T1 SI 3197277 T1 SI3197277 T1 SI 3197277T1 SI 201531778 T SI201531778 T SI 201531778T SI 201531778 T SI201531778 T SI 201531778T SI 3197277 T1 SI3197277 T1 SI 3197277T1
Authority
SI
Slovenia
Prior art keywords
probes
huntingtin protein
imaging
imaging huntingtin
protein
Prior art date
Application number
SI201531778T
Other languages
English (en)
Inventor
Celia Dominguez
John Wityak
Jonathan Bard
Alex Kiselyov
Christopher John Brown
Michael Edward Prime
Peter David Johnson
Daniel Clark-Frew
Original Assignee
Chdi Foundation, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chdi Foundation, Inc. filed Critical Chdi Foundation, Inc.
Publication of SI3197277T1 publication Critical patent/SI3197277T1/sl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0497Organic compounds conjugates with a carrier being an organic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
SI201531778T 2014-08-29 2015-08-28 Sonde za slikanje proteina huntingtina SI3197277T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462043590P 2014-08-29 2014-08-29
PCT/US2015/047401 WO2016033440A1 (en) 2014-08-29 2015-08-28 Probes for imaging huntingtin protein
EP15836261.6A EP3197277B1 (en) 2014-08-29 2015-08-28 Probes for imaging huntingtin protein

Publications (1)

Publication Number Publication Date
SI3197277T1 true SI3197277T1 (sl) 2022-04-29

Family

ID=55400645

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201531778T SI3197277T1 (sl) 2014-08-29 2015-08-28 Sonde za slikanje proteina huntingtina

Country Status (20)

Country Link
US (2) US11104691B2 (sl)
EP (1) EP3197277B1 (sl)
JP (1) JP6754353B2 (sl)
KR (1) KR102410733B1 (sl)
CN (1) CN107105667B (sl)
AU (2) AU2015308769A1 (sl)
BR (1) BR112017004140B1 (sl)
CA (1) CA2959533C (sl)
DK (1) DK3197277T3 (sl)
EA (1) EA039923B1 (sl)
ES (1) ES2905095T3 (sl)
HR (1) HRP20220001T1 (sl)
HU (1) HUE057702T2 (sl)
IL (1) IL250802B (sl)
MX (1) MX386798B (sl)
PL (1) PL3197277T3 (sl)
PT (1) PT3197277T (sl)
SG (1) SG11201701592SA (sl)
SI (1) SI3197277T1 (sl)
WO (1) WO2016033440A1 (sl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3197277T3 (da) 2014-08-29 2022-01-31 Chdi Foundation Inc Prober til billeddannelse af huntingtin-protein
KR102456946B1 (ko) 2014-08-29 2022-10-21 씨에이치디아이 파운데이션, 인코포레이티드 헌팅틴을 단백질 영상화하기 위한 프로브
CN107074817B (zh) 2014-08-29 2023-12-15 Chdi基金会股份有限公司 用于成像亨廷顿蛋白的探针
SG11201701580XA (en) 2014-08-29 2017-03-30 Chdi Foundation Inc Probes for imaging huntingtin protein
MX382156B (es) 2015-08-28 2025-03-13 Chdi Foundation Inc Sondas para formar imagenes de proteina de huntingtina.
AU2018346962A1 (en) * 2017-10-12 2020-05-28 BCN Biosciences L.L.C. Methods of treating radiation induced gastrointestinal syndrome
US11389438B2 (en) 2019-02-25 2022-07-19 Chdi Foundation, Inc. Compounds for targeting mutant huntingtin protein and uses thereof
CA3138873C (en) 2019-05-09 2024-01-09 Kyle Bradley Pascual CLAGG Synthesis of labeled imidazo[1,2-a]pyrimidines
CN114773312B (zh) * 2021-10-29 2024-03-26 北京鑫诺康桥药物研究有限公司 一种盐酸阿罗洛尔中间体的制备工艺

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10050663A1 (de) * 2000-10-13 2002-04-18 Gruenenthal Gmbh Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung
MXPA06001742A (es) * 2003-08-13 2006-08-11 Bf Res Inst Inc Sondas para enfermedades en las cuales se acumula amiloide, agentes para tincion del amiloide, farmacos para tratamiento y profilaxis de enfermedades con amiloide acumulado, y sondas para diagnostico de ovillos neurofibrilares y agentes para tincion
KR20090025282A (ko) * 2006-06-21 2009-03-10 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물
US20100173930A1 (en) * 2006-08-01 2010-07-08 Alex Muci Certain Chemical Entities, Compositions and Methods
EP2098523A4 (en) * 2006-11-17 2011-09-21 Nihon Mediphysics Co Ltd NOVEL COMPOUNDS WITH AFFINITY FOR THE AMYLOID SUBSTANCE
CA2670436A1 (en) * 2006-11-30 2008-06-05 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
EP2125800A1 (en) * 2007-01-22 2009-12-02 AstraZeneca AB Novel heteroaryl substituted imidazo ý1,2 -a¨pyridine derivatives
CN101909658A (zh) * 2007-10-30 2010-12-08 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法
FR2928923B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques
US8420052B2 (en) * 2008-07-24 2013-04-16 Siemens Medical Solutions Usa, Inc. Imaging agents useful for identifying AD pathology
SI2338059T1 (sl) * 2008-09-23 2015-08-31 Wista Laboratories Ltd. Ligandi za agregirane molekule tau
US8614201B2 (en) * 2009-06-05 2013-12-24 Janssen Pharmaceutica Nv Heterocyclic amides as modulators of TRPA1
CN103534253B (zh) * 2011-05-20 2016-02-24 日本医事物理股份有限公司 对淀粉状蛋白具有亲和性的化合物
IN2014DN00185A (sl) * 2011-06-24 2015-07-10 Nihon Mediphysics Co Ltd
JP2013237655A (ja) * 2012-05-17 2013-11-28 Kyoto Univ コンフォメーション病診断用分子プローブ
BR112015010469A2 (pt) * 2012-11-14 2017-07-11 Hoffmann La Roche derivados de imidazopiridina
WO2014139882A1 (en) 2013-03-14 2014-09-18 Galapagos Nv Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
EP3049411B1 (en) * 2013-09-26 2017-04-26 F. Hoffmann-La Roche AG Imidazo[1,2-a]pyridin-7-amines as imaging tools
KR102456946B1 (ko) 2014-08-29 2022-10-21 씨에이치디아이 파운데이션, 인코포레이티드 헌팅틴을 단백질 영상화하기 위한 프로브
SG11201701580XA (en) 2014-08-29 2017-03-30 Chdi Foundation Inc Probes for imaging huntingtin protein
CN107074817B (zh) 2014-08-29 2023-12-15 Chdi基金会股份有限公司 用于成像亨廷顿蛋白的探针
DK3197277T3 (da) 2014-08-29 2022-01-31 Chdi Foundation Inc Prober til billeddannelse af huntingtin-protein
MX382156B (es) 2015-08-28 2025-03-13 Chdi Foundation Inc Sondas para formar imagenes de proteina de huntingtina.

Also Published As

Publication number Publication date
KR102410733B1 (ko) 2022-06-20
BR112017004140A2 (pt) 2017-12-12
IL250802B (en) 2020-08-31
CN107105667B (zh) 2021-08-17
EP3197277A1 (en) 2017-08-02
EP3197277B1 (en) 2021-12-22
KR20170047303A (ko) 2017-05-04
US20210380608A1 (en) 2021-12-09
BR112017004140B1 (pt) 2023-01-10
CA2959533A1 (en) 2016-03-03
AU2019283999A1 (en) 2020-01-23
DK3197277T3 (da) 2022-01-31
US20170283439A1 (en) 2017-10-05
ES2905095T3 (es) 2022-04-07
JP6754353B2 (ja) 2020-09-09
PT3197277T (pt) 2022-02-01
IL250802A0 (en) 2017-04-30
WO2016033440A1 (en) 2016-03-03
PL3197277T3 (pl) 2022-04-04
HUE057702T2 (hu) 2022-05-28
AU2019283999B2 (en) 2021-07-22
US11851446B2 (en) 2023-12-26
HRP20220001T1 (hr) 2022-04-01
CA2959533C (en) 2023-03-07
EA201790400A1 (ru) 2017-09-29
EA039923B1 (ru) 2022-03-28
EP3197277A4 (en) 2018-04-18
JP2017529340A (ja) 2017-10-05
SG11201701592SA (en) 2017-03-30
US11104691B2 (en) 2021-08-31
MX2017002702A (es) 2017-10-23
MX386798B (es) 2025-03-19
AU2015308769A1 (en) 2017-03-23
CN107105667A (zh) 2017-08-29

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