SI2861223T1 - Sestavki in postopki za transmukozalno absorpcijo - Google Patents

Sestavki in postopki za transmukozalno absorpcijo

Info

Publication number: SI2861223T1
Authority: SI; Slovenia
Prior art keywords: compositions; methods; transmucosal absorption; transmucosal; absorption
Prior art date: 2012-06-15

Application number

SI201332010T

Other languages

English (en)

Inventor

Harry Brittain

Seth Lederman

Giorgio Reiner

Original Assignee

Tonix Pharma Holdings Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-06-15

Filing date

2013-06-14

Publication date

2023-01-31

2013-06-14 Application filed by Tonix Pharma Holdings Limited filed Critical Tonix Pharma Holdings Limited

2023-01-31 Publication of SI2861223T1 publication Critical patent/SI2861223T1/sl

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Inorganic Chemistry (AREA)
Anesthesiology (AREA)
Psychiatry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Saccharide Compounds (AREA)
Pyridine Compounds (AREA)

SI201332010T 2012-06-15 2013-06-14 Sestavki in postopki za transmukozalno absorpcijo SI2861223T1 (sl)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US201261660593P	2012-06-15	2012-06-15
US201261667774P	2012-07-03	2012-07-03
US201261725402P	2012-11-12	2012-11-12
US201361792900P	2013-03-15	2013-03-15
EP13804115.7A EP2861223B1 (en)	2012-06-15	2013-06-14	Compositions and methods for transmucosal absorption
PCT/US2013/046023 WO2013188847A1 (en)	2012-06-15	2013-06-14	Compositions and methods for transmucosal absorption

Publications (1)

Publication Number	Publication Date
SI2861223T1 true SI2861223T1 (sl)	2023-01-31

Family

ID=49758769

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI201332010T SI2861223T1 (sl)	2012-06-15	2013-06-14	Sestavki in postopki za transmukozalno absorpcijo

Country Status (26)

Country	Link
US (1)	US20140171515A1 (sl)
EP (1)	EP2861223B1 (sl)
JP (5)	JP6259452B2 (sl)
CN (2)	CN104684550A (sl)
AR (1)	AR092330A1 (sl)
AU (2)	AU2013274003B2 (sl)
BR (1)	BR112014031394B1 (sl)
CA (2)	CA2876902C (sl)
DK (1)	DK2861223T3 (sl)
ES (1)	ES2929133T3 (sl)
HR (1)	HRP20221325T1 (sl)
HU (1)	HUE060175T2 (sl)
IL (1)	IL236268B (sl)
LT (1)	LT2861223T (sl)
MX (2)	MX2021005317A (sl)
MY (1)	MY194495A (sl)
NZ (2)	NZ631144A (sl)
PL (1)	PL2861223T3 (sl)
PT (1)	PT2861223T (sl)
RS (1)	RS63822B1 (sl)
SG (2)	SG10201605407TA (sl)
SI (1)	SI2861223T1 (sl)
SM (1)	SMT202200436T1 (sl)
TW (3)	TWI590820B (sl)
WO (1)	WO2013188847A1 (sl)
ZA (1)	ZA201500288B (sl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2011062614A1 (en)	2009-11-20	2011-05-26	Tonix Pharmaceuticals, Inc.	Methods and compositions for treating symptoms associated with post-traumatic stress disorder using cyclobenzaprine
US20110319389A1 (en)	2010-06-24	2011-12-29	Tonix Pharmaceuticals, Inc.	Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine
US11998516B2 (en)	2011-03-07	2024-06-04	Tonix Pharma Holdings Limited	Methods and compositions for treating depression using cyclobenzaprine
HRP20200055T1 (hr)	2013-03-15	2020-04-03	Tonix Pharma Holdings Limited	Eutektičke formulacije ciklobenzaprin-klorovodika i manitola
JP6614724B2 (ja) *	2014-09-18	2019-12-04	トニックスファーマホールディングスリミテッド	シクロベンザプリン塩酸塩の共融製剤
US20180207147A1 (en) *	2015-07-15	2018-07-26	Theranexus	Use of amitriptyline for blocking brain hemichannels and method for potentiating its effect in vivo
US12337063B2 (en) *	2016-09-02	2025-06-24	University Of Sharjah	Formulation for atropine sulfate rapidly-disintegrating sublingual tablets
CA3069699A1 (en) *	2017-07-13	2019-01-17	Tonix Pharmaceuticals Holding Corp.	Analogs of cyclobenzaprine and amitryptilene
CN107496355B (zh) *	2017-08-24	2021-04-30	正大制药（青岛）有限公司	一种盐酸环苯扎林舌下喷雾剂及其制备方法
CN107519142B (zh) *	2017-08-24	2021-02-26	正大制药（青岛）有限公司	一种盐酸环苯扎林舌下片及其制备方法
IL275144B2 (en) *	2017-12-08	2024-12-01	Hoffmann La Roche	Pharmaceutical formulation
JP2021505629A (ja)	2017-12-11	2021-02-18	トニックスファーマホールディングスリミテッド	認知症および神経変性状態における興奮、精神病および認知機能低下のためのシクロベンザプリン処置
CN108721240A (zh) *	2018-06-08	2018-11-02	华益药业科技(安徽)有限公司	一种25mg阿米替林薄膜包衣片处方和工艺规程
AU2019323764B2 (en) *	2018-08-20	2025-06-05	Tonix Pharma Holdings Limited	Methods of treating acute stress disorder and posttraumatic stress disorder
CA3156118A1 (en) *	2019-09-30	2021-04-08	Cadila Healthcare Limited	Intranasal pharmaceutical compositions of cyclobenzaprine
US20210315841A1 (en) *	2020-04-08	2021-10-14	Tonix Pharmaceuticals Holding Corp.	Cyclobenzaprine treatment for sexual dysfunction
CN116887830A (zh) *	2020-11-20	2023-10-13	通尼克斯医药控股公司	酒精使用障碍的环苯扎林治疗
CA3204202A1 (en)	2020-12-07	2022-06-16	Tonix Pharmaceuticals Holding Corp.	Cyclobenzaprine treatment for fibromyalgia
WO2022170107A2 (en)	2021-02-04	2022-08-11	Tonix Pharmaceuticals Holding Corp.	An improved method of assessing clinical response in the treatment of ptsd symptoms
EP4412602A1 (en)	2021-10-06	2024-08-14	Tonix Pharmaceuticals Holding Corp.	Cyclobenzaprine for treatment or prevention of sexual dysfunction associated with mental health conditions in female patients
CA3260042A1 (en)	2022-06-21	2023-12-28	TONIX Pharmaceuticals Holding Corp	CYCLOBENZAPRINE TREATMENT FOR POST-ACUTE SEQUELAE OF A (SARS)-COV-2 (PASC) INFECTION
WO2025160302A1 (en)	2024-01-25	2025-07-31	Tonix Pharmaceuticals Holding Corp.	Cyclobenzaprine treatment for acute stress reaction or acute stress disorder

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4968507A (en) *	1984-06-20	1990-11-06	Merck & Co., Inc.	Controlled porosity osmotic pump
US20030077227A1 (en) *	1997-10-01	2003-04-24	Dugger Harry A.	Buccal, polar and non-polar spray or capsule containing drugs for treating disorders of the central nervous system
WO1999018937A1 (en) *	1997-10-16	1999-04-22	Merck & Co., Inc.	New cyclobenzaprine composition
ES2187156T3 (es) *	1998-05-14	2003-05-16	Alza Corp	Terapia antidepresiva.
ES2192156B1 (es)	1999-08-13	2005-02-16	Vela Pharmaceuticals, Inc.	Composiciones de uso para tratar o prevenir alteraciones del sueño usando dosis muy bajas de ciclobenzaprina.
ES2212737B1 (es)	1999-08-13	2005-10-01	Vela Pharmaceuticals Inc.	Ciclobenzaprina para tratar trastornos de ansiedad generalizada y composiciones de la misma.
WO2001089476A1 (en) *	2000-05-19	2001-11-29	Npd Llc	Chewing gums, lozenges, candies, tablets, liquids, and sprays for efficient delivery of medications and dietary supplements
WO2002094229A1 (en) *	2001-05-24	2002-11-28	Alexza Molecular Delivery Corporation	Delivery of muscle relaxants through an inhalation route
US7501113B2 (en) *	2003-02-04	2009-03-10	Philip Morris Usa Inc.	Aerosol formulations and aerosol delivery of buprenorphine
US20090117054A1 (en) *	2005-03-29	2009-05-07	University Of Kentucky Research Foundation	Sublingual spray for the treatment of pain
US20090148532A1 (en) *	2007-12-06	2009-06-11	Venkatesh Gopi M	Preparation of controlled release skeletal muscle relaxant dosage forms
JP2009079060A (ja) *	2008-10-15	2009-04-16	Novadel Pharma Inc	極性または非極性の、バッカルスプレーまたはカプセル
US20100266682A1 (en) *	2008-12-10	2010-10-21	Nipun Davar	Polyethylene glycol-coated sodium carbonate as a pharmaceutical excipient and compositions produced from the same
US20100247586A1 (en) *	2009-03-27	2010-09-30	Andreas Hugerth	Multi-Portion Intra-Oral Dosage Form With Organoleptic Properties
WO2011062614A1 (en) *	2009-11-20	2011-05-26	Tonix Pharmaceuticals, Inc.	Methods and compositions for treating symptoms associated with post-traumatic stress disorder using cyclobenzaprine
US20110319389A1 (en) *	2010-06-24	2011-12-29	Tonix Pharmaceuticals, Inc.	Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine
ITMI20110558A1 (it) *	2011-04-06	2012-10-07	Campiglio Consulting Srl	Composizione farmaceutica contenente ciclobenzaprina adatta alla somministrazione endonasale
HRP20200055T1 (hr) *	2013-03-15	2020-04-03	Tonix Pharma Holdings Limited	Eutektičke formulacije ciklobenzaprin-klorovodika i manitola

2013
- 2013-06-14 US US13/918,692 patent/US20140171515A1/en active Pending
- 2013-06-14 EP EP13804115.7A patent/EP2861223B1/en active Active
- 2013-06-14 JP JP2015517469A patent/JP6259452B2/ja active Active
- 2013-06-14 BR BR112014031394-6A patent/BR112014031394B1/pt active IP Right Grant
- 2013-06-14 MY MYPI2014703784A patent/MY194495A/en unknown
- 2013-06-14 TW TW102121267A patent/TWI590820B/zh active
- 2013-06-14 WO PCT/US2013/046023 patent/WO2013188847A1/en not_active Ceased
- 2013-06-14 TW TW107117266A patent/TWI683660B/zh active
- 2013-06-14 PT PT138041157T patent/PT2861223T/pt unknown
- 2013-06-14 SM SM20220436T patent/SMT202200436T1/it unknown
- 2013-06-14 HU HUE13804115A patent/HUE060175T2/hu unknown
- 2013-06-14 NZ NZ631144A patent/NZ631144A/en unknown
- 2013-06-14 RS RS20221005A patent/RS63822B1/sr unknown
- 2013-06-14 ES ES13804115T patent/ES2929133T3/es active Active
- 2013-06-14 LT LTEPPCT/US2013/046023T patent/LT2861223T/lt unknown
- 2013-06-14 NZ NZ726488A patent/NZ726488A/en unknown
- 2013-06-14 SG SG10201605407TA patent/SG10201605407TA/en unknown
- 2013-06-14 PL PL13804115.7T patent/PL2861223T3/pl unknown
- 2013-06-14 HR HRP20221325TT patent/HRP20221325T1/hr unknown
- 2013-06-14 CA CA2876902A patent/CA2876902C/en active Active
- 2013-06-14 CN CN201380039522.6A patent/CN104684550A/zh active Pending
- 2013-06-14 SI SI201332010T patent/SI2861223T1/sl unknown
- 2013-06-14 AR ARP130102101A patent/AR092330A1/es not_active Application Discontinuation
- 2013-06-14 AU AU2013274003A patent/AU2013274003B2/en active Active
- 2013-06-14 CA CA3118913A patent/CA3118913C/en active Active
- 2013-06-14 MX MX2021005317A patent/MX2021005317A/es unknown
- 2013-06-14 MX MX2014015436A patent/MX382516B/es unknown
- 2013-06-14 TW TW106117185A patent/TWI642429B/zh active
- 2013-06-14 CN CN202010024102.2A patent/CN111388430A/zh active Pending
- 2013-06-14 SG SG11201408318RA patent/SG11201408318RA/en unknown
- 2013-06-14 DK DK13804115.7T patent/DK2861223T3/da active
2014
- 2014-12-15 IL IL236268A patent/IL236268B/en unknown
2015
- 2015-01-15 ZA ZA2015/00288A patent/ZA201500288B/en unknown
2017
- 2017-10-02 JP JP2017192713A patent/JP2017222726A/ja not_active Withdrawn
2018
- 2018-10-04 AU AU2018241128A patent/AU2018241128B2/en active Active
2019
- 2019-05-14 JP JP2019091262A patent/JP2019123757A/ja not_active Withdrawn
2021
- 2021-06-16 JP JP2021100154A patent/JP2021138765A/ja not_active Withdrawn
2024
- 2024-02-02 JP JP2024014696A patent/JP2024032964A/ja active Pending

Also Published As

Publication number	Publication date
WO2013188847A1 (en)	2013-12-19
IL236268A0 (en)	2015-02-26
HUE060175T2 (hu)	2023-02-28
CA2876902A1 (en)	2013-12-19
HK1209361A1 (en)	2016-04-01
JP2024032964A (ja)	2024-03-12
SG11201408318RA (en)	2015-01-29
CA3118913A1 (en)	2013-12-19
MX2014015436A (es)	2015-07-14
PL2861223T3 (pl)	2022-12-12
WO2013188847A8 (en)	2015-02-05
JP6259452B2 (ja)	2018-01-10
AU2018241128B2 (en)	2020-05-21
CA3118913C (en)	2024-04-30
TWI590820B (zh)	2017-07-11
PT2861223T (pt)	2022-11-07
BR112014031394A8 (pt)	2021-11-03
BR112014031394A2 (pt)	2017-06-27
MX2021005317A (es)	2022-12-16
AU2018241128A1 (en)	2018-10-25
SG10201605407TA (en)	2016-08-30
JP2019123757A (ja)	2019-07-25
JP2017222726A (ja)	2017-12-21
JP2021138765A (ja)	2021-09-16
TWI683660B (zh)	2020-02-01
AU2013274003B2 (en)	2018-07-05
HRP20221325T1 (hr)	2022-12-23
TW201408281A (zh)	2014-03-01
BR112014031394B1 (pt)	2022-10-18
SMT202200436T1 (it)	2023-01-13
CN104684550A (zh)	2015-06-03
TW201842903A (zh)	2018-12-16
TW201731494A (zh)	2017-09-16
TWI642429B (zh)	2018-12-01
EP2861223A1 (en)	2015-04-22
IL236268B (en)	2022-03-01
MX382516B (es)	2025-03-13
NZ726488A (en)	2018-10-26
ES2929133T3 (es)	2022-11-25
DK2861223T3 (da)	2022-11-07
EP2861223A4 (en)	2016-01-27
AR092330A1 (es)	2015-04-15
EP2861223B1 (en)	2022-08-03
AU2013274003A1 (en)	2015-02-05
JP2015519404A (ja)	2015-07-09
ZA201500288B (en)	2022-05-25
LT2861223T (lt)	2022-12-12
CN111388430A (zh)	2020-07-10
NZ631144A (en)	2016-12-23
CA2876902C (en)	2021-07-13
RS63822B1 (sr)	2023-01-31
US20140171515A1 (en)	2014-06-19
MY194495A (en)	2022-11-30

Publication	Publication Date	Title
ZA201500288B (en)	2022-05-25	Compositions and methods for transmucosal absorption
EP2922861A4 (en)	2016-09-14	BIOMARKER COMPOSITIONS AND METHODS
EP2823306A4 (en)	2015-11-11	BIOMARKER COMPOSITIONS AND METHODS
ZA201408594B (en)	2015-12-23	Xylitol-based anti-mucosal compositions and related methods and compositions
IL238416A0 (en)	2015-06-30	Preparations and methods for the treatment of diseases caused by protein pathology
GB201318361D0 (en)	2013-12-04	Content protection
GB201200707D0 (en)	2012-02-29	Composition
EP2878295A4 (en)	2015-12-23	COMPOSITION
GB201315350D0 (en)	2013-10-09	Methods and compositions
GB201315347D0 (en)	2013-10-09	Methods and compositions
GB201206035D0 (en)	2012-05-16	Composition
EP2910537A4 (en)	2016-06-29	AGENT COMPOSITION GENERATING GAS
GB201222820D0 (en)	2013-01-30	Woolscouring method and composition
GB201209597D0 (en)	2012-07-11	Composition
GB201208133D0 (en)	2012-06-20	Composition
IL239426A0 (en)	2015-07-30	Methods and compositions of biomarkers
GB201206859D0 (en)	2012-05-30	Method and composition
ZA201500172B (en)	2016-10-26	Plant-disease-control composition and plant-disease-control method
LT2830587T (lt)	2017-09-11	Odą apsauganti ir odos pusiausvyrą palaikanti kompozicija
GB201222736D0 (en)	2013-01-30	Composition and process
GB201210989D0 (en)	2012-08-01	Composition and device
GB201222810D0 (en)	2013-01-30	Woolscouring method and composition
GB201204512D0 (en)	2012-04-25	Method and composition
GB201218322D0 (en)	2012-11-28	Herbal composition
GB201213124D0 (en)	2012-09-05	Herbal composition