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SI2994153T1 - Peptidi in konjugati peptid-učinkovina za renalno ciljanje - Google Patents

Peptidi in konjugati peptid-učinkovina za renalno ciljanje

Info

Publication number
SI2994153T1
SI2994153T1 SI201430960T SI201430960T SI2994153T1 SI 2994153 T1 SI2994153 T1 SI 2994153T1 SI 201430960 T SI201430960 T SI 201430960T SI 201430960 T SI201430960 T SI 201430960T SI 2994153 T1 SI2994153 T1 SI 2994153T1
Authority
SI
Slovenia
Prior art keywords
conjugate
targeting
peptides
peptide
active ingredient
Prior art date
Application number
SI201430960T
Other languages
English (en)
Inventor
Armin Kuebelbeck
Gregor Larbig
Stefan Arnold
Walter Mier
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SI2994153T1 publication Critical patent/SI2994153T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/192Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SI201430960T 2013-05-07 2014-04-16 Peptidi in konjugati peptid-učinkovina za renalno ciljanje SI2994153T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13002432 2013-05-07
PCT/EP2014/001026 WO2014180534A1 (de) 2013-05-07 2014-04-16 Peptide und peptid-wirkstoff-konjugate für renales targeting
EP14720485.3A EP2994153B1 (de) 2013-05-07 2014-04-16 Peptide und peptid-wirkstoff-konjugate für renales targeting

Publications (1)

Publication Number Publication Date
SI2994153T1 true SI2994153T1 (sl) 2018-12-31

Family

ID=48325358

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201430960T SI2994153T1 (sl) 2013-05-07 2014-04-16 Peptidi in konjugati peptid-učinkovina za renalno ciljanje

Country Status (12)

Country Link
US (1) US10065993B2 (sl)
EP (1) EP2994153B1 (sl)
JP (1) JP6510494B2 (sl)
CN (1) CN105188728B (sl)
CA (1) CA2911542C (sl)
DK (1) DK2994153T3 (sl)
ES (1) ES2697348T3 (sl)
HR (1) HRP20181882T1 (sl)
HU (1) HUE040491T2 (sl)
LT (1) LT2994153T (sl)
SI (1) SI2994153T1 (sl)
WO (1) WO2014180534A1 (sl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2911478C (en) * 2013-05-07 2023-06-13 Merck Patent Gmbh Conjugates for protection against nephrotoxic active compounds
US11559580B1 (en) 2013-09-17 2023-01-24 Blaze Bioscience, Inc. Tissue-homing peptide conjugates and methods of use thereof
CN105169404B (zh) * 2015-09-02 2018-06-26 上海市普陀区中心医院 一种用于治疗去势抵抗性前列腺癌的靶向前药及其纳米制剂和制备方法
CN108135970B (zh) 2015-09-09 2023-09-01 弗莱德哈钦森癌症中心 软骨归巢肽
WO2017100700A2 (en) * 2015-12-11 2017-06-15 Fred Hutchinson Cancer Research Center Peptides for renal therapy
AU2018210157B2 (en) 2017-01-18 2022-10-06 Fred Hutchinson Cancer Center Peptide compositions and methods of use thereof for disrupting TEAD interactions
EP3595699A4 (en) 2017-03-16 2020-12-23 Blaze Bioscience, Inc. PEPTIDIC CONJUGATES OF CARTILAGE ECOTROPISM AND THEIR METHODS OF USE
CA3064436A1 (en) 2017-06-15 2018-12-20 Blaze Bioscience, Inc. Renal-homing peptide conjugates and methods of use thereof
AU2018388583A1 (en) 2017-12-19 2020-06-11 Blaze Bioscience, Inc. Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof
CN111867615A (zh) * 2018-02-21 2020-10-30 小利兰.斯坦福大学托管委员会 具有次级作用方式的新型抗微生物剂组合物及方法
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections
EP4262880A1 (en) 2020-12-21 2023-10-25 Cornell University Peptide-linked drug delivery system
KR102866913B1 (ko) * 2022-07-05 2025-10-02 한림대학교 산학협력단 화물분자 수송 도메인 sy1, 이를 포함하는 융합 화합물 및 이 융합 화합물을 포함하는 약학 조성물
WO2024118760A1 (en) * 2022-11-29 2024-06-06 Cornell University Peptide-linked drug delivery system
CN116832171B (zh) * 2023-06-05 2024-03-05 中国人民解放军总医院第八医学中心 靶向损伤肾脏组织的外泌体载药系统、构建方法及其应用
WO2025072672A2 (en) 2023-09-27 2025-04-03 Judo Bio, Inc. Slc6a19-targeting modulatory nucleic acid agents
WO2025072699A1 (en) 2023-09-27 2025-04-03 Judo Bio, Inc. Aminoglycosides for delivery of agents to the kidney
WO2025072713A1 (en) 2023-09-27 2025-04-03 Judo Bio, Inc. Polymyxins for delivery of agents to the kidney

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4645661A (en) 1984-06-29 1987-02-24 St. Jude Children's Research Hospital Method for alleviating cisplatin-induced nephrotoxicity and dithiocarbamate compounds for effecting same
CA2265454A1 (en) * 1996-09-09 1998-03-19 Zealand Pharmaceuticals A/S Peptide prodrugs containing an alpha-hydroxyacid linker
EP1950224A3 (en) 1998-03-09 2008-12-17 Zealand Pharma A/S Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
EP1299327A4 (en) * 2000-05-31 2005-03-02 Pestka Biomedical Lab Inc Phosphorylated polypeptides and uses related thereto
US20030135888A1 (en) * 2001-09-26 2003-07-17 Tong Zhu Genes that are modulated by posttranscriptional gene silencing
SI1919947T1 (sl) * 2005-08-26 2013-06-28 Abbvie Inc. Terapevtsko aktivni alfa-msh analogi
DE102007004424A1 (de) 2007-01-23 2008-07-24 Bayer Schering Pharma Aktiengesellschaft Eisenoxid-bindende Peptide
EP2277547A1 (de) 2009-07-20 2011-01-26 Merck Patent GmbH Epsilon-Polylysin-Konjugate und deren Verwendung

Also Published As

Publication number Publication date
HUE040491T2 (hu) 2019-03-28
US10065993B2 (en) 2018-09-04
CA2911542A1 (en) 2014-11-13
CN105188728B (zh) 2021-11-09
CA2911542C (en) 2022-06-07
HRP20181882T1 (hr) 2019-01-11
DK2994153T3 (en) 2018-11-26
JP2016519134A (ja) 2016-06-30
EP2994153B1 (de) 2018-08-15
ES2697348T3 (es) 2019-01-23
EP2994153A1 (de) 2016-03-16
US20160199505A1 (en) 2016-07-14
WO2014180534A1 (de) 2014-11-13
CN105188728A (zh) 2015-12-23
LT2994153T (lt) 2018-11-26
JP6510494B2 (ja) 2019-05-08

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