SI3027613T1 - Derivati pirolokvinolina kot 5-HT6 antagonisti, postopek priprave in uporabe le-teh - Google Patents
Derivati pirolokvinolina kot 5-HT6 antagonisti, postopek priprave in uporabe le-tehInfo
- Publication number
- SI3027613T1 SI3027613T1 SI201331078T SI201331078T SI3027613T1 SI 3027613 T1 SI3027613 T1 SI 3027613T1 SI 201331078 T SI201331078 T SI 201331078T SI 201331078 T SI201331078 T SI 201331078T SI 3027613 T1 SI3027613 T1 SI 3027613T1
- Authority
- SI
- Slovenia
- Prior art keywords
- antagonists
- preparation
- pyrroloquinoline derivatives
- pyrroloquinoline
- derivatives
- Prior art date
Links
- 229940124801 5-HT6 antagonist Drugs 0.000 title 1
- SLHCMPVPVQSTBV-UHFFFAOYSA-N C1=CNC2=C3C=CN=C3C=CC2=C1 Chemical class C1=CNC2=C3C=CN=C3C=CC2=C1 SLHCMPVPVQSTBV-UHFFFAOYSA-N 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Addiction (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/PL2013/000097 WO2015012704A1 (en) | 2013-07-25 | 2013-07-25 | Pyrroloquinoline derivatives as 5-ht6 antagonists, preparation method and use thereof |
| EP13759883.5A EP3027613B1 (en) | 2013-07-25 | 2013-07-25 | Pyrroloquinoline derivatives as 5-ht6 antagonists, preparation method and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3027613T1 true SI3027613T1 (sl) | 2018-10-30 |
Family
ID=49151293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201331078T SI3027613T1 (sl) | 2013-07-25 | 2013-07-25 | Derivati pirolokvinolina kot 5-HT6 antagonisti, postopek priprave in uporabe le-teh |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9676772B2 (sl) |
| EP (1) | EP3027613B1 (sl) |
| JP (1) | JP6267334B2 (sl) |
| KR (1) | KR20160034403A (sl) |
| CN (1) | CN105531272B (sl) |
| AU (1) | AU2013394970B2 (sl) |
| BR (1) | BR112016001545A2 (sl) |
| CA (1) | CA2919147A1 (sl) |
| DK (1) | DK3027613T3 (sl) |
| ES (1) | ES2674476T3 (sl) |
| HR (1) | HRP20180977T1 (sl) |
| HU (1) | HUE038084T2 (sl) |
| LT (1) | LT3027613T (sl) |
| MX (1) | MX363632B (sl) |
| PL (1) | PL3027613T3 (sl) |
| PT (1) | PT3027613T (sl) |
| RS (1) | RS57379B1 (sl) |
| RU (1) | RU2688161C2 (sl) |
| SI (1) | SI3027613T1 (sl) |
| TR (1) | TR201808781T4 (sl) |
| WO (1) | WO2015012704A1 (sl) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2953004C (en) | 2014-07-08 | 2023-02-21 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
| CN108431000A (zh) | 2015-11-16 | 2018-08-21 | 基础应用医学研究基金会 | 作为dna甲基转移酶抑制剂的新型化合物 |
| WO2019180176A1 (en) | 2018-03-21 | 2019-09-26 | Spherium Biomed, S.L. | Composition for the treatment of schizophrenia and/or psychosis |
| CN115010707B (zh) * | 2021-12-31 | 2023-09-19 | 淮阴师范学院 | 喹啉并吡咯衍生物的制备方法 |
| WO2025008012A1 (en) * | 2023-07-01 | 2025-01-09 | Univerzita Palackeho V Olomouci | Pyrroloquinolines and their use as tubuline assembly inhibitors |
| CN119708407A (zh) * | 2025-02-20 | 2025-03-28 | 吉林创盈科技有限公司 | 一种低voc聚氨酯发泡催化剂及制备工艺 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5216162A (en) | 1992-08-28 | 1993-06-01 | American Home Products Corporation | Substituted pyrrolo[3,2-c]quinolines |
| GB2316072B (en) | 1996-08-05 | 2000-05-10 | Pharmacia Spa | Pyrrolo[3,2-c]quinoline derivatives |
| DZ2376A1 (fr) | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
| CA2301510A1 (en) | 1998-07-02 | 2000-01-13 | Korea Research Institute Of Chemical Technology | 3-alkylpyrrolo[3,2-c]quinoline derivatives |
| GB9819019D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds II |
| US6951881B2 (en) | 2002-05-10 | 2005-10-04 | Wyeth | (1-substituted-indol-3-yl) alkylidenehydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands |
| US7943639B2 (en) * | 2002-06-20 | 2011-05-17 | Proximagen Limited | Compounds |
| MXPA05013822A (es) * | 2003-06-30 | 2006-02-28 | Altana Pharma Ag | Pirrolodihidroisoquinolinas utiles en el tratamiento del cancer. |
| GB0322510D0 (en) | 2003-09-25 | 2003-10-29 | Glaxo Group Ltd | Novel compounds |
| GB0522715D0 (en) * | 2005-11-08 | 2005-12-14 | Helperby Therapeutics Ltd | New use |
| TWI428334B (zh) | 2006-09-22 | 2014-03-01 | Abbvie Bahamas Ltd | 作為５-ｈｔ6拮抗劑之磺醯基吡唑及磺醯基吡唑啉的甲脒衍生物 |
| CA2667857A1 (en) | 2006-10-30 | 2008-05-08 | Biovitrum Ab (Publ) | 8-sulfonyl-1, 3, 4, 8-tetrahydr0-2h- [1, 4] oxazepino [6, 7-e] indole derivatives and their use as 5-ht6 receptor ligands |
| SI2155674T1 (sl) | 2007-05-03 | 2011-10-28 | Suven Life Sciences Ltd | Aminoalkoksi aril sulfonamid spojine in njih uporaba kot 5-ht6 ligandi |
| BRPI0811225A2 (pt) | 2007-05-24 | 2014-10-29 | Memory Pharm Corp | Composto 4'-substituídos tendo afinidade pelo receptor 5-ht6. |
| EP2184990A4 (en) | 2007-08-15 | 2011-10-19 | Memory Pharm Corp | 3'-SUBSTITUTED COMPOUNDS WITH 5-HT6 RECEPTOR AFFINITY |
| UY32111A (es) * | 2008-09-10 | 2010-04-30 | Alcon Res Ltd | Inhibidores heterociclicos de los receptores de histamina para el tratamiento de una enfermedad |
| US8575186B2 (en) | 2009-10-05 | 2013-11-05 | Albany Molecular Research, Inc. | Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof |
-
2013
- 2013-07-25 JP JP2016529738A patent/JP6267334B2/ja not_active Expired - Fee Related
- 2013-07-25 WO PCT/PL2013/000097 patent/WO2015012704A1/en not_active Ceased
- 2013-07-25 SI SI201331078T patent/SI3027613T1/sl unknown
- 2013-07-25 HU HUE13759883A patent/HUE038084T2/hu unknown
- 2013-07-25 HR HRP20180977TT patent/HRP20180977T1/hr unknown
- 2013-07-25 LT LTEP13759883.5T patent/LT3027613T/lt unknown
- 2013-07-25 PT PT137598835T patent/PT3027613T/pt unknown
- 2013-07-25 EP EP13759883.5A patent/EP3027613B1/en not_active Not-in-force
- 2013-07-25 RS RS20180713A patent/RS57379B1/sr unknown
- 2013-07-25 AU AU2013394970A patent/AU2013394970B2/en not_active Ceased
- 2013-07-25 PL PL13759883T patent/PL3027613T3/pl unknown
- 2013-07-25 RU RU2016106096A patent/RU2688161C2/ru not_active IP Right Cessation
- 2013-07-25 BR BR112016001545A patent/BR112016001545A2/pt not_active Application Discontinuation
- 2013-07-25 KR KR1020167004760A patent/KR20160034403A/ko not_active Ceased
- 2013-07-25 DK DK13759883.5T patent/DK3027613T3/en active
- 2013-07-25 MX MX2016001080A patent/MX363632B/es unknown
- 2013-07-25 TR TR2018/08781T patent/TR201808781T4/tr unknown
- 2013-07-25 ES ES13759883.5T patent/ES2674476T3/es active Active
- 2013-07-25 US US14/907,050 patent/US9676772B2/en not_active Expired - Fee Related
- 2013-07-25 CN CN201380078490.0A patent/CN105531272B/zh not_active Expired - Fee Related
- 2013-07-25 CA CA2919147A patent/CA2919147A1/en not_active Abandoned
-
2017
- 2017-05-05 US US15/588,225 patent/US20170239237A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HUE038084T2 (hu) | 2018-09-28 |
| AU2013394970A1 (en) | 2016-03-10 |
| AU2013394970B2 (en) | 2017-11-23 |
| WO2015012704A1 (en) | 2015-01-29 |
| US20160159790A1 (en) | 2016-06-09 |
| JP2016525542A (ja) | 2016-08-25 |
| HRP20180977T1 (hr) | 2018-08-10 |
| PL3027613T3 (pl) | 2018-10-31 |
| MX363632B (es) | 2019-03-29 |
| RU2016106096A (ru) | 2017-08-30 |
| US9676772B2 (en) | 2017-06-13 |
| EP3027613A1 (en) | 2016-06-08 |
| JP6267334B2 (ja) | 2018-01-24 |
| TR201808781T4 (tr) | 2018-07-23 |
| KR20160034403A (ko) | 2016-03-29 |
| US20170239237A1 (en) | 2017-08-24 |
| RU2688161C2 (ru) | 2019-05-20 |
| MX2016001080A (es) | 2016-06-21 |
| EP3027613B1 (en) | 2018-03-28 |
| BR112016001545A2 (pt) | 2017-08-29 |
| PT3027613T (pt) | 2018-07-04 |
| DK3027613T3 (en) | 2018-06-25 |
| CN105531272B (zh) | 2017-12-22 |
| ES2674476T3 (es) | 2018-07-02 |
| CN105531272A (zh) | 2016-04-27 |
| RS57379B1 (sr) | 2018-08-31 |
| LT3027613T (lt) | 2018-07-25 |
| CA2919147A1 (en) | 2015-01-29 |
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