SI3031799T1 - Aromatska spojina - Google Patents
Aromatska spojina Download PDFInfo
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- SI3031799T1 SI3031799T1 SI201430745T SI201430745T SI3031799T1 SI 3031799 T1 SI3031799 T1 SI 3031799T1 SI 201430745 T SI201430745 T SI 201430745T SI 201430745 T SI201430745 T SI 201430745T SI 3031799 T1 SI3031799 T1 SI 3031799T1
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- halogen atom
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- 150000001491 aromatic compounds Chemical class 0.000 title claims 2
- 150000003839 salts Chemical class 0.000 claims abstract 15
- 150000001875 compounds Chemical class 0.000 claims abstract 13
- -1 aromatic ring compound Chemical class 0.000 claims abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract 2
- 125000005843 halogen group Chemical group 0.000 claims 23
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 10
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 7
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 6
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 2
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims 2
- 125000002393 azetidinyl group Chemical group 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- IBGVSYCBCNHZOS-PMERELPUSA-N (3S)-3-cyclopropyl-3-[2-[[1-[2-[2,2-dimethylpropyl-(4,6-dimethylpyrimidin-2-yl)carbamoyl]-5-methoxyphenyl]piperidin-4-yl]methoxy]pyridin-4-yl]propanoic acid Chemical compound C1(CC1)[C@H](CC(=O)O)C1=CC(=NC=C1)OCC1CCN(CC1)C1=C(C=CC(=C1)OC)C(N(C1=NC(=CC(=N1)C)C)CC(C)(C)C)=O IBGVSYCBCNHZOS-PMERELPUSA-N 0.000 claims 1
- VVRXREQIOCYUKN-PMERELPUSA-N (3s)-3-cyclopropyl-3-[2-[[1-[2-[2,2-dimethylpropyl-(6-methylpyridin-2-yl)carbamoyl]-5-methoxyphenyl]piperidin-4-yl]methoxy]pyridin-4-yl]propanoic acid Chemical compound C1CC(COC=2N=CC=C(C=2)[C@@H](CC(O)=O)C2CC2)CCN1C1=CC(OC)=CC=C1C(=O)N(CC(C)(C)C)C1=CC=CC(C)=N1 VVRXREQIOCYUKN-PMERELPUSA-N 0.000 claims 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 102100026148 Free fatty acid receptor 1 Human genes 0.000 claims 1
- 101000912510 Homo sapiens Free fatty acid receptor 1 Proteins 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- DGENZVKCTGIDRZ-UHFFFAOYSA-N 3-[4-[(3-phenoxyphenyl)methylamino]phenyl]propanoic acid Chemical compound C1=CC(CCC(=O)O)=CC=C1NCC1=CC=CC(OC=2C=CC=CC=2)=C1 DGENZVKCTGIDRZ-UHFFFAOYSA-N 0.000 abstract 2
- 102100025101 GATA-type zinc finger protein 1 Human genes 0.000 abstract 2
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 abstract 2
- 229940125827 GPR40 agonist Drugs 0.000 abstract 2
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 230000000580 secretagogue effect Effects 0.000 abstract 2
- 208000002249 Diabetes Complications Diseases 0.000 abstract 1
- 206010012655 Diabetic complications Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 208000001076 sarcopenia Diseases 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (14)
1. Spojina, predstavljena s formulo (I):
kjer obroč A je nadalje po izbiri substituiran aromatski obroč; obroč B je nadalje po izbiri substituiran 4-6-členski dušik-vsebujoč nasičen obroč; X je -N= ali -CH=; 1 9 R in R sta vsak neodvisno atom vodika ali substituent; R in R sta po izbiri vezana drug na drugega, da tvorita, skupaj s sosednjim atomom dušika, po izbiri substituiran 3- do 10-členski obroč; R3 in R4 sta vsak neodvisno atom vodika, atom halogena ali Ci.6 alkilna skupina; R5, R7, R8 in R9 so vsak neodvisno atom vodika, atom halogena, Ci.6 alkilna skupina ali Ci.6 alkoksi skupina; R6 je atom halogena, po izbiri substituirana Ci.6 alkilna skupina, po izbiri substituirana C ,.6 alkoksi skupina ali po izbiri substituirana C3.i0 cikloalkilna skupina; in R6 in R7 sta po izbiri vezana drug na drugega, da tvorita, skupaj s sosednjim atomom ogljika, po izbiri substituiran 3- do 10-členski obroč, ali njena sol.
2. Spojina po zahtevku 1, kjer je obroč A benzenski obroč, po izbiri nadalje substituiran z 1 ali 2 substituentoma, izbranima izmed naslednjih: (1) Ci_6 alkilsulfonilna skupina; (2) karbamoilna skupina; (3) hidroksi skupina; (4) C μ6 alkoksi skupina, po izbiri substituirana z 1 do 3 atomi halogenov; (5) Ci.6 alkiltio skupina; (6) ciano skupina; (7) atom halogena; in (8) Ci_6 alkilna skupina, ali njena sol.
3. Spojina po zahtevku 1, kjer je obroč B (1) azetidinski obroč, (2) pirolidinski obroč ali (3) piperidinski obroč, po izbiri nadalje substituiran z 1 ali 2 substituentoma, izbranima izmed atoma halogena in Ci.6 alkilne skupine, ali njena sol.
4. Spojina po zahtevku 1, kjer je X -N=, ali njena sol.
5. Spojina po zahtevku 1, kjer sta R1 in R2 vsak neodvisno (i) Ci.8 alkilna skupina, po izbiri substituirana z 1 ali 2 substituentoma, izbranima izmed naslednjih: (1) ciano, (2) hidroksi, (3) C3.io cikloalkilna skupina, po izbiri substituirana z 1 do 3 substituenti, izbranimi izmed atoma halogena in Ci.6 alkilne skupine, (4) Ci.6 alkoksi skupina, po izbiri substituirana z 1 do 3 atomi halogenov, (5) C6-i4 arilna skupina, po izbiri substituirana z 1 do 3 atomi halogenov, (6) aromatska heterociklična skupina, (7) nearomatska heterociklična skupina, (8) C1.6 alkilsulfonilna skupina, (9) mono- ali di-Ci.6 alkilamino skupina, po izbiri substituirana z 1 do 3 atomi halogenov, in (10) atom halogena, ali (ii) aromatska heterociklična skupina, po izbiri substituirana z 1 ali 2 substituentoma, izbranima izmed naslednjih: (1) ciano, (2) atom halogena, (3) C 1.6 alkilna skupina, po izbiri substituirana z 1 do 3 atomi halogenov, (4) C3.10 cikloalkilna skupina, (5) C 1.6 alkoksi skupina, (6) dušik-vsebujoča heterociklil-karbonilna skupina in (7) mono- ali di-Ci.6 alkilkarbamoilna skupina, ali njena sol.
6. Spojina po zahtevku 1, kjer so R3, R4, R5, R7, R8 in R9 atomi vodika, ali njena sol.
7. Spojina po zahtevku 1, kjer je R6 C3.i0 cikloalkilna skupina, ali njena sol.
8. Spojina po zahtevku 1, kjer obroč A je benzenski obroč, po izbiri nadalje substituiran z 1 ali 2 substituentoma, izbranima izmed naslednjih (1) Ci_6 alkilsulfonilna skupina; (2) karbamoilna skupina; (3) hidroksi skupina; (4) Ci.6 alkoksi skupina, po izbiri substituirana z 1 do 3 atomi halogenov; (5) Ci.6 alkiltio skupina; (6) ciano skupina; (7) atom halogena; in (8) C i.6 alkilna skupina, obroč B je (1) azetidinski obroč, (2) pirolidinski obroč ali (3) piperidinski obroč, po izbiri nadalje substituiran z 1 ali 2 substituentoma, izbranima izmed atoma halogena in Ci.6 alkilne skupine, x je -N=, R1 in R2 sta vsak neodvisno (i) Ci.8 alkilna skupina, po izbiri substituirana z 1 ali 2 substituentoma, izbranima izmed naslednjih: (1) ciano, (2) hidroksi, (3) C3.10 cikloalkilna skupina, po izbiri substituirana z 1 do 3 substituenti, izbranimi izmed atoma halogena in Ci.6 alkilne skupine, (4) C1.6 alkoksi skupina, po izbiri substituirana z 1 do 3 atomi halogenov, (5) C6-i4 arilna skupina, po izbiri substituirana z 1 do 3 atomi halogenov, (6) aromatska heterociklična skupina, (7) nenaromatska heterociklična skupina, (8) Ci.6 alkilsulfonilna skupina, (9) mono- ali di-Ci.6 alkil-amino skupina, po izbiri substituirana z 1 do 3 atomi halogenov in (10) atom halogena, ali (ii) aromatska heterociklična skupina, po izbiri substituirana z 1 ali 2 substituentoma, izbranima izmed naslednjih: (1) ciano, (2) atom halogena, (3) Ci.6 alkilna skupina, po izbiri substituirana z 1 do 3 atomi halogenov, (4) C3.io cikloalkilna skupina, (5) Ci.6 alkoksi skupina, (6) dušik-vsebujoča heterociklil-karbonilna skupina in (7) mono- ali di-Ci.6 alkilkarbamoilna skupina, R3, R4, R5, R7, R8 in R9 so atomi vodika in R6 je C3.10 cikloalkilna skupina, ali njena sol.
9. (3 S)-3 -ciklopropil-3 -(2-(( 1 -(2-((2,2-dimetilpropil)(6-metilpiridin-2-il)karbamoil)-5-metoksifenil)piperidin-4-il)metoksi)piridin-4-il)propanojska kislina ali njena sol.
10. (3S)-3-ciklopropil-3-(2-((l-(2-((2,2-dimetilpropil)(4,6-dimetilpirimidin-2-il)karbamoil)-5-metoksifenil)piperidin-4-il)metoksi)piridin-4-il)propanojska kislina ali njena sol.
11. (3 S)-3-ciklopropil-3-(2-(( 1-(2-((2,2-dimetilpropil)(piridin-2-il)karbamoil)-5-metoksifenil)piperidin-4-il)metoksi)piridin-4-il) propanojska kislina ali njena sol.
12. Spojina po zahtevku 1 ali njena sol za uporabo kot zdravilo.
13. Spojina za uporabo po zahtevku 12, ki je regulator GPR40 receptorske funkcije.
14. Spojina po zahtevku 1 ali njena sol za uporabo v postopku preprečevanja ali zdravljenja diabetesa pri sesalcu, ki obsega dajanje sesalcu učinkovite količine spojine ali njene soli.
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| PCT/JP2014/070972 WO2015020184A1 (ja) | 2013-08-09 | 2014-08-08 | 芳香環化合物 |
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| US10059667B2 (en) | 2014-02-06 | 2018-08-28 | Merck Sharp & Dohme Corp. | Antidiabetic compounds |
| AR111199A1 (es) | 2017-03-31 | 2019-06-12 | Takeda Pharmaceuticals Co | Compuesto aromático agonista de gpr40 |
| CN110719903A (zh) * | 2017-03-31 | 2020-01-21 | 武田药品工业株式会社 | 芳族环化合物 |
| JP7062792B2 (ja) | 2018-02-13 | 2022-05-06 | ギリアード サイエンシーズ， インコーポレイテッド | Ｐｄ－１／ｐｄ－ｌ１阻害剤 |
| CN108498868B (zh) * | 2018-04-03 | 2020-09-15 | 北京大学口腔医学院 | 具有细胞外基质电学拓扑特征的带电复合膜及其制备方法 |
| EP3781556B1 (en) | 2018-04-19 | 2025-06-18 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| CN118221646A (zh) | 2018-07-13 | 2024-06-21 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
| KR102635333B1 (ko) | 2018-10-24 | 2024-02-15 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| CA3123871A1 (en) | 2018-12-20 | 2020-06-25 | Amgen Inc. | Kif18a inhibitors |
| JP2022552655A (ja) | 2019-10-07 | 2022-12-19 | キャリーオペ，インク． | Ｇｐｒ１１９アゴニスト |
| PH12022552277A1 (en) | 2020-02-28 | 2024-03-04 | Kallyope Inc | Gpr40 agonists |
| CA3178994A1 (en) | 2020-05-19 | 2021-11-25 | Iyassu Sebhat | Ampk activators |
| JP2023531726A (ja) | 2020-06-26 | 2023-07-25 | キャリーオペ，インク． | Ａｍｐｋアクチベーター |
| TW202317092A (zh) | 2021-08-26 | 2023-05-01 | 美商佛拉斯托醫療公司 | Ｋｉｆ１８ａ之吲哚啉抑制劑 |
| JP2025502110A (ja) * | 2022-01-14 | 2025-01-24 | 寧康瑞珠生物制薬（珠海）有限公司 | 抗糖尿病化合物及び組成物 |
| WO2024188313A1 (zh) * | 2023-03-14 | 2024-09-19 | 凯思凯迪（上海）医药科技有限公司 | 苯并杂环类化合物、其制备方法和其应用 |
| CN118724796A (zh) * | 2023-03-28 | 2024-10-01 | 广东众生睿创生物科技有限公司 | 苯丙酸衍生物及其制备方法和应用 |
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| AR035016A1 (es) | 1999-08-25 | 2004-04-14 | Takeda Chemical Industries Ltd | Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima. |
| AU2001269531A1 (en) | 2000-07-17 | 2002-01-30 | Takeda Chemical Industries Ltd. | Sulfone derivatives, process for their production and use thereof |
| JP2003048887A (ja) * | 2001-06-01 | 2003-02-21 | Tanabe Seiyaku Co Ltd | フェニルカルボキサミド誘導体およびその製法 |
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| JP2005035966A (ja) * | 2002-09-06 | 2005-02-10 | Takeda Chem Ind Ltd | フランまたはチオフェン誘導体およびその医薬用途 |
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| WO2005030740A1 (ja) | 2003-09-30 | 2005-04-07 | Takeda Pharmaceutical Company Limited | チアゾリン誘導体およびその用途 |
| JP4769082B2 (ja) | 2003-12-17 | 2011-09-07 | 武田薬品工業株式会社 | ウレア誘導体、その製造法及び用途 |
| BRPI0418148A (pt) | 2003-12-25 | 2007-04-17 | Takeda Pharmaceutical | composto, prodroga de um composto, modulador da função do receptor gpr40, agente farmacêutico, uso de um composto e métodos de modificação de uma função do receptor gpr40 em um mamìfero, de profilaxia ou tratamento de diabetes em um mamìfero e de produção de um composto |
| US7585880B2 (en) | 2003-12-26 | 2009-09-08 | Takeda Pharmaceutical Company Limited | Phenylpropanoic acid derivatives |
| EP1726580A4 (en) | 2004-03-15 | 2008-02-13 | Takeda Pharmaceutical | AMINOPHNYLPROPANO ACID DERIVATIVE |
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| US20090054435A1 (en) | 2005-07-29 | 2009-02-26 | Hiroshi Imoto | Phenoxyalkanoic Acid Compound |
| US8153694B2 (en) | 2005-07-29 | 2012-04-10 | Takeda Pharmaceutical Company Limited | Cyclopropanecarboxylic acid compound |
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| JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
| TW200815377A (en) * | 2006-04-24 | 2008-04-01 | Astellas Pharma Inc | Oxadiazolidinedione compound |
| CA2838448A1 (en) | 2006-06-27 | 2008-01-03 | Takeda Pharmaceutical Company Limited | Fused cyclic compounds |
| EP2077267A4 (en) | 2006-10-18 | 2010-04-07 | Takeda Pharmaceutical | CONDENSED HETEROCYCLIC COMPOUND |
| CA2666973C (en) | 2006-10-19 | 2015-03-31 | Takeda Pharmaceutical Company Limited | Indole compound having a glucokinase activating action |
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| WO2008136428A1 (ja) | 2007-04-27 | 2008-11-13 | Takeda Pharmaceutical Company Limited | 含窒素５員複素環化合物 |
| EP2157859A4 (en) | 2007-06-19 | 2011-01-12 | Takeda Pharmaceutical | INDAZOL COMPOUNDS FOR THE ACTIVATION OF GLUCCOKINASE |
| BRPI0818253A2 (pt) | 2007-10-10 | 2015-04-07 | Amgen Inc | Moduladores de gpr40 bifenil substituídos |
| US9382188B2 (en) * | 2012-02-13 | 2016-07-05 | Takeda Pharmaceutical Company Limited | Aromatic ring compound |
| EP2816032A4 (en) | 2012-02-13 | 2015-09-30 | Takeda Pharmaceutical | AROMATIC RING CONNECTION |
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2014
- 2014-08-08 HU HUE14834225A patent/HUE039259T2/hu unknown
- 2014-08-08 EP EP14834225.6A patent/EP3031799B1/en active Active
- 2014-08-08 SM SM20180339T patent/SMT201800339T1/it unknown
- 2014-08-08 PT PT148342256T patent/PT3031799T/pt unknown
- 2014-08-08 WO PCT/JP2014/070972 patent/WO2015020184A1/ja not_active Ceased
- 2014-08-08 US US14/898,633 patent/US9776962B2/en active Active
- 2014-08-08 JP JP2015530972A patent/JP6397410B2/ja active Active
- 2014-08-08 RS RS20180697A patent/RS57359B1/sr unknown
- 2014-08-08 SI SI201430745T patent/SI3031799T1/sl unknown
- 2014-08-08 PL PL14834225T patent/PL3031799T3/pl unknown
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- 2014-08-08 HR HRP20181011TT patent/HRP20181011T1/hr unknown
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- 2014-08-08 LT LTEP14834225.6T patent/LT3031799T/lt unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| CY1120855T1 (el) | 2019-12-11 |
| HUE039259T2 (hu) | 2018-12-28 |
| PL3031799T3 (pl) | 2018-09-28 |
| PT3031799T (pt) | 2018-07-04 |
| JP6397410B2 (ja) | 2018-09-26 |
| US9776962B2 (en) | 2017-10-03 |
| SMT201800339T1 (it) | 2018-09-13 |
| DK3031799T3 (en) | 2018-05-28 |
| RS57359B1 (sr) | 2018-08-31 |
| EP3031799A1 (en) | 2016-06-15 |
| ES2672992T3 (es) | 2018-06-19 |
| LT3031799T (lt) | 2018-06-25 |
| US20160115128A1 (en) | 2016-04-28 |
| HRP20181011T1 (hr) | 2018-08-24 |
| WO2015020184A1 (ja) | 2015-02-12 |
| JPWO2015020184A1 (ja) | 2017-03-02 |
| EP3031799B1 (en) | 2018-04-04 |
| EP3031799A4 (en) | 2017-01-11 |
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