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SI2928868T1 - Piridin-2-amidi, uporabni kot agonisti CB2 - Google Patents

Piridin-2-amidi, uporabni kot agonisti CB2

Info

Publication number
SI2928868T1
SI2928868T1 SI201330793T SI201330793T SI2928868T1 SI 2928868 T1 SI2928868 T1 SI 2928868T1 SI 201330793 T SI201330793 T SI 201330793T SI 201330793 T SI201330793 T SI 201330793T SI 2928868 T1 SI2928868 T1 SI 2928868T1
Authority
SI
Slovenia
Prior art keywords
agonists
pyridine
amides useful
amides
useful
Prior art date
Application number
SI201330793T
Other languages
English (en)
Inventor
Stefanie Bendels
Uwe Grether
Atsushi Kimbara
Matthias Nettekoven
Stephan Roever
Mark Rogers-Evans
Ernst Schaffter
Tanja Schulz-Gasch
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of SI2928868T1 publication Critical patent/SI2928868T1/sl

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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SI201330793T 2012-12-07 2013-12-04 Piridin-2-amidi, uporabni kot agonisti CB2 SI2928868T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12196032 2012-12-07
EP13799544.5A EP2928868B1 (en) 2012-12-07 2013-12-04 Pyridine-2-amides useful as cb2 agonists
PCT/EP2013/075443 WO2014086806A1 (en) 2012-12-07 2013-12-04 Pyridine-2-amides useful as cb2 agonists

Publications (1)

Publication Number Publication Date
SI2928868T1 true SI2928868T1 (sl) 2017-11-30

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SI201330793T SI2928868T1 (sl) 2012-12-07 2013-12-04 Piridin-2-amidi, uporabni kot agonisti CB2

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US (1) US9303012B2 (sl)
EP (1) EP2928868B1 (sl)
JP (1) JP6426619B2 (sl)
KR (1) KR20150091080A (sl)
CN (1) CN104854092B (sl)
AR (1) AR093806A1 (sl)
AU (1) AU2013354114B2 (sl)
BR (1) BR112015009600A2 (sl)
CA (1) CA2885987A1 (sl)
CL (1) CL2015001538A1 (sl)
CR (1) CR20150204A (sl)
DK (1) DK2928868T3 (sl)
EA (1) EA025841B1 (sl)
ES (1) ES2643058T3 (sl)
HR (1) HRP20171445T1 (sl)
IL (1) IL237988A (sl)
LT (1) LT2928868T (sl)
MA (2) MA40308A1 (sl)
MX (1) MX2015007033A (sl)
MY (1) MY182328A (sl)
PE (1) PE20151089A1 (sl)
PH (1) PH12015501073A1 (sl)
PL (1) PL2928868T3 (sl)
PT (1) PT2928868T (sl)
RS (1) RS56423B1 (sl)
SG (1) SG11201504122YA (sl)
SI (1) SI2928868T1 (sl)
TW (1) TWI617551B (sl)
UA (1) UA114655C2 (sl)
WO (1) WO2014086806A1 (sl)
ZA (1) ZA201502872B (sl)

Families Citing this family (16)

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Publication number Priority date Publication date Assignee Title
JP6514119B2 (ja) 2013-03-07 2019-05-15 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 新規ピラゾール誘導体
NO2978755T3 (sl) 2013-03-26 2018-06-02
PE20151977A1 (es) 2013-05-02 2016-01-07 Hoffmann La Roche Nuevos derivados de purina
KR20160002857A (ko) 2013-05-02 2016-01-08 에프. 호프만-라 로슈 아게 CB2 수용체 작용제로서의 피롤로[2,3-d]피리미딘 유도체
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